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Investigation of the protective effect of selenium supplementation on renal function in cisplatin-administered rats Skip to content Yıl 2024, Cilt: 49 Sayı: 2, 304 – 313, 30.06.2024
Melek Altunkaya , Gülsüm Abuşoğlu , Bahadir Ozturk
https://doi.org/10.17826/cumj.1400660
Öz Amaç: Selenyum, hücreleri cisplatin kaynaklı toksisitenin önemli bir belirteci olan oksidatif stresten koruma yeteneğine sahip önemli bir antioksidan ve antikarsinojendir. Bu çalışma, böbrek hasarı ile ilişkili kreatinin, nötrofil jelatinaz ile ilişkili lipokalin (NGAL) ve galektin-3’teki değişiklikleri inceleyerek, cisplatin kaynaklı nefrotoksisitede selenyumun serbest radikaller üzerindeki etkisini ortaya çıkarmayı amaçlamıştır. Gereç ve Yöntem: 60 günlük 24 Wistar albino sıçan eşit olarak dört gruba ayrıldı: kontrol, cisplatin, selenyum ve cisplatin+selenyum. Deney, sıçanların doğumundan sonraki 39. günde başladı. Kontrollere intraperitoneal olarak tek doz fizyolojik salin uygulandı. Selenyum ve cisplatin+selenyum gruplarındaki sıçanlara 21 gün boyunca günde 1 mg/kg selenyum gastrik gavaj yoluyla verildi. Cisplatin ve cisplatin+selenyum gruplarındaki sıçanlara 57. günde 7,5 mg/kg cisplatin intraperitoneal olarak uygulandı. Deney, cisplatin uygulamasından üç gün sonra sonlandırıldı. Doku örnekleri selenyum için ICP-MS yöntemi, plazma kreatinin için biyokimyasal yöntem, NGAL ve galektin-3 için ELISA yöntemi kullanılarak analiz edildi. Bulgular: Böbrek dokusu selenyum düzeyleri selenyum takviyesi verilen gruplarda anlamlı derecede yüksekti (kontrol;146.8 ± 10.8 ng/dl, selenyum;520.2 ± 31.2 ng/dl, cisplatin;140 ± 6.4 ng/dl, cisplatin + selenyum; 363.4 ± 33.6 ng/dl (). Plazma kreatinin seviyeleri cisplatin uygulanan gruplarda istatistiksel olarak anlamlı derecede yüksekti (kontrol; 0.33 ± 0.01 mg/dl, selenyum; 0.30 ± 0.01 mg/dl, cisplatin; 0.47 ± 0.02 mg/dl, cisplatin + selenyum; 0.45 ± 0.04). Böbrek dokusunda gruplar arasında NGAL düzeyinde fark bulunmazken, Galectin-3 düzeyinde diğer gruplara göre cisplatin grubunda artış görüldü. Bu artış cisplatin+selenyum grubunda cisplatin grubuna göre daha düşüktü. Kalp dokusu NGAL ve galektin-3 düzeyleri cisplatin grubunda daha yüksekti. Sonuç: Selenyum takviyesinin, kreatinin, NGAL ve galektin-3 seviyelerindeki değişikliklerden de anlaşılacağı üzere cisplatinin neden olduğu nefrotoksisite ve kardiyotoksisite üzerinde iyileştirici bir etkisi olabilir.
Anahtar Kelimeler Böbrek, kalp, cisplatin, selenyum, NGAL, galektin-3
Etik Beyan This study was approved by the Animal Experiments Ethics Committee of Selçuk University Experimental Medicine Application and Research Center with decision number 2023-23, dated April 28, 2023.
Destekleyen Kurum This work was financially supported by the Scientific Research Projects (BAP) Department of Selçuk University (23401079).
