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The effects of exposure to microplastics in drinking water on sperm parameters and TNP1 and TNP2 sperm nuclear protein genes Skip to content Yıl 2024, Cilt: 49 Sayı: 2, 320 – 331, 30.06.2024
Harika Topal Önal , Tiinçe Aksak , İzzet Oğuz
https://doi.org/10.17826/cumj.1415350
Öz Amaç: Mikroplastikler, çevresel kirlilik arttıkça önemli bir endişe kaynağı haline gelmiştir. Ancak, mikroplastiklerin içme suyundaki potansiyel etkileri hala yeterince anlaşılamamıştır. Bu çalışma, plastik şişe ve damacana su tüketen erkekler ile şebeke suyu tüketen erkekler arasındaki içme suyundaki mikroplastiklere maruziyeti araştırmayı amaçlamaktadır. Gereç ve Yöntem: Çalışmaya toplamda 100 hasta dahil edildi, bunlardan 50’si sadece şebeke suyu kullanırken 50’si plastik şişe ve damacana suyu kullanmaktaydı. Ayrıca, bu çalışma maruziyetin sperm parametreleri üzerindeki etkisini ve sperm nüklear protein genlerinden Transition Protein 1 geni (TNP1) ve TNP2’nin ekspresyon düzeyleri üzerindeki potansiyel etkileri değerlendirdi. Bulgular: Elde edilen sonuçlara göre, plastik şişe suyu kullananlarda amorf baş anomalisinin, şebeke suyu kullananlara göre belirgin şekilde daha yüksek olduğu saptandı. Ayrıca, plastik şişe kullananlarda bükülmüş kuyruk anomalisi ve kuyruktaki terminal damla anomalisinin de şebeke suyu kullananlara göre anlamlı olarak daha yüksek bulundu. Sonuçlar, içme suyundaki mikroplastiklere maruziyetin erkek sperm parametrelerini etkileyebileceğini ve TNP1 ile TNP2 genlerinin ekspresyonunu değiştirebileceğini göstermektedir. Sonuç: Çalışma plastik şişe ve damacana su tüketenler ile şebeke suyu tüketenler arasında maruziyet düzeylerinde farklılıklar olduğunu ortaya koymuştur.
Anahtar Kelimeler Mikroplastik, plastik şişe, sperm parametreleri, TNP1, TNP2, gen ekspresyonu
Kaynakça Singh S, Li S. Epigenetic effects of environmental chemicals bisphenol A and phthalates. Epigenetics Pathol. 2013;13:267-78. Ho SM, Cheong A, Adgent MA, Veevers J, Suen AA, Tam NN et al. Environmental factors, epigenetics, and developmental origin of reproductive disorders. Reprod Toxicol. 2017;68:85-104. D’Angelo S, Scafuro M, Meccariello R. BPA and nutraceuticals, simultaneous effects on endocrine functions. Endocrine Metab Immune Disord Drug Targets. 2019;19:594-604. Vethaak AD, Legler J. Microplastics and human health. Science. 2021;371:672-4. Yee MSL, Hii LW, Looi CK, Lim WM, Wong SF, Kok YY et al. Impact of microplastics and nanoplastics on human health. Nanomaterials. 2021;11:496. Smith M, Love DC, Rochman CM, Neff RA. Microplastics in seafood and the implications for human health. Curr Environ Health Rep. 2018;5:375-86. Bhuyan MS. Effects of microplastics on fish and in human health. Front Environ Sci. 2022;10:82728. Welle F, Franz R. Microplastic in bottled natural mineral water–literature review and considerations on exposure and risk assessment. Food Addit Contam Part A. 2018;35:2482-92. Önal HT, Ayaz F. Effects of microplastics on the biological systems. Adv Eng Days (AED). 2022;4:36-8. Oßmann BE, Sarau G, Holtmannspötter H, Pischetsrieder M, Christiansen SH, Dicke W. Small-sized microplastics and pigmented particles in bottled mineral water. Water Res. 2018;141:307-16. Danopoulos E, Twiddy M, Rotchell JM. Microplastic contamination of drinking water: A systematic review. PLoS One. 2020;15:e0236838. Amor H, Zeyad A, Hammadeh ME. Tobacco smoking and its impact on the expression level of sperm nuclear protein genes: H2BFWT, TNP1, TNP2, PRM1, and PRM2. Andrologia. 2021;53:e13964. Doorn PF, Campbell PA, Amstutz HC. Metal versus polyethylene wear particles in total hip replacements: a review. Clin Orthop Relat Res (1976-2007). 