');mask-image:url('data:image/svg+xml;utf8, ');mask-mode:alpha;-webkit-mask-repeat:no-repeat;mask-repeat:no-repeat;-webkit-mask-size:contain;mask-size:contain;-webkit-mask-position:center;mask-position:center;border-radius:0}}.wp-block-image :where(.has-border-color){border-style:solid}.wp-block-image :where([style*=border-top-color]){border-top-style:solid}.wp-block-image :where([style*=border-right-color]){border-right-style:solid}.wp-block-image :where([style*=border-bottom-color]){border-bottom-style:solid}.wp-block-image :where([style*=border-left-color]){border-left-style:solid}.wp-block-image :where([style*=border-width]){border-style:solid}.wp-block-image :where([style*=border-top-width]){border-top-style:solid}.wp-block-image :where([style*=border-right-width]){border-right-style:solid}.wp-block-image :where([style*=border-bottom-width]){border-bottom-style:solid}.wp-block-image :where([style*=border-left-width]){border-left-style:solid}.wp-block-image figure{margin:0}ol.wp-block-latest-comments{margin-left:0}.wp-block-latest-comments .wp-block-latest-comments{padding-left:0}.wp-block-latest-comments__comment{line-height:1.1;list-style:none;margin-bottom:1em}.has-avatars .wp-block-latest-comments__comment{min-height:2.25em;list-style:none}.has-avatars .wp-block-latest-comments__comment .wp-block-latest-comments__comment-excerpt,.has-avatars .wp-block-latest-comments__comment .wp-block-latest-comments__comment-meta{margin-left:3.25em}.has-dates .wp-block-latest-comments__comment,.has-excerpts .wp-block-latest-comments__comment{line-height:1.5}.wp-block-latest-comments__comment-excerpt p{font-size:.875em;line-height:1.8;margin:.36em 0 1.4em}.wp-block-latest-comments__comment-date{display:block;font-size:.75em}.wp-block-latest-comments .avatar,.wp-block-latest-comments__comment-avatar{border-radius:1.5em;display:block;float:left;height:2.5em;margin-right:.75em;width:2.5em}.wp-block-latest-posts.alignleft{margin-right:2em}.wp-block-latest-posts.alignright{margin-left:2em}.wp-block-latest-posts.wp-block-latest-posts__list{list-style:none;padding-left:0}.wp-block-latest-posts.wp-block-latest-posts__list li{clear:both}.wp-block-latest-posts.is-grid{display:flex;flex-wrap:wrap;padding:0}.wp-block-latest-posts.is-grid li{margin:0 1.25em 1.25em 0;width:100%}@media (min-width:600px){.wp-block-latest-posts.columns-2 li{width:calc(50% - .625em)}.wp-block-latest-posts.columns-2 li:nth-child(2n){margin-right:0}.wp-block-latest-posts.columns-3 li{width:calc(33.33333% - .83333em)}.wp-block-latest-posts.columns-3 li:nth-child(3n){margin-right:0}.wp-block-latest-posts.columns-4 li{width:calc(25% - .9375em)}.wp-block-latest-posts.columns-4 li:nth-child(4n){margin-right:0}.wp-block-latest-posts.columns-5 li{width:calc(20% - 1em)}.wp-block-latest-posts.columns-5 li:nth-child(5n){margin-right:0}.wp-block-latest-posts.columns-6 li{width:calc(16.66667% - 1.04167em)}.wp-block-latest-posts.columns-6 li:nth-child(6n){margin-right:0}}.wp-block-latest-posts__post-author,.wp-block-latest-posts__post-date{display:block;font-size:.8125em}.wp-block-latest-posts__post-excerpt{margin-top:.5em;margin-bottom:1em}.wp-block-latest-posts__featured-image a{display:inline-block}.wp-block-latest-posts__featured-image img{height:auto;width:auto;max-width:100%}.wp-block-latest-posts__featured-image.alignleft{margin-right:1em;float:left}.wp-block-latest-posts__featured-image.alignright{margin-left:1em;float:right}.wp-block-latest-posts__featured-image.aligncenter{margin-bottom:1em;text-align:center}ol,ul{box-sizing:border-box}ol.has-background,ul.has-background{padding:1.25em 2.375em}.wp-block-media-text{direction:ltr;display:grid;grid-template-columns:50% 1fr;grid-template-rows:auto;box-sizing:border-box}.wp-block-media-text.has-media-on-the-right{grid-template-columns:1fr 50%}.wp-block-media-text.is-vertically-aligned-top .wp-block-media-text__content,.wp-block-media-text.is-vertically-aligned-top .wp-block-media-text__media{align-self:start}.wp-block-media-text.is-vertically-aligned-center .wp-block-media-text__content,.wp-block-media-text.is-vertically-aligned-center .wp-block-media-text__media,.wp-block-media-text .wp-block-media-text__content,.wp-block-media-text .wp-block-media-text__media{align-self:center}.wp-block-media-text.is-vertically-aligned-bottom .wp-block-media-text__content,.wp-block-media-text.is-vertically-aligned-bottom .wp-block-media-text__media{align-self:end}.wp-block-media-text .wp-block-media-text__media{grid-column:1;grid-row:1;margin:0}.wp-block-media-text .wp-block-media-text__content{direction:ltr;grid-column:2;grid-row:1;padding:0 8%;word-break:break-word}.wp-block-media-text.has-media-on-the-right .wp-block-media-text__media{grid-column:2;grid-row:1}.wp-block-media-text.has-media-on-the-right .wp-block-media-text__content{grid-column:1;grid-row:1}.wp-block-media-text__media img,.wp-block-media-text__media video{height:auto;max-width:unset;width:100%;vertical-align:middle}.wp-block-media-text.is-image-fill .wp-block-media-text__media{height:100%;min-height:250px;background-size:cover}.wp-block-media-text.is-image-fill .wp-block-media-text__media>a{display:block;height:100%}.wp-block-media-text.is-image-fill .wp-block-media-text__media img{position:absolute;width:1px;height:1px;padding:0;margin:-1px;overflow:hidden;clip:rect(0,0,0,0);border:0}@media (max-width:600px){.wp-block-media-text.is-stacked-on-mobile{grid-template-columns:100%!important}.wp-block-media-text.is-stacked-on-mobile .wp-block-media-text__media{grid-column:1;grid-row:1}.wp-block-media-text.is-stacked-on-mobile .wp-block-media-text__content{grid-column:1;grid-row:2}}.wp-block-navigation{position:relative;--navigation-layout-justification-setting:flex-start;--navigation-layout-direction:row;--navigation-layout-wrap:wrap;--navigation-layout-justify:flex-start;--navigation-layout-align:center}.wp-block-navigation ul{margin-top:0;margin-bottom:0;margin-left:0;padding-left:0}.wp-block-navigation ul,.wp-block-navigation ul li{list-style:none;padding:0}.wp-block-navigation .wp-block-navigation-item{display:flex;align-items:center;position:relative}.wp-block-navigation .wp-block-navigation-item .wp-block-navigation__submenu-container:empty{display:none}.wp-block-navigation .wp-block-navigation-item__content{display:block}.wp-block-navigation.has-text-decoration-underline .wp-block-navigation-item__content,.wp-block-navigation.has-text-decoration-underline .wp-block-navigation-item__content:active,.wp-block-navigation.has-text-decoration-underline .wp-block-navigation-item__content:focus{text-decoration:underline}.wp-block-navigation.has-text-decoration-line-through .wp-block-navigation-item__content,.wp-block-navigation.has-text-decoration-line-through .wp-block-navigation-item__content:active,.wp-block-navigation.has-text-decoration-line-through .wp-block-navigation-item__content:focus{text-decoration:line-through}.wp-block-navigation:where(:not([class*=has-text-decoration])) a,.wp-block-navigation:where(:not([class*=has-text-decoration])) a:active,.wp-block-navigation:where(:not([class*=has-text-decoration])) a:focus{text-decoration:none}.wp-block-navigation .wp-block-navigation__submenu-icon{align-self:center;line-height:0;display:inline-block;font-size:inherit;padding:0;background-color:inherit;color:currentColor;border:none;width:.6em;height:.6em;margin-left:.25em}.wp-block-navigation .wp-block-navigation__submenu-icon svg{display:inline-block;stroke:currentColor;width:inherit;height:inherit;margin-top:.075em}.wp-block-navigation.is-vertical{--navigation-layout-direction:column;--navigation-layout-justify:initial;--navigation-layout-align:flex-start}.wp-block-navigation.no-wrap{--navigation-layout-wrap:nowrap}.wp-block-navigation.items-justified-center{--navigation-layout-justification-setting:center;--navigation-layout-justify:center}.wp-block-navigation.items-justified-center.is-vertical{--navigation-layout-align:center}.wp-block-navigation.items-justified-right{--navigation-layout-justification-setting:flex-end;--navigation-layout-justify:flex-end}.wp-block-navigation.items-justified-right.is-vertical{--navigation-layout-align:flex-end}.wp-block-navigation.items-justified-space-between{--navigation-layout-justification-setting:space-between;--navigation-layout-justify:space-between}.wp-block-navigation .has-child .wp-block-navigation__submenu-container{background-color:inherit;color:inherit;position:absolute;z-index:2;display:flex;flex-direction:column;align-items:normal;opacity:0;transition:opacity .1s linear;visibility:hidden;width:0;height:0;overflow:hidden;left:-1px;top:100%}.wp-block-navigation .has-child .wp-block-navigation__submenu-container>.wp-block-navigation-item>.wp-block-navigation-item__content{display:flex;flex-grow:1}.wp-block-navigation .has-child .wp-block-navigation__submenu-container>.wp-block-navigation-item>.wp-block-navigation-item__content .wp-block-navigation__submenu-icon{margin-right:0;margin-left:auto}.wp-block-navigation .has-child .wp-block-navigation__submenu-container .wp-block-navigation-item__content{margin:0}@media (min-width:782px){.wp-block-navigation .has-child .wp-block-navigation__submenu-container .wp-block-navigation__submenu-container{left:100%;top:-1px}.wp-block-navigation .has-child .wp-block-navigation__submenu-container .wp-block-navigation__submenu-container:before{content:"";position:absolute;right:100%;height:100%;display:block;width:.5em;background:0 0}.wp-block-navigation .has-child .wp-block-navigation__submenu-container .wp-block-navigation__submenu-icon{margin-right:.25em}.wp-block-navigation .has-child .wp-block-navigation__submenu-container .wp-block-navigation__submenu-icon svg{transform:rotate(-90deg)}}.wp-block-navigation .has-child:not(.open-on-click):hover>.wp-block-navigation__submenu-container{visibility:visible;overflow:visible;opacity:1;width:auto;height:auto;min-width:200px}.wp-block-navigation .has-child:not(.open-on-click):not(.open-on-hover-click):focus-within>.wp-block-navigation__submenu-container{visibility:visible;overflow:visible;opacity:1;width:auto;height:auto;min-width:200px}.wp-block-navigation .has-child .wp-block-navigation-submenu__toggle[aria-expanded=true]~.wp-block-navigation__submenu-container{visibility:visible;overflow:visible;opacity:1;width:auto;height:auto;min-width:200px}.wp-block-navigation.has-background .has-child .wp-block-navigation__submenu-container{left:0;top:100%}@media (min-width:782px){.wp-block-navigation.has-background .has-child .wp-block-navigation__submenu-container .wp-block-navigation__submenu-container{left:100%;top:0}}.wp-block-navigation-submenu{position:relative;display:flex}.wp-block-navigation-submenu .wp-block-navigation__submenu-icon svg{stroke:currentColor}button.wp-block-navigation-item__content{background-color:transparent;border:none;color:currentColor;font-size:inherit;font-family:inherit;line-height:inherit;font-style:inherit;font-weight:inherit;text-transform:inherit;text-align:left}.wp-block-navigation-submenu__toggle{cursor:pointer}.wp-block-navigation-item.open-on-click .wp-block-navigation-submenu__toggle{padding-right:.85em}.wp-block-navigation-item.open-on-click .wp-block-navigation-submenu__toggle+.wp-block-navigation__submenu-icon{margin-left:-.6em;pointer-events:none}.wp-block-navigation .wp-block-page-list,.wp-block-navigation__container,.wp-block-navigation__responsive-close,.wp-block-navigation__responsive-container,.wp-block-navigation__responsive-container-content,.wp-block-navigation__responsive-dialog{gap:inherit}:where(.wp-block-navigation.has-background .wp-block-navigation-item a:not(.wp-element-button)),:where(.wp-block-navigation.has-background .wp-block-navigation-submenu a:not(.wp-element-button)),:where(.wp-block-navigation .wp-block-navigation__submenu-container .wp-block-navigation-item a:not(.wp-element-button)),:where(.wp-block-navigation .wp-block-navigation__submenu-container .wp-block-navigation-submenu a:not(.wp-element-button)){padding:.5em 1em}.wp-block-navigation.items-justified-right .wp-block-navigation__container .has-child .wp-block-navigation__submenu-container,.wp-block-navigation.items-justified-right .wp-block-page-list>.has-child .wp-block-navigation__submenu-container,.wp-block-navigation.items-justified-space-between .wp-block-page-list>.has-child:last-child .wp-block-navigation__submenu-container,.wp-block-navigation.items-justified-space-between>.wp-block-navigation__container>.has-child:last-child .wp-block-navigation__submenu-container{left:auto;right:0}.wp-block-navigation.items-justified-right .wp-block-navigation__container .has-child .wp-block-navigation__submenu-container .wp-block-navigation__submenu-container,.wp-block-navigation.items-justified-right .wp-block-page-list>.has-child .wp-block-navigation__submenu-container .wp-block-navigation__submenu-container,.wp-block-navigation.items-justified-space-between .wp-block-page-list>.has-child:last-child .wp-block-navigation__submenu-container .wp-block-navigation__submenu-container,.wp-block-navigation.items-justified-space-between>.wp-block-navigation__container>.has-child:last-child .wp-block-navigation__submenu-container .wp-block-navigation__submenu-container{left:-1px;right:-1px}@media (min-width:782px){.wp-block-navigation.items-justified-right .wp-block-navigation__container .has-child .wp-block-navigation__submenu-container .wp-block-navigation__submenu-container,.wp-block-navigation.items-justified-right .wp-block-page-list>.has-child .wp-block-navigation__submenu-container .wp-block-navigation__submenu-container,.wp-block-navigation.items-justified-space-between .wp-block-page-list>.has-child:last-child .wp-block-navigation__submenu-container .wp-block-navigation__submenu-container,.wp-block-navigation.items-justified-space-between>.wp-block-navigation__container>.has-child:last-child .wp-block-navigation__submenu-container .wp-block-navigation__submenu-container{left:auto;right:100%}}.wp-block-navigation:not(.has-background) .wp-block-navigation__submenu-container{background-color:#fff;color:#000;border:1px solid rgba(0,0,0,.15)}.wp-block-navigation__container{display:flex;flex-wrap:var(--navigation-layout-wrap,wrap);flex-direction:var(--navigation-layout-direction,initial);justify-content:var(--navigation-layout-justify,initial);align-items:var(--navigation-layout-align,initial);list-style:none;margin:0;padding-left:0}.wp-block-navigation__container .is-responsive{display:none}.wp-block-navigation__container:only-child,.wp-block-page-list:only-child{flex-grow:1}@keyframes