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Investigation of Sterol structures and biological activities in Cochineal and Hibiscus sabdariffa extracts Skip to content Yıl 2024, Cilt: 11 Sayı: 2, 266 – 276, 03.06.2024
Dilek Bahar , Nilgün Kuşçulu , Mehmet Çadır
https://doi.org/10.21448/ijsm.1335924
Öz In the future, it is necessary to discover natural resources with no or less toxicity and side effects instead of synthetic drugs. Therefore, it is crucial to recognize, isolate, measure, and reveal the biological activities of substances in the structure of natural resources. In this study, the two extracts prepared from the plant (Hibiscus sabdariffa) and the insect (Dactylopius coccus) were examined. Sampling of the released substances was performed using Gas-Chromatography-Mass Spectrometry (GC-MS). In addition, viability, apoptosis, and oxidative stress of the derivatized samples were determined. Due to the biological differences between the samples, the chemical structures observed in the GC-MS analysis were not the same. It was observed that stigmasterol and its derivatives were found in the pomegranate sample, whereas naphthol and its derivatives were more abundant in the Cochineal insect sample. The cell viability increased with increasing concentrations of stigmasterol, which is present in large amounts in the structure of the pomegranate flower. However, the cell viability decreased with the Cochineal insect sample. Apoptosis and oxidative stress test results were also found to be different and contrasted for both samples. Therefore, the present study presents a new, natural, and different source that can be used as an antiviral and anticancer agent.
Anahtar Kelimeler Cochineal, Naphthol, Sterol structure, Cell culture, Cell viability
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Journal of Agricultural and Food Chemistry, 50(24), 6968-6974. https://doi.org/10.1021/jf025756r González, E.A., García, E.M., & Nazareno, M.A. (2010). Free radical scavenging capacity and antioxidant activity of cochineal (Dactylopius coccus C.) extracts. Food Chemistry, 119(1), 358-362. https://doi.org/10.1016/j.foodchem.2009.06.030 Guo, Y.H., Ma, L.Y., Zheng, H., Zhang, H., Gan, J., Li, K. (2010). Free radical scavenging capacity of carminic acid. Food Science, 31, 73-76. Hsu, H.J., Huang, R.F., Kao, T.H., Inbaraj, B.S., & Chen, B.H. (2017). Preparation of carotenoid extracts and nanoemulsions from Lycium barbarum L. and their effects on growth of HT 29 colon cancer cells. Nanotechnology, 28(13), 135103. https://doi.org/10.1088/1361-6528/aa5e86 Kim, E.J., Lee, Y.J., Shin, H.K., & Park, J.H.Y. (2005). Induction of apoptosis by the aqueous extract of Rubus coreanum in HT-29 human colon cancer cells. Nutrition, 21(11-12), 1141-1148. https://doi.org/10.1016/j.nut.2005.02.012 Kumar, D., Kumar, S., & Shekhar, C. (2020). Nutritional components in green leafy vegetables: A review. Journal of Pharmacognosy and Phytochemistry, 9(5), 2498-2502. Li, C., & Wang, M.H. (2013). Aristolochia debilis Sieb. et Zucc. induces apoptosis and reactive oxygen species in the HT-29 human colon cancer cell line. Cancer Biotherapy and Radiopharmaceuticals, 28(10), 717-724. https://doi.org/10.1089/cbr.2013.1486 Li, Q., Xu, Q., Tan, J., Hu, L., Ge, C., Xu, M. (2021). Carminic acid supplementation protects against fructose-induced kidney injury mainly through suppressing inflammation and oxidative stress via improving Nrf-2 signaling. Aging (Albany NY), 13(7), 10326. https://doi.org/10.18632/aging.202794 Mármol, I., Sánchez-de-Diego, C., Pradilla Dieste, A., Cerrada, E., & Rodriguez Yoldi, M.J. (2017). Colorectal carcinoma: a general overview and future perspectives in colorectal cancer. International Journal of Molecular Sciences, 18(1), 197. https://doi.org/10.3390/ijms18010197 Mata, R., Nakkala, J.R., & Sadras, S.R. (2016). Polyphenol stabilized colloidal gold nanoparticles from Abutilon indicum leaf extract induce apoptosis in HT-29 colon cancer cells. Colloids and Surfaces B: Biointerfaces, 143, 499 510. https://doi.org/10.1016/j.colsurfb.2016.03.069 Nallar, M., Tenaglia, N., Morose, G., & Wong, H.W. (2021). Safer solvent blends for food, dye, and environmental analyses using reversed-phase high performance liquid chromatography. Chromatographia, 84(8), 769-780. https://doi.org/10.1007/s10337-021-04061-8 Nemeikaitė-Čėnienė, A., Sergedienė, E., Nivinskas, H., & Čėnas, N. (2002). Cytotoxicity of natural hydroxyanthraquinones: Role of oxidative stress. Zeitschrift für Naturforschung C, 57(9-10), 822-827. https://doi.org/10.1515/znc-2002-9-1012 Nguyen, C., Baskaran, K., Pupulin, A., Ruvinov, I., Zaitoon, O., Grewal, S., & Pandey, S. (2019). Hibiscus