The Effects of Colloidal Silver Solution and Hypochlorous Acid on Wound Healing in the New Zealand Rabbit

Yıl 2024, Cilt: 17 Sayı: 2, 142 – 149, 30.06.2024

Harun Çınar

https://doi.org/10.30607/kvj.1403315

Öz

Bu çalışmanın amacı, kolloidal gümüş ve hipokloröz asit çözeltilerinin yara iyileşmesi üzerine etkilerinin araştırmak ve değerlendirmektir. Kolloidal gümüş çözeltisi ve hipokloröz asit solüsyonlarının yara iyileştirme aktivitesini değerlendirmek için Yeni Zelanda tavşanlarında (n = 21) in vivo ekzisyonel yara modeli uygulandı. Tavşanlar, her grupta yedi bireyden oluşacak şekilde rastgele 3 gruba ayrıldı. Grup 1 negatif kontrol olarak kullanıldı ve hiçbir tedavi uygulanmadı. Grup 2 ve 3 sırasıyla kristalin (hipokloröz asit) ve kolloidal gümüş ile tedavi edildi. Tedaviler yara bölgesine topikal olarak (sprey şeklinde), her tavşanın yara bölgesine günlük olarak uygulandı. Yara çapları 4, 8 ve 12. günlerde kumpas kullanılarak ölçülmüş ve tedavinin yine 4, 8 ve 12. günlerinde histopatolojik incelemeler yapılmıştır. Yara kapanması açısından, hem hipokloröz asit hem de kolloidal gümüş solüsyonları kontrol grubu ile karşılaştırılabilir yara iyileştirme aktivitesi göstermiştir. Sonuç olarak, hipokloröz asit ve kolloidal gümüş tavşanlarda dermal yara iyileşmesi üzerinde olumlu bir etki göstermektedir.

