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Identification and assessment of biological activities of Gymnanthemum amygdalinum (Delile) Sch.Bip. ex Walp. collected from Bongabon, Nueva Ecija Skip to content Yıl 2024, Cilt: 11 Sayı: 2, 220 – 234, 03.06.2024
Shıena Marıe Fermin Dana Theresa De Leon , Rıch Mılton Dulay Jerwin R. Undan , Angeles De Leon
https://doi.org/10.21448/ijsm.1381647
Öz The medicinal potential of plants encompasses a diverse array of compounds with therapeutic applications. These compounds have the potential to contribute to the development of innovative pharmaceuticals that enhance overall health. This study highlights the molecular identification, phytochemical analysis, teratogenic and cytotoxic effects of Gymnanthemum amygdalinum collected from Bongabon, Nueva Ecija. Morphological and molecular identification confirmed the identity of G. amygdalinum having 100 % similarity to their corresponding sequences. Also, G. amygdalinum exhibited secondary metabolites such as essential oils, phenols, sugars, anthraquinones, coumarins, anthrones, tannins, flavonoids, steroids, and alkaloids. The plant extract has teratogenic effects as mortality rate was observed at 1000 and 10,000 ppm, correlated with low hatchability rate at the same concentrations. These findings demonstrated the potential for anticancer, leading to further evaluation of cytotoxicity employing Artemia salina and hepatocellular carcinoma cell lines (HepG2). As a result, G. amygdalinum was found to be moderately toxic in brine shrimp lethality assay with a mortality rate of 10 ppm and higher. Similarly, it is moderately toxic in HepG2 at a median concentration of 1000 ppm and highly toxic at 4000 ppm. Collectively, G. amygdalinum extract exhibits teratogenic and cytotoxic effects and is suitable for further studies at the same or higher concentrations. Accordingly, it is recommended to proceed to the next phase of study for anticancer and antiproliferative. This study provides a scientific foundation for future research, supporting the researchers in uncovering the medicinal potentials of not only G. amygdalinum but other medicinal plants as well.
Anahtar Kelimeler Brine shrimp, Cancer cells, Phytochemical, rbcL, Zebra Fish
Etik Beyan Central Luzon State University, 2023-511
Destekleyen Kurum CENTRAL LUZON STATE UNIVERSITY
Teşekkür The authors would like to thank International Journal of Secondary Metabolite for providing the platform to publish this research. We are grateful for the valuable feedback and support that we will received from the editors and reviewers. Thank you so much.
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Evaluation of antioxidant and cytotoxic properties of Vernonia amygdalina. International Journal of Cell Science & Molecular Biology, 4(4), 81-86. Patnaik, S., & Bhatnagar, S. (2015). Evaluation of Cytotoxic and Antioxidant properties and Phytochemical analysis of Vernonia anthelmentica. Willid. leaf extracts. International Journal of Biosciences and Technology, 8(1), 1. Simpson, M.G. (2019). Plant systematics. Academic Press. Soković, M., Skaltsa, H., & Ferreira, I. C. (2019). bioactive phytochemicals in Asteraceae: structure, function, and biological activity. Frontiers in Plant Science, 10, 1464. Tnh, L.H., Lee, S.L., Tan, A.L., Lee, C.T., Ng, K.K.S., Ng, C.H., & Farhanah, Z.N. (2019). DNA barcode database of common herbal plants in the tropics: a resource for herbal product authentication. Food Control, 95, 318-326. Weigt, S., Huebler, N., Strecker, R., Braunbeck, T., & Broschard, T.H. (2011). Zebrafish (Danio rerio) embryos as a model for testing proteratogens. Toxicology, 281(1-3), 25-36. Wong, F.C., Woo, C.C., Hsu, A., & Tan, B.K.H. (2013). The anti-cancer activities of Vernonia amygdalina extract in human breast cancer cell lines are mediated through caspase-dependent and p53-independent pathways. Plos One, 8(10), e78021. Zhao, Y., Qu, D., & Ma, Y. (2022). Characterization of the chloroplast genome of Argyranthemum frutescens and a comparison with other species in anthemideae. Genes, 13(10), 1720.
Identification and assessment of biological activities of Gymnanthemum amygdalinum (Delile) Sch.Bip. ex Walp. collected from Bongabon, Nueva Ecija Yıl 2024, Cilt: 11 Sayı: 2, 220 – 234, 03.06.2024
Shıena Marıe Fermin Dana Theresa De Leon , Rıch Mılton Dulay Jerwin R. Undan , Angeles De Leon
https://doi.org/10.21448/ijsm.1381647
Öz The medicinal potential of plants encompasses a diverse array of compounds with therapeutic applications. These compounds have the potential to contribute to the development of innovative pharmaceuticals that enhance overall health. This study highlights the molecular identification, phytochemical analysis, teratogenic and cytotoxic effects of Gymnanthemum amygdalinum collected from Bongabon, Nueva Ecija. Morphological and molecular identification confirmed the identity of G. amygdalinum having 100 % similarity to their corresponding sequences. Also, G. amygdalinum exhibited secondary metabolites such as essential oils, phenols, sugars, anthraquinones, coumarins, anthrones, tannins, flavonoids, steroids, and alkaloids. The plant extract has teratogenic effects as mortality rate was observed at 1000 and 10,000 ppm, correlated with low hatchability rate at the same concentrations. These findings demonstrated the potential for anticancer, leading to further evaluation of cytotoxicity employing Artemia salina and hepatocellular carcinoma cell lines (HepG2). As a result, G. amygdalinum was found to be moderately toxic in brine shrimp lethality assay with a mortality rate of 10 ppm and higher. Similarly, it is moderately toxic in HepG2 at a median concentration of 1000 ppm and highly toxic at 4000 ppm. Collectively, G. amygdalinum extract exhibits teratogenic and cytotoxic effects and is suitable for further studies at the same or higher concentrations. Accordingly, it is recommended to proceed to the next phase of study for anticancer and antiproliferative. This study provides a scientific foundation for future research, supporting the researchers in uncovering the medicinal potentials of not only G. amygdalinum but other medicinal plants as well.
