');mask-image:url('data:image/svg+xml;utf8, ');mask-mode:alpha;-webkit-mask-repeat:no-repeat;mask-repeat:no-repeat;-webkit-mask-size:contain;mask-size:contain;-webkit-mask-position:center;mask-position:center;border-radius:0}}.wp-block-image :where(.has-border-color){border-style:solid}.wp-block-image :where([style*=border-top-color]){border-top-style:solid}.wp-block-image :where([style*=border-right-color]){border-right-style:solid}.wp-block-image :where([style*=border-bottom-color]){border-bottom-style:solid}.wp-block-image :where([style*=border-left-color]){border-left-style:solid}.wp-block-image :where([style*=border-width]){border-style:solid}.wp-block-image :where([style*=border-top-width]){border-top-style:solid}.wp-block-image :where([style*=border-right-width]){border-right-style:solid}.wp-block-image :where([style*=border-bottom-width]){border-bottom-style:solid}.wp-block-image :where([style*=border-left-width]){border-left-style:solid}.wp-block-image figure{margin:0}ol.wp-block-latest-comments{margin-left:0}.wp-block-latest-comments .wp-block-latest-comments{padding-left:0}.wp-block-latest-comments__comment{line-height:1.1;list-style:none;margin-bottom:1em}.has-avatars .wp-block-latest-comments__comment{min-height:2.25em;list-style:none}.has-avatars .wp-block-latest-comments__comment .wp-block-latest-comments__comment-excerpt,.has-avatars .wp-block-latest-comments__comment .wp-block-latest-comments__comment-meta{margin-left:3.25em}.has-dates .wp-block-latest-comments__comment,.has-excerpts .wp-block-latest-comments__comment{line-height:1.5}.wp-block-latest-comments__comment-excerpt p{font-size:.875em;line-height:1.8;margin:.36em 0 1.4em}.wp-block-latest-comments__comment-date{display:block;font-size:.75em}.wp-block-latest-comments .avatar,.wp-block-latest-comments__comment-avatar{border-radius:1.5em;display:block;float:left;height:2.5em;margin-right:.75em;width:2.5em}.wp-block-latest-posts.alignleft{margin-right:2em}.wp-block-latest-posts.alignright{margin-left:2em}.wp-block-latest-posts.wp-block-latest-posts__list{list-style:none;padding-left:0}.wp-block-latest-posts.wp-block-latest-posts__list li{clear:both}.wp-block-latest-posts.is-grid{display:flex;flex-wrap:wrap;padding:0}.wp-block-latest-posts.is-grid li{margin:0 1.25em 1.25em 0;width:100%}@media (min-width:600px){.wp-block-latest-posts.columns-2 li{width:calc(50% - .625em)}.wp-block-latest-posts.columns-2 li:nth-child(2n){margin-right:0}.wp-block-latest-posts.columns-3 li{width:calc(33.33333% - .83333em)}.wp-block-latest-posts.columns-3 li:nth-child(3n){margin-right:0}.wp-block-latest-posts.columns-4 li{width:calc(25% - .9375em)}.wp-block-latest-posts.columns-4 li:nth-child(4n){margin-right:0}.wp-block-latest-posts.columns-5 li{width:calc(20% - 1em)}.wp-block-latest-posts.columns-5 li:nth-child(5n){margin-right:0}.wp-block-latest-posts.columns-6 li{width:calc(16.66667% - 1.04167em)}.wp-block-latest-posts.columns-6 li:nth-child(6n){margin-right:0}}.wp-block-latest-posts__post-author,.wp-block-latest-posts__post-date{display:block;font-size:.8125em}.wp-block-latest-posts__post-excerpt{margin-top:.5em;margin-bottom:1em}.wp-block-latest-posts__featured-image a{display:inline-block}.wp-block-latest-posts__featured-image img{height:auto;width:auto;max-width:100%}.wp-block-latest-posts__featured-image.alignleft{margin-right:1em;float:left}.wp-block-latest-posts__featured-image.alignright{margin-left:1em;float:right}.wp-block-latest-posts__featured-image.aligncenter{margin-bottom:1em;text-align:center}ol,ul{box-sizing:border-box}ol.has-background,ul.has-background{padding:1.25em 2.375em}.wp-block-media-text{direction:ltr;display:grid;grid-template-columns:50% 1fr;grid-template-rows:auto;box-sizing:border-box}.wp-block-media-text.has-media-on-the-right{grid-template-columns:1fr 50%}.wp-block-media-text.is-vertically-aligned-top .wp-block-media-text__content,.wp-block-media-text.is-vertically-aligned-top .wp-block-media-text__media{align-self:start}.wp-block-media-text.is-vertically-aligned-center .wp-block-media-text__content,.wp-block-media-text.is-vertically-aligned-center .wp-block-media-text__media,.wp-block-media-text .wp-block-media-text__content,.wp-block-media-text .wp-block-media-text__media{align-self:center}.wp-block-media-text.is-vertically-aligned-bottom .wp-block-media-text__content,.wp-block-media-text.is-vertically-aligned-bottom .wp-block-media-text__media{align-self:end}.wp-block-media-text .wp-block-media-text__media{grid-column:1;grid-row:1;margin:0}.wp-block-media-text .wp-block-media-text__content{direction:ltr;grid-column:2;grid-row:1;padding:0 8%;word-break:break-word}.wp-block-media-text.has-media-on-the-right .wp-block-media-text__media{grid-column:2;grid-row:1}.wp-block-media-text.has-media-on-the-right .wp-block-media-text__content{grid-column:1;grid-row:1}.wp-block-media-text__media img,.wp-block-media-text__media video{height:auto;max-width:unset;width:100%;vertical-align:middle}.wp-block-media-text.is-image-fill .wp-block-media-text__media{height:100%;min-height:250px;background-size:cover}.wp-block-media-text.is-image-fill .wp-block-media-text__media>a{display:block;height:100%}.wp-block-media-text.is-image-fill .wp-block-media-text__media img{position:absolute;width:1px;height:1px;padding:0;margin:-1px;overflow:hidden;clip:rect(0,0,0,0);border:0}@media (max-width:600px){.wp-block-media-text.is-stacked-on-mobile{grid-template-columns:100%!important}.wp-block-media-text.is-stacked-on-mobile .wp-block-media-text__media{grid-column:1;grid-row:1}.wp-block-media-text.is-stacked-on-mobile .wp-block-media-text__content{grid-column:1;grid-row:2}}.wp-block-navigation{position:relative;--navigation-layout-justification-setting:flex-start;--navigation-layout-direction:row;--navigation-layout-wrap:wrap;--navigation-layout-justify:flex-start;--navigation-layout-align:center}.wp-block-navigation ul{margin-top:0;margin-bottom:0;margin-left:0;padding-left:0}.wp-block-navigation ul,.wp-block-navigation ul li{list-style:none;padding:0}.wp-block-navigation .wp-block-navigation-item{display:flex;align-items:center;position:relative}.wp-block-navigation .wp-block-navigation-item .wp-block-navigation__submenu-container:empty{display:none}.wp-block-navigation .wp-block-navigation-item__content{display:block}.wp-block-navigation.has-text-decoration-underline .wp-block-navigation-item__content,.wp-block-navigation.has-text-decoration-underline .wp-block-navigation-item__content:active,.wp-block-navigation.has-text-decoration-underline .wp-block-navigation-item__content:focus{text-decoration:underline}.wp-block-navigation.has-text-decoration-line-through .wp-block-navigation-item__content,.wp-block-navigation.has-text-decoration-line-through .wp-block-navigation-item__content:active,.wp-block-navigation.has-text-decoration-line-through .wp-block-navigation-item__content:focus{text-decoration:line-through}.wp-block-navigation:where(:not([class*=has-text-decoration])) a,.wp-block-navigation:where(:not([class*=has-text-decoration])) a:active,.wp-block-navigation:where(:not([class*=has-text-decoration])) a:focus{text-decoration:none}.wp-block-navigation .wp-block-navigation__submenu-icon{align-self:center;line-height:0;display:inline-block;font-size:inherit;padding:0;background-color:inherit;color:currentColor;border:none;width:.6em;height:.6em;margin-left:.25em}.wp-block-navigation .wp-block-navigation__submenu-icon svg{display:inline-block;stroke:currentColor;width:inherit;height:inherit;margin-top:.075em}.wp-block-navigation.is-vertical{--navigation-layout-direction:column;--navigation-layout-justify:initial;--navigation-layout-align:flex-start}.wp-block-navigation.no-wrap{--navigation-layout-wrap:nowrap}.wp-block-navigation.items-justified-center{--navigation-layout-justification-setting:center;--navigation-layout-justify:center}.wp-block-navigation.items-justified-center.is-vertical{--navigation-layout-align:center}.wp-block-navigation.items-justified-right{--navigation-layout-justification-setting:flex-end;--navigation-layout-justify:flex-end}.wp-block-navigation.items-justified-right.is-vertical{--navigation-layout-align:flex-end}.wp-block-navigation.items-justified-space-between{--navigation-layout-justification-setting:space-between;--navigation-layout-justify:space-between}.wp-block-navigation .has-child .wp-block-navigation__submenu-container{background-color:inherit;color:inherit;position:absolute;z-index:2;display:flex;flex-direction:column;align-items:normal;opacity:0;transition:opacity .1s linear;visibility:hidden;width:0;height:0;overflow:hidden;left:-1px;top:100%}.wp-block-navigation .has-child .wp-block-navigation__submenu-container>.wp-block-navigation-item>.wp-block-navigation-item__content{display:flex;flex-grow:1}.wp-block-navigation .has-child .wp-block-navigation__submenu-container>.wp-block-navigation-item>.wp-block-navigation-item__content .wp-block-navigation__submenu-icon{margin-right:0;margin-left:auto}.wp-block-navigation .has-child .wp-block-navigation__submenu-container .wp-block-navigation-item__content{margin:0}@media (min-width:782px){.wp-block-navigation .has-child .wp-block-navigation__submenu-container .wp-block-navigation__submenu-container{left:100%;top:-1px}.wp-block-navigation .has-child .wp-block-navigation__submenu-container .wp-block-navigation__submenu-container:before{content:"";position:absolute;right:100%;height:100%;display:block;width:.5em;background:0 0}.wp-block-navigation .has-child .wp-block-navigation__submenu-container .wp-block-navigation__submenu-icon{margin-right:.25em}.wp-block-navigation .has-child .wp-block-navigation__submenu-container .wp-block-navigation__submenu-icon svg{transform:rotate(-90deg)}}.wp-block-navigation .has-child:not(.open-on-click):hover>.wp-block-navigation__submenu-container{visibility:visible;overflow:visible;opacity:1;width:auto;height:auto;min-width:200px}.wp-block-navigation .has-child:not(.open-on-click):not(.open-on-hover-click):focus-within>.wp-block-navigation__submenu-container{visibility:visible;overflow:visible;opacity:1;width:auto;height:auto;min-width:200px}.wp-block-navigation .has-child .wp-block-navigation-submenu__toggle[aria-expanded=true]~.wp-block-navigation__submenu-container{visibility:visible;overflow:visible;opacity:1;width:auto;height:auto;min-width:200px}.wp-block-navigation.has-background .has-child .wp-block-navigation__submenu-container{left:0;top:100%}@media (min-width:782px){.wp-block-navigation.has-background .has-child .wp-block-navigation__submenu-container .wp-block-navigation__submenu-container{left:100%;top:0}}.wp-block-navigation-submenu{position:relative;display:flex}.wp-block-navigation-submenu .wp-block-navigation__submenu-icon svg{stroke:currentColor}button.wp-block-navigation-item__content{background-color:transparent;border:none;color:currentColor;font-size:inherit;font-family:inherit;line-height:inherit;font-style:inherit;font-weight:inherit;text-transform:inherit;text-align:left}.wp-block-navigation-submenu__toggle{cursor:pointer}.wp-block-navigation-item.open-on-click .wp-block-navigation-submenu__toggle{padding-right:.85em}.wp-block-navigation-item.open-on-click .wp-block-navigation-submenu__toggle+.wp-block-navigation__submenu-icon{margin-left:-.6em;pointer-events:none}.wp-block-navigation .wp-block-page-list,.wp-block-navigation__container,.wp-block-navigation__responsive-close,.wp-block-navigation__responsive-container,.wp-block-navigation__responsive-container-content,.wp-block-navigation__responsive-dialog{gap:inherit}:where(.wp-block-navigation.has-background .wp-block-navigation-item a:not(.wp-element-button)),:where(.wp-block-navigation.has-background .wp-block-navigation-submenu a:not(.wp-element-button)),:where(.wp-block-navigation .wp-block-navigation__submenu-container .wp-block-navigation-item a:not(.wp-element-button)),:where(.wp-block-navigation .wp-block-navigation__submenu-container .wp-block-navigation-submenu a:not(.wp-element-button)){padding:.5em 1em}.wp-block-navigation.items-justified-right .wp-block-navigation__container .has-child .wp-block-navigation__submenu-container,.wp-block-navigation.items-justified-right .wp-block-page-list>.has-child .wp-block-navigation__submenu-container,.wp-block-navigation.items-justified-space-between .wp-block-page-list>.has-child:last-child .wp-block-navigation__submenu-container,.wp-block-navigation.items-justified-space-between>.wp-block-navigation__container>.has-child:last-child .wp-block-navigation__submenu-container{left:auto;right:0}.wp-block-navigation.items-justified-right .wp-block-navigation__container .has-child .wp-block-navigation__submenu-container .wp-block-navigation__submenu-container,.wp-block-navigation.items-justified-right .wp-block-page-list>.has-child .wp-block-navigation__submenu-container .wp-block-navigation__submenu-container,.wp-block-navigation.items-justified-space-between .wp-block-page-list>.has-child:last-child .wp-block-navigation__submenu-container .wp-block-navigation__submenu-container,.wp-block-navigation.items-justified-space-between>.wp-block-navigation__container>.has-child:last-child .wp-block-navigation__submenu-container .wp-block-navigation__submenu-container{left:-1px;right:-1px}@media (min-width:782px){.wp-block-navigation.items-justified-right .wp-block-navigation__container .has-child .wp-block-navigation__submenu-container .wp-block-navigation__submenu-container,.wp-block-navigation.items-justified-right .wp-block-page-list>.has-child .wp-block-navigation__submenu-container .wp-block-navigation__submenu-container,.wp-block-navigation.items-justified-space-between .wp-block-page-list>.has-child:last-child .wp-block-navigation__submenu-container .wp-block-navigation__submenu-container,.wp-block-navigation.items-justified-space-between>.wp-block-navigation__container>.has-child:last-child .wp-block-navigation__submenu-container .wp-block-navigation__submenu-container{left:auto;right:100%}}.wp-block-navigation:not(.has-background) .wp-block-navigation__submenu-container{background-color:#fff;color:#000;border:1px solid rgba(0,0,0,.15)}.wp-block-navigation__container{display:flex;flex-wrap:var(--navigation-layout-wrap,wrap);flex-direction:var(--navigation-layout-direction,initial);justify-content:var(--navigation-layout-justify,initial);align-items:var(--navigation-layout-align,initial);list-style:none;margin:0;padding-left:0}.wp-block-navigation__container .is-responsive{display:none}.wp-block-navigation__container:only-child,.wp-block-page-list:only-child{flex-grow:1}@keyframes overlay-menu__fade-in-animation{0%{opacity:0;transform:translateY(.5em)}to{opacity:1;transform:translateY(0)}}.wp-block-navigation__responsive-container{display:none;position:fixed;top:0;left:0;right:0;bottom:0}.wp-block-navigation__responsive-container .wp-block-navigation-link a{color:inherit}.wp-block-navigation__responsive-container .wp-block-navigation__responsive-container-content{display:flex;flex-wrap:var(--navigation-layout-wrap,wrap);flex-direction:var(--navigation-layout-direction,initial);justify-content:var(--navigation-layout-justify,initial);align-items:var(--navigation-layout-align,initial)}.wp-block-navigation__responsive-container:not(.is-menu-open.is-menu-open){color:inherit!important;background-color:inherit!important}.wp-block-navigation__responsive-container.is-menu-open{display:flex;flex-direction:column;background-color:inherit;animation:overlay-menu__fade-in-animation .1s