Anahtar Kelimeler

Tavşan, Hipokloröz asit, Kolloidal gümüş, Yara iyileşme

Kaynakça

  • Akhavan, O., & Ghaderi, E. (2009). Enhancement of antibacterial properties of Ag nanorods by electric field. Science and Technology of Advanced Materials. 10(1), 015003. Bibcode:2009STAdM..10a5003A. https://doi.org/10.1088/1468-6996/10/1/015003
  • Alexander J.W. (2009). History of the medical use of silver. Surgical Infections. 10 (3), 289-292. https://doi.org/10.1089/sur.2008.9941
  • Alonso, J., Lee, J., Burgess, A.R., & Browner, B.D. (1996). The management of complex orthopaedic injuries. Surg Clin North Am., 76: 879– 903. https://doi.org/10.1016/s0039-6109(05)70486-2
  • Attinger, C.E., Janis, J.E., Steinberg, J., Schwartz, J., Al-Attar, A., & Couch, K. (2006). Clinical approach to wounds: debridement and wound bed preparation including the use of dressings and woundhealing adjuvants. Plast Reconstr Surg., 117(7S), 72-109. https://doi.org/10.1097/01.prs.0000225470.42514.8f
  • Beattie, M. (2011). Can silver alloy catheters reduce infection rates? Nursing Times. 107 (29) 19–22.Schumm, K., & Lam, T.B.L. (2008). Types of urethral catheters for management of short-term voiding problems in hospitalized adults: a short version cochrane review. Neurourology and Urodynamics. 27 (8). https://doi.org/10.1002/14651858.cd004013.pub3
  • Broughton, G., Janis, J.E., & Attinger, C.E. (2006). The basic science of wound healing. Plast Reconstr Surg.117(7 SUPPL.). doi:10.1097/01.prs.0000225430.42531.c2
  • Colloidal Silver. (2011). https://www.mskcc.org/cancer-care/integrative-medicine/herbs/colloidal-silver.
  • Colloidal Silver. (2014). https://nccih.nih.gov/health/colloidalsilver. (Erişim Tarihi: Ekim 2016)
  • Deery, C. (2009). Silver lining for caries cloud? Evidence-Based Dentistry. 10 (3), 68. https://doi.org/10.1038/sj.ebd.6400661
  • Diegelmann, R.F., & Evans, M.C. (2004). Wound healing: an overview of acute, fibrotic and delayed healing. Front Biosci., 1: 283-289. https://doi.org/10.2741/1184
  • Fung, M.C., & Bowen, D.L. (1996). Silver products for medical ındications: risk-benefit assessment. Journal of Toxicology: Clinical Toxicology. 34: 119-126. https://doi.org/10.3109/15563659609020246
  • Gold, M.H., Andriessen, A., Bhatia, A.C., Bitter, P., Chilukuri, S., Cohen, J.L., & Robb, C.W. (2019). Topical stabilized hypochlorous acid: The future gold standard for wound care and scar management in dermatologic and plastic surgery procedures. J Cosmet Dermatol. 1-8. https://doi.org/10.1111/jocd.13280
  • Gurtner, G.C., Werner, S., Barrandon, Y., & Longaker, M.T. (2008). Wound repair and regeneration. Nature, 453(7193):314-21. https://doi.org/10.1038/nature07039
  • Gül Satar, N.Y., Cangül, I.T., Topal, A., Kurt, H., Ipek, V., & Onel, G.I. (2017). The effects of Tarantula cubensis venom on open wound healing in rats. J Wound Care: 26(2):66-71. doi:10.12968/jowc.2017.26.2.66
  • Güzel, S., Özay, Y., Kumaş, M., Uzun, C., Özkorkmaz, E.G., Yıldırım, Z., Ülger, M., Güler, G., Çelik, A., Çamlıca, Y., & Kahraman, A. (2018). Wound healing properties, antimicrobial and antioxidant activities of Salvia kronenburgii Rech. f. and Salvia euphratica Montbret, Aucher & Rech. f. var. euphratica on excision and incision wound models in diabetic rats. Biomed Pharmacother. 2019;111(September 2018):1260-1276. doi:10.1016/j.biopha.2019.01.038
  • Huang, L.P., Wang, G.Q., Jia, Z.S., Chen, J.W., Wang, G., & Wang, X.L (2015). Paclitaxel reduces formation of hypertrophic scars in the rabbit ear model. Ther Clin Risk Manag. 11:1089. doi:10.2147/TCRM.S82961 Jean-Yves, M., & Philippe, H. (2013). Silver as an antimicrobial: facts and gaps in knowledge. Critical Reviews in Microbiology. 39 (4): 373-383. https://doi.org/10.3109/1040841x.2012.713323
  • Kuwabara, M., Ishihara, M., Fukuda, K., Nakamura, S., Murakami, K., Sato, Y., Yokoe, H., & Kiyosawa, T. (2018). Disinfection of Pseudomonas aeruginosa-infected wounds in diabetic db/db mice by weakly acidic hypochlorous acid. Wound Medicine, 23, 1–5. https://doi.org/10.1016/j.wndm.2018.09.001
