Cytotoxic effect of Eleutherococcus trifoliatus (L.) S.Y. Hu stem bark extracts on Gastric, Lung, and Hepatocellular cancer cells

Yıl 2024, Cilt: 11 Sayı: 3, 551 – 561, 29.08.2024

https://doi.org/10.21448/ijsm.1415631

Öz

Eleutherococcus trifoliatus is a popular medicinal species used in Asian folk medicine with many uses in treating human diseases. Scientific research on this plant has been limited, but some scientific publications have described this herb’s anti-inflammatory, antibacterial, antioxidant, and anti-cancer activities. Although it is a frequently used part of traditional medicine, current scientific evidence on the biological activities of E. trifoliatus stem bark is still lacking. By performing chemical reactions, free radical scavenging experiments, toxicity experiments on brine shrimp, and cytotoxicity tests using MTT dye, the study has shown the diversity in the metabolic composition of E. trifoliatus stem bark as well as the antioxidant capacity and safety of the total extract. The anticancer effect of the total extract was investigated and indicated the dramatical ability to inhibit the cell growth of liver cancer HCC-J5 cells (IC50 = 19.35 ± 4.89 µg/mL), lung cancer cells A549 (IC50 = 5.34 ± 1.62 µg/mL) and gastric cancer cells AGS (IC50 = 0.22 ± 0.20 µg/mL); the selectivity in effects was also observed. The chloroform fraction had the most potential to be further exploited in the direction of inhibiting cancer cells.