1996;329:206-16. Kim Y, Jeong J, Lee S, Choi I, Choi J. Identification of adverse outcome pathway related to high-density polyethylene microplastics exposure: Caenorhabditis elegans transcription factor RNAi screening and zebrafish study. J Hazard Mater. 2020;388:121725. Andersson AM, Jørgensen N, Main KM, Toppari J, Meyts ERD, Leffers H et al. Adverse trends in male reproductive health: we may have reached a crucial ‘tipping point’. Int J Androl. 2008;31:74-80. Krausz C, Riera-Escamilla A. Genetics of male infertility. Nat Rev Urol. 2018;15:369-84. Chianese R, Troisi J, Richards S, Scafuro M, Fasano S, Guida M et al. Bisphenol A in reproduction: epigenetic effects. Curr Med Chem. 2018;25:748-70. Chianese R, Viggiano A, Urbanek K, Cappetta D, Troisi J, Scafuro M,et al. Chronic exposure to low doses of bisphenol A impacts the first round of spermatogenesis via SIRT1 modulation. Sci Rep. 2018;8:2961. Li HM, Dai YW, Yu JY, Duan P, Ma XL, Dong WW et al. Comprehensive circRNA/miRNA/mRNA analysis reveals circRNAs protect against toxicity induced by BPA in GC-2 cells. Epigenomics. 2019;11:935-49. Chioccarelli T, Manfrevola F, Migliaccio M, Altucci L, Porreca V, Fasano S et al. Fetal-perinatal exposure to bisphenol-A affects the quality of spermatozoa in adult mice. Int J Endocrinol. 2020;2750501 Radwan M, Wielgomas B, Dziewirska E, Radwan P, Kałużny P, Klimowska A et al. Urinary bisphenol A levels and male fertility. Am J Mens Health. 2018;12:2144-51. Pollard SH, Cox KJ, Blackburn BE, Wilkins DG, Carrell DT, Stanford JB, Porucznik CA. Male exposure to bisphenol A (BPA) and semen quality in the Home Observation of Periconceptional Exposures (HOPE) cohort. Reprod Toxicol. 2019;90:82-7. Omran GA, Gaber HD, Mostafa NAM, Abdel-Gaber RM, Salah EA. Potential hazards of bisphenol A exposure to semen quality and sperm DNA integrity among infertile men. Reprod Toxicol. 2018;81:188-95. Caporossi L, Alteri A, Campo G, Paci E, Tranfo G, Capanna S, et al. Cross-sectional study on exposure to BPA and phthalates and semen parameters in men attending a fertility center. Int J Environ Res Public Health. 2020;17:489. Güneş S, Kulaç T. The role of epigenetics in spermatogenesis. Turk J Urol. 2013;39:181-87. Jodar M, Selvaraju S, Sendler E, Diamond MP, Krawetz SA, Network RM. The presence, role and clinical use of spermatozoal RNAs. Hum Reprod Update. 2013;19:604-24. Sendler E, Johnson GD, Mao S, Goodrich RJ, Diamond MP, Hauser R, Krawetz SA. Stability, delivery, and functions of human sperm RNAs at fertilization. Nucleic Acids Res. 2013;41:4104-17. Meistrich ML, Mohapatra B, Shirley CR, Zhao M. Roles of transition nuclear proteins in spermiogenesis. Chromosoma. 2003;111:483-88. Inhorn MC, Patrizio P. Infertility around the globe: new thinking on gender, reproductive technologies and global movements in the 21st century. Hum Reprod Update. 2015;21:411-26. Jin H, Ma T, Sha X, Liu Z, Zhou Y, Meng X et al. Polystyrene microplastics induced male reproductive toxicity in mice. J Hazard Mater. 2021;401:123430. Almeida S, Rato L, Sousa M, Alves MG, Oliveira PF. Fertility and sperm quality in the aging male. Curr Pharm Des. 2017;23:4429-4437. Paoli D, Pecora G, Pallotti F, Faja F, Pelloni M, Lenzi A, Lombardo F. Cytological and molecular aspects of the aging sperm. Hum Reprod. 2019;34:218-27. Zhao M, Shirley CR, Yu YE, Mohapatra B, Zhang Y, Unni E, et al. Targeted disruption of the transition protein 2 gene affects sperm chromatin structure and reduces fertility in mice. Mol Cell Biol. 2001;21:7243-55. Yu YE, Zhang Y, Unni E, Shirley CR, Deng JM, Russell LD, et al. Abnormal spermatogenesis and reduced fertility in transition nuclear protein 1-deficient mice. Proc Natl Acad Sci USA. 2000;97:4683-88. Amereh F, Babaei M, Eslami A, Fazelipour S, Rafiee M. The emerging risk of exposure to nano (micro) plastics on endocrine disturbance and reproductive toxicity: From a hypothetical scenario to a global public health challenge. Environ Pollut. 