Secondary metabolites of Santolina africana: chemical profiles and assessment of biological activities

Yıl 2024, Cilt: 11 Sayı: 3, 472 – 485, 29.08.2024

https://doi.org/10.21448/ijsm.1353012

Öz

Chemicals and antibiotics are serious problems that cause the resistance of bacteria and the persistence of chemical residues in food. These chemical products affect human health and promote diseases. Therefore, the use of natural resources, especially plants, appears as an alternative to avoid the harmful impacts of such products. Plant active substances such as essential oils, alkaloids and phenols are of great interest to scientists and have been studied for their biological activities. Essential oils (Eos) from the stems of Santolina africana were extracted by hydrodistillation and analyzed by Gaz Chromatography/ Mass Spectrometry (GC-MS). The antioxidant activity of crude extracts and Eos was evaluated by the DPPH assay and the antibacterial activity was evaluated by the disc diffusion method and the broth microdilution method against Gram-positive strains (Bacillus subtilis, Staphylococcus aureus) and Gram-negative strains (Escherichia coli, Salmonella paratyphi, and Pseudomonas aeruginosa). S.africana Eos from Morocco and Tunisia were found to be rich in artemisia ketone (35.4% and 44.3%, respectively), santolina alcohol (16.2%and 3.2%, respectively) and isoborneol (6.1% and 26.6%, respectively). Methanol extracts were rich in phenolic and flavonoids contents and showed the highest DPPH radical scavenging activity. Results exhibited the sensitivity of the strains to essential oils from S. africana especially against Gram-positive bacteria. This current research will provide new information about this plant that can be used as a natural antioxidant and antibacterial for industrial purposes.