Proje Numarası 23401079
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J Nephropathol. 2013;2:129-34. Hu Y-J, Chen Y, Zhang Y-Q, Zhou M-Z, Song X-M, Zhang B-Z et al. The protective role of selenium on the toxicity of cisplatin-contained chemotherapy regimen in cancer patients. Biol Trace Elem Res. 1997;56:331-41. Karavelioglu E, Boyaci MG, Simsek N, Sonmez MA, Koc R, Karademir M et al. Selenium protects cerebral cells by cisplatin induced neurotoxicity. Acta Cir Bras. 2015;30:394-400. Nakahara S, Oka N, Wang Y, Hogan V, Inohara H, Raz A. Characterization of the nuclear import pathways of galectin-3. Canser Res. 2006;66:9995-10006. Lala RI, Lungeanu D, Darabantiu D, Pilat L, Puschita M. Galectin-3 as a marker for clinical prognosis and cardiac remodeling in acute heart failure. Herz. 2018;43:146-55. Mackinnon AC, Tonev D, Jacoby B, Pinzani M, Slack RJ. Galectin-3: therapeutic targeting in liver disease. Expert Opin Ther Targets. 2023;27:779-91. Sanchez-Mas J, Lax A, Asensio-Lopez MC, Fernandez-Del Palacio MJ, Caballero L, Garrido IP et al. Galectin-3 expression in cardiac remodeling after myocardial infarction. Int J Cardiol. 2014;172:e98-101. Blanda V, Bracale UM, Di Taranto MD, Fortunato G. Galectin-3 in cardiovascular diseases. Int J Mol Sci. 2020;21:9232. Sun H, Jiang H, Eliaz A, Kellum JA, Peng Z, Eliaz I. Galectin-3 in septic acute kidney injury: a translational study. J Crit Care. 2021;25:1-11. Supavekin S, Zhang W, Kucherlapati R, Kaskel FJ, Moore LC, Devarajan P. Differential gene expression following early renal ischemia/reperfusion. Kidney Int. 2003;63:1714-24. Cho H, Jung JY, Yoon HK, Yang SM, Lee HJ, Kim WH et al. Serum neutrophil gelatinase-associated lipocalin and lactate level during surgery predict acute kidney injury and early allograft dysfunction after liver transplantation. Sci. Rep. 2023;13:8643. Maisel AS, Katz N, Hillege HL, Shaw A, Zanco P, Bellomo R et al. Biomarkers in kidney and heart disease. Nephrol Dial Transplant. 2011;26:62-74. Mishra J, Mori K, Ma Q, Kelly C, Barasch J, Devarajan P. Neutrophil gelatinase-associated lipocalin: a novel early urinary biomarker for cisplatin nephrotoxicity. Am J Nephrol. 2004;24:307-15. Mori K, Nakao K. Neutrophil gelatinase-associated lipocalin as the real-time indicator of active kidney damage. Kidney Int. 2007;71:967-70. Babur E, Tan B, Süer C, Dursun N. Genç sıçanlarda selenyumun öğrenme ve bellek üzerine etkisi ve Tau ilişkisi. 17. Ulusal Sinirbilim Kongresi. Trabzon. 2019:34-35. Antunes LMG, Darin JDAC, Maria de Lourdes PB. Effects of the antioxidants curcumin or selenium on cisplatin-induced nephrotoxicity and lipid peroxidation in rats. Pharmacol Res. 2001;43:145-50. Kumburovic I, Selakovic D, Juric T, Jovicic N, Mihailovic V, Stankovic JK et al. Antioxidant effects of satureja hortensis l. attenuate the anxiogenic effect of cisplatin in rats. Oxid Med Cell Longev. 