2020;261:114158. Deng Y, Yan Z, Shen R, Huang Y, Ren H, Zhang Y. Enhanced reproductive toxicities induced by phthalates contaminated microplastics in male mice (Mus musculus). J Hazard Mater. 2021;406:124644. D’Angelo S, Meccariello R. Microplastics: a threat for male fertility. Int J Environ Res Public Health. 2021;18:2392. Lim CC, Lewis SE, Kennedy M, Donnelly ET, Thompson W. Human sperm morphology and in vitro fertilization: sperm tail defects are prognostic for fertilization failure. Andrologia. 1998;30:43-7. Bianchi PG, Manicardi GC, Urner F, Campana A, Sakkas D. Chromatin packaging and morphology in ejaculated human spermatozoa: evidence of hidden anomalies in normal spermatozoa. MHR Basic Sci Reprod Med. 1996;2:139-44. Hu M, Palić D. Micro-and nano-plastics activation of oxidative and inflammatory adverse outcome pathways. Redox Biol. 2020;37:101620. Menkveld R. Clinical significance of the low normal sperm morphology value as proposed in the fifth edition of the WHO Laboratory Manual for the Examination and Processing of Human Semen. Asian J Androl. 2010;12:47. Chemes HE, Sedo CA. Tales of the tail and sperm headaches to change concepts on the prognostic significance of sperm pathologies affecting the head, neck, and tail. Asian J Androl. 2012;14:14. Nikolettos N, Küpker W, Demirel C, Schöpper B, Blasig C, Sturm R et al. Fertilization potential of spermatozoa with abnormal morphology. Hum Reprod. 1999;14:47-70. Lehti MS, Sironen A. Formation and function of sperm tail structures in association with sperm motility defects. Biol Reprod. 2017;97:522-36. Ding D, Pang MY, Deng M, Nguyen TT, Sun X, Xu Z et al. Testis-specific H2BFWT disrupts nucleosome integrity through reductions of DNA-histone interactions. bioRxiv. 2022; doi:10.1101/2022.07.20.500751
The effects of exposure to microplastics in drinking water on sperm parameters and TNP1 and TNP2 sperm nuclear protein genes Yıl 2024, Cilt: 49 Sayı: 2, 320 – 331, 30.06.2024
Harika Topal Önal , Tiinçe Aksak , İzzet Oğuz
https://doi.org/10.17826/cumj.1415350
Öz Purpose: Microplastics have emerged as a significant concern amid the rise in environmental pollution. Nevertheless, the potential impacts of microplastics present in drinking water on human health remain inadequately understood. This study aims to explore the exposure to microplastics in drinking water among men who consume water from plastic bottles and carboys compared to those who consume tap water. Materials and Methods: A total of 100 patients were included in the study, 50 of whom used only tap water and 50 of whom used plastic bottles and carboys. In addition, this study evaluated the effects of exposure on sperm parameters and potential effects on the expression levels of the sperm nuclear protein genes transition protein 1 gene (TNP1) and TNP2. Results: According to the findings, it was observed that the incidence of amorphous headache anomalies among individuals using plastic bottled water was significantly higher compared to those using tap water. In addition, the coiled tail anomaly and the terminal droplet anomaly in the tail were also observed to be significantly higher in people using plastic bottles compared to those using tap water. The results show that exposure to microplastics in drinking water can affect male sperm parameters and alter the expression of TNP1 and TNP2 genes. Conclusion: It was found that there were differences in exposure levels between those who consumed plastic bottles and carboy water, and those who consumed municipal water.