overlay-menu__fade-in-animation{0%{opacity:0;transform:translateY(.5em)}to{opacity:1;transform:translateY(0)}}.wp-block-navigation__responsive-container{display:none;position:fixed;top:0;left:0;right:0;bottom:0}.wp-block-navigation__responsive-container .wp-block-navigation-link a{color:inherit}.wp-block-navigation__responsive-container .wp-block-navigation__responsive-container-content{display:flex;flex-wrap:var(--navigation-layout-wrap,wrap);flex-direction:var(--navigation-layout-direction,initial);justify-content:var(--navigation-layout-justify,initial);align-items:var(--navigation-layout-align,initial)}.wp-block-navigation__responsive-container:not(.is-menu-open.is-menu-open){color:inherit!important;background-color:inherit!important}.wp-block-navigation__responsive-container.is-menu-open{display:flex;flex-direction:column;background-color:inherit;animation:overlay-menu__fade-in-animation .1s ease-out;animation-fill-mode:forwards;padding:var(--wp--style--root--padding-top,2rem) var(--wp--style--root--padding-right,2rem) var(--wp--style--root--padding-bottom,2rem) var(--wp--style--root--padding-left,2rem);overflow:auto;z-index:100000}@media (prefers-reduced-motion:reduce){.wp-block-navigation__responsive-container.is-menu-open{animation-duration:1ms;animation-delay:0s}}.wp-block-navigation__responsive-container.is-menu-open .wp-block-navigation__responsive-container-content{padding-top:calc(2rem + 24px);overflow:visible;display:flex;flex-direction:column;flex-wrap:nowrap;align-items:var(--navigation-layout-justification-setting,inherit)}.wp-block-navigation__responsive-container.is-menu-open .wp-block-navigation__responsive-container-content,.wp-block-navigation__responsive-container.is-menu-open .wp-block-navigation__responsive-container-content .wp-block-navigation__container,.wp-block-navigation__responsive-container.is-menu-open .wp-block-navigation__responsive-container-content .wp-block-page-list{justify-content:flex-start}.wp-block-navigation__responsive-container.is-menu-open .wp-block-navigation__responsive-container-content .wp-block-navigation__submenu-icon{display:none}.wp-block-navigation__responsive-container.is-menu-open .wp-block-navigation__responsive-container-content .has-child .submenu-container,.wp-block-navigation__responsive-container.is-menu-open .wp-block-navigation__responsive-container-content .has-child .wp-block-navigation__submenu-container{opacity:1;visibility:visible;height:auto;width:auto;overflow:initial;min-width:200px;position:static;border:none;padding-left:2rem;padding-right:2rem}.wp-block-navigation__responsive-container.is-menu-open .wp-block-navigation__responsive-container-content .wp-block-navigation__container,.wp-block-navigation__responsive-container.is-menu-open .wp-block-navigation__responsive-container-content .wp-block-navigation__submenu-container{gap:inherit}.wp-block-navigation__responsive-container.is-menu-open .wp-block-navigation__responsive-container-content .wp-block-navigation__submenu-container{padding-top:var(--wp--style--block-gap,2em)}.wp-block-navigation__responsive-container.is-menu-open .wp-block-navigation__responsive-container-content .wp-block-navigation-item__content{padding:0}.wp-block-navigation__responsive-container.is-menu-open .wp-block-navigation__responsive-container-content .wp-block-navigation-item,.wp-block-navigation__responsive-container.is-menu-open .wp-block-navigation__responsive-container-content .wp-block-navigation__container,.wp-block-navigation__responsive-container.is-menu-open .wp-block-navigation__responsive-container-content .wp-block-page-list{display:flex;flex-direction:column;align-items:var(--navigation-layout-justification-setting,initial)}.wp-block-navigation__responsive-container.is-menu-open .wp-block-navigation-item,.wp-block-navigation__responsive-container.is-menu-open .wp-block-navigation-item .wp-block-navigation__submenu-container,.wp-block-navigation__responsive-container.is-menu-open .wp-block-page-list{color:inherit!important;background:transparent!important}.wp-block-navigation__responsive-container.is-menu-open .wp-block-navigation__submenu-container.wp-block-navigation__submenu-container.wp-block-navigation__submenu-container.wp-block-navigation__submenu-container{right:auto;left:auto}@media (min-width:600px){.wp-block-navigation__responsive-container:not(.hidden-by-default):not(.is-menu-open){display:block;width:100%;position:relative;z-index:auto;background-color:inherit}.wp-block-navigation__responsive-container:not(.hidden-by-default):not(.is-menu-open) .wp-block-navigation__responsive-container-close{display:none}.wp-block-navigation__responsive-container.is-menu-open .wp-block-navigation__submenu-container.wp-block-navigation__submenu-container.wp-block-navigation__submenu-container.wp-block-navigation__submenu-container{left:0}}.wp-block-navigation:not(.has-background) .wp-block-navigation__responsive-container.is-menu-open{background-color:#fff;color:#000}.wp-block-navigation__toggle_button_label{font-size:1rem;font-weight:700}.wp-block-navigation__responsive-container-close,.wp-block-navigation__responsive-container-open{vertical-align:middle;cursor:pointer;color:currentColor;background:0 0;border:none;margin:0;padding:0;text-transform:inherit}.wp-block-navigation__responsive-container-close svg,.wp-block-navigation__responsive-container-open svg{fill:currentColor;pointer-events:none;display:block;width:24px;height:24px}.wp-block-navigation__responsive-container-open{display:flex}@media (min-width:600px){.wp-block-navigation__responsive-container-open:not(.always-shown){display:none}}.wp-block-navigation__responsive-container-close{position:absolute;top:0;right:0;z-index:2}.wp-block-navigation__responsive-close{width:100%;max-width:var(--wp--style--global--wide-size,100%);margin-left:auto;margin-right:auto}.wp-block-navigation__responsive-close:focus{outline:none}.is-menu-open .wp-block-navigation__responsive-close,.is-menu-open .wp-block-navigation__responsive-container-content,.is-menu-open .wp-block-navigation__responsive-dialog{box-sizing:border-box}.wp-block-navigation__responsive-dialog{position:relative}.has-modal-open .admin-bar .is-menu-open .wp-block-navigation__responsive-dialog{margin-top:46px}@media (min-width:782px){.has-modal-open .admin-bar .is-menu-open .wp-block-navigation__responsive-dialog{margin-top:32px}}html.has-modal-open{overflow:hidden}.wp-block-navigation .wp-block-navigation-item__label{word-break:normal;overflow-wrap:break-word}.wp-block-navigation .wp-block-navigation-item__description{display:none}.wp-block-navigation .wp-block-page-list{display:flex;flex-direction:var(--navigation-layout-direction,initial);justify-content:var(--navigation-layout-justify,initial);align-items:var(--navigation-layout-align,initial);flex-wrap:var(--navigation-layout-wrap,wrap);background-color:inherit}.wp-block-navigation .wp-block-navigation-item{background-color:inherit}.is-small-text{font-size:.875em}.is-regular-text{font-size:1em}.is-large-text{font-size:2.25em}.is-larger-text{font-size:3em}.has-drop-cap:not(:focus):first-letter {float:left;font-size:8.4em;line-height:.68;font-weight:100;margin:.05em .1em 0 0;text-transform:uppercase;font-style:normal}p.has-drop-cap.has-background{overflow:hidden}p.has-background{padding:1.25em 2.375em}:where(p.has-text-color:not(.has-link-color)) a{color:inherit}.wp-block-post-author{display:flex;flex-wrap:wrap}.wp-block-post-author__byline{width:100%;margin-top:0;margin-bottom:0;font-size:.5em}.wp-block-post-author__avatar{margin-right:1em}.wp-block-post-author__bio{margin-bottom:.7em;font-size:.7em}.wp-block-post-author__content{flex-grow:1;flex-basis:0}.wp-block-post-author__name{margin:0}.wp-block-post-comments-form[style*=font-weight] :where(.comment-reply-title){font-weight:inherit}.wp-block-post-comments-form[style*=font-family] :where(.comment-reply-title){font-family:inherit}.wp-block-post-comments-form[class*=-font-size] :where(.comment-reply-title),.wp-block-post-comments-form[style*=font-size] :where(.comment-reply-title){font-size:inherit}.wp-block-post-comments-form[style*=line-height] :where(.comment-reply-title){line-height:inherit}.wp-block-post-comments-form[style*=font-style] :where(.comment-reply-title){font-style:inherit}.wp-block-post-comments-form[style*=letter-spacing] :where(.comment-reply-title){letter-spacing:inherit}.wp-block-post-comments-form input[type=submit]{box-shadow:none;cursor:pointer;display:inline-block;text-align:center;overflow-wrap:break-word}.wp-block-post-comments-form input:not([type=submit]),.wp-block-post-comments-form textarea{border:1px solid #949494;font-size:1em;font-family:inherit}.wp-block-post-comments-form input:not([type=submit]):not([type=checkbox]),.wp-block-post-comments-form textarea{padding:calc(.667em + 2px)}.wp-block-post-comments-form .comment-form input:not([type=submit]):not([type=checkbox]),.wp-block-post-comments-form .comment-form textarea{display:block;box-sizing:border-box;width:100%}.wp-block-post-comments-form .comment-form-author label,.wp-block-post-comments-form .comment-form-email label,.wp-block-post-comments-form .comment-form-url label{display:block;margin-bottom:.25em}.wp-block-post-comments-form .comment-form-cookies-consent{display:flex;gap:.25em}.wp-block-post-comments-form .comment-form-cookies-consent #wp-comment-cookies-consent{margin-top:.35em}.wp-block-post-comments-form .comment-reply-title{margin-bottom:0}.wp-block-post-comments-form .comment-reply-title :where(small){font-size:var(--wp--preset--font-size--medium,smaller);margin-left:.5em}.wp-block-post-date{box-sizing:border-box}.wp-block-post-excerpt__more-link{display:inline-block}.wp-block-post-featured-image{margin-left:0;margin-right:0}.wp-block-post-featured-image a{display:block}.wp-block-post-featured-image img{max-width:100%;width:100%;height:auto;vertical-align:bottom;box-sizing:border-box}.wp-block-post-featured-image.alignfull img,.wp-block-post-featured-image.alignwide img{width:100%}.wp-block-post-featured-image .wp-block-post-featured-image__overlay.has-background-dim{position:absolute;inset:0;background-color:#000}.wp-block-post-featured-image{position:relative}.wp-block-post-featured-image .wp-block-post-featured-image__overlay.has-background-gradient{background-color:transparent}.wp-block-post-featured-image .wp-block-post-featured-image__overlay.has-background-dim-0{opacity:0}.wp-block-post-featured-image .wp-block-post-featured-image__overlay.has-background-dim-10{opacity:.1}.wp-block-post-featured-image .wp-block-post-featured-image__overlay.has-background-dim-20{opacity:.2}.wp-block-post-featured-image .wp-block-post-featured-image__overlay.has-background-dim-30{opacity:.3}.wp-block-post-featured-image .wp-block-post-featured-image__overlay.has-background-dim-40{opacity:.4}.wp-block-post-featured-image .wp-block-post-featured-image__overlay.has-background-dim-50{opacity:.5}.wp-block-post-featured-image .wp-block-post-featured-image__overlay.has-background-dim-60{opacity:.6}.wp-block-post-featured-image .wp-block-post-featured-image__overlay.has-background-dim-70{opacity:.7}.wp-block-post-featured-image .wp-block-post-featured-image__overlay.has-background-dim-80{opacity:.8}.wp-block-post-featured-image .wp-block-post-featured-image__overlay.has-background-dim-90{opacity:.9}.wp-block-post-featured-image .wp-block-post-featured-image__overlay.has-background-dim-100{opacity:1}.wp-block-post-terms__separator{white-space:pre-wrap}.wp-block-post-title{word-break:break-word;box-sizing:border-box}.wp-block-post-title a{display:inline-block}.wp-block-preformatted{white-space:pre-wrap}.wp-block-preformatted.has-background{padding:1.25em 2.375em}.wp-block-pullquote{margin:0 0 1em;padding:3em 0;text-align:center;overflow-wrap:break-word;box-sizing:border-box}.wp-block-pullquote blockquote,.wp-block-pullquote cite,.wp-block-pullquote p{color:inherit}.wp-block-pullquote.alignleft,.wp-block-pullquote.alignright{max-width:420px}.wp-block-pullquote cite,.wp-block-pullquote footer{position:relative}.wp-block-pullquote .has-text-color a{color:inherit}.wp-block-pullquote.has-text-align-left blockquote{text-align:left}.wp-block-pullquote.has-text-align-right blockquote{text-align:right}.wp-block-pullquote.is-style-solid-color{border:none}.wp-block-pullquote.is-style-solid-color blockquote{margin-left:auto;margin-right:auto;max-width:60%}.wp-block-pullquote.is-style-solid-color blockquote p{margin-top:0;margin-bottom:0;font-size:2em}.wp-block-pullquote.is-style-solid-color blockquote cite{text-transform:none;font-style:normal}.wp-block-pullquote cite{color:inherit}.wp-block-post-template{margin-top:0;margin-bottom:0;max-width:100%;list-style:none;padding:0}.wp-block-post-template.wp-block-post-template{background:0 0}.wp-block-post-template.is-flex-container{flex-direction:row;display:flex;flex-wrap:wrap;gap:1.25em}.wp-block-post-template.is-flex-container li{margin:0;width:100%}@media (min-width:600px){.wp-block-post-template.is-flex-container.is-flex-container.columns-2>li{width:calc(50% - .625em)}.wp-block-post-template.is-flex-container.is-flex-container.columns-3>li{width:calc(33.33333% - .83333em)}.wp-block-post-template.is-flex-container.is-flex-container.columns-4>li{width:calc(25% - .9375em)}.wp-block-post-template.is-flex-container.is-flex-container.columns-5>li{width:calc(20% - 1em)}.wp-block-post-template.is-flex-container.is-flex-container.columns-6>li{width:calc(16.66667% - 1.04167em)}}.wp-block-query-pagination>.wp-block-query-pagination-next,.wp-block-query-pagination>.wp-block-query-pagination-numbers,.wp-block-query-pagination>.wp-block-query-pagination-previous{margin-right:.5em;margin-bottom:.5em}.wp-block-query-pagination>.wp-block-query-pagination-next:last-child,.wp-block-query-pagination>.wp-block-query-pagination-numbers:last-child,.wp-block-query-pagination>.wp-block-query-pagination-previous:last-child{margin-right:0}.wp-block-query-pagination.is-content-justification-space-between>.wp-block-query-pagination-next:last-child{margin-inline-start:auto}.wp-block-query-pagination.is-content-justification-space-between>.wp-block-query-pagination-previous:first-child{margin-inline-end:auto}.wp-block-query-pagination .wp-block-query-pagination-previous-arrow{margin-right:1ch;display:inline-block}.wp-block-query-pagination .wp-block-query-pagination-previous-arrow:not(.is-arrow-chevron){transform:scaleX(1)}.wp-block-query-pagination .wp-block-query-pagination-next-arrow{margin-left:1ch;display:inline-block}.wp-block-query-pagination .wp-block-query-pagination-next-arrow:not(.is-arrow-chevron){transform:scaleX(1)}.wp-block-query-pagination.aligncenter{justify-content:center}.wp-block-query-title,.wp-block-quote{box-sizing:border-box}.wp-block-quote{overflow-wrap:break-word}.wp-block-quote.is-large:not(.is-style-plain),.wp-block-quote.is-style-large:not(.is-style-plain){margin-bottom:1em;padding:0 1em}.wp-block-quote.is-large:not(.is-style-plain) p,.wp-block-quote.is-style-large:not(.is-style-plain) p{font-size:1.5em;font-style:italic;line-height:1.6}.wp-block-quote.is-large:not(.is-style-plain) cite,.wp-block-quote.is-large:not(.is-style-plain) footer,.wp-block-quote.is-style-large:not(.is-style-plain) cite,.wp-block-quote.is-style-large:not(.is-style-plain) footer{font-size:1.125em;text-align:right}.wp-block-read-more{display:block;width:-moz-fit-content;width:fit-content}.wp-block-read-more:not([style*=text-decoration]),.wp-block-read-more:not([style*=text-decoration]):active,.wp-block-read-more:not([style*=text-decoration]):focus{text-decoration:none}ul.wp-block-rss{list-style:none;padding:0}ul.wp-block-rss.wp-block-rss{box-sizing:border-box}ul.wp-block-rss.alignleft{margin-right:2em}ul.wp-block-rss.alignright{margin-left:2em}ul.wp-block-rss.is-grid{display:flex;flex-wrap:wrap;padding:0;list-style:none}ul.wp-block-rss.is-grid li{margin:0 1em 1em 0;width:100%}@media (min-width:600px){ul.wp-block-rss.columns-2 li{width:calc(50% - 1em)}ul.wp-block-rss.columns-3 li{width:calc(33.33333% - 1em)}ul.wp-block-rss.columns-4 li{width:calc(25% - 1em)}ul.wp-block-rss.columns-5 li{width:calc(20% - 1em)}ul.wp-block-rss.columns-6 li{width:calc(16.66667% - 1em)}}.wp-block-rss__item-author,.wp-block-rss__item-publish-date{display:block;font-size:.8125em}.wp-block-search__button{margin-left:.625em;word-break:normal}.wp-block-search__button.has-icon{line-height:0}.wp-block-search__button svg{min-width:1.5em;min-height:1.5em;fill:currentColor;vertical-align:text-bottom}:where(.wp-block-search__button){border:1px solid #ccc;padding:.375em .625em}.wp-block-search__inside-wrapper{display:flex;flex:auto;flex-wrap:nowrap;max-width:100%}.wp-block-search__label{width:100%}.wp-block-search__input{padding:8px;flex-grow:1;margin-left:0;margin-right:0;min-width:3em;border:1px solid #949494;text-decoration:unset!important}.wp-block-search.wp-block-search__button-only .wp-block-search__button{margin-left:0}:where(.wp-block-search__button-inside .wp-block-search__inside-wrapper){padding:4px;border:1px solid #949494}:where(.wp-block-search__button-inside .wp-block-search__inside-wrapper) .wp-block-search__input{border-radius:0;border:none;padding:0 0 0 .25em}:where(.wp-block-search__button-inside .wp-block-search__inside-wrapper) .wp-block-search__input:focus{outline:none}:where(.wp-block-search__button-inside .wp-block-search__inside-wrapper) :where(.wp-block-search__button){padding:.125em .5em}.wp-block-search.aligncenter .wp-block-search__inside-wrapper{margin:auto}.wp-block-separator{border:1px solid;border-right:none;border-left:none}.wp-block-separator.is-style-dots{background:none!important;border:none;text-align:center;line-height:1;height:auto}.wp-block-separator.is-style-dots:before{content:"···";color:currentColor;font-size:1.5em;letter-spacing:2em;padding-left:2em;font-family:serif}.wp-block-site-logo{box-sizing:border-box;line-height:0}.wp-block-site-logo a{display:inline-block}.wp-block-site-logo.is-default-size img{width:120px;height:auto}.wp-block-site-logo img{height:auto;max-width:100%}.wp-block-site-logo a,.wp-block-site-logo img{border-radius:inherit}.wp-block-site-logo.aligncenter{margin-left:auto;margin-right:auto;text-align:center}.wp-block-site-logo.is-style-rounded{border-radius:9999px}.wp-block-social-links{box-sizing:border-box;padding-left:0;padding-right:0;text-indent:0;margin-left:0;background:0 0}.wp-block-social-links .wp-social-link a,.wp-block-social-links .wp-social-link a:hover{text-decoration:none;border-bottom:0;box-shadow:none}.wp-block-social-links .wp-social-link a{padding:.25em}.wp-block-social-links .wp-social-link svg{width:1em;height:1em}.wp-block-social-links .wp-social-link span:not(.screen-reader-text){margin-left:.5em;margin-right:.5em;font-size:.65em}.wp-block-social-links.has-small-icon-size{font-size:16px}.wp-block-social-links,.wp-block-social-links.has-normal-icon-size{font-size:24px}.wp-block-social-links.has-large-icon-size{font-size:36px}.wp-block-social-links.has-huge-icon-size{font-size:48px}.wp-block-social-links.aligncenter{justify-content:center;display:flex}.wp-block-social-links.alignright{justify-content:flex-end}.wp-block-social-link{display:block;border-radius:9999px;transition:transform .1s ease;height:auto}@media (prefers-reduced-motion:reduce){.wp-block-social-link{transition-duration:0s;transition-delay:0s}}.wp-block-social-link a{align-items:center;display:flex;line-height:0;transition:transform .1s ease}.wp-block-social-link:hover{transform:scale(1.1)}.wp-block-social-links .wp-block-social-link .wp-block-social-link-anchor,.wp-block-social-links .wp-block-social-link .wp-block-social-link-anchor:active,.wp-block-social-links .wp-block-social-link .wp-block-social-link-anchor:hover,.wp-block-social-links .wp-block-social-link .wp-block-social-link-anchor:visited,.wp-block-social-links .wp-block-social-link .wp-block-social-link-anchor svg{color:currentColor;fill:currentColor}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link{background-color:#f0f0f0;color:#444}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-amazon{background-color:#f90;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-bandcamp{background-color:#1ea0c3;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-behance{background-color:#0757fe;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-codepen{background-color:#1e1f26;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-deviantart{background-color:#02e49b;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-dribbble{background-color:#e94c89;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-dropbox{background-color:#4280ff;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-etsy{background-color:#f45800;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-facebook{background-color:#1778f2;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-fivehundredpx{background-color:#000;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-flickr{background-color:#0461dd;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-foursquare{background-color:#e65678;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-github{background-color:#24292d;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-goodreads{background-color:#eceadd;color:#382110}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-google{background-color:#ea4434;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-instagram{background-color:#f00075;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-lastfm{background-color:#e21b24;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-linkedin{background-color:#0d66c2;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-mastodon{background-color:#3288d4;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-medium{background-color:#02ab6c;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-meetup{background-color:#f6405f;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-patreon{background-color:#ff424d;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-pinterest{background-color:#e60122;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-pocket{background-color:#ef4155;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-reddit{background-color:#ff4500;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-skype{background-color:#0478d7;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-snapchat{background-color:#fefc00;color:#fff;stroke:#000}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-soundcloud{background-color:#ff5600;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-spotify{background-color:#1bd760;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-telegram{background-color:#2aabee;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-tiktok{background-color:#000;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-tumblr{background-color:#011835;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-twitch{background-color:#6440a4;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-twitter{background-color:#1da1f2;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-vimeo{background-color:#1eb7ea;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-vk{background-color:#4680c2;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-wordpress{background-color:#3499cd;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-whatsapp{background-color:#25d366;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-yelp{background-color:#d32422;color:#fff}.wp-block-social-links:not(.is-style-logos-only) .wp-social-link-youtube{background-color:red;color:#fff}.wp-block-social-links.is-style-logos-only .wp-social-link{background:0 0}.wp-block-social-links.is-style-logos-only .wp-social-link a{padding:0}.wp-block-social-links.is-style-logos-only .wp-social-link svg{width:1.25em;height:1.25em}.wp-block-social-links.is-style-logos-only .wp-social-link-amazon{color:#f90}.wp-block-social-links.is-style-logos-only .wp-social-link-bandcamp{color:#1ea0c3}.wp-block-social-links.is-style-logos-only .wp-social-link-behance{color:#0757fe}.wp-block-social-links.is-style-logos-only .wp-social-link-codepen{color:#1e1f26}.wp-block-social-links.is-style-logos-only .wp-social-link-deviantart{color:#02e49b}.wp-block-social-links.is-style-logos-only .wp-social-link-dribbble{color:#e94c89}.wp-block-social-links.is-style-logos-only .wp-social-link-dropbox{color:#4280ff}.wp-block-social-links.is-style-logos-only .wp-social-link-etsy{color:#f45800}.wp-block-social-links.is-style-logos-only .wp-social-link-facebook{color:#1778f2}.wp-block-social-links.is-style-logos-only .wp-social-link-fivehundredpx{color:#000}.wp-block-social-links.is-style-logos-only .wp-social-link-flickr{color:#0461dd}.wp-block-social-links.is-style-logos-only .wp-social-link-foursquare{color:#e65678}.wp-block-social-links.is-style-logos-only .wp-social-link-github{color:#24292d}.wp-block-social-links.is-style-logos-only .wp-social-link-goodreads{color:#382110}.wp-block-social-links.is-style-logos-only .wp-social-link-google{color:#ea4434}.wp-block-social-links.is-style-logos-only .wp-social-link-instagram{color:#f00075}.wp-block-social-links.is-style-logos-only .wp-social-link-lastfm{color:#e21b24}.wp-block-social-links.is-style-logos-only .wp-social-link-linkedin{color:#0d66c2}.wp-block-social-links.is-style-logos-only .wp-social-link-mastodon{color:#3288d4}.wp-block-social-links.is-style-logos-only .wp-social-link-medium{color:#02ab6c}.wp-block-social-links.is-style-logos-only .wp-social-link-meetup{color:#f6405f}.wp-block-social-links.is-style-logos-only .wp-social-link-patreon{color:#ff424d}.wp-block-social-links.is-style-logos-only .wp-social-link-pinterest{color:#e60122}.wp-block-social-links.is-style-logos-only .wp-social-link-pocket{color:#ef4155}.wp-block-social-links.is-style-logos-only .wp-social-link-reddit{color:#ff4500}.wp-block-social-links.is-style-logos-only .wp-social-link-skype{color:#0478d7}.wp-block-social-links.is-style-logos-only .wp-social-link-snapchat{color:#fff;stroke:#000}.wp-block-social-links.is-style-logos-only .wp-social-link-soundcloud{color:#ff5600}.wp-block-social-links.is-style-logos-only .wp-social-link-spotify{color:#1bd760}.wp-block-social-links.is-style-logos-only .wp-social-link-telegram{color:#2aabee}.wp-block-social-links.is-style-logos-only .wp-social-link-tiktok{color:#000}.wp-block-social-links.is-style-logos-only .wp-social-link-tumblr{color:#011835}.wp-block-social-links.is-style-logos-only .wp-social-link-twitch{color:#6440a4}.wp-block-social-links.is-style-logos-only .wp-social-link-twitter{color:#1da1f2}.wp-block-social-links.is-style-logos-only .wp-social-link-vimeo{color:#1eb7ea}.wp-block-social-links.is-style-logos-only .wp-social-link-vk{color:#4680c2}.wp-block-social-links.is-style-logos-only .wp-social-link-whatsapp{color:#25d366}.wp-block-social-links.is-style-logos-only .wp-social-link-wordpress{color:#3499cd}.wp-block-social-links.is-style-logos-only .wp-social-link-yelp{color:#d32422}.wp-block-social-links.is-style-logos-only .wp-social-link-youtube{color:red}.wp-block-social-links.is-style-pill-shape .wp-social-link{width:auto}.wp-block-social-links.is-style-pill-shape .wp-social-link a{padding-left:.66667em;padding-right:.66667em}.wp-block-spacer{clear:both}.wp-block-tag-cloud.aligncenter{text-align:center;justify-content:center}.wp-block-tag-cloud.alignfull{padding-left:1em;padding-right:1em}.wp-block-tag-cloud a{display:inline-block;margin-right:5px}.wp-block-tag-cloud span{display:inline-block;margin-left:5px;text-decoration:none}.wp-block-tag-cloud.is-style-outline{display:flex;flex-wrap:wrap;gap:1ch}.wp-block-tag-cloud.is-style-outline a{border:1px solid;font-size:unset!important;margin-right:0;padding:1ch 2ch;text-decoration:none!important}.wp-block-table{overflow-x:auto}.wp-block-table table{border-collapse:collapse;width:100%}.wp-block-table td,.wp-block-table th{border:1px solid;padding:.5em}.wp-block-table .has-fixed-layout{table-layout:fixed;width:100%}.wp-block-table .has-fixed-layout td,.wp-block-table .has-fixed-layout th{word-break:break-word}.wp-block-table.aligncenter,.wp-block-table.alignleft,.wp-block-table.alignright{display:table;width:auto}.wp-block-table.aligncenter td,.wp-block-table.aligncenter th,.wp-block-table.alignleft td,.wp-block-table.alignleft th,.wp-block-table.alignright td,.wp-block-table.alignright th{word-break:break-word}.wp-block-table .has-subtle-light-gray-background-color{background-color:#f3f4f5}.wp-block-table .has-subtle-pale-green-background-color{background-color:#e9fbe5}.wp-block-table .has-subtle-pale-blue-background-color{background-color:#e7f5fe}.wp-block-table .has-subtle-pale-pink-background-color{background-color:#fcf0ef}.wp-block-table.is-style-stripes{border-spacing:0;border-collapse:inherit;background-color:transparent;border-bottom:1px solid #f0f0f0}.wp-block-table.is-style-stripes tbody tr:nth-child(odd){background-color:#f0f0f0}.wp-block-table.is-style-stripes.has-subtle-light-gray-background-color tbody