2019;2019:8307196. Yildirim Z, Sogut S, Odaci E, Iraz M, Ozyurt H, Kotuk M et al. Oral erdosteine administration attenuates cisplatin-induced renal tubular damage in rats. Pharmacol Res. 2003;47:149-56. Güntürk EE, Yücel B, Güntürk I, Yazıcı C, Kader K. Sisplatin kardiyotoksisitesinde oksidatif ve nitrozatif stresin rolü. Mersin Univ Saglık Bilim Derg. 2020;13:218-26. Stojic IM, Zivkovic VI, Srejovic IM, Nikolic TR, Jeremic NS, Jeremic JN et al. Cisplatin and cisplatin analogues perfusion through isolated rat heart: the effects of acute application on oxidative stress biomarkers. Mol Cell Biochem. 2018;439:19-33. Hakiminia B, Goudarzi A, Moghaddas A. Has vitamin E any shreds of evidence in cisplatin-induced toxicity. J Biochem Mol Toxicol. 2019;33:e22349. Naik AK, Tandan SK, Dudhgaonkar SP, Jadhav SH, Kataria M, Prakash VR et al. Role of oxidative stress in pathophysiology of peripheral neuropathy and modulation by N-acetyl-L-cysteine in rats. Eur J. Pain. 2006;10:573-79. Wang LJ, Zhang HW, Zhou JY, Liu Y, Yang Y, Chen XL et al. Betaine attenuates hepatic steatosis by reducing methylation of the MTTP promoter and elevating genomic methylation in mice fed a high-fat diet. J Nutr Biochem. 2014;25:329-36. Ghorbani A. Renal protective effect of selenium on cisplatin-induced nephrotoxicity. J Renal Inj Prev. 2012;1:31-2. Fraga CG, Arias RF, Llesuy S, Koch OR, Boveris A. Effect of vitamin E-and selenium-deficiency on rat liver chemiluminescence. Biochem J. 1987;242:383-86. Saad SY, Al-Rikabi AC. Protection effects of Taurine supplementation against cisplatin-induced nephrotoxicity in rats. Chemotherapy. 2002;48:42-8. Kawai Y, Taniuchi S, Okahara S, Nakamura M, Gemba M. Relationship between cisplatin or nedaplatin-induced nephrotoxicity and renal accumulation. Biol Pharm Bull. 2005;28:1385-88. El-Sayed E-SM, Abd-Ellah MF, Attia SM. Protective effect of captopril against cisplatin-induced nephrotoxicity in rats. Pak J Pharm Sci. 2008;21:255-61. Yousef M, Saad A, El-Shennawy L. Protective effect of grape seed proanthocyanidin extract against oxidative stress induced by cisplatin in rats. Food Chem Toxicol. 2009;47:1176-83. Ronco C. NGAL: an emerging biomarker of acute kidney injury. Int J Artif Organs. 2008;31:199-200. Florova B, Rajdl D, Racek J, Fiala O, Matejka VM, Trefil L. NGAL, albumin and cystatin C during cisplatin therapy. Physiol Res. 2020;69:307-17. Collins S, Sperling M, Storrow A, Fermann G, Maron D, McPherson J et al. Urinary NGAL levels predict acute kidney injury in emergency department patients with acute heart failure. J Card Fail. 2010;16:29-30. Soni SS, Cruz D, Bobek I, Chionh CY, Nalesso F, Lentini P et al. NGAL: a biomarker of acute kidney injury and other systemic conditions. Int Urol Nephrol. 2010;42:141-50. Haase M, Bellomo R, Devarajan P, Schlattmann P, Haase-Fielitz A. Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis. Am J Kidney Dis. 2009;54:1012-24. Gaspari F, Cravedi P, Mandalà M, Perico N, De Leon FR, Stucchi N et al. Predicting cisplatin-induced acute kidney injury by urinary neutrophil gelatinase-associated lipocalin excretion: a pilot prospective case-control study. Nephron Clin Pract. 