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Phytochemical constituents of the roots of Heliotropium verdcourtii (Boraginaceae) Skip to content Yıl 2024, Cilt: 11 Sayı: 2, 211 – 219, 03.06.2024
Tegene Tesfaye Tole , Habtamu Hailu Feso Legesse Adane
https://doi.org/10.21448/ijsm.1301392
Öz The medicinal value of medicinal plants lies in some bioactive constituents that produce a definite physiological action on the human body. Heliotropium verdcourtii is a deciduous shrub or small tree traditionally used in the treatment of various diseases including fever, dry cough, measles, convulsions, epilepsy, diarrhea, and other ailments. The chemical constituents of the roots of the plant were not investigated to date. The aim of the study was to investigate the phytochemicals present in the roots of Heliotropium verdcourtii. The freshly collected root of the plant was chopped and air dried under shade. The dried and finely grounded plant root was extracted through maceration with n-hexane, chloroform/methanol (v/v 1:1), and methanol successively. The extracts were subjected to qualitative phytochemical tests for screening the classes of secondary metabolites present in the plant. Compound isolation of the chloroform/methanol (v/v 1:1) extract was performed through silica gel chromatographic separation. The structures of all isolated compounds were determined by spectroscopic methods as well as comparison with previous reports in the literature. The yields of n-hexane, chloroform/methanol (v/v 1:1), and methanol extracts were 2.2 g (0.4%), 25 g (5.0%), and 19.8 g (4.0%), respectively. The qualitative phytochemical test of the extracts revealed the presence of flavonoids, terpenoids, phenolics, saponins, glycosides and alkaloids. Silica gel chromatographic separation afforded a mixture of three isomeric triterpenoids identified as α-amyrin, β-amyrin, and bauerenol. To the best of our knowledge these bioactive compounds were isolated from the root of this plant, for the first time.
Anahtar Kelimeler α-Amyrin, β-Amyrin, Bauerenol, Ehretia cymosa, Chemical constituents
Destekleyen Kurum Hawassa University
Proje Numarası Private project
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Phytochemical constituents of the roots of Heliotropium verdcourtii (Boraginaceae) Yıl 2024, Cilt: 11 Sayı: 2, 211 – 219, 03.06.2024
Tegene Tesfaye Tole , Habtamu Hailu Feso Legesse Adane
https://doi.org/10.21448/ijsm.1301392
Öz The medicinal value of medicinal plants lies in some bioactive constituents that produce a definite physiological action on the human body. Heliotropium verdcourtii is a deciduous shrub or small tree traditionally used in the treatment of various diseases including fever, dry cough, measles, convulsions, epilepsy, diarrhea, and other ailments. The chemical constituents of the roots of the plant were not investigated to date. The aim of the study was to investigate the phytochemicals present in the roots of Heliotropium verdcourtii. The freshly collected root of the plant was chopped and air dried under shade. The dried and finely grounded plant root was extracted through maceration with n-hexane, chloroform/methanol (v/v 1:1), and methanol successively. The extracts were subjected to qualitative phytochemical tests for screening the classes of secondary metabolites present in the plant. Compound isolation of the chloroform/methanol (v/v 1:1) extract was performed through silica gel chromatographic separation. The structures of all isolated compounds were determined by spectroscopic methods as well as comparison with previous reports in the literature. The yields of n-hexane, chloroform/methanol (v/v 1:1), and methanol extracts were 2.2 g (0.4%), 25 g (5.0%), and 19.8 g (4.0%), respectively. The qualitative phytochemical test of the extracts revealed the presence of flavonoids, terpenoids, phenolics, saponins, glycosides and alkaloids. Silica gel chromatographic separation afforded a mixture of three isomeric triterpenoids identified as α-amyrin, β-amyrin, and bauerenol. To the best of our knowledge these bioactive compounds were isolated from the root of this plant, for the first time.
Anahtar Kelimeler α-Amyrin, β-Amyrin, Bauerenol, Ehretia cymosa, Chemical constituents
Proje Numarası Private project
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Phytochemical screening of some plants from Western regions of India. Plant Arch., 8(2), 657-662. Prashant, T., Bimlesh, K., Mandeep, K., Gurpreet, K., Harleen, K. (2011). Phytochemical screening and extraction: A review. Int. J. Pharm. Sci., 1(1), 98-106. Raga, D.D., Herrera, A.A., Shen, C.C., Ragasa, C.Y. (2013). Triterpenes from Ardisia squamulosa C. Presl (Myrsinaceae) limit angiogenesis and the expression of von willebrand factor in duck chorioallantoic membrane. J. Chem. Pharm. Res., 5(10), 230-239. Retief, E., Van Wyk, A.E. (2001). The genus Ehretia (Boraginaceae: Ehretioideae) In Southern Africa. Bothalia, 31(1), 9-23. Sathish, K.P., Viswanathan, M.B.G., Venkatesan, M., Balakrishna, K. (2017). Bauerenol, a triterpenoid from Indian Suregada angustifolia: Induces reactive oxygen species–mediated P38MAPK activation and apoptosis in human hepatocellular carcinoma (HepG2) cells. Tumor Biol., 39(4), 1-15. Soto-Blanco, B. (2022). 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Ayrıntılar Birincil Dil İngilizce Konular Organik Kimya Bölüm Makaleler Yazarlar Tegene Tesfaye Tole Hawassa University 0000-0002-5858-9239 Ethiopia
Habtamu Hailu Feso Hawassa University 0009-0005-9718-4065 Ethiopia
Legesse Adane Hawassa University 0000-0001-5153-6946 Ethiopia
Proje Numarası Private project Erken Görünüm Tarihi 22 Nisan 2024 Yayımlanma Tarihi 3 Haziran 2024 Gönderilme Tarihi 23 Mayıs 2023 Yayımlandığı Sayı Yıl 2024 Cilt: 11 Sayı: 2
Kaynak Göster APA Tole, T. T., Feso, H. H., & Adane, L. (2024). Phytochemical constituents of the roots of Heliotropium verdcourtii (Boraginaceae). International Journal of Secondary Metabolite, 11(2), 211-219. https://doi.org/10.21448/ijsm.1301392
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