Anahtar Kelimeler

Eleutherococcus trifoliatus, Anticancer, HCC-J5, A549, AGS

Proje Numarası

No Application

Kaynakça

  • Ayoola, G., Coker, H., Adesegun, S., Adepoju-Bello, A., Obaweya, K., Ezennia, E., & Atangbayila, T. (2008). Phytochemical Screening and Antioxidant Activities of Some Selected Medicinal Plants Used for Malaria Therapy in Southwestern Nigeria. Tropical Journal of Pharmaceutical Research, 7(3), 7. https://doi.org/10.4314/tjpr.v7i3.14686
  • Baumli, J., Antal, N., Casoni, D., & Cimpoiu, C. (2023). Use of Secondary Metabolites Profiling and Antioxidant Activity to Unravel the Differences between Two Species of Nettle. Plants, 12(18), 3233. https://www.mdpi.com/2223-7747/12/18/3233
  • Blois, M.S. (1958). Antioxidant Determinations by the Use of a Stable Free Radical. Nature, 181(4617), 1199-1200. https://doi.org/10.1038/1811199a0
  • Ciulei, I. (1993). Plante medicinale , fitochimie si fitoterapie. (Vol. II). Editura medicală.
  • Chen, Z., Cheng, S., Lin, H., Wu, W., Liang, L., Chen, X., . . ., Zhang, K. (2021). Antibacterial, anti-inflammatory, analgesic, and hemostatic activities of Acanthopanax trifoliatus (L.) merr. Food Science & Nutrition, 9(4), 2191-2202. https://doi.org/10.1002/fsn3.2190
  • Chien, T.-M., Hsieh, P.-C., Huang, S.-S., Deng, J.-S., Ho, Y.-L., Chang, Y.-S., & Huang, G.-J. (2015). Acanthopanax trifoliatus inhibits lipopolysaccharide-induced inflammatory response in vitro and in vivo. The Kaohsiung Journal of Medical Sciences, 31(10), 499-509. https://doi.org/10.1016/j.kjms.2015.07.007
  • Dedvisitsakul, P., & Watla-Iad, K. (2022). Antioxidant activity and antidiabetic activities of Northern Thai indigenous edible plant extracts and their phytochemical constituents. Heliyon, 8(9), e10740. https://doi.org/10.1016/j.heliyon.2022.e10740
  • Edeoga, H.O., Okwu, D.E. & Mbaebie, B.O. . (2005). Phytochemical constituents of some Nigerian medicinal plants. African Journal of Biotechnology. African Journal of Biotechnology, 4(7), 685-688.
  • Einafshar, E., Mobasheri, L., Hasanpour, M., Rashidi, R., & Ghorbani, A. (2024). Pro-apoptotic effect of chloroform fraction of Moraea sisyrinchium bulb against glioblastoma cells. Biomedicine & Pharmacotherapy, 170, 115931. https://doi.org/10.1016/j.biopha.2023.115931
  • Ferraz, C.A., Pastorinho, M.R., Palmeira-de-Oliveira, A., & Sousa, A.C.A. (2022). Ecotoxicity of plant extracts and essential oils: A review. Environmental Pollution, 292, 118319. https://doi.org/10.1016/j.envpol.2021.118319
  • Ganogpichayagrai, A., & Suksaard, C. (2020). Proximate composition, vitamin and mineral composition, antioxidant capacity, and anticancer activity of Acanthopanax trifoliatus. Journal of Advanced Pharmaceutical Technology & Research, 11(4), 179-183. https://doi.org/10.4103/japtr.JAPTR_61_20
  • Harwig, J., & Scott, P.M. (1971). Brine shrimp (Artemia salina L.) larvae as a screening system for fungal toxins. Applied Microbiology, 21(6), 1011 1016. https://doi.org/10.1128/am.21.6.1011-1016.1971
  • Huyen, P.T., Tap, N.V., Son, L.T., Phuong, N.D., Long, C.H., My, D.V., . . . , Thin, N N. (2006). Nghiên cứu khả năng nhân giống và bảo tồn ngũ gia bì hương và ngũ gia bì gai ở Việt Nam [Research on the possibility of propagating and preserving Eleutherococcus nodiflorus and Eleutherococcus trifoliatus in Vietnam]. Tạp chí Dược liệu, 11(3), 108-113.
  • Indrayanto, G., Putra, G.S., & Suhud, F. (2021). Validation of in-vitro bioassay methods: Application in herbal drug research. Profiles of Drug Substances, Excipients and Related Methodology, 46, 273-307. https://doi.org/10.1016/bs.podrm.2020.07.005