Anahtar Kelimeler

Ormenis africana, Essential oil, Crude extract, GC-MS, Biological activity

Kaynakça

  • Andrade, M.A., Braga, M.A., Cesar, P.H.S., Trento, M.V.C., Espósito, M.A., Silva, L.F., & Marcussi, S. (2018). Anticancer properties of essential oils: an overview. Current Cancer Drug Targets, 18(10), 957-966. https://doi.org/10.2174/1568009618666180102105843
  • Bajpai, V.K, Sharma, A., & Baek, K.H. (2013). Antibacterial mode of action of Cudrania tricuspidata fruit essential oil, affecting membrane permeability and surface characteristics of food borne pathogens. Food Control, 32(2), 582 590. https://doi.org/10.1016/j.foodcont.2013.01.032
  • Béjaoui, A., Boulila, A., Ben Salem, I., & Boussaid, M. (2017). Chemical composition and bioactivities of the polyphenolic-rich extract of Ormenis africana Jord. and Fourr. International Journal of Food Properties, 20(8), 1786 1795. https://doi.org/10.1080/10942912.2016.1219368
  • Béjaoui, A., Boulila, A., Mahouachi, I., & Boussaid, M. (2013). Metabolic profile of the bioactive compounds of Ormenis africana Jord. and Fourr (Asteraceae) an endemic species from Tunisia. International Journal of Advanced Research, 1(9), 124-131.
  • Bel Hadj Salah-Fatnassi, K., Hassayoun, F., Cheraif, I., Khan, S., Jannet, H.B., Hammami, M., Aouni, M., & Harzallah-Skhiri, F. (2017). Chemical composition, antibacterial and antifungal activities of flowerhead and root essential oils of Santolina chamaecyparissus L., growing wild in Tunisia. Saudi Journal of Biological Sciences, 24(4), 875-882. https://doi.org/10.1016/j.sjbs.2016.03.005
  • Ben Mansour, R., Gargouri, B., Bouaziz, M., Elloumi, N., Belhadj Jilani, I., Ghrabi, Z., & Lassoued, S. (2011). Antioxidant activity of ethanolic extract of inflorescence of Ormenis Africana in vitro and in cell cultures. Lipids in Health and Disease, 10(78). https://doi.org/10.1186/1476-511X-10-78
  • Bouaziz, M., Dhouib, H., Smaoui, S., Loukil, S., Boukhris, M., & Sayadi, S. (2009). Polyphenols, antioxidant and antimicrobial activities of some wild medicinal plants collected in southern Tunisia. African Journal of Biotechnology, 8(24), 7017-7027.
  • Boudjedjou, L., Ramdani, M., Zeraib, A., Benmeddour, T., & Fercha, A. (2019) .Chemical composition and biological activities of Algerian Santolina africana essential oil. Scientific African, 4. https://doi.org/10.1016/j.sciaf.2019.e00090
  • Ceylan, E., Fung, D.Y.C. (2004). Antimicrobial activity of spices. Journal of Rapid Methods and Automation in Microbiology, 12(155). https://doi.org/10.1111/j.1745 4581.2004.tb00046.x
  • Chang, C.C., Yang, M.H., Wen, H.M., & Chern, J.C. (2002). Estimation of total flavonoid content in propolis by two complementary colorimetric methods. Journal of Food Drug Analysis, 10, 178–182. https://doi.org/10.38212/2224-6614.2748
  • Chibani, S., Labed, A., Kabouche,A., Semra, Z., Smati, F., Aburjai, T., & Kabouche, Z. (2013) .Antibacterial activity and chemical composition of essential oil of Santolina rosmarinifolia L. (Asteraceae) from Algeria. Der Pharmacia Lettre, 5(3), 206–210.
  • Cox, S.D., Mann, C.M., Markham, J.L, Bell, H.C., Gustafson, J.E., Warmington, J.R., & Wyllie, S.G. (2000). The mode of antimicrobial action of the essential oil of Melaleuca alternifolia (tea tree oil). Journal of Applied Microbiology, 88(1), 170-175. https://doi.org.10.1046/j.1365-2672.2000.00943.x
  • Dai, J., & Mumper, R.J. (2010). Plant phenolics: extraction, analysis and their antioxidant and anticancer properties. Molecules (Basel, Switzerland), 15, 7313 7352. https://doi.org/10.3390/molecules15107313
  • Darwish, R.S., Hammoda, H.M., Ghareeb, D. A., Abdelhamid, A.S.A., Bellah El Naggar, E. M., Harraz, F.M., & Shawky, E. (2020). Efficacy-directed discrimination of the essential oils of three Juniperus species based on their in-vitro antimicrobial and anti-inflammatory activities. Journal of Ethnopharmacology, 259. https://doi.org/10.1016/j.jep.2020.112971
  • Dewanto, V., Wu, X., Adom, K.K., & Liu, R.H. (2002). Thermal Processing Enhances the Nutritional Value of Tomatoes by Increasing Total Antioxidant Activity. Journal of Agricultural and Food Chemistry, 50(10), 3010-3014. https://doi.org/10.1021/jf0115589
  • Díaz-Maroto, M.C., Pérez-Coello, M.S., Esteban, J., & Sanz, J. (2006). Comparison of the volatile composition of wild fennel samples (Foeniculum vulgare Mill.) from central Spain. Journal of Agricultural and Food Chemistry, 54(18), 6814-6818. https ://doi.org/ 10.1021/jf0609532
  • Dohoun, N., Yamni, K., Tahrouch, K., Idrissi hassani, L.M, Badoc, A., & Gmira, N. (2003). Screening phytochimique d’une endémique ibéro-marocaine, Thymelaea lythroides. Bulletin de la Société de Pharmacie Bordeaux, 142, 61-78.
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  • Javed, H., Meeran, M.F.N., Jha, N.K., & Ojha, S. (2021). Carvacrol, a Plant Metabolite Targeting Viral Protease (Mpro) and ACE2 in HostCells Can Be a Possible Candidate for COVID-19. Frontiers in Plant Science, 11. https://doi.org/10.3389/fpls.2020.601335
  • Karumi, Y., Onyeyili, PA., & Ogugbuaja, V.O. (2004). Identification of active principles of M.balsamina (Balsam Apple) leaf extract. Journal of Medical Science, 4(3), 179-182.
  • Khammassi, M., Ben Ayed, R., Khedhri, S., Souihi, M., Hanana, M., Amri, I., & Hamrouni, L. (2022). Crude extracts and essential oil of Platycladus orientalis (L.) Franco: a source of phenolics with antioxidant and antibacterial potential as assessed through achemometric approach. Turkish Journal of Agriculture Forestry, 46(4), 477 487. https://doi.org/10.55730/1300-011X.3019
  • Khammassi, M., Ben Ayed, R., Loupasaki, S., Amri, I., Hanana, M., Hamrouni, L., Jamoussi, B., & Khaldi, A. (2023). Chemical diversity of wild fennel essential oils (Foeniculum vulgare Mill.): A source of antimicrobial and antioxidant activities. South African Journal of Botany, 153, 136-146. https://doi.org/10.1016/j.sajb.2022.12.022
  • Khammassi, M., Ben Mansour, M., Laabidi, A., Amri, I., Boudkhili, M., Hamrouni, L., Greeche, H., Khaldi, A., & Jamoussi, B. (2018). Antifungal activity of essential oils and crude extracts of Santolina africana from Tunisia and Morocco. Journal of Material and Environmental Science, 9, 2963-2869.
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  • Khammassi, M., Mighri, H., Ben Mansour, M., Amri, I., Jamoussi, B., & Khaldi, A. (2022). Metabolite profiling and potential antioxidantactivity of sixteen fennel (Foeniculum vulgare Mill.) populations wild-growing in Tunisia. South African Journal of Botany, 148, 407- 414. https://doi.org/10.1016/j.sajb.2022.05.02122
  • Liu, K., Rossi, P.G., Ferrari, B., Berti, L., Casanova, J., & Tomi, F. (2007). Composition, irregular terpenoids, chemical variability and antibacterial activity of the essential oil from Santolina corsica Jordan et Fourr. Phytochemistry, 68(12), 1698 1705. https://doi.org/10.1016/j.phytochem.2007.04.027
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Secondary metabolites of Santolina africana: chemical profiles and assessment of biological activities