flower extract selectively induces apoptosis in breast cancer cells and positively interacts with common chemotherapeutics. BMC Complementary and Alternative Medicine, 19(1), 1-14. https://doi.org/10.1186/s12906-019-2505-9 Obeng, E. (2020). Apoptosis (programmed cell death) and its signals-A review. Brazilian Journal of Biology, 81, 1133-1143. https://doi.org/10.1590/1519-6984.228437 Ogunyemi, O.M., Gyebi, G.A., Elfiky, A.A., Afolabi, S.O., Ogunro, O.B., Adegunloye, A.P., & Ibrahim, I.M. (2020). Alkaloids and flavonoids from African phytochemicals as potential inhibitors of SARS-Cov-2 RNA-dependent RNA polymerase: an in silico perspective. Antiviral Chemistry and Chemotherapy, 28. https://doi.org/10.1177/2040206620984076 Rouhollahi, E., Zorofchian Moghadamtousi, S., Paydar, M., Fadaeinasab, M., Zahedifard, M., Hajrezaie, M., Mohamed, Z. (2015). Inhibitory effect of Curcuma purpurascens BI. rhizome on HT-29 colon cancer cells through mitochondrial-dependent apoptosis pathway. BMC Complementary and Alternative Medicine, 15(1), 1-12. https://doi.org/10.1186/s12906-015-0534-6 Saxena, S., Raja, A.S.M. (2014). Natural dyes: sources, chemistry, application and sustainability issues. Muthu, S. S. (Ed), Roadmap to sustainable textiles and clothing: eco-friendly raw materials, technologies, and processing methods (pp. 37-80). Singapore: Springer Singapore. Serrano, A., Sousa, M.M., Hallett, J., Lopes, J.A., Oliveira, M.C. (2011). Analysis of natural red dyes (cochineal) in textiles of historical importance using HPLC and multivariate data analysis. Analytical and Bioanalytical Chemistry, 401, 735 743. https://pubmed.ncbi.nlm.nih.gov/21626194/ Singh R. (2017) Sources of natural nye – A critical review. International Journal of Engineering, Science and Mathematics, 6(5), 180-185. Srinivas, G., Anto, R.J., Srinivas, P., Vidhyalakshmi, S., Senan, V.P., & Karunagaran, D. (2003). Emodin induces apoptosis of human cervical cancer cells through poly (ADP-ribose) polymerase cleavage and activation of caspase-9. European Journal of Pharmacology, 473(2-3), 117-125. https://doi.org/10.1016/s0014-2999(03)01976-9 Sunkara, R., Shackelford, L., Walker, L., & Verghese, M. (2015). Inhibition of chemically-induced colon cancer by dietary treatment of Hibiscus sabdariffa L. Dried Calyx in rats. Food and Nutrition Sciences, 6(12), 1174. https://doi.org/ 10.4236/fns.2015.612123 Telford, W.G., King, L.E., & Fraker, P.J. (1992). Comparative evaluation of several DNA binding dyes in the detection of apoptosis‐associated chromatin degradation by flow cytometry. Cytometry: The Journal of the International Society for Analytical Cytology, 13(2), 137-143. https://doi.org/10.1002/cyto.990130205 Yousaf, M.M., Majeed, M., Hussain, M., Shah, M.J., Ahmad, B., Ghazali, H.M.Z.U., & Muhammad, R.W. (2018). Calcium alginate entrapment of Aspergillus nidulans IMPP-0785 laccase for enhanced enzyme catalytic ability, thermost ability and dye-decolorization. Bangladesh Journal of Botany, 47(4), 903-909. https://doi.org/10.3329/bjb.v47i4.47380
Investigation of Sterol structures and biological activities in Cochineal and Hibiscus sabdariffa extracts Yıl 2024, Cilt: 11 Sayı: 2, 266 – 276, 03.06.2024
Dilek Bahar , Nilgün Kuşçulu , Mehmet Çadır
https://doi.org/10.21448/ijsm.1335924
Öz In the future, it is necessary to discover natural resources with no or less toxicity and side effects instead of synthetic drugs. Therefore, it is crucial to recognize, isolate, measure, and reveal the biological activities of substances in the structure of natural resources. In this study, the two extracts prepared from the plant (Hibiscus sabdariffa) and the insect (Dactylopius coccus) were examined. Sampling of the released substances was performed using Gas-Chromatography-Mass Spectrometry (GC-MS). In addition, viability, apoptosis, and oxidative stress of the derivatized samples were determined. Due to the biological differences between the samples, the chemical structures observed in the GC-MS analysis were not the same. It was observed that stigmasterol and its derivatives were found in the pomegranate sample, whereas naphthol and its derivatives were more abundant in the Cochineal insect sample. The cell viability increased with increasing concentrations of stigmasterol, which is present in large amounts in the structure of the pomegranate flower. However, the cell viability decreased with the Cochineal insect sample. Apoptosis and oxidative stress test results were also found to be different and contrasted for both samples. Therefore, the present study presents a new, natural, and different source that can be used as an antiviral and anticancer agent.