  • Jha, D., Panda, L., Pandian, L., Ramaiah, S., & Anbarasu, A. (2012). Detection and Confirmation of Alkaloids in Leaves of Justicia adhatoda and Bioinformatics Approach to Elicit Its Anti-tuberculosis Activity. Applied Biochemistry and Biotechnology, 168. https://doi.org/10.1007/s12010-012-9834-1
  • Kancheva, V.D., & Kasaikina, O.T. (2013). Bio-antioxidants – a chemical base of their antioxidant activity and beneficial effect on human health. Current Medicinal Chemistry, 20(37), 4784-4805. https://doi.org/10.2174/09298673113209990161
  • Li, D., Li, Z., Yang, J., Hao, Z., Yang, J., & Lin, C. (2021). Protective Effect of Acanthopanax trifoliatus Extract on Rats with Alcoholic Liver Injury. Science and Technology of Food Industry, 42(18), 380-386. https://doi.org/10.13386/j.issn1002-0306.2021010238
  • Li, D.L., Zheng, X., Chen, Y.C., Jiang, S., Zhang, Y., Zhang, W.M., . . . Zhang, K. (2016). Terpenoid composition and the anticancer activity of Acanthopanax trifoliatus. Archives of Pharmacal Research, 39(1), 51-58. https://doi.org/10.1007/s12272-015-0655-y
  • Li, X., Wu, Q., Xie, Y., Ding, Y., Du, W.W., Sdiri, M., & Yang, B.B. (2015). Ergosterol purified from medicinal mushroom Amauroderma rude inhibits cancer growth in vitro and in vivo by up-regulating multiple tumor suppressors. Oncotarget, 6(19), 17832-17846. https://doi.org/10.18632/oncotarget.4026
  • Lin, Y., Pan, J., Liu, Y., Yang, H., Wu, G., & Pan, Y. (2023). Acanthopanax trifoliatus (L.) Merr polysaccharides ameliorates hyperglycemia by regulating hepatic glycogen metabolism in type 2 diabetic mice. Frontiers in Nutrition, 10, 1 13. https://doi.org/10.3389/fnut.2023.1111287 Lobo, V., Patil, A., Phatak, A., & Chandra, N. (2010). Free radicals, antioxidants and functional foods: Impact on human health. Pharmacognosy Reviews, 4(8), 118 126. https://doi.org/10.4103/0973-7847.70902
  • Loi, D.T. (2004). Những cây thuốc và vị thuốc Việt Nam [Vietnamese medicinal plants and herbs] (D.T. Loi, Ed. Vol. 1). Medical publishing house.
  • Ly, B., Quan, N., Dao, L., Nguyen, H., Lam, M., & Hoang, C. (2019). Evaluation of Antimicrobial, Antioxidant and Cytotoxic Activities of Dialium cochinchinensis Seed Extract. Indian Journal of Pharmaceutical Sciences, 81(5), 975 980. https://doi.org/10.36468/pharmaceutical-sciences.594
  • MacWillliam, I.C., & Wenn, R.V. (1972). Interpretation of colour tests for polyphenols and melanoidins. Brewing Industry Research Foundation, Nutfield, Surrey, 78, 309.
  • Muhammed, A., Nakalembe, I., Olila, D., Afodun, A., & Mbugua, R. (2021). Anticancer and Apoptotic Potentials of Gliricidia sepium Leaf Extract on Breast HCC1395, Prostate DU145 and Colorectal CT26 Cell Lines. Journal of Cancer and Tumor International, 11(4), 89-100. https://doi.org/10.9734/jcti/2021/v11i430163
  • Mujeeb, F., Bajpai, P., & Pathak, N. (2014). Phytochemical evaluation, antimicrobial activity, and determination of bioactive components from leaves of Aegle marmelos. BioMed Research International, 2014, 497606. https://doi.org/10.1155/2014/497606
  • Muselli, A., Hoi, T.M., Cu, L.D., Moi, L.D., Bessière, J.-M., Bighelli, A., & Casanova, J. (1999). Composition of the essential oil of Acanthopanax trifoliatus (L.) Merr. (Araliacaea) from Vietnam. Flavour and Fragrance Journal, 14(1), 41 44. https://doi.org/10.1002/(SICI)1099-1026(199901/02)14:1