  • Kuwabara, M., Sato, Y., Ishihara, M., Takayama, T., Nakamura, S., Fukuda, K., Murakami K., Yokoe H., & Kiyosawa, T. (2020). Healing of Pseudomonas aeruginosa-infected wounds in diabetic db/db mice by weakly acidic hypochlorous acid cleansing and silver nanoparticle/chitin-nanofiber sheet covering. Wound Medicine, 100183 https://doi.org/10.1016/j.wndm.2020.100183.
  • Lancaster, T., & Stead, L.F. (2012). Silver acetate for smoking cessation. Cochrane Database of Systematic Reviews (9), 191. https://doi.org/10.1002/14651858.cd000191
  • Lansdown, A.B.G. (2006). Silver in health care: antimicrobial effects and safety in use. Biofunctional Textiles and the Skin. Current Problems in Dermatology. 33, 17-34. https://doi.org/10.1159/000093928 Lederer, J.W., Jarvis, W.R., Thomas, L., & Ritter, J. (2014). Multicenter cohort study to assess the impact of a silver-alloy and hydrogel-coatd urinary catheter on symptomatic catheter-associated urinary tract ınfections. Journal Of Wound, Ostomy And Continence Nursing. 41 (5): 473–480. https://doi.org/10.1097/won.0000000000000056
  • Masood, N., Ahmed, R., Tariq, M., Ahmed, Z., Masoud, M. S., Ali, I., Asghar, R., Andleeb, A., & Hasan, A. (2019).
  • Silver Nanoparticle Impregnated Chitosan-PEG Hydrogel Enhances Wound Healing in Diabetes induced Rabbits. International Journal of Pharmaceutics. https://doi.org/10.1016/j.ijpharm.2019.01.019
  • Medici, M., Peana, M., Crisponi G., Nurchi, N.V., Lachowicz, J.I., Remelli, M., & Zoroddu, M.Z.(2016). Silver coordination compounds: A new horizon in medicine. Coordination Chemistry Reviews. 327-359. https://doi.org/10.1016/j.ccr.2016.05.015
  • Mekkawy, M.M., & Kamal, A. (2014). A Randomized Clinical Trial: The Efficacy of Hypochlorous Acid on Septic Traumatic Wound. J Ed Prac.: 5(16); 89-100.
  • Pansara, C., Mishra, R., Mehta, T., Parikh, A., & Garg, S. (2020). Formulation of chitosan stabilized silver nanoparticle-containing wound healing film: In-vitro and in-vivo characterization. Journal of Pharmaceutical Sciences. https://doi.org/10.1016/j.xphs.2020.03.028
  • Robson, M.C., Steed, D.L., & Franz, M.G. (2001). Wound healing: biologic features and approaches to maximize healing trajectories. Curr Probl Surg., 38: 72-140. https://doi.org/10.1067/msg.2001.111167
  • Rosenblatt, A., Stamford, T.C.M., & Niederman, R. (2009). Silver diamine fluoride: a caries "silver-fluoride bullet. Journal of Dental Research. 88 (2): 116-125. https://doi.org/10.1177/0022034508329406.
  • Sakarya, S. (2019). İmmün sistemimizden gelen yeni nesil antimikrobiyal ve yara bakım ajanı: Hipokloröz asit. https://www.klimik.org.tr/wp-content/uploads/2018/05/5- %C4%B0mm%C3%BCn-sistemimizden-gelen-yeni-nesil-antimikrobiyal-ve-yara-bak%C4%B1m-ajan%C4%B1-Hipoklor%C3%B6z-asit-Serhan-Sakarya.pdf (Erişim tarihi: 12.01.2020).
  • Serenella, M., Massimiliano, P., Marina, N.V., & Antonietta, Z.M. (2019). Medical uses of silver: history, Myths, and Scientific Evidence J Med. Chem. 62 (13):5923-5943. doi:10.1021/acs.jmedchem.8b01439.
  • Spadaro, J.A., Berger, T.J., Barranco, S.D., Chapin, S.E., & Becker, R.O. (1974). Antibacterial effects of silver electrodes with weak direct current. Antimicrobial agents and chemotherapy. 6(5) 637-642. https://doi.org/10.1128/aac.6.5.637
  • Tsai, C.F., Chung, J.J., Ding, S.J., & Chen, C.C. (2023). In vitro cytotoxicity and antibacterial activity of hypochlorous acid antimicrobial agent. J Dent Sci. https://doi.org/10.1016/j.jds.2023.07.007
  • Valenta, C., & Auner, B.G. (2004). The use of polymers for dermal and transdermal delivery Eur J Pharm Biopharm., 58, 279-289. https://doi.org/10.1016/j.ejpb.2004.02.017
  • Wakshlak, R.B.K., Pedahzur, R., & Avnir, D. (2015). Antibacterial activity of silver-killed bacteria: The "zombies" effect. Scientific Reports. 5 9555. Bibcode:2015NatSR5E9555W. doi:10.1038/srep09555. PMC 5386105. PMID 25906433.