tr:nth-child(odd){background-color:#f3f4f5}.wp-block-table.is-style-stripes.has-subtle-pale-green-background-color tbody tr:nth-child(odd){background-color:#e9fbe5}.wp-block-table.is-style-stripes.has-subtle-pale-blue-background-color tbody tr:nth-child(odd){background-color:#e7f5fe}.wp-block-table.is-style-stripes.has-subtle-pale-pink-background-color tbody tr:nth-child(odd){background-color:#fcf0ef}.wp-block-table.is-style-stripes td,.wp-block-table.is-style-stripes th{border-color:transparent}.wp-block-table .has-border-color>*,.wp-block-table .has-border-color td,.wp-block-table .has-border-color th,.wp-block-table .has-border-color tr{border-color:inherit}.wp-block-table table[style*=border-top-color]>*,.wp-block-table table[style*=border-top-color]>* td,.wp-block-table table[style*=border-top-color]>* th,.wp-block-table table[style*=border-top-color] tr:first-child,.wp-block-table table[style*=border-top-color] tr:first-child td,.wp-block-table table[style*=border-top-color] tr:first-child th{border-top-color:inherit}.wp-block-table table[style*=border-top-color] tr:not(:first-child){border-top-color:currentColor}.wp-block-table table[style*=border-right-color]>*,.wp-block-table table[style*=border-right-color] td:last-child,.wp-block-table table[style*=border-right-color] th,.wp-block-table table[style*=border-right-color] tr{border-right-color:inherit}.wp-block-table table[style*=border-bottom-color]>*,.wp-block-table table[style*=border-bottom-color]>* td,.wp-block-table table[style*=border-bottom-color]>* th,.wp-block-table table[style*=border-bottom-color] tr:last-child,.wp-block-table table[style*=border-bottom-color] tr:last-child td,.wp-block-table table[style*=border-bottom-color] tr:last-child th{border-bottom-color:inherit}.wp-block-table table[style*=border-bottom-color] tr:not(:last-child){border-bottom-color:currentColor}.wp-block-table table[style*=border-left-color]>*,.wp-block-table table[style*=border-left-color] td:first-child,.wp-block-table table[style*=border-left-color] th,.wp-block-table table[style*=border-left-color] tr{border-left-color:inherit}.wp-block-table table[style*=border-style]>*,.wp-block-table table[style*=border-style] td,.wp-block-table table[style*=border-style] th,.wp-block-table table[style*=border-style] tr{border-style:inherit}.wp-block-table table[style*=border-width]>*,.wp-block-table table[style*=border-width] td,.wp-block-table table[style*=border-width] th,.wp-block-table table[style*=border-width] tr{border-width:inherit;border-style:inherit}.wp-block-text-columns,.wp-block-text-columns.aligncenter{display:flex}.wp-block-text-columns .wp-block-column{margin:0 1em;padding:0}.wp-block-text-columns .wp-block-column:first-child{margin-left:0}.wp-block-text-columns .wp-block-column:last-child{margin-right:0}.wp-block-text-columns.columns-2 .wp-block-column{width:50%}.wp-block-text-columns.columns-3 .wp-block-column{width:33.33333%}.wp-block-text-columns.columns-4 .wp-block-column{width:25%}pre.wp-block-verse{font-family:inherit;overflow:auto;white-space:pre-wrap}.wp-block-video{box-sizing:border-box}.wp-block-video video{width:100%}@supports (position:sticky){.wp-block-video [poster]{-o-object-fit:cover;object-fit:cover}}.wp-block-video.aligncenter{text-align:center}.wp-block-video figcaption{margin-top:.5em;margin-bottom:1em}.wp-element-button{cursor:pointer}:root{--wp--preset--font-size--normal:16px;--wp--preset--font-size--huge:42px}:root .has-very-light-gray-background-color{background-color:#eee}:root .has-very-dark-gray-background-color{background-color:#313131}:root .has-very-light-gray-color{color:#eee}:root .has-very-dark-gray-color{color:#313131}:root .has-vivid-green-cyan-to-vivid-cyan-blue-gradient-background{background:linear-gradient(135deg,#00d084,#0693e3)}:root .has-purple-crush-gradient-background{background:linear-gradient(135deg,#34e2e4,#4721fb 50%,#ab1dfe)}:root .has-hazy-dawn-gradient-background{background:linear-gradient(135deg,#faaca8,#dad0ec)}:root .has-subdued-olive-gradient-background{background:linear-gradient(135deg,#fafae1,#67a671)}:root .has-atomic-cream-gradient-background{background:linear-gradient(135deg,#fdd79a,#004a59)}:root .has-nightshade-gradient-background{background:linear-gradient(135deg,#330968,#31cdcf)}:root .has-midnight-gradient-background{background:linear-gradient(135deg,#020381,#2874fc)}.has-regular-font-size{font-size:1em}.has-larger-font-size{font-size:2.625em}.has-normal-font-size{font-size:var(--wp--preset--font-size--normal)}.has-huge-font-size{font-size:var(--wp--preset--font-size--huge)}.has-text-align-center{text-align:center}.has-text-align-left{text-align:left}.has-text-align-right{text-align:right}#end-resizable-editor-section{display:none}.aligncenter{clear:both}.items-justified-left{justify-content:flex-start}.items-justified-center{justify-content:center}.items-justified-right{justify-content:flex-end}.items-justified-space-between{justify-content:space-between}.screen-reader-text{border:0;clip:rect(1px,1px,1px,1px);-webkit-clip-path:inset(50%);clip-path:inset(50%);height:1px;margin:-1px;overflow:hidden;padding:0;position:absolute;width:1px;word-wrap:normal!important}.screen-reader-text:focus{background-color:#ddd;clip:auto!important;-webkit-clip-path:none;clip-path:none;color:#444;display:block;font-size:1em;height:auto;left:5px;line-height:normal;padding:15px 23px 14px;text-decoration:none;top:5px;width:auto;z-index:100000}html :where(.has-border-color){border-style:solid}html :where([style*=border-top-color]){border-top-style:solid}html :where([style*=border-right-color]){border-right-style:solid}html :where([style*=border-bottom-color]){border-bottom-style:solid}html :where([style*=border-left-color]){border-left-style:solid}html :where([style*=border-width]){border-style:solid}html :where([style*=border-top-width]){border-top-style:solid}html :where([style*=border-right-width]){border-right-style:solid}html :where([style*=border-bottom-width]){border-bottom-style:solid}html :where([style*=border-left-width]){border-left-style:solid}html :where(img[class*=wp-image-]){height:auto;max-width:100%}figure{margin:0 0 1em}
/*! This file is auto-generated */
.wp-block-button__link{color:#fff;background-color:#32373c;border-radius:9999px;box-shadow:none;text-decoration:none;padding:calc(.667em + 2px) calc(1.333em + 2px);font-size:1.125em}body{--wp--preset--color--black:#000;--wp--preset--color--cyan-bluish-gray:#abb8c3;--wp--preset--color--white:#fff;--wp--preset--color--pale-pink:#f78da7;--wp--preset--color--vivid-red:#cf2e2e;--wp--preset--color--luminous-vivid-orange:#ff6900;--wp--preset--color--luminous-vivid-amber:#fcb900;--wp--preset--color--light-green-cyan:#7bdcb5;--wp--preset--color--vivid-green-cyan:#00d084;--wp--preset--color--pale-cyan-blue:#8ed1fc;--wp--preset--color--vivid-cyan-blue:#0693e3;--wp--preset--color--vivid-purple:#9b51e0;--wp--preset--color--contrast:var(--contrast);--wp--preset--color--contrast-2:var(--contrast-2);--wp--preset--color--contrast-3:var(--contrast-3);--wp--preset--color--base:var(--base);--wp--preset--color--base-2:var(--base-2);--wp--preset--color--base-3:var(--base-3);--wp--preset--color--accent:var(--accent);--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple:linear-gradient(135deg,rgba(6,147,227,1) 0%,#9b51e0 100%);--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan:linear-gradient(135deg,#7adcb4 0%,#00d082 100%);--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange:linear-gradient(135deg,rgba(252,185,0,1) 0%,rgba(255,105,0,1) 100%);--wp--preset--gradient--luminous-vivid-orange-to-vivid-red:linear-gradient(135deg,rgba(255,105,0,1) 0%,#cf2e2e 100%);--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray:linear-gradient(135deg,#eee 0%,#a9b8c3 100%);--wp--preset--gradient--cool-to-warm-spectrum:linear-gradient(135deg,#4aeadc 0%,#9778d1 20%,#cf2aba 40%,#ee2c82 60%,#fb6962 80%,#fef84c 100%);--wp--preset--gradient--blush-light-purple:linear-gradient(135deg,#ffceec 0%,#9896f0 100%);--wp--preset--gradient--blush-bordeaux:linear-gradient(135deg,#fecda5 0%,#fe2d2d 50%,#6b003e 100%);--wp--preset--gradient--luminous-dusk:linear-gradient(135deg,#ffcb70 0%,#c751c0 50%,#4158d0 100%);--wp--preset--gradient--pale-ocean:linear-gradient(135deg,#fff5cb 0%,#b6e3d4 50%,#33a7b5 100%);--wp--preset--gradient--electric-grass:linear-gradient(135deg,#caf880 0%,#71ce7e 100%);--wp--preset--gradient--midnight:linear-gradient(135deg,#020381 0%,#2874fc 100%);--wp--preset--duotone--dark-grayscale:url('#wp-duotone-dark-grayscale');--wp--preset--duotone--grayscale:url('#wp-duotone-grayscale');--wp--preset--duotone--purple-yellow:url('#wp-duotone-purple-yellow');--wp--preset--duotone--blue-red:url('#wp-duotone-blue-red');--wp--preset--duotone--midnight:url('#wp-duotone-midnight');--wp--preset--duotone--magenta-yellow:url('#wp-duotone-magenta-yellow');--wp--preset--duotone--purple-green:url('#wp-duotone-purple-green');--wp--preset--duotone--blue-orange:url('#wp-duotone-blue-orange');--wp--preset--font-size--small:13px;--wp--preset--font-size--medium:20px;--wp--preset--font-size--large:36px;--wp--preset--font-size--x-large:42px;--wp--preset--spacing--20:.44rem;--wp--preset--spacing--30:.67rem;--wp--preset--spacing--40:1rem;--wp--preset--spacing--50:1.5rem;--wp--preset--spacing--60:2.25rem;--wp--preset--spacing--70:3.38rem;--wp--preset--spacing--80:5.06rem}:where(.is-layout-flex){gap:.5em}body .is-layout-flow>.alignleft{float:left;margin-inline-start:0;margin-inline-end:2em}body .is-layout-flow>.alignright{float:right;margin-inline-start:2em;margin-inline-end:0}body .is-layout-flow>.aligncenter{margin-left:auto !important;margin-right:auto !important}body .is-layout-constrained>.alignleft{float:left;margin-inline-start:0;margin-inline-end:2em}body .is-layout-constrained>.alignright{float:right;margin-inline-start:2em;margin-inline-end:0}body .is-layout-constrained>.aligncenter{margin-left:auto !important;margin-right:auto !important}body .is-layout-constrained>:where(:not(.alignleft):not(.alignright):not(.alignfull)){max-width:var(--wp--style--global--content-size);margin-left:auto !important;margin-right:auto !important}body .is-layout-constrained>.alignwide{max-width:var(--wp--style--global--wide-size)}body .is-layout-flex{display:flex}body .is-layout-flex{flex-wrap:wrap;align-items:center}body .is-layout-flex>*{margin:0}:where(.wp-block-columns.is-layout-flex){gap:2em}.has-black-color{color:var(--wp--preset--color--black) !important}.has-cyan-bluish-gray-color{color:var(--wp--preset--color--cyan-bluish-gray) !important}.has-white-color{color:var(--wp--preset--color--white) !important}.has-pale-pink-color{color:var(--wp--preset--color--pale-pink) !important}.has-vivid-red-color{color:var(--wp--preset--color--vivid-red) !important}.has-luminous-vivid-orange-color{color:var(--wp--preset--color--luminous-vivid-orange) !important}.has-luminous-vivid-amber-color{color:var(--wp--preset--color--luminous-vivid-amber) !important}.has-light-green-cyan-color{color:var(--wp--preset--color--light-green-cyan) !important}.has-vivid-green-cyan-color{color:var(--wp--preset--color--vivid-green-cyan) !important}.has-pale-cyan-blue-color{color:var(--wp--preset--color--pale-cyan-blue) !important}.has-vivid-cyan-blue-color{color:var(--wp--preset--color--vivid-cyan-blue) !important}.has-vivid-purple-color{color:var(--wp--preset--color--vivid-purple) !important}.has-black-background-color{background-color:var(--wp--preset--color--black) !important}.has-cyan-bluish-gray-background-color{background-color:var(--wp--preset--color--cyan-bluish-gray) !important}.has-white-background-color{background-color:var(--wp--preset--color--white) !important}.has-pale-pink-background-color{background-color:var(--wp--preset--color--pale-pink) !important}.has-vivid-red-background-color{background-color:var(--wp--preset--color--vivid-red) !important}.has-luminous-vivid-orange-background-color{background-color:var(--wp--preset--color--luminous-vivid-orange) !important}.has-luminous-vivid-amber-background-color{background-color:var(--wp--preset--color--luminous-vivid-amber) !important}.has-light-green-cyan-background-color{background-color:var(--wp--preset--color--light-green-cyan) !important}.has-vivid-green-cyan-background-color{background-color:var(--wp--preset--color--vivid-green-cyan) !important}.has-pale-cyan-blue-background-color{background-color:var(--wp--preset--color--pale-cyan-blue) !important}.has-vivid-cyan-blue-background-color{background-color:var(--wp--preset--color--vivid-cyan-blue) !important}.has-vivid-purple-background-color{background-color:var(--wp--preset--color--vivid-purple) !important}.has-black-border-color{border-color:var(--wp--preset--color--black) !important}.has-cyan-bluish-gray-border-color{border-color:var(--wp--preset--color--cyan-bluish-gray) !important}.has-white-border-color{border-color:var(--wp--preset--color--white) !important}.has-pale-pink-border-color{border-color:var(--wp--preset--color--pale-pink) !important}.has-vivid-red-border-color{border-color:var(--wp--preset--color--vivid-red) !important}.has-luminous-vivid-orange-border-color{border-color:var(--wp--preset--color--luminous-vivid-orange) !important}.has-luminous-vivid-amber-border-color{border-color:var(--wp--preset--color--luminous-vivid-amber) !important}.has-light-green-cyan-border-color{border-color:var(--wp--preset--color--light-green-cyan) !important}.has-vivid-green-cyan-border-color{border-color:var(--wp--preset--color--vivid-green-cyan) !important}.has-pale-cyan-blue-border-color{border-color:var(--wp--preset--color--pale-cyan-blue) !important}.has-vivid-cyan-blue-border-color{border-color:var(--wp--preset--color--vivid-cyan-blue) !important}.has-vivid-purple-border-color{border-color:var(--wp--preset--color--vivid-purple) !important}.has-vivid-cyan-blue-to-vivid-purple-gradient-background{background:var(--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple) !important}.has-light-green-cyan-to-vivid-green-cyan-gradient-background{background:var(--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan) !important}.has-luminous-vivid-amber-to-luminous-vivid-orange-gradient-background{background:var(--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange) !important}.has-luminous-vivid-orange-to-vivid-red-gradient-background{background:var(--wp--preset--gradient--luminous-vivid-orange-to-vivid-red) !important}.has-very-light-gray-to-cyan-bluish-gray-gradient-background{background:var(--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray) !important}.has-cool-to-warm-spectrum-gradient-background{background:var(--wp--preset--gradient--cool-to-warm-spectrum) !important}.has-blush-light-purple-gradient-background{background:var(--wp--preset--gradient--blush-light-purple) !important}.has-blush-bordeaux-gradient-background{background:var(--wp--preset--gradient--blush-bordeaux) !important}.has-luminous-dusk-gradient-background{background:var(--wp--preset--gradient--luminous-dusk) !important}.has-pale-ocean-gradient-background{background:var(--wp--preset--gradient--pale-ocean) !important}.has-electric-grass-gradient-background{background:var(--wp--preset--gradient--electric-grass) !important}.has-midnight-gradient-background{background:var(--wp--preset--gradient--midnight) !important}.has-small-font-size{font-size:var(--wp--preset--font-size--small) !important}.has-medium-font-size{font-size:var(--wp--preset--font-size--medium) !important}.has-large-font-size{font-size:var(--wp--preset--font-size--large) !important}.has-x-large-font-size{font-size:var(--wp--preset--font-size--x-large) !important}.wp-block-navigation