  • Nath, M.C., Chakravorty, M.K., & Chowdhury, S.R. (1946). Liebermann-Burchard Reaction for Steroids. Nature, 157(3978), 103-104. https://doi.org/https://doi.org/10.1038/157103b0
  • Nogueira, F., & Rosário, V.E.d. (2010). Methods for assessment of antimalarial activity in the different phases of the Plasmodium life cycle. Revista Pan-Amazônica de Saúde, 1, 109-124.
  • Peña-Morán, O.A., Villarreal, M.L., Álvarez-Berber, L., Meneses-Acosta, A., & Rodríguez-López, V. (2016). Cytotoxicity, Post-Treatment Recovery, and Selectivity Analysis of Naturally Occurring Podophyllotoxins from Bursera fagaroides var. fagaroides on Breast Cancer Cell Lines. Molecules, 21(8). https://doi.org/10.3390/molecules21081013
  • Phuong, N.T., Lee, K.A., Jeong, S.J., Fu, C.X., Choi, J.K., Kim, Y.H., & Kang, J.S. (2006). Capillary electrophoretic method for the determination of diterpenoid isomers in Acanthopanax species. Journal of Pharmaceutical and Biomedical Analysis, 40(1), 56-61. https://doi.org/10.1016/j.jpba.2005.05.023
  • Rieser, M.J., Gu, Z.M., Fang, X.P., Zeng, L., Wood, K.V., & McLaughlin, J.L. (1996). Five novel mono-tetrahydrofuran ring acetogenins from the seeds of Annona muricata. Journal of Natural Products, 59(2), 100-108. https://doi.org/10.1021/np960037q
  • Santos Filipe, M., Isca, V.M.S., Ntungwe, N.E., Princiotto, S., Díaz-Lanza, A.M., & Rijo, P. (2022). Lethality Bioassay using Artemia salina L. Journal of Visualized Experiments : JoVE, 2022 Oct 11 (188). https://doi.org/10.3791/64472
  • Sithisarn, P., & Jarikasem, S. (2009). Antioxidant activity of Acanthopanax trifoliatus. Medical Principles and Practice, 18(5), 393-398. https://doi.org/10.1159/000226294
  • Thi, T., Quan, N., Thanh Chi, H., & Ly, B. (2023). An Investigation into the Phytochemical Content, Antibacterial Effect, and Antioxidant Capacity of the Ethanol Extract of Salacca wallichiana Mart. Peels. European Journal of Biology, 82(2), 179 185. https://doi.org/10.26650/EurJBiol.2023.1316545
  • Thu, N.T.B., & Tuan, D.T. (2013). Anti-inflammatory property of Acanthopanax trifoliatus by suppressing the activity of NF- κB on the macrophagocytes Raw 264.7. Tạp chí Dược học, 53(6), 64-67.
  • Wang, H.-C., Tseng, Y.-H., Wu, H.-R., Chu, F.-H., Kuo, Y.-H., & Wang, S.-Y. (2014). Anti-proliferation Effect on Human Breast Cancer Cells via Inhibition of pRb Phosphorylation by Taiwanin E Isolated from Eleutherococcus trifoliatus. Natural Product Communications, 9(9), 1934578X1400900921. https://doi.org/s10.1177/1934578×1400900921
  • Wang, H.Q., Li, D.L., Lu, Y.J., Cui, X.X., Zhou, X.F., Lin, W.P., . . . Zheng, X. (2014). Anticancer activity of Acanthopanax trifoliatus (L) Merr extracts is associated with inhibition of NF-kB activity and decreased Erk1/2 and Akt phosphorylation. Asian Pacific Journal of Cancer Prevention, 15(21), 9341 9346. https://doi.org/10.7314/apjcp.2014.15.21.9341
  • Weerapreeyakul, N., Nonpunya, A., Barusrux, S., Thitimetharoch, T., & Sripanidkulchai, B. (2012). Evaluation of the anticancer potential of six herbs against a hepatoma cell line. Chinese Medicine, 7(1), 15. https://doi.org/10.1186/1749-8546-7-15
  • Wiart, C. (2007). Ethnopharmacology of medicinal plants: Asia and the Pacific. Springer Science & Business Media.
  • Zhang, X., Bai, Y., Wang, Y., Wang, C., Fu, J., Gao, L., . . ., Deng, Y. (2020). Anticancer Properties of Different Solvent Extracts of Cucumis melo L. Seeds and Whole Fruit and Their Metabolite Profiling Using HPLC and GC-MS. BioMed Research International, 2020, 5282949. https://doi.org/10.1155/2020/5282949