Yıl 2024, Cilt: 11 Sayı: 3, 472 – 485, 29.08.2024

https://doi.org/10.21448/ijsm.1353012

Öz

Chemicals and antibiotics are serious problems that cause the resistance of bacteria and the persistence of chemical residues in food. These chemical products affect human health and promote diseases. Therefore, the use of natural resources, especially plants, appears as an alternative to avoid the harmful impacts of such products. Plant active substances such as essential oils, alkaloids and phenols are of great interest to scientists and have been studied for their biological activities. Essential oils (Eos) from the stems of Santolina africana were extracted by hydrodistillation and analyzed by Gaz Chromatography/ Mass Spectrometry (GC-MS). The antioxidant activity of crude extracts and Eos was evaluated by the DPPH assay and the antibacterial activity was evaluated by the disc diffusion method and the broth microdilution method against Gram-positive strains (Bacillus subtilis, Staphylococcus aureus) and Gram-negative strains (Escherichia coli, Salmonella paratyphi, and Pseudomonas aeruginosa). S.africana Eos from Morocco and Tunisia were found to be rich in artemisia ketone (35.4% and 44.3%, respectively), santolina alcohol (16.2%and 3.2%, respectively) and isoborneol (6.1% and 26.6%, respectively). Methanol extracts were rich in phenolic and flavonoids contents and showed the highest DPPH radical scavenging activity. Results exhibited the sensitivity of the strains to essential oils from S. africana especially against Gram-positive bacteria. This current research will provide new information about this plant that can be used as a natural antioxidant and antibacterial for industrial purposes.