ease-out;animation-fill-mode:forwards;padding:var(--wp--style--root--padding-top,2rem) var(--wp--style--root--padding-right,2rem) var(--wp--style--root--padding-bottom,2rem) var(--wp--style--root--padding-left,2rem);overflow:auto;z-index:100000}@media (prefers-reduced-motion:reduce){.wp-block-navigation__responsive-container.is-menu-open{animation-duration:1ms;animation-delay:0s}}.wp-block-navigation__responsive-container.is-menu-open .wp-block-navigation__responsive-container-content{padding-top:calc(2rem + 24px);overflow:visible;display:flex;flex-direction:column;flex-wrap:nowrap;align-items:var(--navigation-layout-justification-setting,inherit)}.wp-block-navigation__responsive-container.is-menu-open .wp-block-navigation__responsive-container-content,.wp-block-navigation__responsive-container.is-menu-open .wp-block-navigation__responsive-container-content .wp-block-navigation__container,.wp-block-navigation__responsive-container.is-menu-open .wp-block-navigation__responsive-container-content .wp-block-page-list{justify-content:flex-start}.wp-block-navigation__responsive-container.is-menu-open .wp-block-navigation__responsive-container-content .wp-block-navigation__submenu-icon{display:none}.wp-block-navigation__responsive-container.is-menu-open .wp-block-navigation__responsive-container-content .has-child .submenu-container,.wp-block-navigation__responsive-container.is-menu-open .wp-block-navigation__responsive-container-content .has-child .wp-block-navigation__submenu-container{opacity:1;visibility:visible;height:auto;width:auto;overflow:initial;min-width:200px;position:static;border:none;padding-left:2rem;padding-right:2rem}.wp-block-navigation__responsive-container.is-menu-open .wp-block-navigation__responsive-container-content .wp-block-navigation__container,.wp-block-navigation__responsive-container.is-menu-open .wp-block-navigation__responsive-container-content .wp-block-navigation__submenu-container{gap:inherit}.wp-block-navigation__responsive-container.is-menu-open .wp-block-navigation__responsive-container-content .wp-block-navigation__submenu-container{padding-top:var(--wp--style--block-gap,2em)}.wp-block-navigation__responsive-container.is-menu-open .wp-block-navigation__responsive-container-content .wp-block-navigation-item__content{padding:0}.wp-block-navigation__responsive-container.is-menu-open .wp-block-navigation__responsive-container-content .wp-block-navigation-item,.wp-block-navigation__responsive-container.is-menu-open .wp-block-navigation__responsive-container-content .wp-block-navigation__container,.wp-block-navigation__responsive-container.is-menu-open .wp-block-navigation__responsive-container-content .wp-block-page-list{display:flex;flex-direction:column;align-items:var(--navigation-layout-justification-setting,initial)}.wp-block-navigation__responsive-container.is-menu-open .wp-block-navigation-item,.wp-block-navigation__responsive-container.is-menu-open .wp-block-navigation-item .wp-block-navigation__submenu-container,.wp-block-navigation__responsive-container.is-menu-open .wp-block-page-list{color:inherit!important;background:transparent!important}.wp-block-navigation__responsive-container.is-menu-open .wp-block-navigation__submenu-container.wp-block-navigation__submenu-container.wp-block-navigation__submenu-container.wp-block-navigation__submenu-container{right:auto;left:auto}@media (min-width:600px){.wp-block-navigation__responsive-container:not(.hidden-by-default):not(.is-menu-open){display:block;width:100%;position:relative;z-index:auto;background-color:inherit}.wp-block-navigation__responsive-container:not(.hidden-by-default):not(.is-menu-open) .wp-block-navigation__responsive-container-close{display:none}.wp-block-navigation__responsive-container.is-menu-open .wp-block-navigation__submenu-container.wp-block-navigation__submenu-container.wp-block-navigation__submenu-container.wp-block-navigation__submenu-container{left:0}}.wp-block-navigation:not(.has-background) .wp-block-navigation__responsive-container.is-menu-open{background-color:#fff;color:#000}.wp-block-navigation__toggle_button_label{font-size:1rem;font-weight:700}.wp-block-navigation__responsive-container-close,.wp-block-navigation__responsive-container-open{vertical-align:middle;cursor:pointer;color:currentColor;background:0 0;border:none;margin:0;padding:0;text-transform:inherit}.wp-block-navigation__responsive-container-close svg,.wp-block-navigation__responsive-container-open svg{fill:currentColor;pointer-events:none;display:block;width:24px;height:24px}.wp-block-navigation__responsive-container-open{display:flex}@media (min-width:600px){.wp-block-navigation__responsive-container-open:not(.always-shown){display:none}}.wp-block-navigation__responsive-container-close{position:absolute;top:0;right:0;z-index:2}.wp-block-navigation__responsive-close{width:100%;max-width:var(--wp--style--global--wide-size,100%);margin-left:auto;margin-right:auto}.wp-block-navigation__responsive-close:focus{outline:none}.is-menu-open .wp-block-navigation__responsive-close,.is-menu-open .wp-block-navigation__responsive-container-content,.is-menu-open .wp-block-navigation__responsive-dialog{box-sizing:border-box}.wp-block-navigation__responsive-dialog{position:relative}.has-modal-open .admin-bar .is-menu-open .wp-block-navigation__responsive-dialog{margin-top:46px}@media (min-width:782px){.has-modal-open .admin-bar .is-menu-open .wp-block-navigation__responsive-dialog{margin-top:32px}}html.has-modal-open{overflow:hidden}.wp-block-navigation .wp-block-navigation-item__label{word-break:normal;overflow-wrap:break-word}.wp-block-navigation .wp-block-navigation-item__description{display:none}.wp-block-navigation .wp-block-page-list{display:flex;flex-direction:var(--navigation-layout-direction,initial);justify-content:var(--navigation-layout-justify,initial);align-items:var(--navigation-layout-align,initial);flex-wrap:var(--navigation-layout-wrap,wrap);background-color:inherit}.wp-block-navigation .wp-block-navigation-item{background-color:inherit}.is-small-text{font-size:.875em}.is-regular-text{font-size:1em}.is-large-text{font-size:2.25em}.is-larger-text{font-size:3em}.has-drop-cap:not(:focus):first-letter {float:left;font-size:8.4em;line-height:.68;font-weight:100;margin:.05em .1em 0 0;text-transform:uppercase;font-style:normal}p.has-drop-cap.has-background{overflow:hidden}p.has-background{padding:1.25em 2.375em}:where(p.has-text-color:not(.has-link-color)) a{color:inherit}.wp-block-post-author{display:flex;flex-wrap:wrap}.wp-block-post-author__byline{width:100%;margin-top:0;margin-bottom:0;font-size:.5em}.wp-block-post-author__avatar{margin-right:1em}.wp-block-post-author__bio{margin-bottom:.7em;font-size:.7em}.wp-block-post-author__content{flex-grow:1;flex-basis:0}.wp-block-post-author__name{margin:0}.wp-block-post-comments-form[style*=font-weight] :where(.comment-reply-title){font-weight:inherit}.wp-block-post-comments-form[style*=font-family] :where(.comment-reply-title){font-family:inherit}.wp-block-post-comments-form[class*=-font-size] :where(.comment-reply-title),.wp-block-post-comments-form[style*=font-size] :where(.comment-reply-title){font-size:inherit}.wp-block-post-comments-form[style*=line-height] :where(.comment-reply-title){line-height:inherit}.wp-block-post-comments-form[style*=font-style] :where(.comment-reply-title){font-style:inherit}.wp-block-post-comments-form[style*=letter-spacing] :where(.comment-reply-title){letter-spacing:inherit}.wp-block-post-comments-form input[type=submit]{box-shadow:none;cursor:pointer;display:inline-block;text-align:center;overflow-wrap:break-word}.wp-block-post-comments-form input:not([type=submit]),.wp-block-post-comments-form textarea{border:1px solid #949494;font-size:1em;font-family:inherit}.wp-block-post-comments-form input:not([type=submit]):not([type=checkbox]),.wp-block-post-comments-form textarea{padding:calc(.667em + 2px)}.wp-block-post-comments-form .comment-form input:not([type=submit]):not([type=checkbox]),.wp-block-post-comments-form .comment-form textarea{display:block;box-sizing:border-box;width:100%}.wp-block-post-comments-form .comment-form-author label,.wp-block-post-comments-form .comment-form-email label,.wp-block-post-comments-form .comment-form-url label{display:block;margin-bottom:.25em}.wp-block-post-comments-form .comment-form-cookies-consent{display:flex;gap:.25em}.wp-block-post-comments-form .comment-form-cookies-consent #wp-comment-cookies-consent{margin-top:.35em}.wp-block-post-comments-form .comment-reply-title{margin-bottom:0}.wp-block-post-comments-form .comment-reply-title :where(small){font-size:var(--wp--preset--font-size--medium,smaller);margin-left:.5em}.wp-block-post-date{box-sizing:border-box}.wp-block-post-excerpt__more-link{display:inline-block}.wp-block-post-featured-image{margin-left:0;margin-right:0}.wp-block-post-featured-image a{display:block}.wp-block-post-featured-image img{max-width:100%;width:100%;height:auto;vertical-align:bottom;box-sizing:border-box}.wp-block-post-featured-image.alignfull img,.wp-block-post-featured-image.alignwide img{width:100%}.wp-block-post-featured-image .wp-block-post-featured-image__overlay.has-background-dim{position:absolute;inset:0;background-color:#000}.wp-block-post-featured-image{position:relative}.wp-block-post-featured-image .wp-block-post-featured-image__overlay.has-background-gradient{background-color:transparent}.wp-block-post-featured-image .wp-block-post-featured-image__overlay.has-background-dim-0{opacity:0}.wp-block-post-featured-image .wp-block-post-featured-image__overlay.has-background-dim-10{opacity:.1}.wp-block-post-featured-image .wp-block-post-featured-image__overlay.has-background-dim-20{opacity:.2}.wp-block-post-featured-image .wp-block-post-featured-image__overlay.has-background-dim-30{opacity:.3}.wp-block-post-featured-image .wp-block-post-featured-image__overlay.has-background-dim-40{opacity:.4}.wp-block-post-featured-image .wp-block-post-featured-image__overlay.has-background-dim-50{opacity:.5}.wp-block-post-featured-image .wp-block-post-featured-image__overlay.has-background-dim-60{opacity:.6}.wp-block-post-featured-image .wp-block-post-featured-image__overlay.has-background-dim-70{opacity:.7}.wp-block-post-featured-image .wp-block-post-featured-image__overlay.has-background-dim-80{opacity:.8}.wp-block-post-featured-image .wp-block-post-featured-image__overlay.has-background-dim-90{opacity:.9}.wp-block-post-featured-image .wp-block-post-featured-image__overlay.has-background-dim-100{opacity:1}.wp-block-post-terms__separator{white-space:pre-wrap}.wp-block-post-title{word-break:break-word;box-sizing:border-box}.wp-block-post-title a{display:inline-block}.wp-block-preformatted{white-space:pre-wrap}.wp-block-preformatted.has-background{padding:1.25em 2.375em}.wp-block-pullquote{margin:0 0 1em;padding:3em 0;text-align:center;overflow-wrap:break-word;box-sizing:border-box}.wp-block-pullquote blockquote,.wp-block-pullquote cite,.wp-block-pullquote p{color:inherit}.wp-block-pullquote.alignleft,.wp-block-pullquote.alignright{max-width:420px}.wp-block-pullquote cite,.wp-block-pullquote footer{position:relative}.wp-block-pullquote .has-text-color a{color:inherit}.wp-block-pullquote.has-text-align-left blockquote{text-align:left}.wp-block-pullquote.has-text-align-right blockquote{text-align:right}.wp-block-pullquote.is-style-solid-color{border:none}.wp-block-pullquote.is-style-solid-color blockquote{margin-left:auto;margin-right:auto;max-width:60%}.wp-block-pullquote.is-style-solid-color blockquote p{margin-top:0;margin-bottom:0;font-size:2em}.wp-block-pullquote.is-style-solid-color blockquote cite{text-transform:none;font-style:normal}.wp-block-pullquote cite{color:inherit}.wp-block-post-template{margin-top:0;margin-bottom:0;max-width:100%;list-style:none;padding:0}.wp-block-post-template.wp-block-post-template{background:0 0}.wp-block-post-template.is-flex-container{flex-direction:row;display:flex;flex-wrap:wrap;gap:1.25em}.wp-block-post-template.is-flex-container li{margin:0;width:100%}@media (min-width:600px){.wp-block-post-template.is-flex-container.is-flex-container.columns-2>li{width:calc(50% - .625em)}.wp-block-post-template.is-flex-container.is-flex-container.columns-3>li{width:calc(33.33333% - .83333em)}.wp-block-post-template.is-flex-container.is-flex-container.columns-4>li{width:calc(25% - .9375em)}.wp-block-post-template.is-flex-container.is-flex-container.columns-5>li{width:calc(20% - 1em)}.wp-block-post-template.is-flex-container.is-flex-container.columns-6>li{width:calc(16.66667% - 1.04167em)}}.wp-block-query-pagination>.wp-block-query-pagination-next,.wp-block-query-pagination>.wp-block-query-pagination-numbers,.wp-block-query-pagination>.wp-block-query-pagination-previous{margin-right:.5em;margin-bottom:.5em}.wp-block-query-pagination>.wp-block-query-pagination-next:last-child,.wp-block-query-pagination>.wp-block-query-pagination-numbers:last-child,.wp-block-query-pagination>.wp-block-query-pagination-previous:last-child{margin-right:0}.wp-block-query-pagination.is-content-justification-space-between>.wp-block-query-pagination-next:last-child{margin-inline-start:auto}.wp-block-query-pagination.is-content-justification-space-between>.wp-block-query-pagination-previous:first-child{margin-inline-end:auto}.wp-block-query-pagination .wp-block-query-pagination-previous-arrow{margin-right:1ch;display:inline-block}.wp-block-query-pagination .wp-block-query-pagination-previous-arrow:not(.is-arrow-chevron){transform:scaleX(1)}.wp-block-query-pagination .wp-block-query-pagination-next-arrow{margin-left:1ch;display:inline-block}.wp-block-query-pagination .wp-block-query-pagination-next-arrow:not(.is-arrow-chevron){transform:scaleX(1)}.wp-block-query-pagination.aligncenter{justify-content:center}.wp-block-query-title,.wp-block-quote{box-sizing:border-box}.wp-block-quote{overflow-wrap:break-word}.wp-block-quote.is-large:not(.is-style-plain),.wp-block-quote.is-style-large:not(.is-style-plain){margin-bottom:1em;padding:0 1em}.wp-block-quote.is-large:not(.is-style-plain) p,.wp-block-quote.is-style-large:not(.is-style-plain) p{font-size:1.5em;font-style:italic;line-height:1.6}.wp-block-quote.is-large:not(.is-style-plain) cite,.wp-block-quote.is-large:not(.is-style-plain) footer,.wp-block-quote.is-style-large:not(.is-style-plain) cite,.wp-block-quote.is-style-large:not(.is-style-plain) footer{font-size:1.125em;text-align:right}.wp-block-read-more{display:block;width:-moz-fit-content;width:fit-content}.wp-block-read-more:not([style*=text-decoration]),.wp-block-read-more:not([style*=text-decoration]):active,.wp-block-read-more:not([style*=text-decoration]):focus{text-decoration:none}ul.wp-block-rss{list-style:none;padding:0}ul.wp-block-rss.wp-block-rss{box-sizing:border-box}ul.wp-block-rss.alignleft{margin-right:2em}ul.wp-block-rss.alignright{margin-left:2em}ul.wp-block-rss.is-grid{display:flex;flex-wrap:wrap;padding:0;list-style:none}ul.wp-block-rss.is-grid li{margin:0 1em 1em 0;width:100%}@media (min-width:600px){ul.wp-block-rss.columns-2 li{width:calc(50% - 1em)}ul.wp-block-rss.columns-3 li{width:calc(33.33333% - 1em)}ul.wp-block-rss.columns-4 li{width:calc(25% - 1em)}ul.wp-block-rss.columns-5 li{width:calc(20% - 1em)}ul.wp-block-rss.columns-6 li{width:calc(16.66667% - 1em)}}.wp-block-rss__item-author,.wp-block-rss__item-publish-date{display:block;font-size:.8125em}.wp-block-search__button{margin-left:.625em;word-break:normal}.wp-block-search__button.has-icon{line-height:0}.wp-block-search__button svg{min-width:1.5em;min-height:1.5em;fill:currentColor;vertical-align:text-bottom}:where(.wp-block-search__button){border:1px solid #ccc;padding:.375em .625em}.wp-block-search__inside-wrapper{display:flex;flex:auto;flex-wrap:nowrap;max-width:100%}.wp-block-search__label{width:100%}.wp-block-search__input{padding:8px;flex-grow:1;margin-left:0;margin-right:0;min-width:3em;border:1px solid #949494;text-decoration:unset!important}.wp-block-search.wp-block-search__button-only .wp-block-search__button{margin-left:0}:where(.wp-block-search__button-inside .wp-block-search__inside-wrapper){padding:4px;border:1px solid #949494}:where(.wp-block-search__button-inside .wp-block-search__inside-wrapper) .wp-block-search__input{border-radius:0;border:none;padding:0 0 0 .25em}:where(.wp-block-search__button-inside .wp-block-search__inside-wrapper) .wp-block-search__input:focus{outline:none}:where(.wp-block-search__button-inside .wp-block-search__inside-wrapper) :where(.wp-block-search__button){padding:.125em .5em}.wp-block-search.aligncenter .wp-block-search__inside-wrapper{margin:auto}.wp-block-separator{border:1px solid;border-right:none;border-left:none}.wp-block-separator.is-style-dots{background:none!important;border:none;text-align:center;line-height:1;height:auto}.wp-block-separator.is-style-dots:before{content:"···";color:currentColor;font-size:1.5em;letter-spacing:2em;padding-left:2em;font-family:serif}.wp-block-site-logo{box-sizing:border-box;line-height:0}.wp-block-site-logo a{display:inline-block}.wp-block-site-logo.is-default-size img{width:120px;height:auto}.wp-block-site-logo img{height:auto;max-width:100%}.wp-block-site-logo a,.wp-block-site-logo img{border-radius:inherit}.wp-block-site-logo.aligncenter{margin-left:auto;margin-right:auto;text-align:center}.wp-block-site-logo.is-style-rounded{border-radius:9999px}.wp-block-social-links{box-sizing:border-box;padding-left:0;padding-right:0;text-indent:0;margin-left:0;background:0 0}.wp-block-social-links .wp-social-link a,.wp-block-social-links .wp-social-link a:hover{text-decoration:none;border-bottom:0;box-shadow:none}.wp-block-social-links .wp-social-link a{padding:.25em}.wp-block-social-links .wp-social-link svg{width:1em;height:1em}.wp-block-social-links .wp-social-link span:not(.screen-reader-text){margin-left:.5em;margin-right:.5em;font-size:.65em}.wp-block-social-links.has-small-icon-size{font-size:16px}.wp-block-social-links,.wp-block-social-links.has-normal-icon-size{font-size:24px}.wp-block-social-links.has-large-icon-size{font-size:36px}.wp-block-social-links.has-huge-icon-size{font-size:48px}.wp-block-social-links.aligncenter{justify-content:center;display:flex}.wp-block-social-links.alignright{justify-content:flex-end}.wp-block-social-link{display:block;border-radius:9999px;transition:transform .1s ease;height:auto}@media (prefers-reduced-motion:reduce){.wp-block-social-link{transition-duration:0s;transition-delay:0s}}.wp-block-social-link a{align-items:center;display:flex;line-height:0;transition:transform .1s ease}.wp-block-social-link:hover{transform:scale(1.1)}.wp-block-social-links .wp-block-social-link .wp-block-social-link-anchor,.wp-block-social-links .wp-block-social-link .wp-block-social-link-anchor:active,.wp-block-social-links .wp-block-social-link .wp-block-social-link-anchor:hover,.wp-block-social-links .wp-block-social-link .wp-block-social-link-anchor:visited,.wp-block-social-links .wp-block-social-link .wp-block-social-link-anchor svg{color:currentColor;fill:currentColor}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link{background-color:#f0f0f0;color:#444}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-amazon{background-color:#f90;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-bandcamp{background-color:#1ea0c3;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-behance{background-color:#0757fe;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-codepen{background-color:#1e1f26;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-deviantart{background-color:#02e49b;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-dribbble{background-color:#e94c89;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-dropbox{background-color:#4280ff;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-etsy{background-color:#f45800;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-facebook{background-color:#1778f2;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-fivehundredpx{background-color:#000;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-flickr{background-color:#0461dd;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-foursquare{background-color:#e65678;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-github{background-color:#24292d;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-goodreads{background-color:#eceadd;color:#382110}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-google{background-color:#ea4434;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-instagram{background-color:#f00075;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-lastfm{background-color:#e21b24;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-linkedin{background-color:#0d66c2;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-mastodon{background-color:#3288d4;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-medium{background-color:#02ab6c;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-meetup{background-color:#f6405f;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-patreon{background-color:#ff424d;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-pinterest{background-color:#e60122;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-pocket{background-color:#ef4155;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-reddit{background-color:#ff4500;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-skype{background-color:#0478d7;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-snapchat{background-color:#fefc00;color:#fff;stroke:#000}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-soundcloud{background-color:#ff5600;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-spotify{background-color:#1bd760;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-telegram{background-color:#2aabee;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-tiktok{background-color:#000;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-tumblr{background-color:#011835;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-twitch{background-color:#6440a4;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-twitter{background-color:#1da1f2;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-vimeo{background-color:#1eb7ea;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-vk{background-color:#4680c2;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-wordpress{background-color:#3499cd;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-whatsapp{background-color:#25d366;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-yelp{background-color:#d32422;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-youtube{background-color:red;color:#fff}.wp-block-social-links.is-style-logos-only .wp-social-link{background:0 0}.wp-block-social-links.is-style-logos-only .wp-social-link a{padding:0}.wp-block-social-links.is-style-logos-only .wp-social-link svg{width:1.25em;height:1.25em}.wp-block-social-links.is-style-logos-only .wp-social-link-amazon{color:#f90}.wp-block-social-links.is-style-logos-only .wp-social-link-bandcamp{color:#1ea0c3}.wp-block-social-links.is-style-logos-only .wp-social-link-behance{color:#0757fe}.wp-block-social-links.is-style-logos-only .wp-social-link-codepen{color:#1e1f26}.wp-block-social-links.is-style-logos-only .wp-social-link-deviantart{color:#02e49b}.wp-block-social-links.is-style-logos-only .wp-social-link-dribbble{color:#e94c89}.wp-block-social-links.is-style-logos-only .wp-social-link-dropbox{color:#4280ff}.wp-block-social-links.is-style-logos-only .wp-social-link-etsy{color:#f45800}.wp-block-social-links.is-style-logos-only .wp-social-link-facebook{color:#1778f2}.wp-block-social-links.is-style-logos-only .wp-social-link-fivehundredpx{color:#000}.wp-block-social-links.is-style-logos-only .wp-social-link-flickr{color:#0461dd}.wp-block-social-links.is-style-logos-only .wp-social-link-foursquare{color:#e65678}.wp-block-social-links.is-style-logos-only .wp-social-link-github{color:#24292d}.wp-block-social-links.is-style-logos-only .wp-social-link-goodreads{color:#382110}.wp-block-social-links.is-style-logos-only .wp-social-link-google{color:#ea4434}.wp-block-social-links.is-style-logos-only .wp-social-link-instagram{color:#f00075}.wp-block-social-links.is-style-logos-only .wp-social-link-lastfm{color:#e21b24}.wp-block-social-links.is-style-logos-only .wp-social-link-linkedin{color:#0d66c2}.wp-block-social-links.is-style-logos-only .wp-social-link-mastodon{color:#3288d4}.wp-block-social-links.is-style-logos-only .wp-social-link-medium{color:#02ab6c}.wp-block-social-links.is-style-logos-only .wp-social-link-meetup{color:#f6405f}.wp-block-social-links.is-style-logos-only .wp-social-link-patreon{color:#ff424d}.wp-block-social-links.is-style-logos-only .wp-social-link-pinterest{color:#e60122}.wp-block-social-links.is-style-logos-only .wp-social-link-pocket{color:#ef4155}.wp-block-social-links.is-style-logos-only .wp-social-link-reddit{color:#ff4500}.wp-block-social-links.is-style-logos-only .wp-social-link-skype{color:#0478d7}.wp-block-social-links.is-style-logos-only .wp-social-link-snapchat{color:#fff;stroke:#000}.wp-block-social-links.is-style-logos-only .wp-social-link-soundcloud{color:#ff5600}.wp-block-social-links.is-style-logos-only .wp-social-link-spotify{color:#1bd760}.wp-block-social-links.is-style-logos-only .wp-social-link-telegram{color:#2aabee}.wp-block-social-links.is-style-logos-only .wp-social-link-tiktok{color:#000}.wp-block-social-links.is-style-logos-only .wp-social-link-tumblr{color:#011835}.wp-block-social-links.is-style-logos-only .wp-social-link-twitch{color:#6440a4}.wp-block-social-links.is-style-logos-only .wp-social-link-twitter{color:#1da1f2}.wp-block-social-links.is-style-logos-only .wp-social-link-vimeo{color:#1eb7ea}.wp-block-social-links.is-style-logos-only .wp-social-link-vk{color:#4680c2}.wp-block-social-links.is-style-logos-only .wp-social-link-whatsapp{color:#25d366}.wp-block-social-links.is-style-logos-only .wp-social-link-wordpress{color:#3499cd}.wp-block-social-links.is-style-logos-only .wp-social-link-yelp{color:#d32422}.wp-block-social-links.is-style-logos-only .wp-social-link-youtube{color:red}.wp-block-social-links.is-style-pill-shape .wp-social-link{width:auto}.wp-block-social-links.is-style-pill-shape .wp-social-link a{padding-left:.66667em;padding-right:.66667em}.wp-block-spacer{clear:both}.wp-block-tag-cloud.aligncenter{text-align:center;justify-content:center}.wp-block-tag-cloud.alignfull{padding-left:1em;padding-right:1em}.wp-block-tag-cloud a{display:inline-block;margin-right:5px}.wp-block-tag-cloud span{display:inline-block;margin-left:5px;text-decoration:none}.wp-block-tag-cloud.is-style-outline{display:flex;flex-wrap:wrap;gap:1ch}.wp-block-tag-cloud.is-style-outline a{border:1px solid;font-size:unset!important;margin-right:0;padding:1ch 2ch;text-decoration:none!important}.wp-block-table{overflow-x:auto}.wp-block-table table{border-collapse:collapse;width:100%}.wp-block-table td,.wp-block-table th{border:1px solid;padding:.5em}.wp-block-table .has-fixed-layout{table-layout:fixed;width:100%}.wp-block-table .has-fixed-layout td,.wp-block-table .has-fixed-layout th{word-break:break-word}.wp-block-table.aligncenter,.wp-block-table.alignleft,.wp-block-table.alignright{display:table;width:auto}.wp-block-table.aligncenter td,.wp-block-table.aligncenter th,.wp-block-table.alignleft td,.wp-block-table.alignleft th,.wp-block-table.alignright td,.wp-block-table.alignright th{word-break:break-word}.wp-block-table .has-subtle-light-gray-background-color{background-color:#f3f4f5}.wp-block-table .has-subtle-pale-green-background-color{background-color:#e9fbe5}.wp-block-table .has-subtle-pale-blue-background-color{background-color:#e7f5fe}.wp-block-table .has-subtle-pale-pink-background-color{background-color:#fcf0ef}.wp-block-table.is-style-stripes{border-spacing:0;border-collapse:inherit;background-color:transparent;border-bottom:1px solid #f0f0f0}.wp-block-table.is-style-stripes tbody tr:nth-child(odd){background-color:#f0f0f0}.wp-block-table.is-style-stripes.has-subtle-light-gray-background-color tbody tr:nth-child(odd){background-color:#f3f4f5}.wp-block-table.is-style-stripes.has-subtle-pale-green-background-color tbody tr:nth-child(odd){background-color:#e9fbe5}.wp-block-table.is-style-stripes.has-subtle-pale-blue-background-color tbody tr:nth-child(odd){background-color:#e7f5fe}.wp-block-table.is-style-stripes.has-subtle-pale-pink-background-color tbody tr:nth-child(odd){background-color:#fcf0ef}.wp-block-table.is-style-stripes td,.wp-block-table.is-style-stripes th{border-color:transparent}.wp-block-table .has-border-color>*,.wp-block-table .has-border-color td,.wp-block-table .has-border-color th,.wp-block-table .has-border-color tr{border-color:inherit}.wp-block-table table[style*=border-top-color]>*,.wp-block-table table[style*=border-top-color]>* td,.wp-block-table table[style*=border-top-color]>* th,.wp-block-table table[style*=border-top-color] tr:first-child,.wp-block-table table[style*=border-top-color] tr:first-child td,.wp-block-table table[style*=border-top-color] tr:first-child th{border-top-color:inherit}.wp-block-table table[style*=border-top-color] tr:not(:first-child){border-top-color:currentColor}.wp-block-table table[style*=border-right-color]>*,.wp-block-table table[style*=border-right-color] td:last-child,.wp-block-table table[style*=border-right-color] th,.wp-block-table table[style*=border-right-color] tr{border-right-color:inherit}.wp-block-table table[style*=border-bottom-color]>*,.wp-block-table table[style*=border-bottom-color]>* td,.wp-block-table table[style*=border-bottom-color]>* th,.wp-block-table table[style*=border-bottom-color] tr:last-child,.wp-block-table table[style*=border-bottom-color] tr:last-child td,.wp-block-table table[style*=border-bottom-color] tr:last-child th{border-bottom-color:inherit}.wp-block-table table[style*=border-bottom-color] tr:not(:last-child){border-bottom-color:currentColor}.wp-block-table table[style*=border-left-color]>*,.wp-block-table table[style*=border-left-color] td:first-child,.wp-block-table table[style*=border-left-color] th,.wp-block-table table[style*=border-left-color] tr{border-left-color:inherit}.wp-block-table table[style*=border-style]>*,.wp-block-table table[style*=border-style] td,.wp-block-table table[style*=border-style] th,.wp-block-table table[style*=border-style] tr{border-style:inherit}.wp-block-table table[style*=border-width]>*,.wp-block-table table[style*=border-width] td,.wp-block-table table[style*=border-width] th,.wp-block-table table[style*=border-width] tr{border-width:inherit;border-style:inherit}.wp-block-text-columns,.wp-block-text-columns.aligncenter{display:flex}.wp-block-text-columns .wp-block-column{margin:0 1em;padding:0}.wp-block-text-columns .wp-block-column:first-child{margin-left:0}.wp-block-text-columns .wp-block-column:last-child{margin-right:0}.wp-block-text-columns.columns-2 .wp-block-column{width:50%}.wp-block-text-columns.columns-3 .wp-block-column{width:33.33333%}.wp-block-text-columns.columns-4 .wp-block-column{width:25%}pre.wp-block-verse{font-family:inherit;overflow:auto;white-space:pre-wrap}.wp-block-video{box-sizing:border-box}.wp-block-video video{width:100%}@supports (position:sticky){.wp-block-video [poster]{-o-object-fit:cover;object-fit:cover}}.wp-block-video.aligncenter{text-align:center}.wp-block-video figcaption{margin-top:.5em;margin-bottom:1em}.wp-element-button{cursor:pointer}:root{--wp--preset--font-size--normal:16px;--wp--preset--font-size--huge:42px}:root .has-very-light-gray-background-color{background-color:#eee}:root .has-very-dark-gray-background-color{background-color:#313131}:root .has-very-light-gray-color{color:#eee}:root .has-very-dark-gray-color{color:#313131}:root .has-vivid-green-cyan-to-vivid-cyan-blue-gradient-background{background:linear-gradient(135deg,#00d084,#0693e3)}:root .has-purple-crush-gradient-background{background:linear-gradient(135deg,#34e2e4,#4721fb 50%,#ab1dfe)}:root .has-hazy-dawn-gradient-background{background:linear-gradient(135deg,#faaca8,#dad0ec)}:root .has-subdued-olive-gradient-background{background:linear-gradient(135deg,#fafae1,#67a671)}:root .has-atomic-cream-gradient-background{background:linear-gradient(135deg,#fdd79a,#004a59)}:root .has-nightshade-gradient-background{background:linear-gradient(135deg,#330968,#31cdcf)}:root .has-midnight-gradient-background{background:linear-gradient(135deg,#020381,#2874fc)}.has-regular-font-size{font-size:1em}.has-larger-font-size{font-size:2.625em}.has-normal-font-size{font-size:var(--wp--preset--font-size--normal)}.has-huge-font-size{font-size:var(--wp--preset--font-size--huge)}.has-text-align-center{text-align:center}.has-text-align-left{text-align:left}.has-text-align-right{text-align:right}#end-resizable-editor-section{display:none}.aligncenter{clear:both}.items-justified-left{justify-content:flex-start}.items-justified-center{justify-content:center}.items-justified-right{justify-content:flex-end}.items-justified-space-between{justify-content:space-between}.screen-reader-text{border:0;clip:rect(1px,1px,1px,1px);-webkit-clip-path:inset(50%);clip-path:inset(50%);height:1px;margin:-1px;overflow:hidden;padding:0;position:absolute;width:1px;word-wrap:normal!important}.screen-reader-text:focus{background-color:#ddd;clip:auto!important;-webkit-clip-path:none;clip-path:none;color:#444;display:block;font-size:1em;height:auto;left:5px;line-height:normal;padding:15px 23px 14px;text-decoration:none;top:5px;width:auto;z-index:100000}html :where(.has-border-color){border-style:solid}html :where([style*=border-top-color]){border-top-style:solid}html :where([style*=border-right-color]){border-right-style:solid}html :where([style*=border-bottom-color]){border-bottom-style:solid}html :where([style*=border-left-color]){border-left-style:solid}html :where([style*=border-width]){border-style:solid}html :where([style*=border-top-width]){border-top-style:solid}html :where([style*=border-right-width]){border-right-style:solid}html :where([style*=border-bottom-width]){border-bottom-style:solid}html :where([style*=border-left-width]){border-left-style:solid}html :where(img[class*=wp-image-]){height:auto;max-width:100%}figure{margin:0 0 1em}
/*! This file is auto-generated */
.wp-block-button__link{color:#fff;background-color:#32373c;border-radius:9999px;box-shadow:none;text-decoration:none;padding:calc(.667em + 2px) calc(1.333em + 2px);font-size:1.125em}body{--wp--preset--color--black:#000;--wp--preset--color--cyan-bluish-gray:#abb8c3;--wp--preset--color--white:#fff;--wp--preset--color--pale-pink:#f78da7;--wp--preset--color--vivid-red:#cf2e2e;--wp--preset--color--luminous-vivid-orange:#ff6900;--wp--preset--color--luminous-vivid-amber:#fcb900;--wp--preset--color--light-green-cyan:#7bdcb5;--wp--preset--color--vivid-green-cyan:#00d084;--wp--preset--color--pale-cyan-blue:#8ed1fc;--wp--preset--color--vivid-cyan-blue:#0693e3;--wp--preset--color--vivid-purple:#9b51e0;--wp--preset--color--contrast:var(--contrast);--wp--preset--color--contrast-2:var(--contrast-2);--wp--preset--color--contrast-3:var(--contrast-3);--wp--preset--color--base:var(--base);--wp--preset--color--base-2:var(--base-2);--wp--preset--color--base-3:var(--base-3);--wp--preset--color--accent:var(--accent);--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple:linear-gradient(135deg,rgba(6,147,227,1) 0%,#9b51e0 100%);--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan:linear-gradient(135deg,#7adcb4 0%,#00d082 100%);--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange:linear-gradient(135deg,rgba(252,185,0,1) 0%,rgba(255,105,0,1) 100%);--wp--preset--gradient--luminous-vivid-orange-to-vivid-red:linear-gradient(135deg,rgba(255,105,0,1) 0%,#cf2e2e 100%);--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray:linear-gradient(135deg,#eee 0%,#a9b8c3 100%);--wp--preset--gradient--cool-to-warm-spectrum:linear-gradient(135deg,#4aeadc 0%,#9778d1 20%,#cf2aba 40%,#ee2c82 60%,#fb6962 80%,#fef84c 100%);--wp--preset--gradient--blush-light-purple:linear-gradient(135deg,#ffceec 0%,#9896f0 100%);--wp--preset--gradient--blush-bordeaux:linear-gradient(135deg,#fecda5 0%,#fe2d2d 50%,#6b003e 100%);--wp--preset--gradient--luminous-dusk:linear-gradient(135deg,#ffcb70 0%,#c751c0 50%,#4158d0 100%);--wp--preset--gradient--pale-ocean:linear-gradient(135deg,#fff5cb 0%,#b6e3d4 50%,#33a7b5 100%);--wp--preset--gradient--electric-grass:linear-gradient(135deg,#caf880 0%,#71ce7e 100%);--wp--preset--gradient--midnight:linear-gradient(135deg,#020381 0%,#2874fc 100%);--wp--preset--duotone--dark-grayscale:url('#wp-duotone-dark-grayscale');--wp--preset--duotone--grayscale:url('#wp-duotone-grayscale');--wp--preset--duotone--purple-yellow:url('#wp-duotone-purple-yellow');--wp--preset--duotone--blue-red:url('#wp-duotone-blue-red');--wp--preset--duotone--midnight:url('#wp-duotone-midnight');--wp--preset--duotone--magenta-yellow:url('#wp-duotone-magenta-yellow');--wp--preset--duotone--purple-green:url('#wp-duotone-purple-green');--wp--preset--duotone--blue-orange:url('#wp-duotone-blue-orange');--wp--preset--font-size--small:13px;--wp--preset--font-size--medium:20px;--wp--preset--font-size--large:36px;--wp--preset--font-size--x-large:42px;--wp--preset--spacing--20:.44rem;--wp--preset--spacing--30:.67rem;--wp--preset--spacing--40:1rem;--wp--preset--spacing--50:1.5rem;--wp--preset--spacing--60:2.25rem;--wp--preset--spacing--70:3.38rem;--wp--preset--spacing--80:5.06rem}:where(.is-layout-flex){gap:.5em}body .is-layout-flow>.alignleft{float:left;margin-inline-start:0;margin-inline-end:2em}body .is-layout-flow>.alignright{float:right;margin-inline-start:2em;margin-inline-end:0}body .is-layout-flow>.aligncenter{margin-left:auto !important;margin-right:auto !important}body .is-layout-constrained>.alignleft{float:left;margin-inline-start:0;margin-inline-end:2em}body .is-layout-constrained>.alignright{float:right;margin-inline-start:2em;margin-inline-end:0}body .is-layout-constrained>.aligncenter{margin-left:auto !important;margin-right:auto !important}body .is-layout-constrained>:where(:not(.alignleft):not(.alignright):not(.alignfull)){max-width:var(--wp--style--global--content-size);margin-left:auto !important;margin-right:auto !important}body .is-layout-constrained>.alignwide{max-width:var(--wp--style--global--wide-size)}body .is-layout-flex{display:flex}body .is-layout-flex{flex-wrap:wrap;align-items:center}body .is-layout-flex>*{margin:0}:where(.wp-block-columns.is-layout-flex){gap:2em}.has-black-color{color:var(--wp--preset--color--black) !important}.has-cyan-bluish-gray-color{color:var(--wp--preset--color--cyan-bluish-gray) !important}.has-white-color{color:var(--wp--preset--color--white) !important}.has-pale-pink-color{color:var(--wp--preset--color--pale-pink) !important}.has-vivid-red-color{color:var(--wp--preset--color--vivid-red) !important}.has-luminous-vivid-orange-color{color:var(--wp--preset--color--luminous-vivid-orange) !important}.has-luminous-vivid-amber-color{color:var(--wp--preset--color--luminous-vivid-amber) !important}.has-light-green-cyan-color{color:var(--wp--preset--color--light-green-cyan) !important}.has-vivid-green-cyan-color{color:var(--wp--preset--color--vivid-green-cyan) !important}.has-pale-cyan-blue-color{color:var(--wp--preset--color--pale-cyan-blue) !important}.has-vivid-cyan-blue-color{color:var(--wp--preset--color--vivid-cyan-blue) !important}.has-vivid-purple-color{color:var(--wp--preset--color--vivid-purple) !important}.has-black-background-color{background-color:var(--wp--preset--color--black) !important}.has-cyan-bluish-gray-background-color{background-color:var(--wp--preset--color--cyan-bluish-gray) !important}.has-white-background-color{background-color:var(--wp--preset--color--white) !important}.has-pale-pink-background-color{background-color:var(--wp--preset--color--pale-pink) !important}.has-vivid-red-background-color{background-color:var(--wp--preset--color--vivid-red) !important}.has-luminous-vivid-orange-background-color{background-color:var(--wp--preset--color--luminous-vivid-orange) !important}.has-luminous-vivid-amber-background-color{background-color:var(--wp--preset--color--luminous-vivid-amber) !important}.has-light-green-cyan-background-color{background-color:var(--wp--preset--color--light-green-cyan) !important}.has-vivid-green-cyan-background-color{background-color:var(--wp--preset--color--vivid-green-cyan) !important}.has-pale-cyan-blue-background-color{background-color:var(--wp--preset--color--pale-cyan-blue) !important}.has-vivid-cyan-blue-background-color{background-color:var(--wp--preset--color--vivid-cyan-blue) !important}.has-vivid-purple-background-color{background-color:var(--wp--preset--color--vivid-purple) !important}.has-black-border-color{border-color:var(--wp--preset--color--black) !important}.has-cyan-bluish-gray-border-color{border-color:var(--wp--preset--color--cyan-bluish-gray) !important}.has-white-border-color{border-color:var(--wp--preset--color--white) !important}.has-pale-pink-border-color{border-color:var(--wp--preset--color--pale-pink) !important}.has-vivid-red-border-color{border-color:var(--wp--preset--color--vivid-red) !important}.has-luminous-vivid-orange-border-color{border-color:var(--wp--preset--color--luminous-vivid-orange) !important}.has-luminous-vivid-amber-border-color{border-color:var(--wp--preset--color--luminous-vivid-amber) !important}.has-light-green-cyan-border-color{border-color:var(--wp--preset--color--light-green-cyan) !important}.has-vivid-green-cyan-border-color{border-color:var(--wp--preset--color--vivid-green-cyan) !important}.has-pale-cyan-blue-border-color{border-color:var(--wp--preset--color--pale-cyan-blue) !important}.has-vivid-cyan-blue-border-color{border-color:var(--wp--preset--color--vivid-cyan-blue) !important}.has-vivid-purple-border-color{border-color:var(--wp--preset--color--vivid-purple) !important}.has-vivid-cyan-blue-to-vivid-purple-gradient-background{background:var(--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple) !important}.has-light-green-cyan-to-vivid-green-cyan-gradient-background{background:var(--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan) !important}.has-luminous-vivid-amber-to-luminous-vivid-orange-gradient-background{background:var(--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange) !important}.has-luminous-vivid-orange-to-vivid-red-gradient-background{background:var(--wp--preset--gradient--luminous-vivid-orange-to-vivid-red) !important}.has-very-light-gray-to-cyan-bluish-gray-gradient-background{background:var(--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray) !important}.has-cool-to-warm-spectrum-gradient-background{background:var(--wp--preset--gradient--cool-to-warm-spectrum) !important}.has-blush-light-purple-gradient-background{background:var(--wp--preset--gradient--blush-light-purple) !important}.has-blush-bordeaux-gradient-background{background:var(--wp--preset--gradient--blush-bordeaux) !important}.has-luminous-dusk-gradient-background{background:var(--wp--preset--gradient--luminous-dusk) !important}.has-pale-ocean-gradient-background{background:var(--wp--preset--gradient--pale-ocean) !important}.has-electric-grass-gradient-background{background:var(--wp--preset--gradient--electric-grass) !important}.has-midnight-gradient-background{background:var(--wp--preset--gradient--midnight) !important}.has-small-font-size{font-size:var(--wp--preset--font-size--small) !important}.has-medium-font-size{font-size:var(--wp--preset--font-size--medium) !important}.has-large-font-size{font-size:var(--wp--preset--font-size--large) !important}.has-x-large-font-size{font-size:var(--wp--preset--font-size--x-large) !important}.wp-block-navigation a:where(:not(.wp-element-button)){color:inherit}:where(.wp-block-columns.is-layout-flex){gap:2em}.wp-block-pullquote{font-size:1.5em;line-height:1.6}blockquote,body,dd,dl,dt,fieldset,figure,h1,h2,h3,h4,h5,h6,hr,html,iframe,legend,li,ol,p,pre,textarea,ul{margin:0;padding:0;border:0}html{font-family:sans-serif;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%;-webkit-font-smoothing:antialiased;-moz-osx-font-smoothing:grayscale}main{display:block}progress{vertical-align:baseline}html{box-sizing:border-box}*,:after,:before{box-sizing:inherit}button,input,optgroup,select,textarea{font-family:inherit;font-size:100%;margin:0}[type=search]{-webkit-appearance:textfield;outline-offset:-2px}[type=search]::-webkit-search-decoration{-webkit-appearance:none}::-moz-focus-inner{border-style:none;padding:0}:-moz-focusring{outline:1px dotted ButtonText}body,button,input,select,textarea{font-family:-apple-system,system-ui,BlinkMacSystemFont,"Segoe UI",Helvetica,Arial,sans-serif,"Apple Color Emoji","Segoe UI Emoji","Segoe UI Symbol";font-weight:400;text-transform:none;font-size:17px;line-height:1.5}p{margin-bottom:1.5em}h1,h2,h3,h4,h5,h6{font-family:inherit;font-size:100%;font-style:inherit;font-weight:inherit}pre{background:rgba(0,0,0,.05);font-family:inherit;font-size:inherit;line-height:normal;margin-bottom:1.5em;padding:20px;overflow:auto;max-width:100%}blockquote{border-left:5px solid rgba(0,0,0,.05);padding:20px;font-size:1.2em;font-style:italic;margin:0 0 1.5em;position:relative}blockquote p:last-child{margin:0}table,td,th{border:1px solid rgba(0,0,0,.1)}table{border-collapse:separate;border-spacing:0;border-width:1px 0 0 1px;margin:0 0 1.5em;width:100%}td,th{padding:8px}th{border-width:0 1px 1px 0}td{border-width:0 1px 1px 0}hr{background-color:rgba(0,0,0,.1);border:0;height:1px;margin-bottom:40px;margin-top:40px}fieldset{padding:0;border:0;min-width:inherit}fieldset legend{padding:0;margin-bottom:1.5em}h1{font-size:42px;margin-bottom:20px;line-height:1.2em;font-weight:400;text-transform:none}h2{font-size:35px;margin-bottom:20px;line-height:1.2em;font-weight:400;text-transform:none}h3{font-size:29px;margin-bottom:20px;line-height:1.2em;font-weight:400;text-transform:none}h4{font-size:24px}h5{font-size:20px}h4,h5,h6{margin-bottom:20px}ol,ul{margin:0 0 1.5em 3em}ul{list-style:disc}ol{list-style:decimal}li>ol,li>ul{margin-bottom:0;margin-left:1.5em}dt{font-weight:700}dd{margin:0 1.5em 1.5em}b,strong{font-weight:700}cite,dfn,em,i{font-style:italic}address{margin:0 0 1.5em}code,kbd,tt,var{font:15px Monaco,Consolas,"Andale Mono","DejaVu Sans Mono",monospace}abbr,acronym{border-bottom:1px dotted #666;cursor:help}ins,mark{text-decoration:none}sub,sup{font-size:75%;height:0;line-height:0;position:relative;vertical-align:baseline}sup{bottom:1ex}sub{top:.5ex}small{font-size:75%}big{font-size:125%}figure{margin:0}table{margin:0 0 1.5em;width:100%}th{font-weight:700}img{height:auto;max-width:100%}button,input[type=button],input[type=reset],input[type=submit]{background:#55555e;color:#fff;border:1px solid transparent;cursor:pointer;-webkit-appearance:button;padding:10px 