Anahtar Kelimeler Brine shrimp, Cancer cells, Phytochemical, rbcL, Zebra Fish
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Toxic and teratogenic assessment of mangosteen (Garcinia mangostana L.) leaves and stem-bark lyophilized water extracts in zebrafish (Danio rerio) embryos. Adv Environ Biol., 10, 96-101. Kha, M., Khan, M., Adil, S.F., & Alkhathlan, H.Z. (2022). Screening of potential cytotoxic activities of some medicinal plants of Saudi Arabia. Saudi Journal of Biological Sciences, 29(3), 1801-1807. Kumar, A.P.N., Kumar, M., Jose, A., Tomer, V., Oz, E., … & Oz, F. (2023). Major phytochemicals: Recent advances in health benefits and extraction method. Molecules, 28(2), 887. McLaughlin, J.L., Rogers, L.L., & Anderson, J.E. (1998). The use of biological assays to evaluate botanicals. Drug Information Journal, 32(2), 513-524. Murray, M.G., & Thompson, W. (1980). Rapid isolation of high molecular weight plant DNA. Nucleic Acids Research, 8(19), 4321-4326. Omede, A., Suleiman, M.S., Atanu, F.O., Momoh, S., Friday, E.T., Sheneni, V.D., & Jegede, E.R. (2018). Evaluation of antioxidant and cytotoxic properties of Vernonia amygdalina. International Journal of Cell Science & Molecular Biology, 4(4), 81-86. Patnaik, S., & Bhatnagar, S. (2015). Evaluation of Cytotoxic and Antioxidant properties and Phytochemical analysis of Vernonia anthelmentica. Willid. leaf extracts. International Journal of Biosciences and Technology, 8(1), 1. Simpson, M.G. (2019). Plant systematics. Academic Press. Soković, M., Skaltsa, H., & Ferreira, I. C. (2019). bioactive phytochemicals in Asteraceae: structure, function, and biological activity. Frontiers in Plant Science, 10, 1464. Tnh, L.H., Lee, S.L., Tan, A.L., Lee, C.T., Ng, K.K.S., Ng, C.H., & Farhanah, Z.N. (2019). DNA barcode database of common herbal plants in the tropics: a resource for herbal product authentication. Food Control, 95, 318-326. Weigt, S., Huebler, N., Strecker, R., Braunbeck, T., & Broschard, T.H. (2011). Zebrafish (Danio rerio) embryos as a model for testing proteratogens. Toxicology, 281(1-3), 25-36. Wong, F.C., Woo, C.C., Hsu, A., & Tan, B.K.H. (2013). The anti-cancer activities of Vernonia amygdalina extract in human breast cancer cell lines are mediated through caspase-dependent and p53-independent pathways. Plos One, 8(10), e78021. Zhao, Y., Qu, D., & Ma, Y. (2022). Characterization of the chloroplast genome of Argyranthemum frutescens and a comparison with other species in anthemideae. Genes, 13(10), 1720. Toplam 35 adet kaynakça vardır.
Ayrıntılar Birincil Dil İngilizce Konular Bitki Biyoteknolojisi Bölüm Makaleler Yazarlar Shıena Marıe Fermin CENTRAL LUZON STATE UNIVERSITY 0000-0001-7497-6119 Philippines
Dana Theresa De Leon Central Luzon State University 0000-0001-6109-1530 Philippines
Rıch Mılton Dulay CENTRAL LUZON STATE UNIVERSITY 0000-0002-5438-878X Philippines
Jerwin R. Undan Central Luzon State University 0000-0002-3657-1732 Philippines
Angeles De Leon Central Luzon State University 0000-0002-4954-8427 Philippines
Erken Görünüm Tarihi 22 Nisan 2024 Yayımlanma Tarihi 3 Haziran 2024 Gönderilme Tarihi 26 Ekim 2023 Kabul Tarihi 26 Ocak 2024 Yayımlandığı Sayı Yıl 2024 Cilt: 11 Sayı: 2
Kaynak Göster APA Fermin, S. M., De Leon, D. T., Dulay, R. M., Undan, J. R., vd. (2024). Identification and assessment of biological activities of Gymnanthemum amygdalinum (Delile) Sch.Bip. ex Walp. collected from Bongabon, Nueva Ecija. International Journal of Secondary Metabolite, 11(2), 220-234. https://doi.org/10.21448/ijsm.1381647
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