Anahtar Kelimeler Microplastic;, Plastic bottle, Sperm parametres, TNP1, TNP2, Gene expression
Kaynakça Singh S, Li S. Epigenetic effects of environmental chemicals bisphenol A and phthalates. Epigenetics Pathol. 2013;13:267-78. Ho SM, Cheong A, Adgent MA, Veevers J, Suen AA, Tam NN et al. Environmental factors, epigenetics, and developmental origin of reproductive disorders. Reprod Toxicol. 2017;68:85-104. D’Angelo S, Scafuro M, Meccariello R. BPA and nutraceuticals, simultaneous effects on endocrine functions. Endocrine Metab Immune Disord Drug Targets. 2019;19:594-604. Vethaak AD, Legler J. Microplastics and human health. Science. 2021;371:672-4. Yee MSL, Hii LW, Looi CK, Lim WM, Wong SF, Kok YY et al. Impact of microplastics and nanoplastics on human health. Nanomaterials. 2021;11:496. Smith M, Love DC, Rochman CM, Neff RA. Microplastics in seafood and the implications for human health. Curr Environ Health Rep. 2018;5:375-86. Bhuyan MS. Effects of microplastics on fish and in human health. Front Environ Sci. 2022;10:82728. Welle F, Franz R. Microplastic in bottled natural mineral water–literature review and considerations on exposure and risk assessment. Food Addit Contam Part A. 2018;35:2482-92. Önal HT, Ayaz F. Effects of microplastics on the biological systems. Adv Eng Days (AED). 2022;4:36-8. Oßmann BE, Sarau G, Holtmannspötter H, Pischetsrieder M, Christiansen SH, Dicke W. Small-sized microplastics and pigmented particles in bottled mineral water. Water Res. 2018;141:307-16. Danopoulos E, Twiddy M, Rotchell JM. Microplastic contamination of drinking water: A systematic review. PLoS One. 2020;15:e0236838. Amor H, Zeyad A, Hammadeh ME. Tobacco smoking and its impact on the expression level of sperm nuclear protein genes: H2BFWT, TNP1, TNP2, PRM1, and PRM2. Andrologia. 2021;53:e13964. Doorn PF, Campbell PA, Amstutz HC. Metal versus polyethylene wear particles in total hip replacements: a review. Clin Orthop Relat Res (1976-2007). 1996;329:206-16. Kim Y, Jeong J, Lee S, Choi I, Choi J. Identification of adverse outcome pathway related to high-density polyethylene microplastics exposure: Caenorhabditis elegans transcription factor RNAi screening and zebrafish study. J Hazard Mater. 2020;388:121725. Andersson AM, Jørgensen N, Main KM, Toppari J, Meyts ERD, Leffers H et al. Adverse trends in male reproductive health: we may have reached a crucial ‘tipping point’. Int J Androl. 2008;31:74-80. Krausz C, Riera-Escamilla A. Genetics of male infertility. Nat Rev Urol. 2018;15:369-84. Chianese R, Troisi J, Richards S, Scafuro M, Fasano S, Guida M et al. Bisphenol A in reproduction: epigenetic effects. Curr Med Chem. 2018;25:748-70. Chianese R, Viggiano A, Urbanek K, Cappetta D, Troisi J, Scafuro M,et al. Chronic exposure to low doses of bisphenol A impacts the first round of spermatogenesis via SIRT1 modulation. Sci Rep. 2018;8:2961. Li HM, Dai YW, Yu JY, Duan P, Ma XL, Dong WW et al. Comprehensive circRNA/miRNA/mRNA analysis reveals circRNAs protect against toxicity induced by BPA in GC-2 cells. Epigenomics. 