20px}input[type=email],input[type=number],input[type=password],input[type=search],input[type=tel],input[type=text],input[type=url],select,textarea{border:1px solid;border-radius:0;padding:10px 15px;max-width:100%}textarea{width:100%}a,button,input{transition:color .1s ease-in-out,background-color .1s ease-in-out}a{text-decoration:none}.button,.wp-block-button .wp-block-button__link{padding:10px 20px;display:inline-block}.wp-block-button .wp-block-button__link{font-size:inherit;line-height:inherit}.using-mouse :focus{outline:0}.using-mouse ::-moz-focus-inner{border:0}.alignleft{float:left;margin-right:1.5em}.alignright{float:right;margin-left:1.5em}.aligncenter{clear:both;display:block;margin:0 auto}.size-auto,.size-full,.size-large,.size-medium,.size-thumbnail{max-width:100%;height:auto}.no-sidebar .entry-content .alignfull{margin-left:calc(-100vw/2 + 100%/2);margin-right:calc(-100vw/2 + 100%/2);max-width:100vw;width:auto}.screen-reader-text{border:0;clip:rect(1px,1px,1px,1px);-webkit-clip-path:inset(50%);clip-path:inset(50%);height:1px;margin:-1px;overflow:hidden;padding:0;position:absolute!important;width:1px;word-wrap:normal!important}.screen-reader-text:focus{background-color:#f1f1f1;border-radius:3px;box-shadow:0 0 2px 2px rgba(0,0,0,.6);clip:auto!important;-webkit-clip-path:none;clip-path:none;color:#21759b;display:block;font-size:.875rem;font-weight:700;height:auto;left:5px;line-height:normal;padding:15px 23px 14px;text-decoration:none;top:5px;width:auto;z-index:100000}#primary[tabindex="-1"]:focus{outline:0}.main-navigation{z-index:100;padding:0;clear:both;display:block}.main-navigation a{display:block;text-decoration:none;font-weight:400;text-transform:none;font-size:15px}.main-navigation ul{list-style:none;margin:0;padding-left:0}.main-navigation .main-nav ul li a{padding-left:20px;padding-right:20px;line-height:60px}.inside-navigation{position:relative}.main-navigation .inside-navigation{display:flex;align-items:center;flex-wrap:wrap;justify-content:space-between}.main-navigation .main-nav>ul{display:flex;flex-wrap:wrap;align-items:center}.main-navigation li{position:relative}.main-navigation .menu-bar-items{display:flex;align-items:center;font-size:15px}.main-navigation .menu-bar-items a{color:inherit}.main-navigation .menu-bar-item{position:relative}.main-navigation .menu-bar-item.search-item{z-index:20}.main-navigation .menu-bar-item>a{padding-left:20px;padding-right:20px;line-height:60px}.sidebar .main-navigation .main-nav{flex-basis:100%}.sidebar .main-navigation .main-nav>ul{flex-direction:column}.sidebar .main-navigation .menu-bar-items{margin:0 auto}.sidebar .main-navigation .menu-bar-items .search-item{order:10}.nav-align-center .inside-navigation{justify-content:center}.nav-align-center .main-nav>ul{justify-content:center}.nav-align-right .inside-navigation{justify-content:flex-end}.main-navigation ul ul{display:block;box-shadow:1px 1px 0 rgba(0,0,0,.1);float:left;position:absolute;left:-99999px;opacity:0;z-index:99999;width:200px;text-align:left;top:auto;transition:opacity 80ms linear;transition-delay:0s;pointer-events:none;height:0;overflow:hidden}.main-navigation ul ul a{display:block}.main-navigation ul ul li{width:100%}.main-navigation .main-nav ul ul li a{line-height:normal;padding:10px 20px;font-size:14px}.main-navigation .main-nav ul li.menu-item-has-children>a{padding-right:0;position:relative}.main-navigation.sub-menu-left ul ul{box-shadow:-1px 1px 0 rgba(0,0,0,.1)}.main-navigation.sub-menu-left .sub-menu{right:0}.main-navigation:not(.toggled) ul li.sfHover>ul,.main-navigation:not(.toggled) ul li:hover>ul{left:auto;opacity:1;transition-delay:.15s;pointer-events:auto;height:auto;overflow:visible}.main-navigation:not(.toggled) ul ul li.sfHover>ul,.main-navigation:not(.toggled) ul ul li:hover>ul{left:100%;top:0}.main-navigation.sub-menu-left:not(.toggled) ul ul li.sfHover>ul,.main-navigation.sub-menu-left:not(.toggled) ul ul li:hover>ul{right:100%;left:auto}.nav-float-right .main-navigation ul ul ul{top:0}.menu-item-has-children .dropdown-menu-toggle{display:inline-block;height:100%;clear:both;padding-right:20px;padding-left:10px}.menu-item-has-children ul .dropdown-menu-toggle{padding-top:10px;padding-bottom:10px;margin-top:-10px}.sidebar .menu-item-has-children .dropdown-menu-toggle,nav ul ul .menu-item-has-children .dropdown-menu-toggle{float:right}.widget-area .main-navigation li{float:none;display:block;width:100%;padding:0;margin:0}.sidebar .main-navigation.sub-menu-right ul li.sfHover ul,.sidebar .main-navigation.sub-menu-right ul li:hover ul{top:0;left:100%}.sidebar .main-navigation.sub-menu-left ul li.sfHover ul,.sidebar .main-navigation.sub-menu-left ul li:hover ul{top:0;right:100%}.site-main .comment-navigation,.site-main .post-navigation,.site-main .posts-navigation{margin:0 0 2em;overflow:hidden}.site-main .post-navigation{margin-bottom:0}.paging-navigation .nav-next,.paging-navigation .nav-previous{display:none}.paging-navigation .nav-links>*{padding:0 5px}.paging-navigation .nav-links .current{font-weight:700}.nav-links>:first-child{padding-left:0}.site-header{position:relative}.inside-header{padding:20px 40px}.main-title{margin:0;font-size:25px;line-height:1.2em;word-wrap:break-word;font-weight:700;text-transform:none}.site-description{margin:0;line-height:1.5;font-weight:400;text-transform:none;font-size:15px}.site-logo{display:inline-block;max-width:100%}.site-header .header-image{vertical-align:middle}.inside-header{display:flex;align-items:center}.header-widget{margin-left:auto}.header-widget p:last-child{margin-bottom:0}.nav-float-right .header-widget{margin-left:20px}.nav-float-right #site-navigation{margin-left:auto}.nav-float-left #site-navigation{margin-right:auto;order:-10}.nav-float-left .header-widget{margin-left:0;margin-right:20px;order:-15}.header-aligned-center:not([class*=nav-float-]) .inside-header{justify-content:center;flex-direction:column;text-align:center}.header-aligned-center:not([class*=nav-float-]) .header-widget{margin-left:auto;margin-right:auto}.header-aligned-center:not([class*=nav-float-]) .inside-header>:not(:first-child){margin-top:1em}.header-aligned-right:not([class*=nav-float-]) .inside-header{justify-content:flex-end}.header-aligned-right:not([class*=nav-float-]) .header-widget{margin-right:auto;margin-left:0;order:-10}.site-branding-container{display:inline-flex;align-items:center;text-align:left;flex-shrink:0}.site-branding-container .site-logo{margin-right:1em}.sticky{display:block}.entry-header .gp-icon,.posted-on .updated{display:none}.byline,.entry-header .cat-links,.entry-header .comments-link,.entry-header .tags-links,.group-blog .byline,.single .byline{display:inline}footer.entry-meta .byline,footer.entry-meta .posted-on{display:block}.entry-content:not(:first-child),.entry-summary:not(:first-child),.page-content:not(:first-child){margin-top:2em}.page-links{clear:both;margin:0 0 1.5em}.archive .format-aside .entry-header,.archive .format-status .entry-header,.archive .format-status .entry-meta,.archive .format-status .entry-title,.blog .format-aside .entry-header,.blog .format-status .entry-header,.blog .format-status .entry-meta,.blog .format-status .entry-title{display:none}.archive .format-aside .entry-content,.archive .format-status .entry-content,.blog .format-aside .entry-content,.blog .format-status .entry-content{margin-top:0}.archive .format-status .entry-content p:last-child,.blog .format-status .entry-content p:last-child{margin-bottom:0}.entry-header,.site-content{word-wrap:break-word}.entry-title{margin-bottom:0}.author .page-header .page-title{display:flex;align-items:center}.author .page-header .avatar{margin-right:20px}.page-header .author-info>:last-child,.page-header>:last-child{margin-bottom:0}.entry-meta{font-size:85%;margin-top:.5em;line-height:1.5}footer.entry-meta{margin-top:2em}.cat-links,.comments-link,.tags-links{display:block}.entry-content>p:last-child,.entry-summary>p:last-child,.page-content>p:last-child,.read-more-container,.taxonomy-description p:last-child{margin-bottom:0}.wp-caption{margin-bottom:1.5em;max-width:100%;position:relative}.wp-caption img[class*=wp-image-]{display:block;margin:0 auto 0;max-width:100%}.wp-caption .wp-caption-text{font-size:75%;padding-top:5px;opacity:.8}.wp-caption img{position:relative;vertical-align:bottom}.wp-block-image figcaption{font-size:13px;text-align:center}.wp-block-gallery,ul.blocks-gallery-grid{margin-left:0}.wp-block-gallery .blocks-gallery-image figcaption,.wp-block-gallery .blocks-gallery-item figcaption{background:rgba(255,255,255,.7);color:#000;padding:10px;box-sizing:border-box}.gallery{margin-bottom:1.5em}.gallery-item{display:inline-block;text-align:center;vertical-align:top;width:100%}.gallery-columns-2 .gallery-item{max-width:50%}.gallery-columns-3 .gallery-item{max-width:33.33%}.gallery-columns-4 .gallery-item{max-width:25%}.gallery-columns-5 .gallery-item{max-width:20%}.gallery-columns-6 .gallery-item{max-width:16.66%}.gallery-columns-7 .gallery-item{max-width:14.28%}.gallery-columns-8 .gallery-item{max-width:12.5%}.gallery-columns-9 .gallery-item{max-width:11.11%}.gallery-caption{display:block}.site-main .gallery{margin-bottom:1.5em}.gallery-item img{vertical-align:bottom}.gallery-icon{padding:5px}embed,iframe,object{max-width:100%}.wp-block-post-template{margin-left:0}.widget-area .widget{padding:40px}.widget select{max-width:100%}.footer-widgets .widget :last-child,.sidebar .widget :last-child{margin-bottom:0}.widget-title{margin-bottom:30px;font-size:20px;line-height:1.5;font-weight:400;text-transform:none}.widget ol,.widget ul{margin:0}.widget .search-field{width:100%}.widget .search-form{display:flex}.widget .search-form button.search-submit{font-size:15px}.footer-widgets .widget{margin-bottom:30px}.footer-widgets .widget:last-child,.sidebar .widget:last-child{margin-bottom:0}.widget ul li{list-style-type:none;position:relative;margin-bottom:.5em}.widget ul li ul{margin-left:1em;margin-top:.5em}.wp-calendar-table{table-layout:fixed}.site-content{display:flex}.grid-container{margin-left:auto;margin-right:auto;max-width:1200px}.page-header,.sidebar .widget,.site-main>*{margin-bottom:20px}.both-left .inside-left-sidebar,.both-right .inside-left-sidebar{margin-right:10px}.both-left .inside-right-sidebar,.both-right .inside-right-sidebar{margin-left:10px}.one-container.both-right .site-main,.one-container.right-sidebar .site-main{margin-right:40px}.one-container.both-left .site-main,.one-container.left-sidebar .site-main{margin-left:40px}.one-container.both-sidebars .site-main{margin:0 40px}.one-container.archive .post:not(:last-child):not(.is-loop-template-item),.one-container.blog .post:not(:last-child):not(.is-loop-template-item){padding-bottom:40px}.one-container .site-content{padding:40px}.separate-containers .comments-area,.separate-containers .inside-article,.separate-containers .page-header,.separate-containers .paging-navigation{padding:40px}.separate-containers .site-main{margin:20px}.separate-containers.no-sidebar .site-main{margin-left:0;margin-right:0}.separate-containers.both-right .site-main,.separate-containers.right-sidebar .site-main{margin-left:0}.separate-containers.both-left .site-main,.separate-containers.left-sidebar .site-main{margin-right:0}.separate-containers .inside-left-sidebar,.separate-containers .inside-right-sidebar{margin-top:20px;margin-bottom:20px}.inside-page-header{padding:40px}.widget-area .main-navigation{margin-bottom:20px}.one-container .site-main>:last-child,.separate-containers .site-main>:last-child{margin-bottom:0}.full-width-content .container.grid-container{max-width:100%}.full-width-content.no-sidebar.separate-containers .site-main{margin:0}.full-width-content.one-container .site-content,.full-width-content.separate-containers .inside-article{padding:0}.full-width-content .entry-content .alignwide{margin-left:0;width:auto;max-width:unset}.contained-content.one-container .site-content,.contained-content.separate-containers .inside-article{padding:0}.sidebar .grid-container{max-width:100%;width:100%}.both-left .is-left-sidebar,.both-sidebars .is-left-sidebar,.left-sidebar .sidebar{order:-10}.both-left .is-right-sidebar{order:-5}.both-right .is-left-sidebar{order:5}.both-right .is-right-sidebar,.both-sidebars .is-right-sidebar{order:10}.inside-site-info{display:flex;align-items:center;justify-content:center;padding:20px 40px}.site-info{text-align:center;font-size:15px}.post-image:not(:first-child){margin-top:2em}.featured-image{line-height:0}.separate-containers .featured-image{margin-top:20px}.separate-containers .inside-article>.featured-image{margin-top:0;margin-bottom:2em}.one-container .inside-article>.featured-image{margin-top:0;margin-bottom:2em}.gp-icon{display:inline-flex;align-self:center}.gp-icon svg{height:1em;width:1em;top:.125em;position:relative;fill:currentColor}.close-search .icon-search svg:nth-child(1),.icon-menu-bars svg:nth-child(2),.icon-search svg:nth-child(2),.toggled .icon-menu-bars svg:nth-child(1){display:none}.close-search .icon-search svg:nth-child(2),.toggled .icon-menu-bars svg:nth-child(2){display:block}.entry-meta .gp-icon{margin-right:.6em;opacity:.7}nav.toggled .icon-arrow-left svg{transform:rotate(-90deg)}nav.toggled .icon-arrow-right svg{transform:rotate(90deg)}nav.toggled .sfHover>a>.dropdown-menu-toggle .gp-icon svg{transform:rotate(180deg)}nav.toggled .sfHover>a>.dropdown-menu-toggle .gp-icon.icon-arrow-left svg{transform:rotate(-270deg)}nav.toggled .sfHover>a>.dropdown-menu-toggle .gp-icon.icon-arrow-right svg{transform:rotate(270deg)}.container.grid-container{width:auto}.menu-toggle,.mobile-bar-items,.sidebar-nav-mobile{display:none}.menu-toggle{padding:0 20px;line-height:60px;margin:0;font-weight:400;text-transform:none;font-size:15px;cursor:pointer}.menu-toggle .mobile-menu{padding-left:3px}.menu-toggle .gp-icon+.mobile-menu{padding-left:9px}.menu-toggle .mobile-menu:empty{display:none}button.menu-toggle{background-color:transparent;flex-grow:1;border:0;text-align:center}button.menu-toggle:active,button.menu-toggle:focus,button.menu-toggle:hover{background-color:transparent}.has-menu-bar-items button.menu-toggle{flex-grow:0}nav.toggled ul ul.sub-menu{width:100%}.toggled .menu-item-has-children .dropdown-menu-toggle{padding-left:20px}.main-navigation.toggled .main-nav{flex-basis:100%;order:3}.main-navigation.toggled .main-nav>ul{display:block}.main-navigation.toggled .main-nav li{width:100%;text-align:left}.main-navigation.toggled .main-nav ul ul{transition:0s;visibility:hidden;box-shadow:none;border-bottom:1px solid rgba(0,0,0,.05)}.main-navigation.toggled .main-nav ul ul li:last-child>ul{border-bottom:0}.main-navigation.toggled .main-nav ul ul.toggled-on{position:relative;top:0;left:auto!important;right:auto!important;width:100%;pointer-events:auto;height:auto;opacity:1;display:block;visibility:visible;float:none}.main-navigation.toggled .menu-item-has-children .dropdown-menu-toggle{float:right}.mobile-menu-control-wrapper{display:none;margin-left:auto;align-items:center}.has-inline-mobile-toggle #site-navigation.toggled{margin-top:1.5em}.has-inline-mobile-toggle #site-navigation.has-active-search{margin-top:1.5em}.has-inline-mobile-toggle #site-navigation.has-active-search .nav-search-active{position:relative}.has-inline-mobile-toggle #site-navigation.has-active-search .navigation-search input{outline:auto}.nav-float-left .mobile-menu-control-wrapper{order:-10;margin-left:0;margin-right:auto;flex-direction:row-reverse}@media (max-width:768px){.hide-on-mobile{display:none!important}a,body,button,input,select,textarea{transition:all 