2010;115:c154-60. Delanaye P, Rozet E, Krzesinski J-M, Cavalier E. Urinary NGAL measurement: biological variation and ratio to creatinine. Clin Chim Acta. 2011;412:390. Alhaddad OM, Alsebaey A, Amer MO, El-Said HH, Salman TAH. Neutrophil gelatinase-associated lipocalin: a new marker of renal function in C-related end stage liver disease. Gastroenterol Res Pract. . 2015;2015:815484. Palazzuoli A, Beltrami M, Pellegrini M, Nuti R. Natriuretic peptides and NGAL in heart failure: does a link exist? Clin Chim Acta. 2012;413:1832-38. Yndestad A, Landrø L, Ueland T, Dahl CP, Flo TH, Vinge LE et al. Increased systemic and myocardial expression of neutrophil gelatinase-associated lipocalin in clinical and experimental heart failure. Eur Heart J. 2009;30:1229-36. El-Sheikh AAK, Khired Z. Morphine deteriorates cisplatin-ınduced cardiotoxicity in rats and ınduces dose-dependent cisplatin chemoresistance in MCF-7 human breast cancer cells. Cardiovasc Toxicol. 2021;21:553-62. Prud'homme M, Coutrot M, Michel T, Boutin L, Genest M, Poirier F et al. Acute kidney ınjury ınduces remote cardiac damage and dysfunction through the galectin-3 pathway. JACC Basic Transl Sci. 2019;4:717-32. Fernandes Bertocchi AP, Campanhole G, Wang PHM, Gonçalves GM, Damião MJ, Cenedeze MA et al. A role for galectin‐3 in renal tissue damage triggered by ischemia and reperfusion injury. Transpl Int. 2008;21:999-1007. Li H-y, Yang S, Li J-c, Feng J-x. Galectin 3 inhibition attenuates renal injury progression in cisplatin-induced nephrotoxicity. Biosci Rep. 2018;38:BSR20181803. de Boer RA, Yu L, van Veldhuisen DJ. Galectin-3 in cardiac remodeling and heart failure. Curr Heart Fail Rep. 2010;7:1-8. Naziroglu M, Karaoğlu A, Aksoy AO. Selenium and high dose vitamin E administration protects cisplatin-induced oxidative damage to renal, liver and lens tissues in rats. Toxicology. 2004;195:221-30. De Jongh F, Van Veen R, Veltman S, de Wit R, Van der Burg M, Van den Bent M et al. Weekly high-dose cisplatin is a feasible treatment option: analysis on prognostic factors for toxicity in 400 patients. Br J Cancer. 2003;88:1199-206. Hwang D-B, Cha MH, Won D-H, Shin Y-S, Kim S-Y, Kim C et al. Transcriptomic analysis of rat kidney reveals a potential mechanism of sex differences in susceptibility to cisplatin-induced nephrotoxicity. Free Radic Biol Med. 2021;174:100-9. Nematbakhsh M, Ebrahimian S, Tooyserkani M, Eshraghi-Jazi F, Talebi A, Ashrafi F. Gender difference in cisplatin-induced nephrotoxicity in a rat model: greater intensity of damage in male than female. Nephrourol Mon. 2013;5:818-21. Calderone V, Baragatti B, Breschi MC, Nieri P, Martinotti E. Hormonal influence on the release of endothelial nitric oxide: gender‐related dimorphic sensitivity of rat aorta for noradrenaline. J Pharm Pharmacol. 2002;54:523-8. Hayashi T, Ishikawa T, Yamada K, Kuzuya M, Naito M, Hidaka H et al. Biphasic effect of estrogen on neuronal constitutive nitric oxide synthase via Ca2+-calmodulin dependent mechanism. Biochem Biophys Res Commun. 1994;203:1013-9.