2019;11:935-49. Chioccarelli T, Manfrevola F, Migliaccio M, Altucci L, Porreca V, Fasano S et al. Fetal-perinatal exposure to bisphenol-A affects the quality of spermatozoa in adult mice. Int J Endocrinol. 2020;2750501 Radwan M, Wielgomas B, Dziewirska E, Radwan P, Kałużny P, Klimowska A et al. Urinary bisphenol A levels and male fertility. Am J Mens Health. 2018;12:2144-51. Pollard SH, Cox KJ, Blackburn BE, Wilkins DG, Carrell DT, Stanford JB, Porucznik CA. Male exposure to bisphenol A (BPA) and semen quality in the Home Observation of Periconceptional Exposures (HOPE) cohort. Reprod Toxicol. 2019;90:82-7. Omran GA, Gaber HD, Mostafa NAM, Abdel-Gaber RM, Salah EA. Potential hazards of bisphenol A exposure to semen quality and sperm DNA integrity among infertile men. Reprod Toxicol. 2018;81:188-95. Caporossi L, Alteri A, Campo G, Paci E, Tranfo G, Capanna S, et al. Cross-sectional study on exposure to BPA and phthalates and semen parameters in men attending a fertility center. Int J Environ Res Public Health. 2020;17:489. Güneş S, Kulaç T. The role of epigenetics in spermatogenesis. Turk J Urol. 2013;39:181-87. Jodar M, Selvaraju S, Sendler E, Diamond MP, Krawetz SA, Network RM. The presence, role and clinical use of spermatozoal RNAs. Hum Reprod Update. 2013;19:604-24. Sendler E, Johnson GD, Mao S, Goodrich RJ, Diamond MP, Hauser R, Krawetz SA. Stability, delivery, and functions of human sperm RNAs at fertilization. Nucleic Acids Res. 2013;41:4104-17. Meistrich ML, Mohapatra B, Shirley CR, Zhao M. Roles of transition nuclear proteins in spermiogenesis. Chromosoma. 2003;111:483-88. Inhorn MC, Patrizio P. Infertility around the globe: new thinking on gender, reproductive technologies and global movements in the 21st century. Hum Reprod Update. 2015;21:411-26. Jin H, Ma T, Sha X, Liu Z, Zhou Y, Meng X et al. Polystyrene microplastics induced male reproductive toxicity in mice. J Hazard Mater. 2021;401:123430. Almeida S, Rato L, Sousa M, Alves MG, Oliveira PF. Fertility and sperm quality in the aging male. Curr Pharm Des. 2017;23:4429-4437. Paoli D, Pecora G, Pallotti F, Faja F, Pelloni M, Lenzi A, Lombardo F. Cytological and molecular aspects of the aging sperm. Hum Reprod. 2019;34:218-27. Zhao M, Shirley CR, Yu YE, Mohapatra B, Zhang Y, Unni E, et al. Targeted disruption of the transition protein 2 gene affects sperm chromatin structure and reduces fertility in mice. Mol Cell Biol. 2001;21:7243-55. Yu YE, Zhang Y, Unni E, Shirley CR, Deng JM, Russell LD, et al. Abnormal spermatogenesis and reduced fertility in transition nuclear protein 1-deficient mice. Proc Natl Acad Sci USA. 2000;97:4683-88. Amereh F, Babaei M, Eslami A, Fazelipour S, Rafiee M. The emerging risk of exposure to nano (micro) plastics on endocrine disturbance and reproductive toxicity: From a hypothetical scenario to a global public health challenge. Environ Pollut. 