Anahtar Kelimeler

Ormenis africana, Essential oil, Crude extract, GC-MS, Biological activity

Kaynakça

  • Andrade, M.A., Braga, M.A., Cesar, P.H.S., Trento, M.V.C., Espósito, M.A., Silva, L.F., & Marcussi, S. (2018). Anticancer properties of essential oils: an overview. Current Cancer Drug Targets, 18(10), 957-966. https://doi.org/10.2174/1568009618666180102105843
  • Bajpai, V.K, Sharma, A., & Baek, K.H. (2013). Antibacterial mode of action of Cudrania tricuspidata fruit essential oil, affecting membrane permeability and surface characteristics of food borne pathogens. Food Control, 32(2), 582 590. https://doi.org/10.1016/j.foodcont.2013.01.032
  • Béjaoui, A., Boulila, A., Ben Salem, I., & Boussaid, M. (2017). Chemical composition and bioactivities of the polyphenolic-rich extract of Ormenis africana Jord. and Fourr. International Journal of Food Properties, 20(8), 1786 1795. https://doi.org/10.1080/10942912.2016.1219368
  • Béjaoui, A., Boulila, A., Mahouachi, I., & Boussaid, M. (2013). Metabolic profile of the bioactive compounds of Ormenis africana Jord. and Fourr (Asteraceae) an endemic species from Tunisia. International Journal of Advanced Research, 1(9), 124-131.
  • Bel Hadj Salah-Fatnassi, K., Hassayoun, F., Cheraif, I., Khan, S., Jannet, H.B., Hammami, M., Aouni, M., & Harzallah-Skhiri, F. (2017). Chemical composition, antibacterial and antifungal activities of flowerhead and root essential oils of Santolina chamaecyparissus L., growing wild in Tunisia. Saudi Journal of Biological Sciences, 24(4), 875-882. https://doi.org/10.1016/j.sjbs.2016.03.005
  • Ben Mansour, R., Gargouri, B., Bouaziz, M., Elloumi, N., Belhadj Jilani, I., Ghrabi, Z., & Lassoued, S. (2011). Antioxidant activity of ethanolic extract of inflorescence of Ormenis Africana in vitro and in cell cultures. Lipids in Health and Disease, 10(78). https://doi.org/10.1186/1476-511X-10-78
  • Bouaziz, M., Dhouib, H., Smaoui, S., Loukil, S., Boukhris, M., & Sayadi, S. (2009). Polyphenols, antioxidant and antimicrobial activities of some wild medicinal plants collected in southern Tunisia. African Journal of Biotechnology, 8(24), 7017-7027.
  • Boudjedjou, L., Ramdani, M., Zeraib, A., Benmeddour, T., & Fercha, A. (2019) .Chemical composition and biological activities of Algerian Santolina africana essential oil. Scientific African, 4. https://doi.org/10.1016/j.sciaf.2019.e00090
  • Ceylan, E., Fung, D.Y.C. (2004). Antimicrobial activity of spices. Journal of Rapid Methods and Automation in Microbiology, 12(155). https://doi.org/10.1111/j.1745 4581.2004.tb00046.x
  • Chang, C.C., Yang, M.H., Wen, H.M., & Chern, J.C. (2002). Estimation of total flavonoid content in propolis by two complementary colorimetric methods. Journal of Food Drug Analysis, 10, 178–182. https://doi.org/10.38212/2224-6614.2748
  • Chibani, S., Labed, A., Kabouche,A., Semra, Z., Smati, F., Aburjai, T., & Kabouche, Z. (2013) .Antibacterial activity and chemical composition of essential oil of Santolina rosmarinifolia L. (Asteraceae) from Algeria. Der Pharmacia Lettre, 5(3), 206–210.
  • Cox, S.D., Mann, C.M., Markham, J.L, Bell, H.C., Gustafson, J.E., Warmington, J.R., & Wyllie, S.G. (2000). The mode of antimicrobial action of the essential oil of Melaleuca alternifolia (tea tree oil). Journal of Applied Microbiology, 88(1), 170-175. https://doi.org.10.1046/j.1365-2672.2000.00943.x
  • Dai, J., & Mumper, R.J. (2010). Plant phenolics: extraction, analysis and their antioxidant and anticancer properties. Molecules (Basel, Switzerland), 15, 7313 7352. https://doi.org/10.3390/molecules15107313
  • Darwish, R.S., Hammoda, H.M., Ghareeb, D. A., Abdelhamid, A.S.A., Bellah El Naggar, E. M., Harraz, F.M., & Shawky, E. (2020). Efficacy-directed discrimination of the essential oils of three Juniperus species based on their in-vitro antimicrobial and anti-inflammatory activities. Journal of Ethnopharmacology, 259. https://doi.org/10.1016/j.jep.2020.112971
  • Dewanto, V., Wu, X., Adom, K.K., & Liu, R.H. (2002). Thermal Processing Enhances the Nutritional Value of Tomatoes by Increasing Total Antioxidant Activity. Journal of Agricultural and Food Chemistry, 50(10), 3010-3014. https://doi.org/10.1021/jf0115589
  • Díaz-Maroto, M.C., Pérez-Coello, M.S., Esteban, J., & Sanz, J. (2006). Comparison of the volatile composition of wild fennel samples (Foeniculum vulgare Mill.) from central Spain. Journal of Agricultural and Food Chemistry, 54(18), 6814-6818. https ://doi.org/ 10.1021/jf0609532