Anahtar Kelimeler Cochineal, Naphthol, Sterol structure, Cell culture, Cell viability
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Journal of Agricultural and Food Chemistry, 50(24), 6968-6974. https://doi.org/10.1021/jf025756r González, E.A., García, E.M., & Nazareno, M.A. (2010). Free radical scavenging capacity and antioxidant activity of cochineal (Dactylopius coccus C.) extracts. Food Chemistry, 119(1), 358-362. https://doi.org/10.1016/j.foodchem.2009.06.030 Guo, Y.H., Ma, L.Y., Zheng, H., Zhang, H., Gan, J., Li, K. (2010). Free radical scavenging capacity of carminic acid. Food Science, 31, 73-76. Hsu, H.J., Huang, R.F., Kao, T.H., Inbaraj, B.S., & Chen, B.H. (2017). Preparation of carotenoid extracts and nanoemulsions from Lycium barbarum L. and their effects on growth of HT 29 colon cancer cells. Nanotechnology, 28(13), 135103. https://doi.org/10.1088/1361-6528/aa5e86 Kim, E.J., Lee, Y.J., Shin, H.K., & Park, J.H.Y. (2005). Induction of apoptosis by the aqueous extract of Rubus coreanum in HT-29 human colon cancer cells. Nutrition, 21(11-12), 1141-1148. https://doi.org/10.1016/j.nut.2005.02.012 Kumar, D., Kumar, S., & Shekhar, C. (2020). Nutritional components in green leafy vegetables: A review. Journal of Pharmacognosy and Phytochemistry, 9(5), 2498-2502. Li, C., & Wang, M.H. (2013). Aristolochia debilis Sieb. et Zucc. induces apoptosis and reactive oxygen species in the HT-29 human colon cancer cell line. Cancer Biotherapy and Radiopharmaceuticals, 28(10), 717-724. https://doi.org/10.1089/cbr.2013.1486 Li, Q., Xu, Q., Tan, J., Hu, L., Ge, C., Xu, M. (2021). Carminic acid supplementation protects against fructose-induced kidney injury mainly through suppressing inflammation and oxidative stress via improving Nrf-2 signaling. Aging (Albany NY), 13(7), 10326. https://doi.org/10.18632/aging.202794 Mármol, I., Sánchez-de-Diego, C., Pradilla Dieste, A., Cerrada, E., & Rodriguez Yoldi, M.J. (2017). Colorectal carcinoma: a general overview and future perspectives in colorectal cancer. International Journal of Molecular Sciences, 18(1), 197. https://doi.org/10.3390/ijms18010197 Mata, R., Nakkala, J.R., & Sadras, S.R. (2016). Polyphenol stabilized colloidal gold nanoparticles from Abutilon indicum leaf extract induce apoptosis in HT-29 colon cancer cells. Colloids and Surfaces B: Biointerfaces, 143, 499 510. https://doi.org/10.1016/j.colsurfb.2016.03.069 Nallar, M., Tenaglia, N., Morose, G., & Wong, H.W. (2021). Safer solvent blends for food, dye, and environmental analyses using reversed-phase high performance liquid chromatography. Chromatographia, 84(8), 769-780. https://doi.org/10.1007/s10337-021-04061-8 Nemeikaitė-Čėnienė, A., Sergedienė, E., Nivinskas, H., & Čėnas, N. (2002). Cytotoxicity of natural hydroxyanthraquinones: Role of oxidative stress. Zeitschrift für Naturforschung C, 57(9-10), 822-827. https://doi.org/10.1515/znc-2002-9-1012 Nguyen, C., Baskaran, K., Pupulin, A., Ruvinov, I., Zaitoon, O., Grewal, S., & Pandey, S. (2019). Hibiscus flower extract selectively induces apoptosis in breast cancer cells and positively interacts with common chemotherapeutics. BMC Complementary and Alternative Medicine, 19(1), 1-14. https://doi.org/10.1186/s12906-019-2505-9 Obeng, E. (2020). Apoptosis (programmed cell death) and its signals-A review. Brazilian Journal of Biology, 81, 1133-1143. https://doi.org/10.1590/1519-6984.228437 