Cytotoxic effect of Eleutherococcus trifoliatus (L.) S.Y. Hu stem bark extracts on Gastric, Lung, and Hepatocellular cancer cells

Yıl 2024, Cilt: 11 Sayı: 3, 551 – 561, 29.08.2024

https://doi.org/10.21448/ijsm.1415631

Öz

Eleutherococcus trifoliatus is a popular medicinal species used in Asian folk medicine with many uses in treating human diseases. Scientific research on this plant has been limited, but some scientific publications have described this herb’s anti-inflammatory, antibacterial, antioxidant, and anti-cancer activities. Although it is a frequently used part of traditional medicine, current scientific evidence on the biological activities of E. trifoliatus stem bark is still lacking. By performing chemical reactions, free radical scavenging experiments, toxicity experiments on brine shrimp, and cytotoxicity tests using MTT dye, the study has shown the diversity in the metabolic composition of E. trifoliatus stem bark as well as the antioxidant capacity and safety of the total extract. The anticancer effect of the total extract was investigated and indicated the dramatical ability to inhibit the cell growth of liver cancer HCC-J5 cells (IC50 = 19.35 ± 4.89 µg/mL), lung cancer cells A549 (IC50 = 5.34 ± 1.62 µg/mL) and gastric cancer cells AGS (IC50 = 0.22 ± 0.20 µg/mL); the selectivity in effects was also observed. The chloroform fraction had the most potential to be further exploited in the direction of inhibiting cancer cells.

Anahtar Kelimeler

Eleutherococcus trifoliatus, Anticancer, HCC-J5, A549, AGS

Etik Beyan

The study was conducted on cell lines, and the ethics approval is not application.