  • Dohoun, N., Yamni, K., Tahrouch, K., Idrissi hassani, L.M, Badoc, A., & Gmira, N. (2003). Screening phytochimique d’une endémique ibéro-marocaine, Thymelaea lythroides. Bulletin de la Société de Pharmacie Bordeaux, 142, 61-78.
  • European Directorate for the Quality of M (2008). Council of European pharmacopoeia, 6th edn Council of Europe; Stationery Office, Strasbourg, London.
  • Hatano, T., Edamatsu, R., & Mori, A. (1989) Effects of interaction of tannins with coexisting substances. Chemical and Pharmaceutical Bulletin, 38(8), 2016–2021.
  • Ismail, A.,Lamia, H., Mohsen, H., Bassem, J., & Kaouthar, L. (2014). Essential oils as biological alternatives to protect date palm (Phoenix dactylifera L.) against Ectomyelois ceratoniae Zeller (Lepi-doptera: Pyralidae). Chilean Journal of Agricultural Research, 74(3), 273–279. https://doi.org/10.4067/S0718-58392014000300004
  • Javed, H., Meeran, M.F.N., Jha, N.K., & Ojha, S. (2021). Carvacrol, a Plant Metabolite Targeting Viral Protease (Mpro) and ACE2 in HostCells Can Be a Possible Candidate for COVID-19. Frontiers in Plant Science, 11. https://doi.org/10.3389/fpls.2020.601335
  • Karumi, Y., Onyeyili, PA., & Ogugbuaja, V.O. (2004). Identification of active principles of M.balsamina (Balsam Apple) leaf extract. Journal of Medical Science, 4(3), 179-182.
  • Khammassi, M., Ben Ayed, R., Khedhri, S., Souihi, M., Hanana, M., Amri, I., & Hamrouni, L. (2022). Crude extracts and essential oil of Platycladus orientalis (L.) Franco: a source of phenolics with antioxidant and antibacterial potential as assessed through achemometric approach. Turkish Journal of Agriculture Forestry, 46(4), 477 487. https://doi.org/10.55730/1300-011X.3019
  • Khammassi, M., Ben Ayed, R., Loupasaki, S., Amri, I., Hanana, M., Hamrouni, L., Jamoussi, B., & Khaldi, A. (2023). Chemical diversity of wild fennel essential oils (Foeniculum vulgare Mill.): A source of antimicrobial and antioxidant activities. South African Journal of Botany, 153, 136-146. https://doi.org/10.1016/j.sajb.2022.12.022
  • Khammassi, M., Ben Mansour, M., Laabidi, A., Amri, I., Boudkhili, M., Hamrouni, L., Greeche, H., Khaldi, A., & Jamoussi, B. (2018). Antifungal activity of essential oils and crude extracts of Santolina africana from Tunisia and Morocco. Journal of Material and Environmental Science, 9, 2963-2869.
  • Khammassi, M., Kouki, H., Mighri, H. , Souihi, M., Kochti, O., Seçer, E. , Amri, I., Bassem, J., & Mabrouk, Y. (2023). Phytochemical screening of essential oils and methanol extract constituents of wild Foeniculum vulgare Mill.: a Potential natural source for bioactive molecules. Chemistry Africa, 6, 1227-1240. https://doi.org/10.1007/s42250-022-00571-6
  • Khammassi, M., Mighri, H., Ben Mansour, M., Amri, I., Jamoussi, B., & Khaldi, A. (2022). Metabolite profiling and potential antioxidantactivity of sixteen fennel (Foeniculum vulgare Mill.) populations wild-growing in Tunisia. South African Journal of Botany, 148, 407- 414. https://doi.org/10.1016/j.sajb.2022.05.02122
  • Liu, K., Rossi, P.G., Ferrari, B., Berti, L., Casanova, J., & Tomi, F. (2007). Composition, irregular terpenoids, chemical variability and antibacterial activity of the essential oil from Santolina corsica Jordan et Fourr. Phytochemistry, 68(12), 1698 1705. https://doi.org/10.1016/j.phytochem.2007.04.027
  • Lmachraa, I., Fdil, R., Fdil N, & Mouzdahir, A. (2014). Huile essentielle de Santolina africana (Jord. & Fourr.) du Maroc: Composition chimique et isolement des deux principaux constituants (Essential oil of Santolina africana (Jord. & Fourr.) of Morocco: Chemical composition and isolation of the two major constituents). Journal of Material and Environmental Science, 5, 67-72.
  • Malti, C.E.W., Baccati, C., Mariani., M., Hassani., F., Babali., B., Atik-Bekkara, F., Paoli, M., Maury, J., Tomi, F., & Bekhechi, C. (2019). Biological Activities and Chemical Composition of Santolina africana Jord. et Fourr. Aerial Part Essential Oil from Algeria: Occurrence of Polyacetylene Derivatives. Molecules, 24, 204. https://doi.org/10.3390/molecules24010204
  • Mau, J.L., Chao, G.R., & Wu, K.T. (2001). Antioxydant properties of methanolic extracts from several Ear mushrooms. Journal of Agricultural and Food Chemistry, 49, 5461-5467.
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  • Zaiter, L., Benayache, F., Beghidja, N., Figueredo, G., Chalard, P., Chalchat, J.C, Marchioni, E., & Benayache, S. (2015). Essential oils of Santolina africana Jord. & Fourr. and Santolina chamaecyparissus L. Journal of Essential Oil Bearing Plants, 18(6), 1338–1342. https://doi.org/10.1080/0972060X.2014.884769