Investigation of the protective effect of selenium supplementation on renal function in cisplatin-administered rats Yıl 2024, Cilt: 49 Sayı: 2, 304 – 313, 30.06.2024
Melek Altunkaya , Gülsüm Abuşoğlu , Bahadir Ozturk
https://doi.org/10.17826/cumj.1400660
Öz Purpose: Selenium is an important antioxidant and anticarcinogen with the ability to protect cells from oxidative stress, a significant marker of cisplatin-induced toxicity. This study aimed to reveal the effect of selenium on free radicals in cisplatin-induced nephrotoxicity by examining changes in creatinine, neutrophil gelatinase-associated lipocalin (NGAL), and galectin-3, which are associated with kidney damage. Materials and Methods: Twenty-four Wistar albino rats, aged 60 days, were equally divided into four groups: control, cisplatin, selenium, and cisplatin+selenium. The experiment started on the 39th day after the rats were born. Controls were intraperitoneally administered a single dose of physiological saline. Rats in the selenium and cisplatin+selenium groups were administered 1 mg/kg of selenium by gastric gavage per day for 21 days. The rats in the cisplatin and cisplatin+selenium groups were intraperitoneally administered 7.5 mg/kg of cisplatin on the 57th day. The experiment was terminated 3 days after single-dose administration. Tissue samples were analyzed using the ICP-MS method for selenium, the biochemical method for plasma creatinine, and the ELISA method for NGAL and galectin-3. Results: Kidney tissue selenium levels were significantly higher in the selenium-supplemented groups (control;146.8 ± 10.8 ng/dl, selenium;520.2 ± 31.2 ng/dl, cisplatin;140 ± 6.4 ng/dl; cisplatin + selenium; 363.4 ± 33.6 ng/dl). Plasma creatinine levels were statistically significantly higher in the cisplatin-administered groups (control; 0.32 ± 0.01 mg/dl, selenium; 0.32 ± 0.01 mg/dl, cisplatin; 0.47 ± 0.02 mg/dl; cisplatin + selenium; 0.45 ± 0.04). There was no difference in kidney tissue NGAL levels; however, galectin-3 levels were significantly increased in the cisplatin group compared with the other groups. This increase was lower in the cisplatin+selenium group than in the cisplatin group. Heart tissue NGAL and galectin-3 levels were higher in the cisplatin group. Conclusion: Selenium supplementation may have a healing effect on the nephrotoxicity and cardiotoxicity caused by cisplatin, as indicated by changes in creatinine, NGAL, and galectin-3 levels.
Anahtar Kelimeler kidney, heart, cisplatin, selenium, NGAL, galectin-3
Proje Numarası 23401079
Kaynakça Aldossary SA. Review on pharmacology of cisplatin: clinical use, toxicity and mechanism of resistance of cisplatin. Biomedical and Pharmacology Journal. 2019;12:7-15. Dasari S, Njiki S, Mbemi A, Yedjou CG, Tchounwou PB. Pharmacological effects of cisplatin combination with natural products in cancer chemotherapy. Int J Mol Sci. 2022;23:1532. Sabuncuoğlu Suna ÖH. Sisplatin toksisitesi: oksidatif stresin önemi ve antioksidanların etkisi. J Ist Faculty Med. 2011;74:18-25. Liu S, Wen X, Huang Q, Zhu M, Lu J. Selenium status in diet affects nephrotoxicity ınduced by cisplatin in mice. Antioxidants. 2022;11:1141. Avery JC, Hoffmann PR. Selenium, selenoproteins, and immunity. Nutrients. 