0s ease-in-out}.inside-header{flex-direction:column;text-align:center}.site-header .header-widget{margin-top:1.5em;margin-left:auto;margin-right:auto;text-align:center}.site-content{flex-direction:column}.container .site-content .content-area{width:auto}.is-left-sidebar.sidebar,.is-right-sidebar.sidebar{width:auto;order:initial}.is-left-sidebar+.is-right-sidebar .inside-right-sidebar{margin-top:0}.both-left .inside-left-sidebar,.both-left .inside-right-sidebar,.both-right .inside-left-sidebar,.both-right .inside-right-sidebar{margin-right:0;margin-left:0}#main{margin-left:0;margin-right:0}body:not(.no-sidebar) #main{margin-bottom:0}.alignleft,.alignright{float:none;display:block;margin-left:auto;margin-right:auto}.comment .children{padding-left:10px;margin-left:0}.entry-meta{font-size:inherit}.entry-meta a{line-height:1.8em}}@media (min-width:769px) and (max-width:1024px){.hide-on-tablet{display:none!important}}@media (min-width:1025px){.hide-on-desktop{display:none!important}}body{background-color:var(--base-2);color:var(--contrast)}a{color:var(--accent)}a{text-decoration:underline}.entry-title a,.site-branding a,a.button,.wp-block-button__link,.main-navigation a{text-decoration:none}a:hover,a:focus,a:active{color:var(--contrast)}.grid-container{max-width:850px}.wp-block-group__inner-container{max-width:850px;margin-left:auto;margin-right:auto}:root{--contrast:#222;--contrast-2:#575760;--contrast-3:#b2b2be;--base:#f0f0f0;--base-2:#f7f8f9;--base-3:#fff;--accent:#1e73be}:root .has-contrast-color{color:var(--contrast)}:root .has-contrast-background-color{background-color:var(--contrast)}:root .has-contrast-2-color{color:var(--contrast-2)}:root .has-contrast-2-background-color{background-color:var(--contrast-2)}:root .has-contrast-3-color{color:var(--contrast-3)}:root .has-contrast-3-background-color{background-color:var(--contrast-3)}:root .has-base-color{color:var(--base)}:root .has-base-background-color{background-color:var(--base)}:root .has-base-2-color{color:var(--base-2)}:root .has-base-2-background-color{background-color:var(--base-2)}:root .has-base-3-color{color:var(--base-3)}:root .has-base-3-background-color{background-color:var(--base-3)}:root .has-accent-color{color:var(--accent)}:root .has-accent-background-color{background-color:var(--accent)}h2{font-family:Arial;font-size:20px}h1.entry-title{font-family:Arial;font-size:20px}h2.entry-title{font-family:Arial;font-size:20px}h1{font-family:Arial;font-weight:700;font-size:20px}.main-title{font-family:Arial;font-size:20px}.top-bar{background-color:#636363;color:#fff}.top-bar a{color:#fff}.top-bar a:hover{color:#303030}.site-header{background-color:var(--base-3)}.main-title a,.main-title a:hover{color:var(--contrast)}.site-description{color:var(--contrast-2)}.mobile-menu-control-wrapper .menu-toggle,.mobile-menu-control-wrapper .menu-toggle:hover,.mobile-menu-control-wrapper .menu-toggle:focus,.has-inline-mobile-toggle #site-navigation.toggled{background-color:rgba(0,0,0,.02)}.main-navigation,.main-navigation ul ul{background-color:var(--base-3)}.main-navigation .main-nav ul li a,.main-navigation .menu-toggle,.main-navigation .menu-bar-items{color:var(--contrast)}.main-navigation .main-nav ul li:not([class*=current-menu-]):hover>a,.main-navigation .main-nav ul li:not([class*=current-menu-]):focus>a,.main-navigation .main-nav ul li.sfHover:not([class*=current-menu-])>a,.main-navigation .menu-bar-item:hover>a,.main-navigation .menu-bar-item.sfHover>a{color:var(--accent)}button.menu-toggle:hover,button.menu-toggle:focus{color:var(--contrast)}.main-navigation .main-nav ul li[class*=current-menu-]>a{color:var(--accent)}.navigation-search input[type=search],.navigation-search input[type=search]:active,.navigation-search input[type=search]:focus,.main-navigation .main-nav ul li.search-item.active>a,.main-navigation .menu-bar-items .search-item.active>a{color:var(--accent)}.main-navigation ul ul{background-color:var(--base)}.separate-containers .inside-article,.separate-containers .comments-area,.separate-containers .page-header,.one-container .container,.separate-containers .paging-navigation,.inside-page-header{background-color:var(--base-3)}.entry-title a{color:var(--contrast)}.entry-title a:hover{color:var(--contrast-2)}.entry-meta{color:var(--contrast-2)}.sidebar .widget{background-color:var(--base-3)}.footer-widgets{background-color:var(--base-3)}.site-info{background-color:var(--base-3)}input[type=text],input[type=email],input[type=url],input[type=password],input[type=search],input[type=tel],input[type=number],textarea,select{color:var(--contrast);background-color:var(--base-2);border-color:var(--base)}input[type=text]:focus,input[type=email]:focus,input[type=url]:focus,input[type=password]:focus,input[type=search]:focus,input[type=tel]:focus,input[type=number]:focus,textarea:focus,select:focus{color:var(--contrast);background-color:var(--base-2);border-color:var(--contrast-3)}button,html input[type=button],input[type=reset],input[type=submit],a.button,a.wp-block-button__link:not(.has-background){color:#fff;background-color:#55555e}button:hover,html input[type=button]:hover,input[type=reset]:hover,input[type=submit]:hover,a.button:hover,button:focus,html input[type=button]:focus,input[type=reset]:focus,input[type=submit]:focus,a.button:focus,a.wp-block-button__link:not(.has-background):active,a.wp-block-button__link:not(.has-background):focus,a.wp-block-button__link:not(.has-background):hover{color:#fff;background-color:#3f4047}a.generate-back-to-top{background-color:rgba(0,0,0,.4);color:#fff}a.generate-back-to-top:hover,a.generate-back-to-top:focus{background-color:rgba(0,0,0,.6);color:#fff}:root{--gp-search-modal-bg-color:var(--base-3);--gp-search-modal-text-color:var(--contrast);--gp-search-modal-overlay-bg-color:rgba(0,0,0,.2)}@media (max-width:850px){.main-navigation .menu-bar-item:hover>a,.main-navigation .menu-bar-item.sfHover>a{background:0 0;color:var(--contrast)}}.inside-top-bar.grid-container{max-width:930px}.inside-header{padding:0 30px}.inside-header.grid-container{max-width:910px}.separate-containers .inside-article,.separate-containers .comments-area,.separate-containers .page-header,.separate-containers .paging-navigation,.one-container .site-content,.inside-page-header{padding:10px 20px}.site-main .wp-block-group__inner-container{padding:10px 20px}.separate-containers .paging-navigation{padding-top:20px;padding-bottom:20px}.entry-content .alignwide,body:not(.no-sidebar) .entry-content .alignfull{margin-left:-20px;width:calc(100% + 40px);max-width:calc(100% + 40px)}.one-container.right-sidebar .site-main,.one-container.both-right .site-main{margin-right:20px}.one-container.left-sidebar .site-main,.one-container.both-left .site-main{margin-left:20px}.one-container.both-sidebars .site-main{margin:0 20px}.sidebar .widget,.page-header,.widget-area .main-navigation,.site-main>*{margin-bottom:10px}.separate-containers .site-main{margin:10px}.both-right .inside-left-sidebar,.both-left .inside-left-sidebar{margin-right:5px}.both-right .inside-right-sidebar,.both-left .inside-right-sidebar{margin-left:5px}.one-container.archive .post:not(:last-child):not(.is-loop-template-item),.one-container.blog .post:not(:last-child):not(.is-loop-template-item){padding-bottom:10px}.separate-containers .featured-image{margin-top:10px}.separate-containers .inside-right-sidebar,.separate-containers .inside-left-sidebar{margin-top:10px;margin-bottom:10px}.main-navigation .main-nav ul li a,.menu-toggle,.main-navigation .menu-bar-item>a{padding-left:10px;padding-right:10px;line-height:26px}.main-navigation .main-nav ul ul li a{padding:50px 10px}.main-navigation ul ul{width:100px}.navigation-search input[type=search]{height:26px}.rtl .menu-item-has-children .dropdown-menu-toggle{padding-left:10px}.menu-item-has-children .dropdown-menu-toggle{padding-right:10px}.menu-item-has-children ul .dropdown-menu-toggle{padding-top:50px;padding-bottom:50px;margin-top:-50px}.rtl .main-navigation .main-nav ul li.menu-item-has-children>a{padding-right:10px}.widget-area .widget{padding:10px}.footer-widgets-container.grid-container{max-width:930px}.inside-site-info.grid-container{max-width:930px}@media (max-width:768px){.separate-containers .inside-article,.separate-containers .comments-area,.separate-containers .page-header,.separate-containers .paging-navigation,.one-container .site-content,.inside-page-header{padding:10px 20px}.site-main .wp-block-group__inner-container{padding:10px 20px}.inside-top-bar{padding-right:30px;padding-left:30px}.inside-header{padding-top:0;padding-right:30px;padding-bottom:0;padding-left:30px}.widget-area .widget{padding-top:0;padding-right:0;padding-bottom:0;padding-left:0}.footer-widgets-container{padding-top:30px;padding-right:30px;padding-bottom:30px;padding-left:30px}.inside-site-info{padding-right:30px;padding-left:30px}.entry-content .alignwide,body:not(.no-sidebar) .entry-content .alignfull{margin-left:-20px;width:calc(100% + 40px);max-width:calc(100% + 40px)}.one-container .site-main .paging-navigation{margin-bottom:10px}}.is-right-sidebar{width:15%}.is-left-sidebar{width:15%}.site-content .content-area{width:100%}@media (max-width:850px){.main-navigation .menu-toggle,.sidebar-nav-mobile:not(#sticky-placeholder){display:block}.main-navigation ul,.gen-sidebar-nav,.main-navigation:not(.slideout-navigation):not(.toggled) .main-nav>ul,.has-inline-mobile-toggle #site-navigation .inside-navigation>*:not(.navigation-search):not(.main-nav){display:none}.nav-align-right .inside-navigation,.nav-align-center .inside-navigation{justify-content:space-between}}.dynamic-author-image-rounded{border-radius:100%}.dynamic-featured-image,.dynamic-author-image{vertical-align:middle}.one-container.blog .dynamic-content-template:not(:last-child),.one-container.archive .dynamic-content-template:not(:last-child){padding-bottom:0}.dynamic-entry-excerpt>p:last-child{margin-bottom:0}.main-navigation.toggled .main-nav>ul{background-color:var(--base-3)}.sticky-enabled .gen-sidebar-nav.is_stuck .main-navigation{margin-bottom:0}.sticky-enabled .gen-sidebar-nav.is_stuck{z-index:500}.sticky-enabled .main-navigation.is_stuck{box-shadow:0 2px 2px -2px rgba(0,0,0,.2)}.navigation-stick:not(.gen-sidebar-nav){left:0;right:0;width:100% !important}.nav-float-right .navigation-stick{width:100% !important;left:0}.nav-float-right .navigation-stick .navigation-branding{margin-right:auto}.main-navigation.has-sticky-branding:not(.grid-container) .inside-navigation:not(.grid-container) .navigation-branding{margin-left:10px}@media (max-width:850px){.main-navigation .menu-toggle,.main-navigation .mobile-bar-items a,.main-navigation .menu-bar-item>a{padding-left:10px;padding-right:10px}.main-navigation .main-nav ul li a,.main-navigation .menu-toggle,.main-navigation .mobile-bar-items a,.main-navigation .menu-bar-item>a{line-height:20px}.main-navigation .site-logo.navigation-logo img,.mobile-header-navigation .site-logo.mobile-header-logo img,.navigation-search input[type=search]{height:20px}}.post-image:not(:first-child),.page-content:not(:first-child),.entry-content:not(:first-child),.entry-summary:not(:first-child),footer.entry-meta{margin-top:1em}.post-image-above-header .inside-article div.featured-image,.post-image-above-header .inside-article div.post-image{margin-bottom:1em}.main-navigation.slideout-navigation .main-nav>ul>li>a{line-height:30px}.main-navigation.offside{position:fixed;width:var(--gp-slideout-width);height:100%;height:100vh;top:0;z-index:9999;overflow:auto;-webkit-overflow-scrolling:touch}.offside,.offside--left{left:calc(var(--gp-slideout-width)*-1)}.offside--right{left:auto;right:calc(var(--gp-slideout-width)*-1)}.offside--left.is-open:not(.slideout-transition),.offside-js--is-left .offside-sliding-element{transform:translate3d(var(--gp-slideout-width),0,0)}.offside--right.is-open:not(.slideout-transition),.offside-js--is-right .offside-sliding-element{transform:translate3d(calc(var(--gp-slideout-width)*-1),0,0)}.offside-js--interact .offside,.offside-js--interact .offside-sliding-element{transition:transform .2s cubic-bezier(.16,.68,.43,.99);-webkit-backface-visibility:hidden;-webkit-perspective:1000}.offside-js--init{overflow-x:hidden}.no-csstransforms3d .offside{transform:translate3d(0,0,0)}.no-csstransforms3d .offside-sliding-element{overflow-x:hidden;position:relative}.no-csstransforms3d .offside--left.is-open{left:0}.no-csstransforms3d .offside--right.is-open{right:0}.no-csstransforms3d>.offside-js--is-left .offside-sliding-element{right:calc(var(--gp-slideout-width)*-1)}.no-csstransforms3d>.offside-js--is-right .offside-sliding-element{left:calc(var(--gp-slideout-width)*-1)}.slideout-navigation.main-navigation:not(.is-open):not(.slideout-transition){display:none}.slideout-navigation.main-navigation:not(.slideout-transition).do-overlay{opacity:1}.slideout-navigation.main-navigation.slideout-transition.do-overlay{opacity:0}.slideout-overlay{z-index:100000;position:fixed;width:100%;height:100%;height:100vh;min-height:100%;top:0;right:0;bottom:0;left:0;background-color:rgba(0,0,0,.8);visibility:hidden;opacity:0;cursor:pointer;transition:visibility .2s ease,opacity .2s ease}.offside-js--is-open .slideout-overlay{visibility:visible;opacity:1}.slideout-overlay button.slideout-exit{position:fixed;top:0;background-color:transparent;color:#fff;font-size:30px;border:0;opacity:0}.slide-opened .slideout-overlay button.slideout-exit{opacity:1}button.slideout-exit:hover{background-color:transparent}.slideout-navigation button.slideout-exit{background:0 0;width:100%;text-align:left;padding-top:20px;padding-bottom:20px;box-sizing:border-box;border:0}.slide-opened nav.toggled .menu-toggle:before{content:"\f0c9"}.offside-js--is-left.slide-opened .slideout-overlay button.slideout-exit{left:calc(var(--gp-slideout-width) - 5px)}.offside-js--is-right.slide-opened .slideout-overlay button.slideout-exit{right:calc(var(--gp-slideout-width) - 5px)}.slideout-widget{margin:20px}.slideout-navigation .main-nav,.slideout-navigation .slideout-widget:not(:last-child){margin-bottom:40px}.slideout-navigation:not(.do-overlay) .main-nav{width:100%;box-sizing:border-box}.slideout-navigation .mega-menu>ul>li{display:block;width:100%!important}.slideout-navigation .slideout-menu{display:block}#generate-slideout-menu{z-index:100001}#generate-slideout-menu .slideout-menu li{float:none;width:100%;clear:both;text-align:left}.slideout-navigation .slideout-widget li{float:none}#generate-slideout-menu.do-overlay li{text-align:center}#generate-slideout-menu.main-navigation ul ul{display:none}#generate-slideout-menu.main-navigation ul ul.toggled-on{display:block!important}#generate-slideout-menu .slideout-menu li.sfHover>ul,#generate-slideout-menu .slideout-menu li:hover>ul{display:none}#generate-slideout-menu.main-navigation .main-nav ul ul{position:relative;top:0;left:0;width:100%}.slideout-toggle:not(.has-svg-icon) a:before{content:"\f0c9";font-family:'GP Premium';line-height:1em;width:1.28571429em;text-align:center;display:inline-block;position:relative;top:1px}.slide-opened .slideout-exit:not(.has-svg-icon):before,.slideout-navigation button.slideout-exit:not(.has-svg-icon):before{content:"\f00d";font-family:'GP Premium';line-height:1em;width:1.28571429em;text-align:center;display:inline-block}#generate-slideout-menu li.menu-item-float-right{float:none!important;display:inline-block;width:auto}.rtl .slideout-navigation{position:fixed}.slideout-navigation .menu-item-has-children .dropdown-menu-toggle{float:right}.slideout-navigation .slideout-widget .menu li{float:none}.slideout-navigation .slideout-widget ul{display:block}.slideout-navigation.do-overlay{transform:none!important;transition:opacity .2s,visibility .2s;width:100%;text-align:center;left:0;right:0}.slideout-navigation.do-overlay .inside-navigation{display:flex;flex-direction:column;padding:10% 10% 0;max-width:700px}.slideout-navigation.do-overlay .inside-navigation .main-nav,.slideout-navigation.do-overlay .inside-navigation .slideout-widget{margin-left:auto;margin-right:auto;min-width:250px}.slideout-navigation.do-overlay .slideout-exit{position:fixed;right:0;top:0;width:auto;font-size:25px}.slideout-navigation.do-overlay .slideout-menu li a{display:inline-block}.slideout-navigation.do-overlay .slideout-menu li{margin-bottom:5px}#generate-slideout-menu.do-overlay .slideout-menu li,.slideout-navigation.do-overlay .inside-navigation{text-align:center}.slideout-navigation.do-overlay .menu-item-has-children .dropdown-menu-toggle{border-left:1px solid rgba(0,0,0,.07);padding:0 10px;margin:0 0 0 10px}.slideout-navigation.do-overlay ul ul{box-shadow:0 0 0}.nav-aligned-center .slideout-navigation,.nav-aligned-right .slideout-navigation{text-align:left}.slideout-navigation .sfHover>a>.dropdown-menu-toggle>.gp-icon svg{transform:rotate(180deg)}.slideout-navigation .sub-menu .dropdown-menu-toggle .gp-icon svg{transform:rotate(0)}.slideout-both .main-navigation.toggled .main-nav>ul,.slideout-desktop .main-navigation.toggled .main-nav li.slideout-toggle,.slideout-mobile .main-navigation.toggled .main-nav>ul{display:none!important}.slideout-both .has-inline-mobile-toggle #site-navigation.toggled,.slideout-mobile .has-inline-mobile-toggle #site-navigation.toggled{margin-top:0}.sf-menu>li.slideout-toggle{float:right}.gen-sidebar-nav .sf-menu>li.slideout-toggle{float:none}.off-canvas-toggle-label{padding-left:7px}.gp-icon+.off-canvas-toggle-label{padding-left:9px}@media (max-width:768px){.slideout-overlay button.slideout-exit{font-size:20px;padding:10px}.slideout-overlay{top:-100px;height:calc(100% + 100px);height:calc(100vh + 100px);min-height:calc(100% + 100px)}.slideout-navigation.do-overlay .slideout-exit{position:static;text-align:center}}:root{--gp-slideout-width:265px}.slideout-navigation,.slideout-navigation a{color:var(--contrast)}.slideout-navigation button.slideout-exit{color:var(--contrast);padding-left:10px;padding-right:10px}.slide-opened nav.toggled .menu-toggle:before{display:none}@media (max-width:850px){.menu-bar-item.slideout-toggle{display:none}}.navigation-branding,.site-logo.mobile-header-logo{display:flex;align-items:center;order:0;margin-right:10px}.navigation-branding img,.site-logo.mobile-header-logo img{position:relative;padding:10px 0;display:block;transition:height .3s ease}.navigation-branding>div+.main-title{margin-left:10px}.navigation-branding .main-title{transition:line-height .3s ease}.navigation-branding .main-title a{font-family:inherit;font-size:inherit;font-weight:inherit;text-transform:unset}.main-navigation.mobile-header-navigation{display:none;float:none;margin-bottom:0}.mobile-header-navigation.is_stuck{box-shadow:0 2px 2px -2px rgba(0,0,0,.2)}.main-navigation .menu-toggle{flex-grow:1;width:auto}.main-navigation.has-branding .menu-toggle,.main-navigation.has-sticky-branding.navigation-stick .menu-toggle{flex-grow:0;padding-right:20px;order:2}.main-navigation:not(.slideout-navigation) .mobile-bar-items+.menu-toggle{text-align:left}.main-navigation.has-sticky-branding:not(.has-branding):not(.navigation-stick) .navigation-branding{display:none}.nav-align-right .navigation-branding{margin-right:auto}.main-navigation.has-branding:not([class*=nav-align-]):not(.mobile-header-navigation) .inside-navigation,.main-navigation.has-sticky-branding.navigation-stick:not([class*=nav-align-]):not(.mobile-header-navigation) .inside-navigation{justify-content:flex-start}.main-navigation.has-branding:not([class*=nav-align-]):not(.mobile-header-navigation) .menu-bar-items,.main-navigation.has-sticky-branding.navigation-stick:not([class*=nav-align-]):not(.mobile-header-navigation) .menu-bar-items{margin-left:auto}.nav-float-right .main-navigation.has-branding:not(.mobile-header-navigation) .menu-bar-items,.nav-float-right .main-navigation.has-sticky-branding.navigation-stick:not(.mobile-header-navigation) .menu-bar-items{margin-left:0}.mobile-header-navigation.has-menu-bar-items .mobile-header-logo{margin-right:auto}.rtl .navigation-branding>div+.main-title{margin-right:10px}.rtl .main-navigation.nav-align-right:not(.mobile-header-navigation) .navigation-branding{order:-10}.rtl .nav-align-right .navigation-branding{margin-right:10px}.rtl .navigation-branding,.rtl .site-logo.mobile-header-logo{margin-left:auto;margin-right:0}.rtl .nav-align-center .navigation-branding,.rtl .nav-align-center .site-logo.mobile-header-logo,.rtl .nav-align-right .navigation-branding,.rtl .nav-align-right .site-logo.mobile-header-logo{margin-left:10px}.rtl .nav-align-right .menu-bar-items{margin-right:auto}.rtl .mobile-header-navigation.has-menu-bar-items .site-logo{margin-left:auto}@media (max-width:850px){.site-header,#site-navigation,#sticky-navigation{display:none !important;opacity:.0}#mobile-header{display:block !important;width:100% !important}#mobile-header .main-nav>ul{display:none}#mobile-header.toggled .main-nav>ul,#mobile-header .menu-toggle,#mobile-header .mobile-bar-items{display:block}#mobile-header .main-nav{-ms-flex:0 0 100%;flex:0 0 100%;-webkit-box-ordinal-group:5;-ms-flex-order:4;order:4}}.main-navigation.has-branding.grid-container .navigation-branding,.main-navigation.has-branding:not(.grid-container) .inside-navigation:not(.grid-container) .navigation-branding{margin-left:10px}.navigation-branding img,.site-logo.mobile-header-logo img{height:26px;width:auto}.navigation-branding .main-title{line-height:26px}@media (max-width:860px){#site-navigation .navigation-branding,#sticky-navigation .navigation-branding{margin-left:10px}}@media (max-width:850px){.main-navigation.has-branding.nav-align-center .menu-bar-items,.main-navigation.has-sticky-branding.navigation-stick.nav-align-center .menu-bar-items{margin-left:auto}.navigation-branding{margin-right:auto;margin-left:10px}.navigation-branding .main-title,.mobile-header-navigation .site-logo{margin-left:10px}.navigation-branding img,.site-logo.mobile-header-logo{height:20px}.navigation-branding .main-title{line-height:20px}}
SENSITIVITY OF PLATELET-LYMPHOCYTE RATIO, MONOCYTE-LYMPHOCYTE RATIO, NEUTROPHIL-LYMPHOCYTE RATIO, RED BLOOD CELL DISTRIBUTION WIDTH AND SYSTEMIC IMMUNE INFLAMMATORY INDEX IN MULTIPLE SCLEROSIS PATIENTS: RELATIONSHIP WITH DISEASE SUBTYPES AND DISABILITY Skip to content Yıl 2024, Cilt: 25 Sayı: 3, 315 – 321, 18.07.2024
Melike Doğan Ünlü , Serpil Demirci
https://doi.org/10.18229/kocatepetip.1268139
Öz OBJECTIVE: Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system (CNS). Although it is not clear how autoimmune responses occur, it is known that peripheral blood cells may promote the initiation and exacerbation of the inflammatory response in MS. The aim of this study was to evaluate the sensitivity and specificity of neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), platelet-lymphocyte ratio (PLR), erythrocyte distribution width (RDW) and systemic immune inflammation index (SIII) in MS and to determine their relationship with disability. MATERIAL AND METHODS: In this single-center, retrospective case-control study, 104 patients with MS and 65 healthy individuals were included. Disability was assessed with the Expanded Disability Status Scale (EDSS) score, and patients were classified as mild (EDSS<3), moderate (3.5 ≤ EDSS ≥4.5), and severe (EDSS≥5) disabilities. NLR, MLR, PLR, RDW and SIII values were calculated according to the complete blood counts of the patients and the control group. Inflammation markers between the control group and MS patients, MS subtypes, and relapsing-remitting MS (RRMS) attack and remission periods were compared. the relationship between these markers and duration of illness, number of attacks and disability was examined. RESULTS: MLR and RDW were higher in MS than the controls. There was no significant difference in these values between MS subtypes. It was observed that RDW increased as the disease duration, number of attacks and EDSS increased. CONCLUSIONS: In our study, in evaluating inflammation it was seen that MLR and RDW were more determinative than PLR, NLR and SIII. The fact that RDW is higher in MS patients and is affected by disease disability indicates that RDW may have an important role in the follow-up of MS patients and in evaluating the degree of disability.
Anahtar Kelimeler Multiple sclerosis, Inflammatory response, Inflammation, Lymphocyte, Erythrocyte distribution volume
Kaynakça 1. Hemmer B, Kerschensteiner M, Korn T. Role of the innate and adaptive immune responses in the course of multiple sclerosis. Lancet Neurol. 2015;14:406–19. 2. Dendrou C, Fugger L, Friese M. Immunopathology of multiple sclerosis. Nat Rev Immunol. 2015;15(9):545-58. 3. Dargahi N, Katsara M, Tselios T, et al. Multiple sclerosis: immunopathology and treatment update. Brain Sci. 2017;7(7):78. 4. Demirci S, Demirci S, Kutluhan S, Koyuncuoglu HR, Yurekli VA. The clinical significance of the neutrophil-to- lymphocyte ratio in multiple sclerosis. Int J Neurosci. 2016;126(8):700-6. 5. Peng YF, Cao WY, Zhang Q, Chen D, Zhang ZX. Assessment of the relationship between red cell distribution width and multiple sclerosis. Medicine (Baltimore). 2015;94(29):1182. 6. Hemond C, Glaz B, Bakshi R, Chitnis T, Healy B. The neutrophil-to-lymphocyte and monocyte-to- lymphocyte ratios are independently associated with neurological disability and brain atrophy in multiple sclerosis. BMC Neurology. 2019;19:23. 7. Hao X, Li D, Wu D, Zhang N. The relationship between hematological indices and autoimmune rheumatic diseases (ARDs), a meta-analysis. Sci Rep. 2017;7:10833. 8. Saçmacı H, Aktürk T, Tanık N. The Predictive Value of the Systemic Immune-inflammation Index as a New Prognostic Marker for Disability in Patients with Multiple Sclerosis. Turk J Neurol. 2021;27:133-9. 9. Contentti E, López PA, Criniti J, et al. Platelet-to-lymphocyte ratio differs between MS and NMOSD at disease onset and predict disability. Mult Scler Relat Disord. 2022;58:103507. 10. Arhan M, Onal I, Tas A, et al. The role of red cell distribution width as a marker in inflammatory bowel disease. Turk J Med Sci. 2011;41(2):227-34. 11. Dziedzic A, Bijak M. Interactions between platelets and leukocytes in pathogenesis of multiple sclerosis. Adv Clin Exp Med. 2019;28(2):277-85. 12. Liu X, Shao S, Wang L, et al. Predictive value of the systemic immune-inflammation index for intravenous immunoglobulin resistance and cardiovascular complications in Kawasaki disease. Front Cardiovasc Med. 2021;24;8:711007. 13. Thompson AJ, Barwell BL, Barkhof F, et al. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Lancet Neurol. 2018;17(2):162-73. 14. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an Expanded Disability Status Scale (EDSS). Neurology 1983;33:1444-52. 15. Çinar BP, Yorgun YG. What we learned from the history of multiple sclerosis measurement: expanded disability status scale. Noro Psikiyatr Ars. 2018;55:69-75. 16. Pierson ER, Wagner CA, Goverman JM. The contribution of neutrophils to CNS autoimmunity. Clin Immunol. 2018;189:23–8. 17. Soulika AM, Lee E, McCauley E, et al. Initiation and progression of axonopathy in experimental autoimmune encephalomyelitis. J Neurosci. 2009;29:14965–79. 18. Horstman LL, Jy W, Ahn YS, et al. Role of platelets in neuroinflammation: a wide-angle perspective. J Neuroinflam. 2010;7:10. 19. Semple JW, Italiano JE, Freedman J. Platelets and the immune continuum. Nat Rev Immunol. 2011;11:264–74. 20. Hershko KA, Hadi E, Asali A, et al. Neutrophils to lymphocytes ratio and platelets to lymphocytes ratio in pregnancy: a population study. PLoS One. 2018;13(5):e0196706. 21. Zahorec R. Ratio of neutrophil to lymphocyte counts-rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy. 2001;102(1):5-14. 22. Yang DH, Qian MZ, Wei MM, et al. The correlation of neutrophil-tolymphocyte ratio with the presence and activity of myasthenia gravis. Oncotarget. 2017;8:76099-107. 23. Saliba W, Barnett-Griness O, Elias M, Rennert G. Neutrophil to lymphocyte ratio and risk of a first episode of stroke in patients with atrial fibrillation: a cohort study. J Thromb Haemost. 2015;13:1971-9. 24. Lattanzi S, Cagnetti C, Provinciali L, Silvestrini M. Neutrophil-tolymphocyte ratio and neurological deterioration following acute cerebral hemorrhage. Oncotarget. 2017;8:57489-94. 25. Bisgaard AK, Pihl-Jensen G, Frederiksen JL. The neutrophil-to-lymphocyte ratio as disease actvity marker in multiple sclerosis and optic neuritis. Mult Scler Relat Disord. 2017;18:213-7. 26. Al-Hussain F, Alfallaj MM, Alahmari AN, et al. Relationship between neutrophil-to-lymphocyte ratio and stress in multiple sclerosis patients. J Clin Diag Res. 2017;11:1–4. 27. Guzel I, Mungan S, Oztekin ZN, Ak F. Is there an association between the expanded disability status scale and inflammatory markers in multiple sclerosis. J Chinese Med Assoc. 2016;79:54–7. 28. Smith RA, Bosonnet L, Ghaneh P, et al. The plateletlymphocyte ratio improves the predictive value of serum CA19-9 levels in determining patient selection for staging laparoscopy in suspected periampullary cancer. Surgery. 2008;143:658-66. 29. Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des. 2011;17:47-58. 30. Uzar E, Arıkanoğlu A, Yücel Y, et al. Investigation of Mean Platelet Volume in Patients with Multiple Sclerosis. Turk Norol Derg. 2011;17:185-8. 31. Marinkovic D, Zhang X, Yalcin S, et al. Foxo3 is required for the regulation of oxidative stress in erythropoiesis. J Clin Invest. 2007;117:2133-44. 32. Fukuta H, Ohte N, Mukai S, et al. Elevated plasma levels of B-type natriuretic Peptide but not C-reactive protein are associated with higher red cell distribution width in patients with coronary artery disease. Int Heart J. 2009;50:301-12. 33. Patel KV, Mohanty JG, Kanapuru B, et al. Association of the red cell distribution width with red blood cell deformability. Adv Exp Med Biol. 2013;765:211–6. 34. Piagnerelli M, Boudjeltia KZ, Brohee D, et al. Alterations of red blood cell shape and sialic acid membrane content in septic patients. Crit Care Med. 2003;31:2156-62. 35. Tecer D, Sezgin M, Kanık A, et al. Can mean platelet volume and red blood cell distribution width show disease activity in rheumatoid arthritis? Biomark Med. 2016;10:967-74. 36. Song CS, Park DI, Yoon MY, et al. Association Between Red Cell Distribution Width and Disease Activity in Patients with Inflammatory Bowel Disease. Digest Dis Sci. 2012; 57:1033-8. 37. Yuksel O, Helvaci K, Basar O, et al. An overlooked indicator of disease activity in ulcerative colitis: mean platelet volume. Platelets. 2009;20:277-81. 38. Ani C, Ovbiagele B. Relation of baseline presence and severity of renal disease to long-term mortality in persons with known stroke. J Neurol Sci. 2010;288:123-8. 39. Hou D, Wang C, Luo Y, et al. Systemic immune-inflammation index (SII) but not platelet-albumin-bilirubin (PALBI) grade is associated with severity of acute ischemic stroke (AIS). Int J Neurosci. 2020;26:1–6. 40. Mei Y, Yang J, Yuan Y, et al. Systemic Inflammation Index Values Are Associated With Worsened Disease Severity and Poor Response to Autoimmune Encephalitis Treatment. Front. Neurol. 2021;12:709553.