2020;261:114158. Deng Y, Yan Z, Shen R, Huang Y, Ren H, Zhang Y. Enhanced reproductive toxicities induced by phthalates contaminated microplastics in male mice (Mus musculus). J Hazard Mater. 2021;406:124644. D’Angelo S, Meccariello R. Microplastics: a threat for male fertility. Int J Environ Res Public Health. 2021;18:2392. Lim CC, Lewis SE, Kennedy M, Donnelly ET, Thompson W. Human sperm morphology and in vitro fertilization: sperm tail defects are prognostic for fertilization failure. Andrologia. 1998;30:43-7. Bianchi PG, Manicardi GC, Urner F, Campana A, Sakkas D. Chromatin packaging and morphology in ejaculated human spermatozoa: evidence of hidden anomalies in normal spermatozoa. MHR Basic Sci Reprod Med. 1996;2:139-44. Hu M, Palić D. Micro-and nano-plastics activation of oxidative and inflammatory adverse outcome pathways. Redox Biol. 2020;37:101620. Menkveld R. Clinical significance of the low normal sperm morphology value as proposed in the fifth edition of the WHO Laboratory Manual for the Examination and Processing of Human Semen. Asian J Androl. 2010;12:47. Chemes HE, Sedo CA. Tales of the tail and sperm headaches to change concepts on the prognostic significance of sperm pathologies affecting the head, neck, and tail. Asian J Androl. 2012;14:14. Nikolettos N, Küpker W, Demirel C, Schöpper B, Blasig C, Sturm R et al. Fertilization potential of spermatozoa with abnormal morphology. Hum Reprod. 1999;14:47-70. Lehti MS, Sironen A. Formation and function of sperm tail structures in association with sperm motility defects. Biol Reprod. 2017;97:522-36. Ding D, Pang MY, Deng M, Nguyen TT, Sun X, Xu Z et al. Testis-specific H2BFWT disrupts nucleosome integrity through reductions of DNA-histone interactions. bioRxiv. 2022; doi:10.1101/2022.07.20.500751 Toplam 45 adet kaynakça vardır.
Ayrıntılar Birincil Dil İngilizce Konular Tıbbi Genetik (Kanser Genetiği hariç), Üroloji, Histoloji ve Embriyoloji Bölüm Araştırma Yazarlar Harika Topal Önal TOROS ÜNİVERSİTESİ, MESLEK YÜKSEKOKULU, TIBBİ HİZMETLER VE TEKNİKLER BÖLÜMÜ, TIBBİ LABORATUVAR TEKNİKLERİ PR. (ÜCRETLİ) 0000-0002-7466-2942 Türkiye
Tiinçe Aksak TOROS UNIVERSITY 0000-0001-7841-8456 Türkiye
İzzet Oğuz mersin city hostipal 0009-0000-9763-9780 Türkiye
Yayımlanma Tarihi 30 Haziran 2024 Gönderilme Tarihi 5 Ocak 2024 Kabul Tarihi 11 Nisan 2024 Yayımlandığı Sayı Yıl 2024 Cilt: 49 Sayı: 2
Kaynak Göster MLA Topal Önal, Harika vd. “The Effects of Exposure to Microplastics in Drinking Water on Sperm Parameters and TNP1 and TNP2 Sperm Nuclear Protein Genes”. Cukurova Medical Journal, c. 49, sy. 2, 2024, ss. 320-31, doi:10.17826/cumj.1415350.
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