2018;10. Murdolo G, Bartolini D, Tortoioli C, Piroddi M, Torquato P, Galli F. Selenium and cancer stem cells. Adv Cancer Res. 2017;136:235-57. Ghorbani A, Omidvar B, Parsi A. Protective effect of selenium on cisplatin induced nephrotoxicity: A double-blind controlled randomized clinical trial. J Nephropathol. 2013;2:129-34. Hu Y-J, Chen Y, Zhang Y-Q, Zhou M-Z, Song X-M, Zhang B-Z et al. The protective role of selenium on the toxicity of cisplatin-contained chemotherapy regimen in cancer patients. Biol Trace Elem Res. 1997;56:331-41. Karavelioglu E, Boyaci MG, Simsek N, Sonmez MA, Koc R, Karademir M et al. Selenium protects cerebral cells by cisplatin induced neurotoxicity. Acta Cir Bras. 2015;30:394-400. Nakahara S, Oka N, Wang Y, Hogan V, Inohara H, Raz A. Characterization of the nuclear import pathways of galectin-3. Canser Res. 2006;66:9995-10006. Lala RI, Lungeanu D, Darabantiu D, Pilat L, Puschita M. Galectin-3 as a marker for clinical prognosis and cardiac remodeling in acute heart failure. Herz. 2018;43:146-55. Mackinnon AC, Tonev D, Jacoby B, Pinzani M, Slack RJ. Galectin-3: therapeutic targeting in liver disease. Expert Opin Ther Targets. 2023;27:779-91. Sanchez-Mas J, Lax A, Asensio-Lopez MC, Fernandez-Del Palacio MJ, Caballero L, Garrido IP et al. Galectin-3 expression in cardiac remodeling after myocardial infarction. Int J Cardiol. 2014;172:e98-101. Blanda V, Bracale UM, Di Taranto MD, Fortunato G. Galectin-3 in cardiovascular diseases. Int J Mol Sci. 2020;21:9232. Sun H, Jiang H, Eliaz A, Kellum JA, Peng Z, Eliaz I. Galectin-3 in septic acute kidney injury: a translational study. J Crit Care. 2021;25:1-11. Supavekin S, Zhang W, Kucherlapati R, Kaskel FJ, Moore LC, Devarajan P. Differential gene expression following early renal ischemia/reperfusion. Kidney Int. 2003;63:1714-24. Cho H, Jung JY, Yoon HK, Yang SM, Lee HJ, Kim WH et al. Serum neutrophil gelatinase-associated lipocalin and lactate level during surgery predict acute kidney injury and early allograft dysfunction after liver transplantation. Sci. Rep. 2023;13:8643. Maisel AS, Katz N, Hillege HL, Shaw A, Zanco P, Bellomo R et al. Biomarkers in kidney and heart disease. Nephrol Dial Transplant. 2011;26:62-74. Mishra J, Mori K, Ma Q, Kelly C, Barasch J, Devarajan P. Neutrophil gelatinase-associated lipocalin: a novel early urinary biomarker for cisplatin nephrotoxicity. Am J Nephrol. 2004;24:307-15. Mori K, Nakao K. Neutrophil gelatinase-associated lipocalin as the real-time indicator of active kidney damage. Kidney Int. 2007;71:967-70. Babur E, Tan B, Süer C, Dursun N. Genç sıçanlarda selenyumun öğrenme ve bellek üzerine etkisi ve Tau ilişkisi. 17. Ulusal Sinirbilim Kongresi. Trabzon. 2019:34-35. Antunes LMG, Darin JDAC, Maria de Lourdes PB. Effects of the antioxidants curcumin or selenium on cisplatin-induced nephrotoxicity and lipid peroxidation in rats. Pharmacol Res. 2001;43:145-50. Kumburovic I, Selakovic D, Juric T, Jovicic N, Mihailovic V, Stankovic JK et al. Antioxidant effects of satureja hortensis l. attenuate the anxiogenic effect of cisplatin in rats. Oxid Med Cell Longev. 2019;2019:8307196. Yildirim Z, Sogut S, Odaci E, Iraz M, Ozyurt H, Kotuk M et al. Oral erdosteine administration attenuates cisplatin-induced renal tubular damage in rats. Pharmacol Res. 2003;47:149-56. Güntürk EE, Yücel B, Güntürk I, Yazıcı C, Kader K. Sisplatin kardiyotoksisitesinde oksidatif ve nitrozatif stresin rolü. Mersin Univ Saglık Bilim Derg. 2020;13:218-26. Stojic IM, Zivkovic VI, Srejovic IM, Nikolic TR, Jeremic NS, Jeremic JN et al. Cisplatin and cisplatin analogues perfusion through isolated rat heart: the effects of acute application on oxidative stress biomarkers. Mol Cell Biochem. 