Destekleyen Kurum

No application

Proje Numarası

No Application

Teşekkür

No application

Kaynakça

  • Ayoola, G., Coker, H., Adesegun, S., Adepoju-Bello, A., Obaweya, K., Ezennia, E., & Atangbayila, T. (2008). Phytochemical Screening and Antioxidant Activities of Some Selected Medicinal Plants Used for Malaria Therapy in Southwestern Nigeria. Tropical Journal of Pharmaceutical Research, 7(3), 7. https://doi.org/10.4314/tjpr.v7i3.14686
  • Baumli, J., Antal, N., Casoni, D., & Cimpoiu, C. (2023). Use of Secondary Metabolites Profiling and Antioxidant Activity to Unravel the Differences between Two Species of Nettle. Plants, 12(18), 3233. https://www.mdpi.com/2223-7747/12/18/3233
  • Blois, M.S. (1958). Antioxidant Determinations by the Use of a Stable Free Radical. Nature, 181(4617), 1199-1200. https://doi.org/10.1038/1811199a0
  • Ciulei, I. (1993). Plante medicinale , fitochimie si fitoterapie. (Vol. II). Editura medicală.
  • Chen, Z., Cheng, S., Lin, H., Wu, W., Liang, L., Chen, X., . . ., Zhang, K. (2021). Antibacterial, anti-inflammatory, analgesic, and hemostatic activities of Acanthopanax trifoliatus (L.) merr. Food Science & Nutrition, 9(4), 2191-2202. https://doi.org/10.1002/fsn3.2190
  • Chien, T.-M., Hsieh, P.-C., Huang, S.-S., Deng, J.-S., Ho, Y.-L., Chang, Y.-S., & Huang, G.-J. (2015). Acanthopanax trifoliatus inhibits lipopolysaccharide-induced inflammatory response in vitro and in vivo. The Kaohsiung Journal of Medical Sciences, 31(10), 499-509. https://doi.org/10.1016/j.kjms.2015.07.007
  • Dedvisitsakul, P., & Watla-Iad, K. (2022). Antioxidant activity and antidiabetic activities of Northern Thai indigenous edible plant extracts and their phytochemical constituents. Heliyon, 8(9), e10740. https://doi.org/10.1016/j.heliyon.2022.e10740
  • Edeoga, H.O., Okwu, D.E. & Mbaebie, B.O. . (2005). Phytochemical constituents of some Nigerian medicinal plants. African Journal of Biotechnology. African Journal of Biotechnology, 4(7), 685-688.
  • Einafshar, E., Mobasheri, L., Hasanpour, M., Rashidi, R., & Ghorbani, A. (2024). Pro-apoptotic effect of chloroform fraction of Moraea sisyrinchium bulb against glioblastoma cells. Biomedicine & Pharmacotherapy, 170, 115931. https://doi.org/10.1016/j.biopha.2023.115931
  • Ferraz, C.A., Pastorinho, M.R., Palmeira-de-Oliveira, A., & Sousa, A.C.A. (2022). Ecotoxicity of plant extracts and essential oils: A review. Environmental Pollution, 292, 118319. https://doi.org/10.1016/j.envpol.2021.118319
  • Ganogpichayagrai, A., & Suksaard, C. (2020). Proximate composition, vitamin and mineral composition, antioxidant capacity, and anticancer activity of Acanthopanax trifoliatus. Journal of Advanced Pharmaceutical Technology & Research, 11(4), 179-183. https://doi.org/10.4103/japtr.JAPTR_61_20
  • Harwig, J., & Scott, P.M. (1971). Brine shrimp (Artemia salina L.) larvae as a screening system for fungal toxins. Applied Microbiology, 21(6), 1011 1016. https://doi.org/10.1128/am.21.6.1011-1016.1971
  • Huyen, P.T., Tap, N.V., Son, L.T., Phuong, N.D., Long, C.H., My, D.V., . . . , Thin, N N. (2006). Nghiên cứu khả năng nhân giống và bảo tồn ngũ gia bì hương và ngũ gia bì gai ở Việt Nam [Research on the possibility of propagating and preserving Eleutherococcus nodiflorus and Eleutherococcus trifoliatus in Vietnam]. Tạp chí Dược liệu, 11(3), 108-113.
  • Indrayanto, G., Putra, G.S., & Suhud, F. (2021). Validation of in-vitro bioassay methods: Application in herbal drug research. Profiles of Drug Substances, Excipients and Related Methodology, 46, 273-307. https://doi.org/10.1016/bs.podrm.2020.07.005
  • Jha, D., Panda, L., Pandian, L., Ramaiah, S., & Anbarasu, A. (2012). Detection and Confirmation of Alkaloids in Leaves of Justicia adhatoda and Bioinformatics Approach to Elicit Its Anti-tuberculosis Activity. Applied Biochemistry and Biotechnology, 168. https://doi.org/10.1007/s12010-012-9834-1