a:where(:not(.wp-element-button)){color:inherit}:where(.wp-block-columns.is-layout-flex){gap:2em}.wp-block-pullquote{font-size:1.5em;line-height:1.6}blockquote,body,dd,dl,dt,fieldset,figure,h1,h2,h3,h4,h5,h6,hr,html,iframe,legend,li,ol,p,pre,textarea,ul{margin:0;padding:0;border:0}html{font-family:sans-serif;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%;-webkit-font-smoothing:antialiased;-moz-osx-font-smoothing:grayscale}main{display:block}progress{vertical-align:baseline}html{box-sizing:border-box}*,:after,:before{box-sizing:inherit}button,input,optgroup,select,textarea{font-family:inherit;font-size:100%;margin:0}[type=search]{-webkit-appearance:textfield;outline-offset:-2px}[type=search]::-webkit-search-decoration{-webkit-appearance:none}::-moz-focus-inner{border-style:none;padding:0}:-moz-focusring{outline:1px dotted ButtonText}body,button,input,select,textarea{font-family:-apple-system,system-ui,BlinkMacSystemFont,"Segoe UI",Helvetica,Arial,sans-serif,"Apple Color Emoji","Segoe UI Emoji","Segoe UI Symbol";font-weight:400;text-transform:none;font-size:17px;line-height:1.5}p{margin-bottom:1.5em}h1,h2,h3,h4,h5,h6{font-family:inherit;font-size:100%;font-style:inherit;font-weight:inherit}pre{background:rgba(0,0,0,.05);font-family:inherit;font-size:inherit;line-height:normal;margin-bottom:1.5em;padding:20px;overflow:auto;max-width:100%}blockquote{border-left:5px solid rgba(0,0,0,.05);padding:20px;font-size:1.2em;font-style:italic;margin:0 0 1.5em;position:relative}blockquote p:last-child{margin:0}table,td,th{border:1px solid rgba(0,0,0,.1)}table{border-collapse:separate;border-spacing:0;border-width:1px 0 0 1px;margin:0 0 1.5em;width:100%}td,th{padding:8px}th{border-width:0 1px 1px 0}td{border-width:0 1px 1px 0}hr{background-color:rgba(0,0,0,.1);border:0;height:1px;margin-bottom:40px;margin-top:40px}fieldset{padding:0;border:0;min-width:inherit}fieldset legend{padding:0;margin-bottom:1.5em}h1{font-size:42px;margin-bottom:20px;line-height:1.2em;font-weight:400;text-transform:none}h2{font-size:35px;margin-bottom:20px;line-height:1.2em;font-weight:400;text-transform:none}h3{font-size:29px;margin-bottom:20px;line-height:1.2em;font-weight:400;text-transform:none}h4{font-size:24px}h5{font-size:20px}h4,h5,h6{margin-bottom:20px}ol,ul{margin:0 0 1.5em 3em}ul{list-style:disc}ol{list-style:decimal}li>ol,li>ul{margin-bottom:0;margin-left:1.5em}dt{font-weight:700}dd{margin:0 1.5em 1.5em}b,strong{font-weight:700}cite,dfn,em,i{font-style:italic}address{margin:0 0 1.5em}code,kbd,tt,var{font:15px Monaco,Consolas,"Andale Mono","DejaVu Sans Mono",monospace}abbr,acronym{border-bottom:1px dotted #666;cursor:help}ins,mark{text-decoration:none}sub,sup{font-size:75%;height:0;line-height:0;position:relative;vertical-align:baseline}sup{bottom:1ex}sub{top:.5ex}small{font-size:75%}big{font-size:125%}figure{margin:0}table{margin:0 0 1.5em;width:100%}th{font-weight:700}img{height:auto;max-width:100%}button,input[type=button],input[type=reset],input[type=submit]{background:#55555e;color:#fff;border:1px solid transparent;cursor:pointer;-webkit-appearance:button;padding:10px 20px}input[type=email],input[type=number],input[type=password],input[type=search],input[type=tel],input[type=text],input[type=url],select,textarea{border:1px solid;border-radius:0;padding:10px 15px;max-width:100%}textarea{width:100%}a,button,input{transition:color .1s ease-in-out,background-color .1s ease-in-out}a{text-decoration:none}.button,.wp-block-button .wp-block-button__link{padding:10px 20px;display:inline-block}.wp-block-button .wp-block-button__link{font-size:inherit;line-height:inherit}.using-mouse :focus{outline:0}.using-mouse ::-moz-focus-inner{border:0}.alignleft{float:left;margin-right:1.5em}.alignright{float:right;margin-left:1.5em}.aligncenter{clear:both;display:block;margin:0 auto}.size-auto,.size-full,.size-large,.size-medium,.size-thumbnail{max-width:100%;height:auto}.no-sidebar .entry-content .alignfull{margin-left:calc(-100vw/2 + 100%/2);margin-right:calc(-100vw/2 + 100%/2);max-width:100vw;width:auto}.screen-reader-text{border:0;clip:rect(1px,1px,1px,1px);-webkit-clip-path:inset(50%);clip-path:inset(50%);height:1px;margin:-1px;overflow:hidden;padding:0;position:absolute!important;width:1px;word-wrap:normal!important}.screen-reader-text:focus{background-color:#f1f1f1;border-radius:3px;box-shadow:0 0 2px 2px rgba(0,0,0,.6);clip:auto!important;-webkit-clip-path:none;clip-path:none;color:#21759b;display:block;font-size:.875rem;font-weight:700;height:auto;left:5px;line-height:normal;padding:15px 23px 14px;text-decoration:none;top:5px;width:auto;z-index:100000}#primary[tabindex="-1"]:focus{outline:0}.main-navigation{z-index:100;padding:0;clear:both;display:block}.main-navigation a{display:block;text-decoration:none;font-weight:400;text-transform:none;font-size:15px}.main-navigation ul{list-style:none;margin:0;padding-left:0}.main-navigation .main-nav ul li a{padding-left:20px;padding-right:20px;line-height:60px}.inside-navigation{position:relative}.main-navigation .inside-navigation{display:flex;align-items:center;flex-wrap:wrap;justify-content:space-between}.main-navigation .main-nav>ul{display:flex;flex-wrap:wrap;align-items:center}.main-navigation li{position:relative}.main-navigation .menu-bar-items{display:flex;align-items:center;font-size:15px}.main-navigation .menu-bar-items a{color:inherit}.main-navigation .menu-bar-item{position:relative}.main-navigation .menu-bar-item.search-item{z-index:20}.main-navigation .menu-bar-item>a{padding-left:20px;padding-right:20px;line-height:60px}.sidebar .main-navigation .main-nav{flex-basis:100%}.sidebar .main-navigation .main-nav>ul{flex-direction:column}.sidebar .main-navigation .menu-bar-items{margin:0 auto}.sidebar .main-navigation .menu-bar-items .search-item{order:10}.nav-align-center .inside-navigation{justify-content:center}.nav-align-center .main-nav>ul{justify-content:center}.nav-align-right .inside-navigation{justify-content:flex-end}.main-navigation ul ul{display:block;box-shadow:1px 1px 0 rgba(0,0,0,.1);float:left;position:absolute;left:-99999px;opacity:0;z-index:99999;width:200px;text-align:left;top:auto;transition:opacity 80ms linear;transition-delay:0s;pointer-events:none;height:0;overflow:hidden}.main-navigation ul ul a{display:block}.main-navigation ul ul li{width:100%}.main-navigation .main-nav ul ul li a{line-height:normal;padding:10px 20px;font-size:14px}.main-navigation .main-nav ul li.menu-item-has-children>a{padding-right:0;position:relative}.main-navigation.sub-menu-left ul ul{box-shadow:-1px 1px 0 rgba(0,0,0,.1)}.main-navigation.sub-menu-left .sub-menu{right:0}.main-navigation:not(.toggled) ul li.sfHover>ul,.main-navigation:not(.toggled) ul li:hover>ul{left:auto;opacity:1;transition-delay:.15s;pointer-events:auto;height:auto;overflow:visible}.main-navigation:not(.toggled) ul ul li.sfHover>ul,.main-navigation:not(.toggled) ul ul li:hover>ul{left:100%;top:0}.main-navigation.sub-menu-left:not(.toggled) ul ul li.sfHover>ul,.main-navigation.sub-menu-left:not(.toggled) ul ul li:hover>ul{right:100%;left:auto}.nav-float-right .main-navigation ul ul ul{top:0}.menu-item-has-children .dropdown-menu-toggle{display:inline-block;height:100%;clear:both;padding-right:20px;padding-left:10px}.menu-item-has-children ul .dropdown-menu-toggle{padding-top:10px;padding-bottom:10px;margin-top:-10px}.sidebar .menu-item-has-children .dropdown-menu-toggle,nav ul ul .menu-item-has-children .dropdown-menu-toggle{float:right}.widget-area .main-navigation li{float:none;display:block;width:100%;padding:0;margin:0}.sidebar .main-navigation.sub-menu-right ul li.sfHover ul,.sidebar .main-navigation.sub-menu-right ul li:hover ul{top:0;left:100%}.sidebar .main-navigation.sub-menu-left ul li.sfHover ul,.sidebar .main-navigation.sub-menu-left ul li:hover ul{top:0;right:100%}.site-main .comment-navigation,.site-main .post-navigation,.site-main .posts-navigation{margin:0 0 2em;overflow:hidden}.site-main .post-navigation{margin-bottom:0}.paging-navigation .nav-next,.paging-navigation .nav-previous{display:none}.paging-navigation .nav-links>*{padding:0 5px}.paging-navigation .nav-links .current{font-weight:700}.nav-links>:first-child{padding-left:0}.site-header{position:relative}.inside-header{padding:20px 40px}.main-title{margin:0;font-size:25px;line-height:1.2em;word-wrap:break-word;font-weight:700;text-transform:none}.site-description{margin:0;line-height:1.5;font-weight:400;text-transform:none;font-size:15px}.site-logo{display:inline-block;max-width:100%}.site-header .header-image{vertical-align:middle}.inside-header{display:flex;align-items:center}.header-widget{margin-left:auto}.header-widget p:last-child{margin-bottom:0}.nav-float-right .header-widget{margin-left:20px}.nav-float-right #site-navigation{margin-left:auto}.nav-float-left #site-navigation{margin-right:auto;order:-10}.nav-float-left .header-widget{margin-left:0;margin-right:20px;order:-15}.header-aligned-center:not([class*=nav-float-]) .inside-header{justify-content:center;flex-direction:column;text-align:center}.header-aligned-center:not([class*=nav-float-]) .header-widget{margin-left:auto;margin-right:auto}.header-aligned-center:not([class*=nav-float-]) .inside-header>:not(:first-child){margin-top:1em}.header-aligned-right:not([class*=nav-float-]) .inside-header{justify-content:flex-end}.header-aligned-right:not([class*=nav-float-]) .header-widget{margin-right:auto;margin-left:0;order:-10}.site-branding-container{display:inline-flex;align-items:center;text-align:left;flex-shrink:0}.site-branding-container .site-logo{margin-right:1em}.sticky{display:block}.entry-header .gp-icon,.posted-on .updated{display:none}.byline,.entry-header .cat-links,.entry-header .comments-link,.entry-header .tags-links,.group-blog .byline,.single .byline{display:inline}footer.entry-meta .byline,footer.entry-meta .posted-on{display:block}.entry-content:not(:first-child),.entry-summary:not(:first-child),.page-content:not(:first-child){margin-top:2em}.page-links{clear:both;margin:0 0 1.5em}.archive .format-aside .entry-header,.archive .format-status .entry-header,.archive .format-status .entry-meta,.archive .format-status .entry-title,.blog .format-aside .entry-header,.blog .format-status .entry-header,.blog .format-status .entry-meta,.blog .format-status .entry-title{display:none}.archive .format-aside .entry-content,.archive .format-status .entry-content,.blog .format-aside .entry-content,.blog .format-status .entry-content{margin-top:0}.archive .format-status .entry-content p:last-child,.blog .format-status .entry-content p:last-child{margin-bottom:0}.entry-header,.site-content{word-wrap:break-word}.entry-title{margin-bottom:0}.author .page-header .page-title{display:flex;align-items:center}.author .page-header .avatar{margin-right:20px}.page-header .author-info>:last-child,.page-header>:last-child{margin-bottom:0}.entry-meta{font-size:85%;margin-top:.5em;line-height:1.5}footer.entry-meta{margin-top:2em}.cat-links,.comments-link,.tags-links{display:block}.entry-content>p:last-child,.entry-summary>p:last-child,.page-content>p:last-child,.read-more-container,.taxonomy-description p:last-child{margin-bottom:0}.wp-caption{margin-bottom:1.5em;max-width:100%;position:relative}.wp-caption img[class*=wp-image-]{display:block;margin:0 auto 0;max-width:100%}.wp-caption .wp-caption-text{font-size:75%;padding-top:5px;opacity:.8}.wp-caption img{position:relative;vertical-align:bottom}.wp-block-image figcaption{font-size:13px;text-align:center}.wp-block-gallery,ul.blocks-gallery-grid{margin-left:0}.wp-block-gallery .blocks-gallery-image figcaption,.wp-block-gallery .blocks-gallery-item figcaption{background:rgba(255,255,255,.7);color:#000;padding:10px;box-sizing:border-box}.gallery{margin-bottom:1.5em}.gallery-item{display:inline-block;text-align:center;vertical-align:top;width:100%}.gallery-columns-2 .gallery-item{max-width:50%}.gallery-columns-3 .gallery-item{max-width:33.33%}.gallery-columns-4 .gallery-item{max-width:25%}.gallery-columns-5 .gallery-item{max-width:20%}.gallery-columns-6 .gallery-item{max-width:16.66%}.gallery-columns-7 .gallery-item{max-width:14.28%}.gallery-columns-8 .gallery-item{max-width:12.5%}.gallery-columns-9 .gallery-item{max-width:11.11%}.gallery-caption{display:block}.site-main .gallery{margin-bottom:1.5em}.gallery-item img{vertical-align:bottom}.gallery-icon{padding:5px}embed,iframe,object{max-width:100%}.wp-block-post-template{margin-left:0}.widget-area .widget{padding:40px}.widget select{max-width:100%}.footer-widgets .widget :last-child,.sidebar .widget :last-child{margin-bottom:0}.widget-title{margin-bottom:30px;font-size:20px;line-height:1.5;font-weight:400;text-transform:none}.widget ol,.widget ul{margin:0}.widget .search-field{width:100%}.widget .search-form{display:flex}.widget .search-form button.search-submit{font-size:15px}.footer-widgets .widget{margin-bottom:30px}.footer-widgets .widget:last-child,.sidebar .widget:last-child{margin-bottom:0}.widget ul li{list-style-type:none;position:relative;margin-bottom:.5em}.widget ul li ul{margin-left:1em;margin-top:.5em}.wp-calendar-table{table-layout:fixed}.site-content{display:flex}.grid-container{margin-left:auto;margin-right:auto;max-width:1200px}.page-header,.sidebar .widget,.site-main>*{margin-bottom:20px}.both-left .inside-left-sidebar,.both-right .inside-left-sidebar{margin-right:10px}.both-left .inside-right-sidebar,.both-right .inside-right-sidebar{margin-left:10px}.one-container.both-right .site-main,.one-container.right-sidebar .site-main{margin-right:40px}.one-container.both-left .site-main,.one-container.left-sidebar .site-main{margin-left:40px}.one-container.both-sidebars .site-main{margin:0 40px}.one-container.archive .post:not(:last-child):not(.is-loop-template-item),.one-container.blog .post:not(:last-child):not(.is-loop-template-item){padding-bottom:40px}.one-container .site-content{padding:40px}.separate-containers .comments-area,.separate-containers .inside-article,.separate-containers .page-header,.separate-containers .paging-navigation{padding:40px}.separate-containers .site-main{margin:20px}.separate-containers.no-sidebar .site-main{margin-left:0;margin-right:0}.separate-containers.both-right .site-main,.separate-containers.right-sidebar .site-main{margin-left:0}.separate-containers.both-left .site-main,.separate-containers.left-sidebar .site-main{margin-right:0}.separate-containers .inside-left-sidebar,.separate-containers .inside-right-sidebar{margin-top:20px;margin-bottom:20px}.inside-page-header{padding:40px}.widget-area .main-navigation{margin-bottom:20px}.one-container .site-main>:last-child,.separate-containers .site-main>:last-child{margin-bottom:0}.full-width-content .container.grid-container{max-width:100%}.full-width-content.no-sidebar.separate-containers .site-main{margin:0}.full-width-content.one-container .site-content,.full-width-content.separate-containers .inside-article{padding:0}.full-width-content .entry-content .alignwide{margin-left:0;width:auto;max-width:unset}.contained-content.one-container .site-content,.contained-content.separate-containers .inside-article{padding:0}.sidebar .grid-container{max-width:100%;width:100%}.both-left .is-left-sidebar,.both-sidebars .is-left-sidebar,.left-sidebar .sidebar{order:-10}.both-left .is-right-sidebar{order:-5}.both-right .is-left-sidebar{order:5}.both-right .is-right-sidebar,.both-sidebars .is-right-sidebar{order:10}.inside-site-info{display:flex;align-items:center;justify-content:center;padding:20px 40px}.site-info{text-align:center;font-size:15px}.post-image:not(:first-child){margin-top:2em}.featured-image{line-height:0}.separate-containers .featured-image{margin-top:20px}.separate-containers .inside-article>.featured-image{margin-top:0;margin-bottom:2em}.one-container .inside-article>.featured-image{margin-top:0;margin-bottom:2em}.gp-icon{display:inline-flex;align-self:center}.gp-icon svg{height:1em;width:1em;top:.125em;position:relative;fill:currentColor}.close-search .icon-search svg:nth-child(1),.icon-menu-bars svg:nth-child(2),.icon-search svg:nth-child(2),.toggled .icon-menu-bars svg:nth-child(1){display:none}.close-search .icon-search svg:nth-child(2),.toggled .icon-menu-bars svg:nth-child(2){display:block}.entry-meta .gp-icon{margin-right:.6em;opacity:.7}nav.toggled .icon-arrow-left svg{transform:rotate(-90deg)}nav.toggled .icon-arrow-right svg{transform:rotate(90deg)}nav.toggled .sfHover>a>.dropdown-menu-toggle .gp-icon svg{transform:rotate(180deg)}nav.toggled .sfHover>a>.dropdown-menu-toggle .gp-icon.icon-arrow-left svg{transform:rotate(-270deg)}nav.toggled .sfHover>a>.dropdown-menu-toggle .gp-icon.icon-arrow-right svg{transform:rotate(270deg)}.container.grid-container{width:auto}.menu-toggle,.mobile-bar-items,.sidebar-nav-mobile{display:none}.menu-toggle{padding:0 20px;line-height:60px;margin:0;font-weight:400;text-transform:none;font-size:15px;cursor:pointer}.menu-toggle .mobile-menu{padding-left:3px}.menu-toggle .gp-icon+.mobile-menu{padding-left:9px}.menu-toggle .mobile-menu:empty{display:none}button.menu-toggle{background-color:transparent;flex-grow:1;border:0;text-align:center}button.menu-toggle:active,button.menu-toggle:focus,button.menu-toggle:hover{background-color:transparent}.has-menu-bar-items button.menu-toggle{flex-grow:0}nav.toggled ul ul.sub-menu{width:100%}.toggled .menu-item-has-children .dropdown-menu-toggle{padding-left:20px}.main-navigation.toggled .main-nav{flex-basis:100%;order:3}.main-navigation.toggled .main-nav>ul{display:block}.main-navigation.toggled .main-nav li{width:100%;text-align:left}.main-navigation.toggled .main-nav ul ul{transition:0s;visibility:hidden;box-shadow:none;border-bottom:1px solid rgba(0,0,0,.05)}.main-navigation.toggled .main-nav ul ul li:last-child>ul{border-bottom:0}.main-navigation.toggled .main-nav ul ul.toggled-on{position:relative;top:0;left:auto!important;right:auto!important;width:100%;pointer-events:auto;height:auto;opacity:1;display:block;visibility:visible;float:none}.main-navigation.toggled .menu-item-has-children .dropdown-menu-toggle{float:right}.mobile-menu-control-wrapper{display:none;margin-left:auto;align-items:center}.has-inline-mobile-toggle #site-navigation.toggled{margin-top:1.5em}.has-inline-mobile-toggle #site-navigation.has-active-search{margin-top:1.5em}.has-inline-mobile-toggle #site-navigation.has-active-search .nav-search-active{position:relative}.has-inline-mobile-toggle #site-navigation.has-active-search .navigation-search input{outline:auto}.nav-float-left .mobile-menu-control-wrapper{order:-10;margin-left:0;margin-right:auto;flex-direction:row-reverse}@media (max-width:768px){.hide-on-mobile{display:none!important}a,body,button,input,select,textarea{transition:all 0s ease-in-out}.inside-header{flex-direction:column;text-align:center}.site-header .header-widget{margin-top:1.5em;margin-left:auto;margin-right:auto;text-align:center}.site-content{flex-direction:column}.container .site-content .content-area{width:auto}.is-left-sidebar.sidebar,.is-right-sidebar.sidebar{width:auto;order:initial}.is-left-sidebar+.is-right-sidebar .inside-right-sidebar{margin-top:0}.both-left .inside-left-sidebar,.both-left .inside-right-sidebar,.both-right .inside-left-sidebar,.both-right .inside-right-sidebar{margin-right:0;margin-left:0}#main{margin-left:0;margin-right:0}body:not(.no-sidebar) #main{margin-bottom:0}.alignleft,.alignright{float:none;display:block;margin-left:auto;margin-right:auto}.comment .children{padding-left:10px;margin-left:0}.entry-meta{font-size:inherit}.entry-meta a{line-height:1.8em}}@media (min-width:769px) and (max-width:1024px){.hide-on-tablet{display:none!important}}@media (min-width:1025px){.hide-on-desktop{display:none!important}}body{background-color:var(--base-2);color:var(--contrast)}a{color:var(--accent)}a{text-decoration:underline}.entry-title a,.site-branding a,a.button,.wp-block-button__link,.main-navigation a{text-decoration:none}a:hover,a:focus,a:active{color:var(--contrast)}.grid-container{max-width:850px}.wp-block-group__inner-container{max-width:850px;margin-left:auto;margin-right:auto}:root{--contrast:#222;--contrast-2:#575760;--contrast-3:#b2b2be;--base:#f0f0f0;--base-2:#f7f8f9;--base-3:#fff;--accent:#1e73be}:root .has-contrast-color{color:var(--contrast)}:root .has-contrast-background-color{background-color:var(--contrast)}:root .has-contrast-2-color{color:var(--contrast-2)}:root .has-contrast-2-background-color{background-color:var(--contrast-2)}:root .has-contrast-3-color{color:var(--contrast-3)}:root .has-contrast-3-background-color{background-color:var(--contrast-3)}:root .has-base-color{color:var(--base)}:root .has-base-background-color{background-color:var(--base)}:root .has-base-2-color{color:var(--base-2)}:root .has-base-2-background-color{background-color:var(--base-2)}:root .has-base-3-color{color:var(--base-3)}:root .has-base-3-background-color{background-color:var(--base-3)}:root .has-accent-color{color:var(--accent)}:root .has-accent-background-color{background-color:var(--accent)}h2{font-family:Arial;font-size:20px}h1.entry-title{font-family:Arial;font-size:20px}h2.entry-title{font-family:Arial;font-size:20px}h1{font-family:Arial;font-weight:700;font-size:20px}.main-title{font-family:Arial;font-size:20px}.top-bar{background-color:#636363;color:#fff}.top-bar a{color:#fff}.top-bar a:hover{color:#303030}.site-header{background-color:var(--base-3)}.main-title a,.main-title a:hover{color:var(--contrast)}.site-description{color:var(--contrast-2)}.mobile-menu-control-wrapper .menu-toggle,.mobile-menu-control-wrapper .menu-toggle:hover,.mobile-menu-control-wrapper .menu-toggle:focus,.has-inline-mobile-toggle #site-navigation.toggled{background-color:rgba(0,0,0,.02)}.main-navigation,.main-navigation ul ul{background-color:var(--base-3)}.main-navigation .main-nav ul li a,.main-navigation .menu-toggle,.main-navigation .menu-bar-items{color:var(--contrast)}.main-navigation .main-nav ul li:not([class*=current-menu-]):hover>a,.main-navigation .main-nav ul li:not([class*=current-menu-]):focus>a,.main-navigation .main-nav ul li.sfHover:not([class*=current-menu-])>a,.main-navigation .menu-bar-item:hover>a,.main-navigation .menu-bar-item.sfHover>a{color:var(--accent)}button.menu-toggle:hover,button.menu-toggle:focus{color:var(--contrast)}.main-navigation .main-nav ul li[class*=current-menu-]>a{color:var(--accent)}.navigation-search input[type=search],.navigation-search input[type=search]:active,.navigation-search input[type=search]:focus,.main-navigation .main-nav ul li.search-item.active>a,.main-navigation .menu-bar-items .search-item.active>a{color:var(--accent)}.main-navigation ul ul{background-color:var(--base)}.separate-containers .inside-article,.separate-containers .comments-area,.separate-containers .page-header,.one-container .container,.separate-containers .paging-navigation,.inside-page-header{background-color:var(--base-3)}.entry-title a{color:var(--contrast)}.entry-title a:hover{color:var(--contrast-2)}.entry-meta{color:var(--contrast-2)}.sidebar .widget{background-color:var(--base-3)}.footer-widgets{background-color:var(--base-3)}.site-info{background-color:var(--base-3)}input[type=text],input[type=email],input[type=url],input[type=password],input[type=search],input[type=tel],input[type=number],textarea,select{color:var(--contrast);background-color:var(--base-2);border-color:var(--base)}input[type=text]:focus,input[type=email]:focus,input[type=url]:focus,input[type=password]:focus,input[type=search]:focus,input[type=tel]:focus,input[type=number]:focus,textarea:focus,select:focus{color:var(--contrast);background-color:var(--base-2);border-color:var(--contrast-3)}button,html input[type=button],input[type=reset],input[type=submit],a.button,a.wp-block-button__link:not(.has-background){color:#fff;background-color:#55555e}button:hover,html input[type=button]:hover,input[type=reset]:hover,input[type=submit]:hover,a.button:hover,button:focus,html input[type=button]:focus,input[type=reset]:focus,input[type=submit]:focus,a.button:focus,a.wp-block-button__link:not(.has-background):active,a.wp-block-button__link:not(.has-background):focus,a.wp-block-button__link:not(.has-background):hover{color:#fff;background-color:#3f4047}a.generate-back-to-top{background-color:rgba(0,0,0,.4);color:#fff}a.generate-back-to-top:hover,a.generate-back-to-top:focus{background-color:rgba(0,0,0,.6);color:#fff}:root{--gp-search-modal-bg-color:var(--base-3);--gp-search-modal-text-color:var(--contrast);--gp-search-modal-overlay-bg-color:rgba(0,0,0,.2)}@media (max-width:850px){.main-navigation .menu-bar-item:hover>a,.main-navigation .menu-bar-item.sfHover>a{background:0 0;color:var(--contrast)}}.inside-top-bar.grid-container{max-width:930px}.inside-header{padding:0 30px}.inside-header.grid-container{max-width:910px}.separate-containers .inside-article,.separate-containers .comments-area,.separate-containers .page-header,.separate-containers .paging-navigation,.one-container .site-content,.inside-page-header{padding:10px 20px}.site-main .wp-block-group__inner-container{padding:10px 20px}.separate-containers .paging-navigation{padding-top:20px;padding-bottom:20px}.entry-content .alignwide,body:not(.no-sidebar) .entry-content .alignfull{margin-left:-20px;width:calc(100% + 40px);max-width:calc(100% + 40px)}.one-container.right-sidebar .site-main,.one-container.both-right .site-main{margin-right:20px}.one-container.left-sidebar .site-main,.one-container.both-left .site-main{margin-left:20px}.one-container.both-sidebars .site-main{margin:0 20px}.sidebar .widget,.page-header,.widget-area .main-navigation,.site-main>*{margin-bottom:10px}.separate-containers .site-main{margin:10px}.both-right .inside-left-sidebar,.both-left .inside-left-sidebar{margin-right:5px}.both-right .inside-right-sidebar,.both-left .inside-right-sidebar{margin-left:5px}.one-container.archive .post:not(:last-child):not(.is-loop-template-item),.one-container.blog .post:not(:last-child):not(.is-loop-template-item){padding-bottom:10px}.separate-containers .featured-image{margin-top:10px}.separate-containers .inside-right-sidebar,.separate-containers .inside-left-sidebar{margin-top:10px;margin-bottom:10px}.main-navigation .main-nav ul li a,.menu-toggle,.main-navigation .menu-bar-item>a{padding-left:10px;padding-right:10px;line-height:26px}.main-navigation .main-nav ul ul li a{padding:50px 10px}.main-navigation ul ul{width:100px}.navigation-search input[type=search]{height:26px}.rtl .menu-item-has-children .dropdown-menu-toggle{padding-left:10px}.menu-item-has-children .dropdown-menu-toggle{padding-right:10px}.menu-item-has-children ul .dropdown-menu-toggle{padding-top:50px;padding-bottom:50px;margin-top:-50px}.rtl .main-navigation .main-nav ul li.menu-item-has-children>a{padding-right:10px}.widget-area .widget{padding:10px}.footer-widgets-container.grid-container{max-width:930px}.inside-site-info.grid-container{max-width:930px}@media (max-width:768px){.separate-containers .inside-article,.separate-containers .comments-area,.separate-containers .page-header,.separate-containers .paging-navigation,.one-container .site-content,.inside-page-header{padding:10px 20px}.site-main .wp-block-group__inner-container{padding:10px 20px}.inside-top-bar{padding-right:30px;padding-left:30px}.inside-header{padding-top:0;padding-right:30px;padding-bottom:0;padding-left:30px}.widget-area .widget{padding-top:0;padding-right:0;padding-bottom:0;padding-left:0}.footer-widgets-container{padding-top:30px;padding-right:30px;padding-bottom:30px;padding-left:30px}.inside-site-info{padding-right:30px;padding-left:30px}.entry-content .alignwide,body:not(.no-sidebar) .entry-content .alignfull{margin-left:-20px;width:calc(100% + 40px);max-width:calc(100% + 40px)}.one-container .site-main .paging-navigation{margin-bottom:10px}}.is-right-sidebar{width:15%}.is-left-sidebar{width:15%}.site-content .content-area{width:100%}@media (max-width:850px){.main-navigation .menu-toggle,.sidebar-nav-mobile:not(#sticky-placeholder){display:block}.main-navigation