Toplam 51 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Bitki Biyokimyası
BölümMakaleler
Yazarlar

Marwa Khammassi National Institute of Researches on Rural Engineering, Water and Forests 0000-0002-0759-4345 Tunisia

Sana Khedhri National Institute of Researches on Rural Engineering, Water and Forest 0000-0002-1986-8155 Tunisia

Awatef Slama National Institute of Researches on Rural Engineering, Water and Forests 0000-0002-2616-4746 Tunisia

Meriam Boudkhılı Sidi Mohamed Ben Abdellah University, Fez, Morocco 0009-0007-8478-6563 Tunisia

Ismail Amrı National Center for Nuclear Sciences and Technologies, BP 72, 2020 Sidi Thabet, Ariana, Tunisia 0000-0002-3748-0867 Tunisia

Lamia Hamrounı National Institut National Institute of Researches on Rural Engineering, Water and Forest 0000-0002-5577-7306 Tunisia

Bassem Jammoussı Faculty of Meteorology, Environment Arid Land Agriculture, King Abdulaziz University, Jeddah 21589, Saudi Arabia 0000-0003-4520-4202 Tunisia

Erken Görünüm Tarihi6 Ağustos 2024
Yayımlanma Tarihi29 Ağustos 2024
Gönderilme Tarihi31 Ağustos 2023
Yayımlandığı Sayı Yıl 2024 Cilt: 11 Sayı: 3

Kaynak Göster

APAKhammassi, M., Khedhri, S., Slama, A., Boudkhılı, M., vd. (2024). Secondary metabolites of Santolina africana: chemical profiles and assessment of biological activities. International Journal of Secondary Metabolite, 11(3), 472-485. https://doi.org/10.21448/ijsm.1353012

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