  • Kancheva, V.D., & Kasaikina, O.T. (2013). Bio-antioxidants – a chemical base of their antioxidant activity and beneficial effect on human health. Current Medicinal Chemistry, 20(37), 4784-4805. https://doi.org/10.2174/09298673113209990161
  • Li, D., Li, Z., Yang, J., Hao, Z., Yang, J., & Lin, C. (2021). Protective Effect of Acanthopanax trifoliatus Extract on Rats with Alcoholic Liver Injury. Science and Technology of Food Industry, 42(18), 380-386. https://doi.org/10.13386/j.issn1002-0306.2021010238
  • Li, D.L., Zheng, X., Chen, Y.C., Jiang, S., Zhang, Y., Zhang, W.M., . . . Zhang, K. (2016). Terpenoid composition and the anticancer activity of Acanthopanax trifoliatus. Archives of Pharmacal Research, 39(1), 51-58. https://doi.org/10.1007/s12272-015-0655-y
  • Li, X., Wu, Q., Xie, Y., Ding, Y., Du, W.W., Sdiri, M., & Yang, B.B. (2015). Ergosterol purified from medicinal mushroom Amauroderma rude inhibits cancer growth in vitro and in vivo by up-regulating multiple tumor suppressors. Oncotarget, 6(19), 17832-17846. https://doi.org/10.18632/oncotarget.4026
  • Lin, Y., Pan, J., Liu, Y., Yang, H., Wu, G., & Pan, Y. (2023). Acanthopanax trifoliatus (L.) Merr polysaccharides ameliorates hyperglycemia by regulating hepatic glycogen metabolism in type 2 diabetic mice. Frontiers in Nutrition, 10, 1 13. https://doi.org/10.3389/fnut.2023.1111287 Lobo, V., Patil, A., Phatak, A., & Chandra, N. (2010). Free radicals, antioxidants and functional foods: Impact on human health. Pharmacognosy Reviews, 4(8), 118 126. https://doi.org/10.4103/0973-7847.70902
  • Loi, D.T. (2004). Những cây thuốc và vị thuốc Việt Nam [Vietnamese medicinal plants and herbs] (D.T. Loi, Ed. Vol. 1). Medical publishing house.
  • Ly, B., Quan, N., Dao, L., Nguyen, H., Lam, M., & Hoang, C. (2019). Evaluation of Antimicrobial, Antioxidant and Cytotoxic Activities of Dialium cochinchinensis Seed Extract. Indian Journal of Pharmaceutical Sciences, 81(5), 975 980. https://doi.org/10.36468/pharmaceutical-sciences.594
  • MacWillliam, I.C., & Wenn, R.V. (1972). Interpretation of colour tests for polyphenols and melanoidins. Brewing Industry Research Foundation, Nutfield, Surrey, 78, 309.
  • Muhammed, A., Nakalembe, I., Olila, D., Afodun, A., & Mbugua, R. (2021). Anticancer and Apoptotic Potentials of Gliricidia sepium Leaf Extract on Breast HCC1395, Prostate DU145 and Colorectal CT26 Cell Lines. Journal of Cancer and Tumor International, 11(4), 89-100. https://doi.org/10.9734/jcti/2021/v11i430163
  • Mujeeb, F., Bajpai, P., & Pathak, N. (2014). Phytochemical evaluation, antimicrobial activity, and determination of bioactive components from leaves of Aegle marmelos. BioMed Research International, 2014, 497606. https://doi.org/10.1155/2014/497606
  • Muselli, A., Hoi, T.M., Cu, L.D., Moi, L.D., Bessière, J.-M., Bighelli, A., & Casanova, J. (1999). Composition of the essential oil of Acanthopanax trifoliatus (L.) Merr. (Araliacaea) from Vietnam. Flavour and Fragrance Journal, 14(1), 41 44. https://doi.org/10.1002/(SICI)1099-1026(199901/02)14:1
  • Nath, M.C., Chakravorty, M.K., & Chowdhury, S.R. (1946). Liebermann-Burchard Reaction for Steroids. Nature, 157(3978), 103-104. https://doi.org/https://doi.org/10.1038/157103b0
  • Nogueira, F., & Rosário, V.E.d. (2010). Methods for assessment of antimalarial activity in the different phases of the Plasmodium life cycle. Revista Pan-Amazônica de Saúde, 1, 109-124.
  • Peña-Morán, O.A., Villarreal, M.L., Álvarez-Berber, L., Meneses-Acosta, A., & Rodríguez-López, V. (2016). Cytotoxicity, Post-Treatment Recovery, and Selectivity Analysis of Naturally Occurring Podophyllotoxins from Bursera fagaroides var. fagaroides on Breast Cancer Cell Lines. Molecules, 21(8). https://doi.org/10.3390/molecules21081013