MULTİPL SKLEROZ HASTALARINDA PLATELET LENFOSİT ORANI, MONOSİT LENFOSİT ORANI, NÖTROFİL LENFOSİT ORANI, ERİTROSİT DAĞILIM GENİŞLİĞİ VE SİSTEMİK İMMÜN İNFLAMASYON İNDEKSİ DUYARLILIĞI: HASTALIK ALT TİPLERİ VE ENGELLİLİK İLE İLİŞKİSİ Yıl 2024, Cilt: 25 Sayı: 3, 315 – 321, 18.07.2024
Melike Doğan Ünlü , Serpil Demirci
https://doi.org/10.18229/kocatepetip.1268139
Öz AMAÇ: Multipl skleroz (MS) merkezi sinir sisteminin (MSS) süreğen, inflamatuar otoimmün bir hastalığıdır. Otoimmün yanıtların nasıl oluştuğu netlik kazanmasa da periferik kan hücrelerinin MS’te inflamatuar yanıtın başlamasına ve şiddetlenmesine katkıda bulunabileceği bilinmektedir. Bu çalışmanın amacı MS’de nötrofil-lenfosit oranı (NLR), monosit-lenfosit oranı (MLR), platelet-lenfosit oranı (PLR), eritrosit dağılım genişliği (RDW) ve sistemik immün inflamasyon indeksi (SIII) duyarlılığını ve özgüllüğünü değerlendirmek ve engellilik ile arasındaki ilişkiyi belirlemektir. GEREÇ VE YÖNTEM: Bu tek merkezli, retrospektif vaka kontrol çalışmasına toplam 104 MS hastası ile yaş ve cinsiyet uyumlu 65 sağlıklı birey alındı. Engellilik, Genişletilmiş Engellilik Durumu Ölçeği (EDSS) ile değerlendirildi ve buna göre hastalar, hafif (EDSS<3), orta (3,5 ≤ EDSS ≥4,5) ve şiddetli (EDSS≥5) engelliler olarak sınıflandırıldı. Hastaların ve kontrol grubunun tam kan sayımlarına göre NLR, MLR, PLR, RDW ve SIII değerleri hesaplandı. Kontrol grubu ile MS hastaları, MS alt tipleri ve relapsing-remitting MS (RRMS) atak ve remisyon dönemi arasındaki inflamasyon belirteçleri karşılaştırıldı. Bu belirteçler ile hastalık süresi, atak sayısı ve özürlülük arasındaki ilişkiye bakıldı. BULGULAR: MLR ve RDW, MS’de kontrol grubuna göre daha yüksekti. MS alt tiplerin arasında bu değerlerde anlamlı farklılık yoktu. Hastalık süresi, atak sayısı ve EDSS arttıkça RDW’nin de arttığı görüldü. SONUÇ: Çalışmamızda MLR ve RDW’nin PLR, NLR ve SIII’ye göre inflamasyonu değerlendirmede daha belirleyici olduğu görülmüştür. RDW’nin MS hastalarında daha yüksek olması ve hastalık disabilitesinden etkilenmesi, MS hastalarının takibinde ve özürlülük derecesinin değerlendirilmesinde RDW’nin önemli bir rolü olabileceğini göstermektedir.
Anahtar Kelimeler Multipl skleroz, İnflamatuar yanıt, İnflamasyon, Lenfosit, Eritrosit dağılım hacmi
Destekleyen Kurum yoktur
Kaynakça 1. Hemmer B, Kerschensteiner M, Korn T. Role of the innate and adaptive immune responses in the course of multiple sclerosis. Lancet Neurol. 2015;14:406–19. 2. Dendrou C, Fugger L, Friese M. Immunopathology of multiple sclerosis. Nat Rev Immunol. 2015;15(9):545-58. 3. Dargahi N, Katsara M, Tselios T, et al. Multiple sclerosis: immunopathology and treatment update. Brain Sci. 2017;7(7):78. 4. Demirci S, Demirci S, Kutluhan S, Koyuncuoglu HR, Yurekli VA. The clinical significance of the neutrophil-to- lymphocyte ratio in multiple sclerosis. Int J Neurosci. 2016;126(8):700-6. 5. Peng YF, Cao WY, Zhang Q, Chen D, Zhang ZX. Assessment of the relationship between red cell distribution width and multiple sclerosis. Medicine (Baltimore). 2015;94(29):1182. 6. Hemond C, Glaz B, Bakshi R, Chitnis T, Healy B. The neutrophil-to-lymphocyte and monocyte-to- lymphocyte ratios are independently associated with neurological disability and brain atrophy in multiple sclerosis. BMC Neurology. 2019;19:23. 7. Hao X, Li D, Wu D, Zhang N. The relationship between hematological indices and autoimmune rheumatic diseases (ARDs), a meta-analysis. Sci Rep. 2017;7:10833. 8. Saçmacı H, Aktürk T, Tanık N. The Predictive Value of the Systemic Immune-inflammation Index as a New Prognostic Marker for Disability in Patients with Multiple Sclerosis. Turk J Neurol. 2021;27:133-9. 9. Contentti E, López PA, Criniti J, et al. Platelet-to-lymphocyte ratio differs between MS and NMOSD at disease onset and predict disability. Mult Scler Relat Disord. 2022;58:103507. 10. Arhan M, Onal I, Tas A, et al. The role of red cell distribution width as a marker in inflammatory bowel disease. Turk J Med Sci. 2011;41(2):227-34. 11. Dziedzic A, Bijak M. Interactions between platelets and leukocytes in pathogenesis of multiple sclerosis. Adv Clin Exp Med. 2019;28(2):277-85. 12. Liu X, Shao S, Wang L, et al. Predictive value of the systemic immune-inflammation index for intravenous immunoglobulin resistance and cardiovascular complications in Kawasaki disease. Front Cardiovasc Med. 2021;24;8:711007. 13. Thompson AJ, Barwell BL, Barkhof F, et al. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Lancet Neurol. 2018;17(2):162-73. 14. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an Expanded Disability Status Scale (EDSS). Neurology 1983;33:1444-52. 15. Çinar BP, Yorgun YG. What we learned from the history of multiple sclerosis measurement: expanded disability status scale. Noro Psikiyatr Ars. 2018;55:69-75. 16. Pierson ER, Wagner CA, Goverman JM. The contribution of neutrophils to CNS autoimmunity. Clin Immunol. 2018;189:23–8. 17. Soulika AM, Lee E, McCauley E, et al. Initiation and progression of axonopathy in experimental autoimmune encephalomyelitis. J Neurosci. 2009;29:14965–79. 18. Horstman LL, Jy W, Ahn YS, et al. Role of platelets in neuroinflammation: a wide-angle perspective. J Neuroinflam. 2010;7:10. 19. Semple JW, Italiano JE, Freedman J. Platelets and the immune continuum. Nat Rev Immunol. 2011;11:264–74. 20. Hershko KA, Hadi E, Asali A, et al. Neutrophils to lymphocytes ratio and platelets to lymphocytes ratio in pregnancy: a population study. PLoS One. 2018;13(5):e0196706. 21. Zahorec R. Ratio of neutrophil to lymphocyte counts-rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy. 2001;102(1):5-14. 22. Yang DH, Qian MZ, Wei MM, et al. The correlation of neutrophil-tolymphocyte ratio with the presence and activity of myasthenia gravis. Oncotarget. 2017;8:76099-107. 23. Saliba W, Barnett-Griness O, Elias M, Rennert G. Neutrophil to lymphocyte ratio and risk of a first episode of stroke in patients with atrial fibrillation: a cohort study. J Thromb Haemost. 2015;13:1971-9. 24. Lattanzi S, Cagnetti C, Provinciali L, Silvestrini M. Neutrophil-tolymphocyte ratio and neurological deterioration following acute cerebral hemorrhage. Oncotarget. 2017;8:57489-94. 25. Bisgaard AK, Pihl-Jensen G, Frederiksen JL. The neutrophil-to-lymphocyte ratio as disease actvity marker in multiple sclerosis and optic neuritis. Mult Scler Relat Disord. 2017;18:213-7. 26. Al-Hussain F, Alfallaj MM, Alahmari AN, et al. Relationship between neutrophil-to-lymphocyte ratio and stress in multiple sclerosis patients. J Clin Diag Res. 2017;11:1–4. 27. Guzel I, Mungan S, Oztekin ZN, Ak F. Is there an association between the expanded disability status scale and inflammatory markers in multiple sclerosis. J Chinese Med Assoc. 2016;79:54–7. 28. Smith RA, Bosonnet L, Ghaneh P, et al. The plateletlymphocyte ratio improves the predictive value of serum CA19-9 levels in determining patient selection for staging laparoscopy in suspected periampullary cancer. Surgery. 2008;143:658-66. 29. Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des. 2011;17:47-58. 30. Uzar E, Arıkanoğlu A, Yücel Y, et al. Investigation of Mean Platelet Volume in Patients with Multiple Sclerosis. Turk Norol Derg. 2011;17:185-8. 31. Marinkovic D, Zhang X, Yalcin S, et al. Foxo3 is required for the regulation of oxidative stress in erythropoiesis. J Clin Invest. 2007;117:2133-44. 32. Fukuta H, Ohte N, Mukai S, et al. Elevated plasma levels of B-type natriuretic Peptide but not C-reactive protein are associated with higher red cell distribution width in patients with coronary artery disease. Int Heart J. 2009;50:301-12. 33. Patel KV, Mohanty JG, Kanapuru B, et al. Association of the red cell distribution width with red blood cell deformability. Adv Exp Med Biol. 2013;765:211–6. 34. Piagnerelli M, Boudjeltia KZ, Brohee D, et al. Alterations of red blood cell shape and sialic acid membrane content in septic patients. Crit Care Med. 2003;31:2156-62. 35. Tecer D, Sezgin M, Kanık A, et al. Can mean platelet volume and red blood cell distribution width show disease activity in rheumatoid arthritis? Biomark Med. 2016;10:967-74. 36. Song CS, Park DI, Yoon MY, et al. Association Between Red Cell Distribution Width and Disease Activity in Patients with Inflammatory Bowel Disease. Digest Dis Sci. 2012; 57:1033-8. 37. Yuksel O, Helvaci K, Basar O, et al. An overlooked indicator of disease activity in ulcerative colitis: mean platelet volume. Platelets. 2009;20:277-81. 38. Ani C, Ovbiagele B. Relation of baseline presence and severity of renal disease to long-term mortality in persons with known stroke. J Neurol Sci. 2010;288:123-8. 39. Hou D, Wang C, Luo Y, et al. Systemic immune-inflammation index (SII) but not platelet-albumin-bilirubin (PALBI) grade is associated with severity of acute ischemic stroke (AIS). Int J Neurosci. 2020;26:1–6. 40. Mei Y, Yang J, Yuan Y, et al. Systemic Inflammation Index Values Are Associated With Worsened Disease Severity and Poor Response to Autoimmune Encephalitis Treatment. Front. Neurol. 2021;12:709553. Toplam 40 adet kaynakça vardır.
Ayrıntılar Birincil Dil İngilizce Konular Klinik Tıp Bilimleri Bölüm Makaleler-Araştırma Yazıları Yazarlar Melike Doğan Ünlü SÜLEYMAN DEMİREL ÜNİVERSİTESİ 0000-0002-4424-044X Türkiye
Serpil Demirci SÜLEYMAN DEMİREL ÜNİVERSİTESİ 0000-0003-1561-1296 Türkiye
Yayımlanma Tarihi 18 Temmuz 2024 Kabul Tarihi 14 Aralık 2023 Yayımlandığı Sayı Yıl 2024 Cilt: 25 Sayı: 3
Kaynak Göster APA Doğan Ünlü, M., & Demirci, S. (2024). SENSITIVITY OF PLATELET-LYMPHOCYTE RATIO, MONOCYTE-LYMPHOCYTE RATIO, NEUTROPHIL-LYMPHOCYTE RATIO, RED BLOOD CELL DISTRIBUTION WIDTH AND SYSTEMIC IMMUNE INFLAMMATORY INDEX IN MULTIPLE SCLEROSIS PATIENTS: RELATIONSHIP WITH DISEASE SUBTYPES AND DISABILITY. Kocatepe Tıp Dergisi, 25(3), 315-321. https://doi.org/10.18229/kocatepetip.1268139 AMA Doğan Ünlü M, Demirci S. SENSITIVITY OF PLATELET-LYMPHOCYTE RATIO, MONOCYTE-LYMPHOCYTE RATIO, NEUTROPHIL-LYMPHOCYTE RATIO, RED BLOOD CELL DISTRIBUTION WIDTH AND SYSTEMIC IMMUNE INFLAMMATORY INDEX IN MULTIPLE SCLEROSIS PATIENTS: RELATIONSHIP WITH DISEASE SUBTYPES AND DISABILITY. KTD. Temmuz 2024;25(3):315-321. doi:10.18229/kocatepetip.1268139 Chicago Doğan Ünlü, Melike, ve Serpil Demirci. “SENSITIVITY OF PLATELET-LYMPHOCYTE RATIO, MONOCYTE-LYMPHOCYTE RATIO, NEUTROPHIL-LYMPHOCYTE RATIO, RED BLOOD CELL DISTRIBUTION WIDTH AND SYSTEMIC IMMUNE INFLAMMATORY INDEX IN MULTIPLE SCLEROSIS PATIENTS: RELATIONSHIP WITH DISEASE SUBTYPES AND DISABILITY”. Kocatepe Tıp Dergisi 25, sy. 3 (Temmuz 2024): 315-21. https://doi.org/10.18229/kocatepetip.1268139. EndNote Doğan Ünlü M, Demirci S (01 Temmuz 2024) SENSITIVITY OF PLATELET-LYMPHOCYTE RATIO, MONOCYTE-LYMPHOCYTE RATIO, NEUTROPHIL-LYMPHOCYTE RATIO, RED BLOOD CELL DISTRIBUTION WIDTH AND SYSTEMIC IMMUNE INFLAMMATORY INDEX IN MULTIPLE SCLEROSIS PATIENTS: RELATIONSHIP WITH DISEASE SUBTYPES AND DISABILITY. Kocatepe Tıp Dergisi 25 3 315–321. IEEE M. Doğan Ünlü ve S. Demirci, “SENSITIVITY OF PLATELET-LYMPHOCYTE RATIO, MONOCYTE-LYMPHOCYTE RATIO, NEUTROPHIL-LYMPHOCYTE RATIO, RED BLOOD CELL DISTRIBUTION WIDTH AND SYSTEMIC IMMUNE INFLAMMATORY INDEX IN MULTIPLE SCLEROSIS PATIENTS: RELATIONSHIP WITH DISEASE SUBTYPES AND DISABILITY”, KTD , c. 25, sy. 3, ss. 315–321, 2024, doi: 10.18229/kocatepetip.1268139. ISNAD Doğan Ünlü, Melike – Demirci, Serpil. “SENSITIVITY OF PLATELET-LYMPHOCYTE RATIO, MONOCYTE-LYMPHOCYTE RATIO, NEUTROPHIL-LYMPHOCYTE RATIO, RED BLOOD CELL DISTRIBUTION WIDTH AND SYSTEMIC IMMUNE INFLAMMATORY INDEX IN MULTIPLE SCLEROSIS PATIENTS: RELATIONSHIP WITH DISEASE SUBTYPES AND DISABILITY”. Kocatepe Tıp Dergisi 25/3 (Temmuz 2024), 315-321. https://doi.org/10.18229/kocatepetip.1268139. JAMA Doğan Ünlü M, Demirci S. SENSITIVITY OF PLATELET-LYMPHOCYTE RATIO, MONOCYTE-LYMPHOCYTE RATIO, NEUTROPHIL-LYMPHOCYTE RATIO, RED BLOOD CELL DISTRIBUTION WIDTH AND SYSTEMIC IMMUNE INFLAMMATORY INDEX IN MULTIPLE SCLEROSIS PATIENTS: RELATIONSHIP WITH DISEASE SUBTYPES AND DISABILITY. KTD . 2024;25:315–321. MLA Doğan Ünlü, Melike ve Serpil Demirci. “SENSITIVITY OF PLATELET-LYMPHOCYTE RATIO, MONOCYTE-LYMPHOCYTE RATIO, NEUTROPHIL-LYMPHOCYTE RATIO, RED BLOOD CELL DISTRIBUTION WIDTH AND SYSTEMIC IMMUNE INFLAMMATORY INDEX IN MULTIPLE SCLEROSIS PATIENTS: RELATIONSHIP WITH DISEASE SUBTYPES AND DISABILITY”. Kocatepe Tıp Dergisi, c. 25, sy. 3, 2024, ss. 315-21, doi:10.18229/kocatepetip.1268139. Vancouver Doğan Ünlü M, Demirci S. SENSITIVITY OF PLATELET-LYMPHOCYTE RATIO, MONOCYTE-LYMPHOCYTE RATIO, NEUTROPHIL-LYMPHOCYTE RATIO, RED BLOOD CELL DISTRIBUTION WIDTH AND SYSTEMIC IMMUNE INFLAMMATORY INDEX IN MULTIPLE SCLEROSIS PATIENTS: RELATIONSHIP WITH DISEASE SUBTYPES AND DISABILITY. KTD. 2024;25(3):315-21.
Download or read online: Click here