ul,.gen-sidebar-nav,.main-navigation:not(.slideout-navigation):not(.toggled) .main-nav>ul,.has-inline-mobile-toggle #site-navigation .inside-navigation>*:not(.navigation-search):not(.main-nav){display:none}.nav-align-right .inside-navigation,.nav-align-center .inside-navigation{justify-content:space-between}}.dynamic-author-image-rounded{border-radius:100%}.dynamic-featured-image,.dynamic-author-image{vertical-align:middle}.one-container.blog .dynamic-content-template:not(:last-child),.one-container.archive .dynamic-content-template:not(:last-child){padding-bottom:0}.dynamic-entry-excerpt>p:last-child{margin-bottom:0}.main-navigation.toggled .main-nav>ul{background-color:var(--base-3)}.sticky-enabled .gen-sidebar-nav.is_stuck .main-navigation{margin-bottom:0}.sticky-enabled .gen-sidebar-nav.is_stuck{z-index:500}.sticky-enabled .main-navigation.is_stuck{box-shadow:0 2px 2px -2px rgba(0,0,0,.2)}.navigation-stick:not(.gen-sidebar-nav){left:0;right:0;width:100% !important}.nav-float-right .navigation-stick{width:100% !important;left:0}.nav-float-right .navigation-stick .navigation-branding{margin-right:auto}.main-navigation.has-sticky-branding:not(.grid-container) .inside-navigation:not(.grid-container) .navigation-branding{margin-left:10px}@media (max-width:850px){.main-navigation .menu-toggle,.main-navigation .mobile-bar-items a,.main-navigation .menu-bar-item>a{padding-left:10px;padding-right:10px}.main-navigation .main-nav ul li a,.main-navigation .menu-toggle,.main-navigation .mobile-bar-items a,.main-navigation .menu-bar-item>a{line-height:20px}.main-navigation .site-logo.navigation-logo img,.mobile-header-navigation .site-logo.mobile-header-logo img,.navigation-search input[type=search]{height:20px}}.post-image:not(:first-child),.page-content:not(:first-child),.entry-content:not(:first-child),.entry-summary:not(:first-child),footer.entry-meta{margin-top:1em}.post-image-above-header .inside-article div.featured-image,.post-image-above-header .inside-article div.post-image{margin-bottom:1em}.main-navigation.slideout-navigation .main-nav>ul>li>a{line-height:30px}.main-navigation.offside{position:fixed;width:var(--gp-slideout-width);height:100%;height:100vh;top:0;z-index:9999;overflow:auto;-webkit-overflow-scrolling:touch}.offside,.offside--left{left:calc(var(--gp-slideout-width)*-1)}.offside--right{left:auto;right:calc(var(--gp-slideout-width)*-1)}.offside--left.is-open:not(.slideout-transition),.offside-js--is-left .offside-sliding-element{transform:translate3d(var(--gp-slideout-width),0,0)}.offside--right.is-open:not(.slideout-transition),.offside-js--is-right .offside-sliding-element{transform:translate3d(calc(var(--gp-slideout-width)*-1),0,0)}.offside-js--interact .offside,.offside-js--interact .offside-sliding-element{transition:transform .2s cubic-bezier(.16,.68,.43,.99);-webkit-backface-visibility:hidden;-webkit-perspective:1000}.offside-js--init{overflow-x:hidden}.no-csstransforms3d .offside{transform:translate3d(0,0,0)}.no-csstransforms3d .offside-sliding-element{overflow-x:hidden;position:relative}.no-csstransforms3d .offside--left.is-open{left:0}.no-csstransforms3d .offside--right.is-open{right:0}.no-csstransforms3d>.offside-js--is-left .offside-sliding-element{right:calc(var(--gp-slideout-width)*-1)}.no-csstransforms3d>.offside-js--is-right .offside-sliding-element{left:calc(var(--gp-slideout-width)*-1)}.slideout-navigation.main-navigation:not(.is-open):not(.slideout-transition){display:none}.slideout-navigation.main-navigation:not(.slideout-transition).do-overlay{opacity:1}.slideout-navigation.main-navigation.slideout-transition.do-overlay{opacity:0}.slideout-overlay{z-index:100000;position:fixed;width:100%;height:100%;height:100vh;min-height:100%;top:0;right:0;bottom:0;left:0;background-color:rgba(0,0,0,.8);visibility:hidden;opacity:0;cursor:pointer;transition:visibility .2s ease,opacity .2s ease}.offside-js--is-open .slideout-overlay{visibility:visible;opacity:1}.slideout-overlay button.slideout-exit{position:fixed;top:0;background-color:transparent;color:#fff;font-size:30px;border:0;opacity:0}.slide-opened .slideout-overlay button.slideout-exit{opacity:1}button.slideout-exit:hover{background-color:transparent}.slideout-navigation button.slideout-exit{background:0 0;width:100%;text-align:left;padding-top:20px;padding-bottom:20px;box-sizing:border-box;border:0}.slide-opened nav.toggled .menu-toggle:before{content:"\f0c9"}.offside-js--is-left.slide-opened .slideout-overlay button.slideout-exit{left:calc(var(--gp-slideout-width) - 5px)}.offside-js--is-right.slide-opened .slideout-overlay button.slideout-exit{right:calc(var(--gp-slideout-width) - 5px)}.slideout-widget{margin:20px}.slideout-navigation .main-nav,.slideout-navigation .slideout-widget:not(:last-child){margin-bottom:40px}.slideout-navigation:not(.do-overlay) .main-nav{width:100%;box-sizing:border-box}.slideout-navigation .mega-menu>ul>li{display:block;width:100%!important}.slideout-navigation .slideout-menu{display:block}#generate-slideout-menu{z-index:100001}#generate-slideout-menu .slideout-menu li{float:none;width:100%;clear:both;text-align:left}.slideout-navigation .slideout-widget li{float:none}#generate-slideout-menu.do-overlay li{text-align:center}#generate-slideout-menu.main-navigation ul ul{display:none}#generate-slideout-menu.main-navigation ul ul.toggled-on{display:block!important}#generate-slideout-menu .slideout-menu li.sfHover>ul,#generate-slideout-menu .slideout-menu li:hover>ul{display:none}#generate-slideout-menu.main-navigation .main-nav ul ul{position:relative;top:0;left:0;width:100%}.slideout-toggle:not(.has-svg-icon) a:before{content:"\f0c9";font-family:'GP Premium';line-height:1em;width:1.28571429em;text-align:center;display:inline-block;position:relative;top:1px}.slide-opened .slideout-exit:not(.has-svg-icon):before,.slideout-navigation button.slideout-exit:not(.has-svg-icon):before{content:"\f00d";font-family:'GP Premium';line-height:1em;width:1.28571429em;text-align:center;display:inline-block}#generate-slideout-menu li.menu-item-float-right{float:none!important;display:inline-block;width:auto}.rtl .slideout-navigation{position:fixed}.slideout-navigation .menu-item-has-children .dropdown-menu-toggle{float:right}.slideout-navigation .slideout-widget .menu li{float:none}.slideout-navigation .slideout-widget ul{display:block}.slideout-navigation.do-overlay{transform:none!important;transition:opacity .2s,visibility .2s;width:100%;text-align:center;left:0;right:0}.slideout-navigation.do-overlay .inside-navigation{display:flex;flex-direction:column;padding:10% 10% 0;max-width:700px}.slideout-navigation.do-overlay .inside-navigation .main-nav,.slideout-navigation.do-overlay .inside-navigation .slideout-widget{margin-left:auto;margin-right:auto;min-width:250px}.slideout-navigation.do-overlay .slideout-exit{position:fixed;right:0;top:0;width:auto;font-size:25px}.slideout-navigation.do-overlay .slideout-menu li a{display:inline-block}.slideout-navigation.do-overlay .slideout-menu li{margin-bottom:5px}#generate-slideout-menu.do-overlay .slideout-menu li,.slideout-navigation.do-overlay .inside-navigation{text-align:center}.slideout-navigation.do-overlay .menu-item-has-children .dropdown-menu-toggle{border-left:1px solid rgba(0,0,0,.07);padding:0 10px;margin:0 0 0 10px}.slideout-navigation.do-overlay ul ul{box-shadow:0 0 0}.nav-aligned-center .slideout-navigation,.nav-aligned-right .slideout-navigation{text-align:left}.slideout-navigation .sfHover>a>.dropdown-menu-toggle>.gp-icon svg{transform:rotate(180deg)}.slideout-navigation .sub-menu .dropdown-menu-toggle .gp-icon svg{transform:rotate(0)}.slideout-both .main-navigation.toggled .main-nav>ul,.slideout-desktop .main-navigation.toggled .main-nav li.slideout-toggle,.slideout-mobile .main-navigation.toggled .main-nav>ul{display:none!important}.slideout-both .has-inline-mobile-toggle #site-navigation.toggled,.slideout-mobile .has-inline-mobile-toggle #site-navigation.toggled{margin-top:0}.sf-menu>li.slideout-toggle{float:right}.gen-sidebar-nav .sf-menu>li.slideout-toggle{float:none}.off-canvas-toggle-label{padding-left:7px}.gp-icon+.off-canvas-toggle-label{padding-left:9px}@media (max-width:768px){.slideout-overlay button.slideout-exit{font-size:20px;padding:10px}.slideout-overlay{top:-100px;height:calc(100% + 100px);height:calc(100vh + 100px);min-height:calc(100% + 100px)}.slideout-navigation.do-overlay .slideout-exit{position:static;text-align:center}}:root{--gp-slideout-width:265px}.slideout-navigation,.slideout-navigation a{color:var(--contrast)}.slideout-navigation button.slideout-exit{color:var(--contrast);padding-left:10px;padding-right:10px}.slide-opened nav.toggled .menu-toggle:before{display:none}@media (max-width:850px){.menu-bar-item.slideout-toggle{display:none}}.navigation-branding,.site-logo.mobile-header-logo{display:flex;align-items:center;order:0;margin-right:10px}.navigation-branding img,.site-logo.mobile-header-logo img{position:relative;padding:10px 0;display:block;transition:height .3s ease}.navigation-branding>div+.main-title{margin-left:10px}.navigation-branding .main-title{transition:line-height .3s ease}.navigation-branding .main-title a{font-family:inherit;font-size:inherit;font-weight:inherit;text-transform:unset}.main-navigation.mobile-header-navigation{display:none;float:none;margin-bottom:0}.mobile-header-navigation.is_stuck{box-shadow:0 2px 2px -2px rgba(0,0,0,.2)}.main-navigation .menu-toggle{flex-grow:1;width:auto}.main-navigation.has-branding .menu-toggle,.main-navigation.has-sticky-branding.navigation-stick .menu-toggle{flex-grow:0;padding-right:20px;order:2}.main-navigation:not(.slideout-navigation) .mobile-bar-items+.menu-toggle{text-align:left}.main-navigation.has-sticky-branding:not(.has-branding):not(.navigation-stick) .navigation-branding{display:none}.nav-align-right .navigation-branding{margin-right:auto}.main-navigation.has-branding:not([class*=nav-align-]):not(.mobile-header-navigation) .inside-navigation,.main-navigation.has-sticky-branding.navigation-stick:not([class*=nav-align-]):not(.mobile-header-navigation) .inside-navigation{justify-content:flex-start}.main-navigation.has-branding:not([class*=nav-align-]):not(.mobile-header-navigation) .menu-bar-items,.main-navigation.has-sticky-branding.navigation-stick:not([class*=nav-align-]):not(.mobile-header-navigation) .menu-bar-items{margin-left:auto}.nav-float-right .main-navigation.has-branding:not(.mobile-header-navigation) .menu-bar-items,.nav-float-right .main-navigation.has-sticky-branding.navigation-stick:not(.mobile-header-navigation) .menu-bar-items{margin-left:0}.mobile-header-navigation.has-menu-bar-items .mobile-header-logo{margin-right:auto}.rtl .navigation-branding>div+.main-title{margin-right:10px}.rtl .main-navigation.nav-align-right:not(.mobile-header-navigation) .navigation-branding{order:-10}.rtl .nav-align-right .navigation-branding{margin-right:10px}.rtl .navigation-branding,.rtl .site-logo.mobile-header-logo{margin-left:auto;margin-right:0}.rtl .nav-align-center .navigation-branding,.rtl .nav-align-center .site-logo.mobile-header-logo,.rtl .nav-align-right .navigation-branding,.rtl .nav-align-right .site-logo.mobile-header-logo{margin-left:10px}.rtl .nav-align-right .menu-bar-items{margin-right:auto}.rtl .mobile-header-navigation.has-menu-bar-items .site-logo{margin-left:auto}@media (max-width:850px){.site-header,#site-navigation,#sticky-navigation{display:none !important;opacity:.0}#mobile-header{display:block !important;width:100% !important}#mobile-header .main-nav>ul{display:none}#mobile-header.toggled .main-nav>ul,#mobile-header .menu-toggle,#mobile-header .mobile-bar-items{display:block}#mobile-header .main-nav{-ms-flex:0 0 100%;flex:0 0 100%;-webkit-box-ordinal-group:5;-ms-flex-order:4;order:4}}.main-navigation.has-branding.grid-container .navigation-branding,.main-navigation.has-branding:not(.grid-container) .inside-navigation:not(.grid-container) .navigation-branding{margin-left:10px}.navigation-branding img,.site-logo.mobile-header-logo img{height:26px;width:auto}.navigation-branding .main-title{line-height:26px}@media (max-width:860px){#site-navigation .navigation-branding,#sticky-navigation .navigation-branding{margin-left:10px}}@media (max-width:850px){.main-navigation.has-branding.nav-align-center .menu-bar-items,.main-navigation.has-sticky-branding.navigation-stick.nav-align-center .menu-bar-items{margin-left:auto}.navigation-branding{margin-right:auto;margin-left:10px}.navigation-branding .main-title,.mobile-header-navigation .site-logo{margin-left:10px}.navigation-branding img,.site-logo.mobile-header-logo{height:20px}.navigation-branding .main-title{line-height:20px}}
APIUM GRAVEOLENS EKSTRAKTLARININ LNCaP HÜCRELERİNDE KASPAZ-3, -8, -9 ve APAF-1 ÜZERİNE ETKİSİ Skip to content Yıl 2024, Cilt: 25 Sayı: 3, 300 – 306, 18.07.2024
Halit Buğra Koca , Tülay Köken , Tülay Akan
https://doi.org/10.18229/kocatepetip.1340255
Öz AMAÇ: Bu çalışmada, prostat kanseri hücre hattı LNCaP hücrelerinde, apium graveolens (kereviz) bitkisinin etanolik ekstraktlarının hücre canlılığı ve apoptoziste rol alan kaspazlar ve apoptoz proteaz aktivasyon faktörü-1 (Apaf-1) üzerine indükleyici/baskılayıcı olarak anti-kanser etkisinin araştırılması amaçlandı. GEREÇ VE YÖNTEM: Çalışmamızda LNCaP hücre hattı kullanıldı. LNCaP hücreleri; 0, 1500, 2000, 2500 μg/mL arasında değişen ve artan konsantrasyonlarda apium graveolens’in etanolik ekstraktları ile muamele edilen 4 gruba ayrıldı. Belirtilen ekstrakt konsantrasyonları LNCaP hücrelerine 24 ve 48 saat ayrı ayrı uygulandı. Uygulama bitiminde hazırlanan hücre lizatından ELISA yöntemiyle; Kaspaz-3, -8, -9 ve Apaf-1 ölçümü yapıldı. Sonuçlar canlı hücre sayılarıyla oranlanarak ng/ml olarak verildi. BULGULAR: LNCaP prostat kanser hücrelerinin apium graveolens ekstraktları ile 24 ve 48 saatliğine muamelesi kaspaz-3 ve kaspaz-9 düzeylerinde anlamlı bir farklılığa neden olmadı. Bununla birlikte; 24 ve 48 saatlik uygulamada, 2000 ve 2500 μg/ml ekstrakt konsantrasyonlarında kaspaz-8 değerleri kontrol gruplarına göre ve 2500 μg/ml ekstrakt konsantrasyonunda ise Apaf-1 düzeyi kontrol gruplarına göre doza ve zamana bağımlı olarak istatistiksel bakımdan anlamlı artış gösterdi. SONUÇ: Bu çalışmanın sonuçları, apium graveolens bitkisinin etanolik ekstraktlarının uygulandığı LNCaP prostat kanser hücre hattında kaspaz-8 ve Apaf-1 düzeylerini artırarak antikanser ve apoptotik özelliğe sahip olduğunu göstermektedir. Bulgularımızı desteklemek için daha ileri in-vitro ve in-vivo çalışmalara ihtiyaç vardır.