The Effects of Colloidal Silver Solution and Hypochlorous Acid on Wound Healing in the New Zealand Rabbit

Yıl 2024, Cilt: 17 Sayı: 2, 142 – 149, 30.06.2024

Harun Çınar

https://doi.org/10.30607/kvj.1403315

Öz

The aim of this study was to investigate and evaluate the effects of colloidal silver and hypochlorous acid solutions on wound healing. To evaluate the wound healing activity of colloidal silver solution and hypochlorous acid solutions, an in vivo excisional wound model was applied in New Zealand rabbits (n = 21). The rabbits were randomly divided into 3 groups with seven individuals in each group. Group 1 was used as a negative control and no treatment was applied. Groups 2 and 3 were treated with crystalline (hypochlorous acid) and colloidal silver, respectively. The treatments were applied topically (in the form of spray) to the wound area of each rabbit daily. Wound diameters were measured on days 4, 8 and 12 using calipers and histopathological examinations were performed on days 4, 8 and 12 of the treatment. In terms of wound closure, both hypochlorous acid and colloidal silver solutions showed comparable wound healing activity with the control group. In conclusion, hypochlorous acid and colloidal silver have a positive effect on dermal wound healing in rabbits.

Anahtar Kelimeler

Rabbit, Hypochlorous acid, Colloidal silver, Wound healing

Kaynakça

  • Akhavan, O., & Ghaderi, E. (2009). Enhancement of antibacterial properties of Ag nanorods by electric field. Science and Technology of Advanced Materials. 10(1), 015003. Bibcode:2009STAdM..10a5003A. https://doi.org/10.1088/1468-6996/10/1/015003
  • Alexander J.W. (2009). History of the medical use of silver. Surgical Infections. 10 (3), 289-292. https://doi.org/10.1089/sur.2008.9941
  • Alonso, J., Lee, J., Burgess, A.R., & Browner, B.D. (1996). The management of complex orthopaedic injuries. Surg Clin North Am., 76: 879– 903. https://doi.org/10.1016/s0039-6109(05)70486-2
  • Attinger, C.E., Janis, J.E., Steinberg, J., Schwartz, J., Al-Attar, A., & Couch, K. (2006). Clinical approach to wounds: debridement and wound bed preparation including the use of dressings and woundhealing adjuvants. Plast Reconstr Surg., 117(7S), 72-109. https://doi.org/10.1097/01.prs.0000225470.42514.8f
  • Beattie, M. (2011). Can silver alloy catheters reduce infection rates? Nursing Times. 107 (29) 19–22.Schumm, K., & Lam, T.B.L. (2008). Types of urethral catheters for management of short-term voiding problems in hospitalized adults: a short version cochrane review. Neurourology and Urodynamics. 27 (8). https://doi.org/10.1002/14651858.cd004013.pub3
  • Broughton, G., Janis, J.E., & Attinger, C.E. (2006). The basic science of wound healing. Plast Reconstr Surg.117(7 SUPPL.). doi:10.1097/01.prs.0000225430.42531.c2
  • Colloidal Silver. (2011). https://www.mskcc.org/cancer-care/integrative-medicine/herbs/colloidal-silver.
  • Colloidal Silver. (2014). https://nccih.nih.gov/health/colloidalsilver. (Erişim Tarihi: Ekim 2016)
  • Deery, C. (2009). Silver lining for caries cloud? Evidence-Based Dentistry. 10 (3), 68. https://doi.org/10.1038/sj.ebd.6400661
  • Diegelmann, R.F., & Evans, M.C. (2004). Wound healing: an overview of acute, fibrotic and delayed healing. Front Biosci., 1: 283-289. https://doi.org/10.2741/1184
  • Fung, M.C., & Bowen, D.L. (1996). Silver products for medical ındications: risk-benefit assessment. Journal of Toxicology: Clinical Toxicology. 34: 119-126. https://doi.org/10.3109/15563659609020246
  • Gold, M.H., Andriessen, A., Bhatia, A.C., Bitter, P., Chilukuri, S., Cohen, J.L., & Robb, C.W. (2019). Topical stabilized hypochlorous acid: The future gold standard for wound care and scar management in dermatologic and plastic surgery procedures. J Cosmet Dermatol. 1-8. https://doi.org/10.1111/jocd.13280
  • Gurtner, G.C., Werner, S., Barrandon, Y., & Longaker, M.T. (2008). Wound repair and regeneration. Nature, 453(7193):314-21. https://doi.org/10.1038/nature07039
  • Gül Satar, N.Y., Cangül, I.T., Topal, A., Kurt, H., Ipek, V., & Onel, G.I. (2017). The effects of Tarantula cubensis venom on open wound healing in rats. J Wound Care: 26(2):66-71. doi:10.12968/jowc.2017.26.2.66
  • Güzel, S., Özay, Y., Kumaş, M., Uzun, C., Özkorkmaz, E.G., Yıldırım, Z., Ülger, M., Güler, G., Çelik, A., Çamlıca, Y., & Kahraman, A. (2018). Wound healing properties, antimicrobial and antioxidant activities of Salvia kronenburgii Rech. f. and Salvia euphratica Montbret, Aucher & Rech. f. var. euphratica on excision and incision wound models in diabetic rats. Biomed Pharmacother. 2019;111(September 2018):1260-1276. doi:10.1016/j.biopha.2019.01.038