Ogunyemi, O.M., Gyebi, G.A., Elfiky, A.A., Afolabi, S.O., Ogunro, O.B., Adegunloye, A.P., & Ibrahim, I.M. (2020). Alkaloids and flavonoids from African phytochemicals as potential inhibitors of SARS-Cov-2 RNA-dependent RNA polymerase: an in silico perspective. Antiviral Chemistry and Chemotherapy, 28. https://doi.org/10.1177/2040206620984076 Rouhollahi, E., Zorofchian Moghadamtousi, S., Paydar, M., Fadaeinasab, M., Zahedifard, M., Hajrezaie, M., Mohamed, Z. (2015). Inhibitory effect of Curcuma purpurascens BI. rhizome on HT-29 colon cancer cells through mitochondrial-dependent apoptosis pathway. BMC Complementary and Alternative Medicine, 15(1), 1-12. https://doi.org/10.1186/s12906-015-0534-6 Saxena, S., Raja, A.S.M. (2014). Natural dyes: sources, chemistry, application and sustainability issues. Muthu, S. S. (Ed), Roadmap to sustainable textiles and clothing: eco-friendly raw materials, technologies, and processing methods (pp. 37-80). Singapore: Springer Singapore. Serrano, A., Sousa, M.M., Hallett, J., Lopes, J.A., Oliveira, M.C. (2011). Analysis of natural red dyes (cochineal) in textiles of historical importance using HPLC and multivariate data analysis. Analytical and Bioanalytical Chemistry, 401, 735 743. https://pubmed.ncbi.nlm.nih.gov/21626194/ Singh R. (2017) Sources of natural nye – A critical review. International Journal of Engineering, Science and Mathematics, 6(5), 180-185. Srinivas, G., Anto, R.J., Srinivas, P., Vidhyalakshmi, S., Senan, V.P., & Karunagaran, D. (2003). Emodin induces apoptosis of human cervical cancer cells through poly (ADP-ribose) polymerase cleavage and activation of caspase-9. European Journal of Pharmacology, 473(2-3), 117-125. https://doi.org/10.1016/s0014-2999(03)01976-9 Sunkara, R., Shackelford, L., Walker, L., & Verghese, M. (2015). Inhibition of chemically-induced colon cancer by dietary treatment of Hibiscus sabdariffa L. Dried Calyx in rats. Food and Nutrition Sciences, 6(12), 1174. https://doi.org/ 10.4236/fns.2015.612123 Telford, W.G., King, L.E., & Fraker, P.J. (1992). Comparative evaluation of several DNA binding dyes in the detection of apoptosis‐associated chromatin degradation by flow cytometry. Cytometry: The Journal of the International Society for Analytical Cytology, 13(2), 137-143. https://doi.org/10.1002/cyto.990130205 Yousaf, M.M., Majeed, M., Hussain, M., Shah, M.J., Ahmad, B., Ghazali, H.M.Z.U., & Muhammad, R.W. (2018). Calcium alginate entrapment of Aspergillus nidulans IMPP-0785 laccase for enhanced enzyme catalytic ability, thermost ability and dye-decolorization. Bangladesh Journal of Botany, 47(4), 903-909. https://doi.org/10.3329/bjb.v47i4.47380 Toplam 34 adet kaynakça vardır.
Ayrıntılar Birincil Dil İngilizce Konular Bitki Biyokimyası, Farmasotik Botanik Bölüm Makaleler Yazarlar Dilek Bahar ERCİYES ÜNİVERSİTESİ 0000-0002-4916-5071 Türkiye
Nilgün Kuşçulu KAYSERI UNIVERSITY 0000-0003-3022-4876 Türkiye
Mehmet Çadır ERCIYES UNIVERSITY 0000-0001-7641-3328 Türkiye
Erken Görünüm Tarihi 22 Nisan 2024 Yayımlanma Tarihi 3 Haziran 2024 Gönderilme Tarihi 1 Ağustos 2023 Yayımlandığı Sayı Yıl 2024 Cilt: 11 Sayı: 2
Kaynak Göster APA Bahar, D., Kuşçulu, N., & Çadır, M. (2024). Investigation of Sterol structures and biological activities in Cochineal and Hibiscus sabdariffa extracts. International Journal of Secondary Metabolite, 11(2), 266-276. https://doi.org/10.21448/ijsm.1335924
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