Anahtar Kelimeler Prostat Kanseri, Kaspazlar, Bitki Ekstreleri, Hücre kültürü
Destekleyen Kurum Afyon Kocatepe Üniversitesi Bilimsel Araştırma Projeleri Koordinatörlüğü
Proje Numarası 16.KARİYER.188
Kaynakça 1. Wei GJ, Chao YH, Tung YC, et al. tangeretin derivative inhibits the growth of human prostate cancer LNCaP cells by epigenetically restoring p21 gene expression and inhibiting cancer stem-like cell proliferation. The AAPS Journal. 2023;25(4):59. 2. Sekhoacha M, Riet K, Motloung P, et al. Prostate cancer review: Genetics, diagnosis, treatment options, and alternative approaches. Molecules. 2022;27(17):5730. 3. Dasari S, Samy ALPA, Narvekar P, et al. Polygodial analog induces apoptosis in LNCaP prostate cancer cells. European Journal of Pharmacology. 2018;828:154-62. 4. Al Aboody MS. Cytotoxic, antioxidant, and antimicrobial activities of Celery (Apium graveolens L.). Bioinformation. 2021;17(1):147. 5. Jeong SH, Kim HH, Park MY, et al. Flavones: The Apoptosis in Prostate Cancer of Three Flavones Selected as Therapeutic Candidate Models. International Journal of Molecular Sciences. 2023;24(11):9240. 6. Khairullah AR, Solikhah TI, Ansori ANM, et al. Review on the Pharmacological and Health Aspects of Apium Graveolens or Celery: An Update. Systematic Reviews in Pharmacy. 2021;12(1):606-12. 7. Singhal B, Pandey P, Khan F, et al. In vitro elucidation of antiproliferative and apoptotic effects of thymol against prostate cancer LNCaP cells. Biointerface Research in Applied Chemistry. 2022;12(1):1279-89. 8. Köken T, Koca B, Özkurt M, et al. Apium graveolens extract inhibits cell proliferation and expression of vascular endothelial growth factor and induces apoptosis in the human prostatic carcinoma cell line LNCaP. Journal of Medicinal Food. 2016;19(12):1166-71. 9. Asati V. Perspectives of anti-cancer phytoconstituents in pharmacotherapy. Int. J. Med. Pharm. Sci. 2022;12:1. 10. Khan T, Ali M, Khan A, et al. Anticancer plants: A review of the active phytochemicals, applications in animal models, and regulatory aspects. Biomolecules. 2019;10(1):47. 11. Zielinski RR, Eigl BJ, Chi KN. Targeting the apoptosis pathway in prostate cancer. The Cancer Journal. 2013;19(1):79-89. 12. Boice A, Bouchier-Hayes L. Targeting apoptotic caspases in cancer. Biochimica et Biophysica Acta (BBA)- Molecular Cell Research. 2020;1867(6):118688. 13. Ahmedy O. Study of the anticancer potential of celery seed oil against chemically induced hepatocellular carcinoma in rats: a mechanistic approach. Al-azhar Journal of Pharmaceutical Sciences. 2016;53(1):14-28. 14. Becit-Kizilkaya M, Oncu S, Sen S, Celik S. Berberine synergizes with cisplatin via inducing apoptosis on A549 non-small cell lung cancer cells. European Journal of Therapeutics.2023; 29(3):488-496. 15. Oncu S, Becit-Kizilkaya M, Sen S, Ugur-Kaplan AB, Cetin M, Celik S. Daidzein nanosuspension in combination with cisplatin to enhance therapeutic efficacy against A549 non-small lung cancer cells: an in vitro evaluation. Naunyn Schmiedebergs Arch Pharmacol. 2023: 38159158. 16. Lyngdoh A, Baruah TJ, Sharan RN, Kma L. Inhibitory Potential of Apium graveolens L. Extract on Inflammation in Diethylnitrosamine-induced Hepatocellular Carcinoma in Mice. Pharmacognosy Magazine. 2023;09731296231170931. 17. Zhou M, Liu X, Li Z, et al. Caspase‐3 regulates the migration, invasion and metastasis of colon cancer cells. International Journal of Cancer. 2018;143(4):921-30. 18. Xia J, Zhang J, Wang L, et al. Non-apoptotic function of caspase-8 confers prostate cancer enzalutamide resistance via NF-κB activation. Cell Death & Disease. 2021;12(9):833. 19. Gopalakrishnan S, Ismail A. Aromatic monophenols from cinnamon bark act as proteasome inhibitors by upregulating ER stress, suppressing FoxM1 expression, and inducing apoptosis in prostate cancer cells. Phytotherapy Research. 2021;35(10):5781-94. 20. Kaur P, Dhandayuthapani S, Venkatesan T, et al. Molecular mechanism of C-phycocyanin induced apoptosis in LNCaP cells. Bioorganic & Medicinal Chemistry. 2020;28(3):115272. 21. Zhang K, Liu X, Samuel Ravi SOA, et al. Synthesis of silver nanoparticles (AgNPs) from leaf extract of Salvia miltiorrhiza and its anticancer potential in human prostate cancer LNCaP cell lines. Artificial Cells, Nanomedicine, and Biotechnology. 2019;47(1):2846-54. 22. Safavi M, Shakeri R, Ardestani SK, et al. Caspase-dependent apoptosis induced by two synthetic halogenated flavanones, 3', 7-dichloroflavanone and 3', 6-dichloroflavanone, on human breast and prostate cancer cells. In Vitro Cellular & Developmental Biology-Animal. 2018;54:136-46. 23. Javid H, Ahmadi S, Mohamadian E. Therapeutic applications of apigenin and its derivatives: micro and nano aspects. Micro Nano Bio Aspects. 2023;2(1):30-8. 24. Yadav N, Gogada R, O'Malley J, et al. Molecular insights on cytochrome c and nucleotide regulation of apoptosome function and its implication in cancer. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 2020;1867(1):118573. 25. Mu D, Zhou G, Li J, et al. Ursolic acid activates the apoptosis of prostate cancer via ROCK/PTEN mediated mitochondrial translocation of cofilin-1. Oncology Letters. 2018;15(3):3202-6. 26. Avrutsky MI, Troy CM. Caspase-9: a multimodal therapeutic target with diverse cellular expression in human disease. Frontiers in Pharmacology. 2021;12:701301.
EFFECT OF APIUM GRAVEOLENS EXTRACTS ON CASPASE-3, -8, -9 AND APAF-1 IN LNCaP CELLS Yıl 2024, Cilt: 25 Sayı: 3, 300 – 306, 18.07.2024
Halit Buğra Koca , Tülay Köken , Tülay Akan
https://doi.org/10.18229/kocatepetip.1340255
Öz OBJECTIVE: In this study it was aimed to investigate the anti-cancer effect of ethanolic extracts of apium graveolens (celery) plant on cell viability, caspases involved in apoptosis and apoptosis protease activation factor-1 (Apaf-1) as inducer/suppressor in prostate cancer cell line LNCaP cells. MATERIAL AND METHODS: LNCaP cell line was used in our study. LNCaP cells were divided into 4 groups treated with ethanolic extracts of apium graveolens at increasing concentrations ranging from 0, 1500, 2000, 2500 μg/mL. The indicated extract concentrations were applied to LNCaP cells separately for 24 and 48 hours. Caspase-3, -8, -9 and Apaf-1 were measured by ELISA method from the cell lysate prepared at the end of the treatment. The results were expressed as ng/ml in proportion to the number of viable cells. RESULTS: Treatment of LNCaP prostate cancer cells with apium graveolens extracts for 24 and 48 hours did not cause a significant difference in caspase-3 and caspase-9 levels. However, caspase-8 levels were significantly increased at 2000 and 2500 μg/ml extract concentrations and Apaf-1 levels were significantly increased at 2500 μg/ml extract concentration in a dose- and time-dependent manner compared to the control groups at 24 and 48 hours. CONCLUSIONS: The results of this study show that ethanolic extracts of apium graveolens plant have anticancer and apoptotic properties by increasing caspase-8 and Apaf-1 levels in LNCaP prostate cancer cell line. Further in-vitro and in-vivo studies are needed to support our findings.
Anahtar Kelimeler Prostate Cancer, Caspases, Plant extracts, Cell culture
Proje Numarası 16.KARİYER.188
Kaynakça 1. Wei GJ, Chao YH, Tung YC, et al. tangeretin derivative inhibits the growth of human prostate cancer LNCaP cells by epigenetically restoring p21 gene expression and inhibiting cancer stem-like cell proliferation. The AAPS Journal. 2023;25(4):59. 2. Sekhoacha M, Riet K, Motloung P, et al. Prostate cancer review: Genetics, diagnosis, treatment options, and alternative approaches. Molecules. 2022;27(17):5730. 3. Dasari S, Samy ALPA, Narvekar P, et al. Polygodial analog induces apoptosis in LNCaP prostate cancer cells. European Journal of Pharmacology. 2018;828:154-62. 4. Al Aboody MS. Cytotoxic, antioxidant, and antimicrobial activities of Celery (Apium graveolens L.). Bioinformation. 2021;17(1):147. 5. Jeong SH, Kim HH, Park MY, et al. Flavones: The Apoptosis in Prostate Cancer of Three Flavones Selected as Therapeutic Candidate Models. International Journal of Molecular Sciences. 2023;24(11):9240. 6. Khairullah AR, Solikhah TI, Ansori ANM, et al. Review on the Pharmacological and Health Aspects of Apium Graveolens or Celery: An Update. Systematic Reviews in Pharmacy. 2021;12(1):606-12. 7. Singhal B, Pandey P, Khan F, et al. In vitro elucidation of antiproliferative and apoptotic effects of thymol against prostate cancer LNCaP cells. Biointerface Research in Applied Chemistry. 2022;12(1):1279-89. 8. Köken T, Koca B, Özkurt M, et al. Apium graveolens extract inhibits cell proliferation and expression of vascular endothelial growth factor and induces apoptosis in the human prostatic carcinoma cell line LNCaP. Journal of Medicinal Food. 2016;19(12):1166-71. 9. Asati V. Perspectives of anti-cancer phytoconstituents in pharmacotherapy. Int. J. Med. Pharm. Sci. 2022;12:1. 10. Khan T, Ali M, Khan A, et al. Anticancer plants: A review of the active phytochemicals, applications in animal models, and regulatory aspects. Biomolecules. 2019;10(1):47. 11. Zielinski RR, Eigl BJ, Chi KN. Targeting the apoptosis pathway in prostate cancer. The Cancer Journal. 2013;19(1):79-89. 12. Boice A, Bouchier-Hayes L. Targeting apoptotic caspases in cancer. Biochimica et Biophysica Acta (BBA)- Molecular Cell Research. 2020;1867(6):118688. 13. Ahmedy O. Study of the anticancer potential of celery seed oil against chemically induced hepatocellular carcinoma in rats: a mechanistic approach. Al-azhar Journal of Pharmaceutical Sciences. 2016;53(1):14-28. 14. Becit-Kizilkaya M, Oncu S, Sen S, Celik S. Berberine synergizes with cisplatin via inducing apoptosis on A549 non-small cell lung cancer cells. European Journal of Therapeutics.2023; 29(3):488-496. 15. Oncu S, Becit-Kizilkaya M, Sen S, Ugur-Kaplan AB, Cetin M, Celik S. Daidzein nanosuspension in combination with cisplatin to enhance therapeutic efficacy against A549 non-small lung cancer cells: an in vitro evaluation. Naunyn Schmiedebergs Arch Pharmacol. 2023: 38159158. 16. Lyngdoh A, Baruah TJ, Sharan RN, Kma L. Inhibitory Potential of Apium graveolens L. Extract on Inflammation in Diethylnitrosamine-induced Hepatocellular Carcinoma in Mice. Pharmacognosy Magazine. 2023;09731296231170931. 17. Zhou M, Liu X, Li Z, et al. Caspase‐3 regulates the migration, invasion and metastasis of colon cancer cells. International Journal of Cancer. 2018;143(4):921-30. 18. Xia J, Zhang J, Wang L, et al. Non-apoptotic function of caspase-8 confers prostate cancer enzalutamide resistance via NF-κB activation. Cell Death & Disease. 2021;12(9):833. 19. Gopalakrishnan S, Ismail A. Aromatic monophenols from cinnamon bark act as proteasome inhibitors by upregulating ER stress, suppressing FoxM1 expression, and inducing apoptosis in prostate cancer cells. Phytotherapy Research. 2021;35(10):5781-94. 20. Kaur P, Dhandayuthapani S, Venkatesan T, et al. Molecular mechanism of C-phycocyanin induced apoptosis in LNCaP cells. Bioorganic & Medicinal Chemistry. 2020;28(3):115272. 21. Zhang K, Liu X, Samuel Ravi SOA, et al. Synthesis of silver nanoparticles (AgNPs) from leaf extract of Salvia miltiorrhiza and its anticancer potential in human prostate cancer LNCaP cell lines. Artificial Cells, Nanomedicine, and Biotechnology. 2019;47(1):2846-54. 22. Safavi M, Shakeri R, Ardestani SK, et al. Caspase-dependent apoptosis induced by two synthetic halogenated flavanones, 3', 7-dichloroflavanone and 3', 6-dichloroflavanone, on human breast and prostate cancer cells. In Vitro Cellular & Developmental Biology-Animal. 2018;54:136-46. 23. Javid H, Ahmadi S, Mohamadian E. Therapeutic applications of apigenin and its derivatives: micro and nano aspects. Micro Nano Bio Aspects. 2023;2(1):30-8. 24. Yadav N, Gogada R, O'Malley J, et al. Molecular insights on cytochrome c and nucleotide regulation of apoptosome function and its implication in cancer. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 2020;1867(1):118573. 25. Mu D, Zhou G, Li J, et al. Ursolic acid activates the apoptosis of prostate cancer via ROCK/PTEN mediated mitochondrial translocation of cofilin-1. Oncology Letters. 2018;15(3):3202-6. 26. Avrutsky MI, Troy CM. Caspase-9: a multimodal therapeutic target with diverse cellular expression in human disease. Frontiers in Pharmacology. 2021;12:701301. Toplam 27 adet kaynakça vardır.
Ayrıntılar Birincil Dil Türkçe Konular Hücre Gelişimi, Proliferasyon ve Ölümü, Sinyal İletimi Bölüm Makaleler-Araştırma Yazıları Yazarlar Halit Buğra Koca AFYONKARAHİSAR SAĞLIK BİLİMLERİ ÜNİVERSİTESİ 0000-0002-5353-3228 Türkiye
Tülay Köken YÜKSEK İHTİSAS ÜNİVERSİTESİ, TIP FAKÜLTESİ 0000-0001-5510-9415 Türkiye
Tülay Akan YÜKSEK İHTİSAS ÜNİVERSİTESİ, TIP FAKÜLTESİ 0000-0002-6222-315X Türkiye
Proje Numarası 16.KARİYER.188 Yayımlanma Tarihi 18 Temmuz 2024 Kabul Tarihi 8 Kasım 2023 Yayımlandığı Sayı Yıl 2024 Cilt: 25 Sayı: 3
Kaynak Göster APA Koca, H. B., Köken, T., & Akan, T. (2024). APIUM GRAVEOLENS EKSTRAKTLARININ LNCaP HÜCRELERİNDE KASPAZ-3, -8, -9 ve APAF-1 ÜZERİNE ETKİSİ. Kocatepe Tıp Dergisi, 25(3), 300-306. https://doi.org/10.18229/kocatepetip.1340255 AMA Koca HB, Köken T, Akan T. APIUM GRAVEOLENS EKSTRAKTLARININ LNCaP HÜCRELERİNDE KASPAZ-3, -8, -9 ve APAF-1 ÜZERİNE ETKİSİ. KTD. Temmuz 2024;25(3):300-306. doi:10.18229/kocatepetip.1340255 Chicago Koca, Halit Buğra, Tülay Köken, ve Tülay Akan. “APIUM GRAVEOLENS EKSTRAKTLARININ LNCaP HÜCRELERİNDE KASPAZ-3, -8, -9 Ve APAF-1 ÜZERİNE ETKİSİ”. Kocatepe Tıp Dergisi 25, sy. 3 (Temmuz 2024): 300-306. https://doi.org/10.18229/kocatepetip.1340255. EndNote Koca HB, Köken T, Akan T (01 Temmuz 2024) APIUM GRAVEOLENS EKSTRAKTLARININ LNCaP HÜCRELERİNDE KASPAZ-3, -8, -9 ve APAF-1 ÜZERİNE ETKİSİ. Kocatepe Tıp Dergisi 25 3 300–306. IEEE H. B. Koca, T. Köken, ve T. Akan, “APIUM GRAVEOLENS EKSTRAKTLARININ LNCaP HÜCRELERİNDE KASPAZ-3, -8, -9 ve APAF-1 ÜZERİNE ETKİSİ”, KTD , c. 25, sy. 3, ss. 300–306, 2024, doi: 10.18229/kocatepetip.1340255. ISNAD Koca, Halit Buğra vd. “APIUM GRAVEOLENS EKSTRAKTLARININ LNCaP HÜCRELERİNDE KASPAZ-3, -8, -9 Ve APAF-1 ÜZERİNE ETKİSİ”. Kocatepe Tıp Dergisi 25/3 (Temmuz 2024), 300-306. https://doi.org/10.18229/kocatepetip.1340255. JAMA Koca HB, Köken T, Akan T. APIUM GRAVEOLENS EKSTRAKTLARININ LNCaP HÜCRELERİNDE KASPAZ-3, -8, -9 ve APAF-1 ÜZERİNE ETKİSİ. KTD . 2024;25:300–306. MLA Koca, Halit Buğra vd. “APIUM GRAVEOLENS EKSTRAKTLARININ LNCaP HÜCRELERİNDE KASPAZ-3, -8, -9 Ve APAF-1 ÜZERİNE ETKİSİ”. Kocatepe Tıp Dergisi, c. 25, sy. 3, 2024, ss. 300-6, doi:10.18229/kocatepetip.1340255. Vancouver Koca HB, Köken T, Akan T. APIUM GRAVEOLENS EKSTRAKTLARININ LNCaP HÜCRELERİNDE KASPAZ-3, -8, -9 ve APAF-1 ÜZERİNE ETKİSİ. KTD. 2024;25(3):300-6.
Download or read online: Click here