  • Huang, L.P., Wang, G.Q., Jia, Z.S., Chen, J.W., Wang, G., & Wang, X.L (2015). Paclitaxel reduces formation of hypertrophic scars in the rabbit ear model. Ther Clin Risk Manag. 11:1089. doi:10.2147/TCRM.S82961 Jean-Yves, M., & Philippe, H. (2013). Silver as an antimicrobial: facts and gaps in knowledge. Critical Reviews in Microbiology. 39 (4): 373-383. https://doi.org/10.3109/1040841x.2012.713323
  • Kuwabara, M., Ishihara, M., Fukuda, K., Nakamura, S., Murakami, K., Sato, Y., Yokoe, H., & Kiyosawa, T. (2018). Disinfection of Pseudomonas aeruginosa-infected wounds in diabetic db/db mice by weakly acidic hypochlorous acid. Wound Medicine, 23, 1–5. https://doi.org/10.1016/j.wndm.2018.09.001
  • Kuwabara, M., Sato, Y., Ishihara, M., Takayama, T., Nakamura, S., Fukuda, K., Murakami K., Yokoe H., & Kiyosawa, T. (2020). Healing of Pseudomonas aeruginosa-infected wounds in diabetic db/db mice by weakly acidic hypochlorous acid cleansing and silver nanoparticle/chitin-nanofiber sheet covering. Wound Medicine, 100183 https://doi.org/10.1016/j.wndm.2020.100183.
  • Lancaster, T., & Stead, L.F. (2012). Silver acetate for smoking cessation. Cochrane Database of Systematic Reviews (9), 191. https://doi.org/10.1002/14651858.cd000191
  • Lansdown, A.B.G. (2006). Silver in health care: antimicrobial effects and safety in use. Biofunctional Textiles and the Skin. Current Problems in Dermatology. 33, 17-34. https://doi.org/10.1159/000093928 Lederer, J.W., Jarvis, W.R., Thomas, L., & Ritter, J. (2014). Multicenter cohort study to assess the impact of a silver-alloy and hydrogel-coatd urinary catheter on symptomatic catheter-associated urinary tract ınfections. Journal Of Wound, Ostomy And Continence Nursing. 41 (5): 473–480. https://doi.org/10.1097/won.0000000000000056
  • Masood, N., Ahmed, R., Tariq, M., Ahmed, Z., Masoud, M. S., Ali, I., Asghar, R., Andleeb, A., & Hasan, A. (2019).
  • Silver Nanoparticle Impregnated Chitosan-PEG Hydrogel Enhances Wound Healing in Diabetes induced Rabbits. International Journal of Pharmaceutics. https://doi.org/10.1016/j.ijpharm.2019.01.019
  • Medici, M., Peana, M., Crisponi G., Nurchi, N.V., Lachowicz, J.I., Remelli, M., & Zoroddu, M.Z.(2016). Silver coordination compounds: A new horizon in medicine. Coordination Chemistry Reviews. 327-359. https://doi.org/10.1016/j.ccr.2016.05.015
  • Mekkawy, M.M., & Kamal, A. (2014). A Randomized Clinical Trial: The Efficacy of Hypochlorous Acid on Septic Traumatic Wound. J Ed Prac.: 5(16); 89-100.
  • Pansara, C., Mishra, R., Mehta, T., Parikh, A., & Garg, S. (2020). Formulation of chitosan stabilized silver nanoparticle-containing wound healing film: In-vitro and in-vivo characterization. Journal of Pharmaceutical Sciences. https://doi.org/10.1016/j.xphs.2020.03.028
  • Robson, M.C., Steed, D.L., & Franz, M.G. (2001). Wound healing: biologic features and approaches to maximize healing trajectories. Curr Probl Surg., 38: 72-140. https://doi.org/10.1067/msg.2001.111167
  • Rosenblatt, A., Stamford, T.C.M., & Niederman, R. (2009). Silver diamine fluoride: a caries "silver-fluoride bullet. Journal of Dental Research. 88 (2): 116-125. https://doi.org/10.1177/0022034508329406.
  • Sakarya, S. (2019). İmmün sistemimizden gelen yeni nesil antimikrobiyal ve yara bakım ajanı: Hipokloröz asit. https://www.klimik.org.tr/wp-content/uploads/2018/05/5- %C4%B0mm%C3%BCn-sistemimizden-gelen-yeni-nesil-antimikrobiyal-ve-yara-bak%C4%B1m-ajan%C4%B1-Hipoklor%C3%B6z-asit-Serhan-Sakarya.pdf (Erişim tarihi: 12.01.2020).
  • Serenella, M., Massimiliano, P., Marina, N.V., & Antonietta, Z.M. (2019). Medical uses of silver: history, Myths, and Scientific Evidence J Med. Chem. 62 (13):5923-5943. doi:10.1021/acs.jmedchem.8b01439.
  • Spadaro, J.A., Berger, T.J., Barranco, S.D., Chapin, S.E., & Becker, R.O. (1974). Antibacterial effects of silver electrodes with weak direct current. Antimicrobial agents and chemotherapy. 6(5) 637-642. https://doi.org/10.1128/aac.6.5.637
  • Tsai, C.F., Chung, J.J., Ding, S.J., & Chen, C.C. (2023). In vitro cytotoxicity and antibacterial activity of hypochlorous acid antimicrobial agent. J Dent Sci. https://doi.org/10.1016/j.jds.2023.07.007
  • Valenta, C., & Auner, B.G. (2004). The use of polymers for dermal and transdermal delivery Eur J Pharm Biopharm., 58, 279-289. https://doi.org/10.1016/j.ejpb.2004.02.017
  • Wakshlak, R.B.K., Pedahzur, R., & Avnir, D. (2015). Antibacterial activity of silver-killed bacteria: The "zombies" effect. Scientific Reports. 5 9555. Bibcode:2015NatSR5E9555W. doi:10.1038/srep09555. PMC 5386105. PMID 25906433.