2018;439:19-33. Hakiminia B, Goudarzi A, Moghaddas A. Has vitamin E any shreds of evidence in cisplatin-induced toxicity. J Biochem Mol Toxicol. 2019;33:e22349. Naik AK, Tandan SK, Dudhgaonkar SP, Jadhav SH, Kataria M, Prakash VR et al. Role of oxidative stress in pathophysiology of peripheral neuropathy and modulation by N-acetyl-L-cysteine in rats. Eur J. Pain. 2006;10:573-79. Wang LJ, Zhang HW, Zhou JY, Liu Y, Yang Y, Chen XL et al. Betaine attenuates hepatic steatosis by reducing methylation of the MTTP promoter and elevating genomic methylation in mice fed a high-fat diet. J Nutr Biochem. 2014;25:329-36. Ghorbani A. Renal protective effect of selenium on cisplatin-induced nephrotoxicity. J Renal Inj Prev. 2012;1:31-2. Fraga CG, Arias RF, Llesuy S, Koch OR, Boveris A. Effect of vitamin E-and selenium-deficiency on rat liver chemiluminescence. Biochem J. 1987;242:383-86. Saad SY, Al-Rikabi AC. Protection effects of Taurine supplementation against cisplatin-induced nephrotoxicity in rats. Chemotherapy. 2002;48:42-8. Kawai Y, Taniuchi S, Okahara S, Nakamura M, Gemba M. Relationship between cisplatin or nedaplatin-induced nephrotoxicity and renal accumulation. Biol Pharm Bull. 2005;28:1385-88. El-Sayed E-SM, Abd-Ellah MF, Attia SM. Protective effect of captopril against cisplatin-induced nephrotoxicity in rats. Pak J Pharm Sci. 2008;21:255-61. Yousef M, Saad A, El-Shennawy L. Protective effect of grape seed proanthocyanidin extract against oxidative stress induced by cisplatin in rats. Food Chem Toxicol. 2009;47:1176-83. Ronco C. NGAL: an emerging biomarker of acute kidney injury. Int J Artif Organs. 2008;31:199-200. Florova B, Rajdl D, Racek J, Fiala O, Matejka VM, Trefil L. NGAL, albumin and cystatin C during cisplatin therapy. Physiol Res. 2020;69:307-17. Collins S, Sperling M, Storrow A, Fermann G, Maron D, McPherson J et al. Urinary NGAL levels predict acute kidney injury in emergency department patients with acute heart failure. J Card Fail. 2010;16:29-30. Soni SS, Cruz D, Bobek I, Chionh CY, Nalesso F, Lentini P et al. NGAL: a biomarker of acute kidney injury and other systemic conditions. Int Urol Nephrol. 2010;42:141-50. Haase M, Bellomo R, Devarajan P, Schlattmann P, Haase-Fielitz A. Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis. Am J Kidney Dis. 2009;54:1012-24. Gaspari F, Cravedi P, Mandalà M, Perico N, De Leon FR, Stucchi N et al. Predicting cisplatin-induced acute kidney injury by urinary neutrophil gelatinase-associated lipocalin excretion: a pilot prospective case-control study. Nephron Clin Pract. 2010;115:c154-60. Delanaye P, Rozet E, Krzesinski J-M, Cavalier E. Urinary NGAL measurement: biological variation and ratio to creatinine. Clin Chim Acta. 2011;412:390. Alhaddad OM, Alsebaey A, Amer MO, El-Said HH, Salman TAH. Neutrophil gelatinase-associated lipocalin: a new marker of renal function in C-related end stage liver disease. Gastroenterol Res Pract. . 