  • Phuong, N.T., Lee, K.A., Jeong, S.J., Fu, C.X., Choi, J.K., Kim, Y.H., & Kang, J.S. (2006). Capillary electrophoretic method for the determination of diterpenoid isomers in Acanthopanax species. Journal of Pharmaceutical and Biomedical Analysis, 40(1), 56-61. https://doi.org/10.1016/j.jpba.2005.05.023
  • Rieser, M.J., Gu, Z.M., Fang, X.P., Zeng, L., Wood, K.V., & McLaughlin, J.L. (1996). Five novel mono-tetrahydrofuran ring acetogenins from the seeds of Annona muricata. Journal of Natural Products, 59(2), 100-108. https://doi.org/10.1021/np960037q
  • Santos Filipe, M., Isca, V.M.S., Ntungwe, N.E., Princiotto, S., Díaz-Lanza, A.M., & Rijo, P. (2022). Lethality Bioassay using Artemia salina L. Journal of Visualized Experiments : JoVE, 2022 Oct 11 (188). https://doi.org/10.3791/64472
  • Sithisarn, P., & Jarikasem, S. (2009). Antioxidant activity of Acanthopanax trifoliatus. Medical Principles and Practice, 18(5), 393-398. https://doi.org/10.1159/000226294
  • Thi, T., Quan, N., Thanh Chi, H., & Ly, B. (2023). An Investigation into the Phytochemical Content, Antibacterial Effect, and Antioxidant Capacity of the Ethanol Extract of Salacca wallichiana Mart. Peels. European Journal of Biology, 82(2), 179 185. https://doi.org/10.26650/EurJBiol.2023.1316545
  • Thu, N.T.B., & Tuan, D.T. (2013). Anti-inflammatory property of Acanthopanax trifoliatus by suppressing the activity of NF- κB on the macrophagocytes Raw 264.7. Tạp chí Dược học, 53(6), 64-67.
  • Wang, H.-C., Tseng, Y.-H., Wu, H.-R., Chu, F.-H., Kuo, Y.-H., & Wang, S.-Y. (2014). Anti-proliferation Effect on Human Breast Cancer Cells via Inhibition of pRb Phosphorylation by Taiwanin E Isolated from Eleutherococcus trifoliatus. Natural Product Communications, 9(9), 1934578X1400900921. https://doi.org/s10.1177/1934578×1400900921
  • Wang, H.Q., Li, D.L., Lu, Y.J., Cui, X.X., Zhou, X.F., Lin, W.P., . . . Zheng, X. (2014). Anticancer activity of Acanthopanax trifoliatus (L) Merr extracts is associated with inhibition of NF-kB activity and decreased Erk1/2 and Akt phosphorylation. Asian Pacific Journal of Cancer Prevention, 15(21), 9341 9346. https://doi.org/10.7314/apjcp.2014.15.21.9341
  • Weerapreeyakul, N., Nonpunya, A., Barusrux, S., Thitimetharoch, T., & Sripanidkulchai, B. (2012). Evaluation of the anticancer potential of six herbs against a hepatoma cell line. Chinese Medicine, 7(1), 15. https://doi.org/10.1186/1749-8546-7-15
  • Wiart, C. (2007). Ethnopharmacology of medicinal plants: Asia and the Pacific. Springer Science & Business Media.
  • Zhang, X., Bai, Y., Wang, Y., Wang, C., Fu, J., Gao, L., . . ., Deng, Y. (2020). Anticancer Properties of Different Solvent Extracts of Cucumis melo L. Seeds and Whole Fruit and Their Metabolite Profiling Using HPLC and GC-MS. BioMed Research International, 2020, 5282949. https://doi.org/10.1155/2020/5282949

Toplam 40 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Biyokimya ve Hücre Biyolojisi (Diğer)
BölümMakaleler
Yazarlar

Nguyen Quan University of Science, Vietnam National University Ho Chi Minh City 0000-0002-6436-4693 Vietnam

Bui Thi Kim Ly Thu Dau Mot University, Vietnam 0000-0002-8433-7035 Vietnam

Hoang Thanh Chi Thu Dau Mot University 0000-0002-6638-1235 Vietnam

Proje NumarasıNo Application
Erken Görünüm Tarihi6 Ağustos 2024
Yayımlanma Tarihi29 Ağustos 2024
Gönderilme Tarihi6 Ocak 2024
Kabul Tarihi6 Mayıs 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 11 Sayı: 3

Kaynak Göster

APAQuan, N., Ly, B. T. K., & Chi, H. T. (2024). Cytotoxic effect of Eleutherococcus trifoliatus (L.) S.Y. Hu stem bark extracts on Gastric, Lung, and Hepatocellular cancer cells. International Journal of Secondary Metabolite, 11(3), 551-561. https://doi.org/10.21448/ijsm.1415631

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