Toplam 33 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Veteriner Cerrahi
BölümARAŞTIRMA MAKALESİ
Yazarlar

Harun Çınar MEHMET AKİF ERSOY ÜNİVERSİTESİ VETERİNER FAKÜLTESİ 0000-0003-4412-8949 Türkiye

Erken Görünüm Tarihi12 Haziran 2024
Yayımlanma Tarihi30 Haziran 2024
Gönderilme Tarihi12 Aralık 2023
Kabul Tarihi24 Mayıs 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 17 Sayı: 2

Kaynak Göster

APAÇınar, H. (2024). The Effects of Colloidal Silver Solution and Hypochlorous Acid on Wound Healing in the New Zealand Rabbit. Kocatepe Veterinary Journal, 17(2), 142-149. https://doi.org/10.30607/kvj.1403315
AMAÇınar H. The Effects of Colloidal Silver Solution and Hypochlorous Acid on Wound Healing in the New Zealand Rabbit. kvj. Haziran 2024;17(2):142-149. doi:10.30607/kvj.1403315
ChicagoÇınar, Harun. “The Effects of Colloidal Silver Solution and Hypochlorous Acid on Wound Healing in the New Zealand Rabbit”. Kocatepe Veterinary Journal 17, sy. 2 (Haziran 2024): 142-49. https://doi.org/10.30607/kvj.1403315.
EndNoteÇınar H (01 Haziran 2024) The Effects of Colloidal Silver Solution and Hypochlorous Acid on Wound Healing in the New Zealand Rabbit. Kocatepe Veterinary Journal 17 2 142–149.
IEEEH. Çınar, “The Effects of Colloidal Silver Solution and Hypochlorous Acid on Wound Healing in the New Zealand Rabbit”, kvj, c. 17, sy. 2, ss. 142–149, 2024, doi: 10.30607/kvj.1403315.
ISNADÇınar, Harun. “The Effects of Colloidal Silver Solution and Hypochlorous Acid on Wound Healing in the New Zealand Rabbit”. Kocatepe Veterinary Journal 17/2 (Haziran 2024), 142-149. https://doi.org/10.30607/kvj.1403315.
JAMAÇınar H. The Effects of Colloidal Silver Solution and Hypochlorous Acid on Wound Healing in the New Zealand Rabbit. kvj. 2024;17:142–149.
MLAÇınar, Harun. “The Effects of Colloidal Silver Solution and Hypochlorous Acid on Wound Healing in the New Zealand Rabbit”. Kocatepe Veterinary Journal, c. 17, sy. 2, 2024, ss. 142-9, doi:10.30607/kvj.1403315.
VancouverÇınar H. The Effects of Colloidal Silver Solution and Hypochlorous Acid on Wound Healing in the New Zealand Rabbit. kvj. 2024;17(2):142-9.

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