2015;2015:815484. Palazzuoli A, Beltrami M, Pellegrini M, Nuti R. Natriuretic peptides and NGAL in heart failure: does a link exist? Clin Chim Acta. 2012;413:1832-38. Yndestad A, Landrø L, Ueland T, Dahl CP, Flo TH, Vinge LE et al. Increased systemic and myocardial expression of neutrophil gelatinase-associated lipocalin in clinical and experimental heart failure. Eur Heart J. 2009;30:1229-36. El-Sheikh AAK, Khired Z. Morphine deteriorates cisplatin-ınduced cardiotoxicity in rats and ınduces dose-dependent cisplatin chemoresistance in MCF-7 human breast cancer cells. Cardiovasc Toxicol. 2021;21:553-62. Prud'homme M, Coutrot M, Michel T, Boutin L, Genest M, Poirier F et al. Acute kidney ınjury ınduces remote cardiac damage and dysfunction through the galectin-3 pathway. JACC Basic Transl Sci. 2019;4:717-32. Fernandes Bertocchi AP, Campanhole G, Wang PHM, Gonçalves GM, Damião MJ, Cenedeze MA et al. A role for galectin‐3 in renal tissue damage triggered by ischemia and reperfusion injury. Transpl Int. 2008;21:999-1007. Li H-y, Yang S, Li J-c, Feng J-x. Galectin 3 inhibition attenuates renal injury progression in cisplatin-induced nephrotoxicity. Biosci Rep. 2018;38:BSR20181803. de Boer RA, Yu L, van Veldhuisen DJ. Galectin-3 in cardiac remodeling and heart failure. Curr Heart Fail Rep. 2010;7:1-8. Naziroglu M, Karaoğlu A, Aksoy AO. Selenium and high dose vitamin E administration protects cisplatin-induced oxidative damage to renal, liver and lens tissues in rats. Toxicology. 2004;195:221-30. De Jongh F, Van Veen R, Veltman S, de Wit R, Van der Burg M, Van den Bent M et al. Weekly high-dose cisplatin is a feasible treatment option: analysis on prognostic factors for toxicity in 400 patients. Br J Cancer. 2003;88:1199-206. Hwang D-B, Cha MH, Won D-H, Shin Y-S, Kim S-Y, Kim C et al. Transcriptomic analysis of rat kidney reveals a potential mechanism of sex differences in susceptibility to cisplatin-induced nephrotoxicity. Free Radic Biol Med. 2021;174:100-9. Nematbakhsh M, Ebrahimian S, Tooyserkani M, Eshraghi-Jazi F, Talebi A, Ashrafi F. Gender difference in cisplatin-induced nephrotoxicity in a rat model: greater intensity of damage in male than female. Nephrourol Mon. 2013;5:818-21. Calderone V, Baragatti B, Breschi MC, Nieri P, Martinotti E. Hormonal influence on the release of endothelial nitric oxide: gender‐related dimorphic sensitivity of rat aorta for noradrenaline. J Pharm Pharmacol. 2002;54:523-8. Hayashi T, Ishikawa T, Yamada K, Kuzuya M, Naito M, Hidaka H et al. Biphasic effect of estrogen on neuronal constitutive nitric oxide synthase via Ca2+-calmodulin dependent mechanism. Biochem Biophys Res Commun. 1994;203:1013-9. Toplam 56 adet kaynakça vardır.
Ayrıntılar Birincil Dil İngilizce Konular Tıbbi Biyokimya ve Metabolomik (Diğer) Bölüm Araştırma Yazarlar Melek Altunkaya SELCUK UNIVERSITY 0000-0002-6228-7831 Türkiye
Gülsüm Abuşoğlu SELCUK UNIVERSITY 0000-0003-1630-1257 Türkiye
Bahadir Ozturk SELCUK UNIVERSITY, SCHOOL OF MEDICINE 0000-0003-2654-7621 Türkiye
Proje Numarası 23401079 Yayımlanma Tarihi 30 Haziran 2024 Gönderilme Tarihi 15 Aralık 2023 Kabul Tarihi 30 Nisan 2024 Yayımlandığı Sayı Yıl 2024 Cilt: 49 Sayı: 2
Kaynak Göster MLA Altunkaya, Melek vd. “Investigation of the Protective Effect of Selenium Supplementation on Renal Function in Cisplatin-Administered Rats”. Cukurova Medical Journal, c. 49, sy. 2, 2024, ss. 304-13, doi:10.17826/cumj.1400660.
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